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DICER1 Gene

protein-coding   GIFtS: 62

GC14M075736
dicer 1, ribonuclease type III
(Previous names: Dicer1, Dcr-1 homolog (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
dicer 1, ribonuclease type III1 2     DCR12
HERNA1 2 3 5     endoribonuclease Dicer2
KIAA09281 2 3 5     dicer 1, double-stranded RNA-specific endoribonuclease2
Dicer1 2     Dicer1, Dcr-1 homolog2
K12H4.8-LIKE1 2     helicase-moi2
Helicase with RNase motif2 3     DICER3
Helicase MOI2 3     EC 3.1.26.-3
Dicer1, Dcr-1 homolog (Drosophila)1     

External Ids:    HGNC: 170981   Entrez Gene: 234052   Ensembl: ENSG000001006977   UniProtKB: Q9UPY33   

Export aliases for DICER1 gene to outside databases

Previous GC identifers: GC14M093065 GC14M089372 GC14M093542 GC14M094622 GC14M095552


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DICER1:
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA
motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference
and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression.
Alternative splicing results in multiple transcript variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3
Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex
(RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and
TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs
and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may
subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs
(siRNAs) which target the selective destruction of complementary RNAs

Gene Wiki entry for DICER1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DICER1 gene promoter:
         AP-1   c-Fos   c-Jun   FOXO4   FOXF2   FOXO1a   RFX1   FOXO3a   FOXO3b   PPAR-gamma2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DICER1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DICER1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.2

DICER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DICER1 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M075736:  view genomic region     (about GC identifiers)

Start:
75,736,521 bp from pter
End:
75,807,615 bp from pter
Size:
71,095 bases
Orientation:
minus strand

1 alternative location:
Chr14- 95,552,566-95,623,759     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3 (See protein sequence)
Recommended Name: Endoribonuclease Dicer  
Size: 1922 amino acids; 218682 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (Probable)
Subunit: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed
of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9,
EIF2C1, PIWIL1 and PRKRA. Associates with the 60S ribosome
Subcellular location: Cytoplasm
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=CAB38857.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
PDB structures from and Proteopedia :
2EB1 (3D)    
Secondary accessions: A7E2D3 O95943 Q9UQ02

Explore the universe of human proteins at neXtProt for DICER1: NX_Q9UPY3 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001182502.1  NP_085124.2  NP_803187.1  


    ENSEMBL proteins: 
    ENSP00000376783 ENSP00000343745 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for DICER1 