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DHX9 Gene

protein-coding   GIFtS: 53

GC01P154044
DEAH (Asp-Glu-Ala-His) box polypeptide 9
(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II; leukophysin) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: LKP, DDX9)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
DEAH (Asp-Glu-Ala-His) box polypeptide 91 2     NDHII2 5
DDX92 3 5     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA
helicase II; leukophysin)1
RHA1 2     leukophysin2
Nuclear DNA helicase II2 3     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 92
LKP2 3     ATP-dependent RNA helicase A2
DEAH box protein 92 3     NDH II3
NDH22 3     EC 3.6.4.133

External Ids:    HGNC: 27501   Entrez Gene: 16602   Ensembl: ENSG000001358297   UniProtKB: Q082113   

Export aliases for DHX9 gene to outside databases

Previous GC identifers: GC01P179328 GC01P180047 GC01P180029 GC01P179540 GC01P181075 GC01P182808


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX9:
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that
catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the
nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the
expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants.
Pseudogenes of this gene are found on chromosomes 11 and 13.

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may
subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator.
Component of the CRD-mediated complex that promotes MYC mRNA stability

Gene Wiki entry for DHX9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHX9 gene promoter:
         CREB   deltaCREB   p300   p53   Pax-6   E2F   E2F-1   E2F-2   E2F-3a   E2F-4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DHX9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DHX9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

DHX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX9 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154044:  view genomic region     (about GC identifiers)

Start:
154,044,114 bp from pter
End:
154,092,793 bp from pter
Size:
48,680 bases
Orientation:
plus strand

1 alternative location:
Chr1+ 182,808,504-182,856,886     
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase A  
Size: 1270 amino acids; 140958 Da
Subunit: Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP
and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1,
PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4,
DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL,
PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts
with IGF2BP1. Binds MBD2, HRMT1L2/PRMT1, and RELA. May act to directly link BRCA1, CREBBP or SMN1 and the RNA
polymerase II complex. Can also interact with XRCC5 and with TOP2A in an RNA dependent manner; these interactions may
be indirect. Interaction with TOP2A is promoted by UBC9. Interacts with histone H2AFX and this requires
phosphorylation of H2AFX on 'Ser-139'
Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs. Can shuttle between nucleus and cytoplasm
PDB structures from and Proteopedia :
3LLM (3D)    
Secondary accessions: B2RNV4 Q5VY62 Q6PD69 Q99556

Explore the universe of human proteins at neXtProt for DHX9: NX_Q08211 

Post-translational modifications:

  • Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization1
  • May be phosphorylated by PRKDC/XRCC7. Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001348.2  

    ENSEMBL proteins: 
    ENSP00000356520 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for DHX9 
    Novus Biologicals Protein for DHX9
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IDA17498979
    GO:0005654 nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IEA--
    About this table

    DHX9 for ontologies           About GeneDecksing



    Antibodies for DHX9: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DHX9
    Browse R&D Systems for Antibodies
    OriGene Antibodies: DHX9
    GenScript Custom Superior Antibodies Services for DHX9 
    Novus Biologicals Antibodies for DHX9
    Browse antibodies at Epitomics

    Assays for DHX9: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DHX9 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DHX9 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DHX9 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR007502 Helicase-assoc_dom
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR001159 Ds-RNA-bd
     IPR011709 DUF1605
     IPR002464 DNA/RNA_helicase_DEAH_CS

    Graphical View of Domain Structure for InterPro Entry Q08211

    ProtoNet protein and cluster: Q08211

    3 Blocks protein families:
    IPB001159 Double-stranded RNA binding (DsRBD) domain
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
    Domain: The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and
    sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
    Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may
    subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator.
    Component of the CRD-mediated complex that promotes MYC mRNA stability
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Enzyme Number (IUBMB): EC 3.6.4.13 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for DHX9
    Sigma-Aldrich shRNA Panels and shRNA for DHX9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): DHX9
    OriGene shRNA RFP (see all 3): DHX9
    OriGene basic RS shRNA (see all 3): DHX9
    OriGene siRNA (see all 3): DHX9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DHX9 
    miRNA:Sigma-Aldrich microRNA Mimics for DHX9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DHX9 
    1 SABiosciences Assays for microRNA that regulate DHX9:
    hsa-miR-34b

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DHX9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DHX9
    OriGene untagged cDNA clones in CMV expression vector: DHX9
    OriGene 3'-UTR clone: DHX9 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DHX9 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for DHX9 

    5/12 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding IEA--
    GO:0003724 RNA helicase activity TAS8690889
    GO:0003725 double-stranded RNA binding IEA--
    About this table

    DHX9 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dhx9):

    cellularembryogenesislethality-prenatal/perinatal

    DHX9 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for DHX9 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DHX9

    5/719 Interacting proteins for DHX9 (Q082111, 2) via UniProtKB, MINT, and/or STRING (see all 719)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU91, 2EBI-352022,EBI-398874 MINT-16997 MINT-16996
    LYARQ9NX581, 2EBI-352022,EBI-713507 MINT-6488590
    RELAQ042061, 2EBI-352022,EBI-73886 MINT-48949
    ARHGDIAP525651EBI-352022,EBI-712693
    CNBPP626331EBI-352022,EBI-1047529
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398 nuclear mRNA splicing, via spliceosome TAS--
    GO:0008380 RNA splicing EXP12226669
    GO:0010467 gene expression TAS--
    GO:0034605 cellular response to heat IEA--
    GO:0070934 CRD-mediated mRNA stabilization IMP19029303
    About this table

    DHX9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    DHX9 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHX9
    3 Novoseek chemical compound relationships for DHX9 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 25.4 3 15613478 (2), 14729462 (1)
    nacl 14.2 1 10198287 (1)
    atp 10.1 7 11416126 (2), 12851713 (1), 1718963 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for DHX9
    Sigma-Aldrich shRNA Panels and shRNA for DHX9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): DHX9
    OriGene shRNA RFP (see all 3): DHX9
    OriGene basic RS shRNA (see all 3): DHX9
    OriGene siRNA (see all 3): DHX9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DHX9 
    miRNA: Sigma-Aldrich microRNA Mimics for DHX9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DHX9 
    1 SABiosciences Assays for microRNA that regulate DHX9:
    hsa-miR-34b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DHX9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DHX9
    OriGene untagged cDNA clones in CMV expression vector: DHX9
    OriGene 3'-UTR Clone: DHX9 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DHX9 
    Primers: OriGene genome-wide validated SYBR primer pairs: DHX9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DHX9: PPH18261A

    REFSEQ mRNAs for DHX9 gene: 

    NM_001357.4  

    Additional cDNA sequence: 

    AB451248.1 AB451372.1 AF086352.1 AK130564.1 AK226102.1 AK308165.1 BC008773.1 BC014246.2 
    BC025245.1 BC032742.1 BC058896.1 BC071950.1 BC107881.1 BC137136.1 BC144494.1 L13848.1 
    U03643.1 Y10658.1 

    24/33 DOTS entries (see all 33):

    DT.100037728  DT.97857621  DT.101956398  DT.97780909  DT.100825185  DT.95152857  DT.92462616  DT.95152845 
    DT.100825188  DT.100875933  DT.95183937  DT.86859905  DT.91703276  DT.100825183  DT.452719  DT.99930132 
    DT.121373055  DT.219389  DT.92462587  DT.95152848  DT.100825182  DT.121373013  DT.121373032  DT.121373073 

    24/578 AceView cDNA sequences (see all 578):

    CN479031 CK000200 AI963268 AL121011 BE295797 BU194867 BC008773 AI752843 
    BC025245 BM458581 BE300538 N50352 AI097518 CA487486 BP365217 BU683291 
    BM797775 AA922290 BM016136 AA236277 BM809500 AA333187 AA379817 BC058896 

    highest scoring ESTs for DHX9:

    AA005154 AA028972 AA058949 AA059454 AA101836 AA158783 AA342461 AA384451 AA480634 AA528737 

    Unigene Cluster for DHX9:

    DEAH (Asp-Glu-Ala-His) box polypeptide 9
    Hs.191518  [show with all ESTs]
    Unigene Representative Sequence: NM_001357


    GeneLoc Exon Structure

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367549(uc001gpr.2 uc001gps.2 uc009wyd.2) ENST00000474446
    ENST00000490519 ENST00000477802 ENST00000473076 ENST00000485081(uc001gpt.2)
    ENST00000479271 ENST00000483416

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DHX9 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching DHX9 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    67983_g_at2, 3 U95-D 2 1.00 0.97 0.88 1.10 AA523305 0.60 1.00 0.82 1
    36153_at2, 3 U95-A 2 0.81 0.96 0.94 1.03 L13848 0.80 0.80 0.80 1
    662_at2, 3 U95-A 1 0.75 1.00 0.57 0.86 L13848 0.80 0.80 0.80 1
    202420_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001357 0.40 0.67 0.55 1
    212105_s_at2, 3 U133-A 2 1.00 0.95 -- -- BF313832 0.60 1.00 0.82 1
    212107_s_at2, 3 U133-A 2 1.00 0.91 -- -- BE561014 0.60 1.00 0.82 1
    202420_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212105_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    212107_s_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
    About this table

    DHX9 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DHX9 gene expression
    DHX9 gene electronic northern expression
    DHX9 gene sage expression
    About these images

    CGAP SAGE TAG: CTATGTGTTA

    SOURCE GeneReport for Unigene cluster: Hs.191518

    Expression variation in blood from EXPOLDB for DHX9

    Primers: OriGene genome-wide validated SYBR primer pairs: DHX9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DHX9: PPH18261A
        SABiosciences Custom PCR Arrays for DHX9 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for DHX9 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    DHX91   -- DEAH (Asp-Glu-Ala-His) box polypeptide 9 91.68(n)
    95.02(a)
    480032  XM_537154.2  XP_537154.2 
    cow
    (Bos taurus)
    DHX91   -- DEAH (Asp-Glu-Ala-His) box polypeptide 9 91.44(n)
    94.79(a)
    281115  NM_174036.2  NP_776461.1 
    rat
    (Rattus norvegicus)
    Dhx91   -- DEAH (Asp-Glu-Ala-His) box polypeptide 9 86.96(n)
    90.77(a)
    304859  XM_239780.4  XP_239780.4 
    mouse
    (Mus musculus)
    Dhx91 , 5 1 (65.37 cM)5
    DEAH (Asp-Glu-Ala-His) box polypeptide 91, 5 87.07(n)1
    90.68(a)1
    132111  NM_007842.11  NP_031868.11 
     AF0235305  AI3268425  (see all 24)
    zebrafish
    (Danio rerio)
    Dr.281932   -- Danio rerio cDNA clone IMAGE3819779 75.49(n)  BC058323.1 
    About this table        Species with no ortholog for DHX9

    ENSEMBL Gene Tree for DHX9 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DHX9 gene
    DHX292  DHX362  DHX302  TDRD92  DHX572  YTHDC22  

    DHX9 for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/400 NCBI SNPs in DHX9 are shown (see all 400)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs8601,2
    --182856740(+) TGATTT/GTGTTT 2 -- ut311Minor allele frequency- G:0.00MN 184
    rs8611,2
    --182856650(+) TATGTT/ATATTT 2 -- ut311Minor allele frequency- A:0.00MN 184
    rs8621,2
    F182856822(+) GCCTTA/TAAATA 2 -- ut311Minor allele frequency- T:0.48MN 184
    rs8631,2
    --182856797(+) TTTTTT/CCTTTA 2 -- ut31 trp31Minor allele frequency- C:0.00MN 184
    rs8641,2
    --182856744(+) TTTGTT/ATATAT 2 -- ut311Minor allele frequency- A:0.00MN 184
    rs8651,2
    F182856691(+) TTCTGT/GGGTTC 2 -- ut31 ese31Minor allele frequency- G:0.01MN 184
    rs8661,2
    --182856801(+) TTCTTT/AAAGGA 2 -- ut31 ese3 trp31Minor allele frequency- A:0.00MN 184
    rs113321,2
    C,F,182844020(+) ATGACC/TCACTT 4 T ref1 syn12Minor allele frequency- T:0.18MN EA 1544
    rs10492481,2
    H182835678(+) AGTCTA/GTACTT 4 I V ref1 mis15Minor allele frequency- G:0.00MN NS EA 590
    rs10492491,2
    H182835688(+) TCCTCG/TTCCTC 4 R L ref1 mis1 ese35Minor allele frequency- T:0.00MN NS EA 588
    About this table

    HapMap Linkage Disequilibrium images for DHX9 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DHX9
         1 Indel: 97579

    QIAGEN SeqTarget long-range PCR primers for resequencing DHX9 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DHX9 for disorders           About GeneDecksing

    OMIM: 603115

    4 Novoseek disease relationships for DHX9 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    werner syndrome 69.1 4 15995249 (2), 17498979 (1)
    tumors 0 2 10918303 (1), 14729462 (1)
    cancer 0 1 14769796 (1)
    immunodeficiency 0 1 16527808 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: DHX9 (1 document)

    Export disorders and mutations for DHX9 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/105 PubMed articles for DHX9 gene, integrated from 7 sources (see all 105):
    (articles sorted by number of sources associating them with DHX9)
    1. Domain structure of human nuclear DNA helicase II (RNA helicase A). (PubMed id 9111062)1, 2, 3, 7 Zhang S. and Grosse F. (1997)
    2. Human RNA helicase A is homologous to the maleless protein of Drosophila. (PubMed id 8344961)1, 2, 3 Lee C.-G. and Hurwitz J. (1993)
    3. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. (PubMed id 15613478)1, 2, 7 Mischo H.E.... Zhang S. (2005)
    4. Dual roles of RNA helicase A in CREB-dependent transcription. (PubMed id 11416126)1, 2, 7 Aratani S.... Nakajima T. (2001)
    5. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. (PubMed id 14704337)1, 2, 7 Zhang S.... Grosse F. (2004)
    6. RNA helicase A interacts with dsDNA and topoisomerase IIalpha. (PubMed id 12711669)1, 2, 7 Zhou K.... Lee C.-G. (2003)
    7. A functional interaction between the survival motor neuron complex and RNA polymerase II. (PubMed id 11149922)1, 2, 7 Pellizzoni L.... Dreyfuss G. (2001)
    8. Arginine methylation of RNA helicase a determines its subcellular localization. (PubMed id 15084609)1, 2, 7 Smith W.A.... David M. (2004)
    9. Antithetic effects of MBD2a on gene regulation. (PubMed id 12665568)1, 2, 7 Fujita H.... Nakajima T. (2003)
    10. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2 Weidensdorfer D....HA1ttelmaier S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1660 HGNC: 2750 AceView: DHX9 Ensembl:ENSG00000135829 euGenes: HUgn1660
    ECgene: DHX9 H-InvDB: DHX9

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for DHX9 gene:
    Search GeneIP for patents involving DHX9

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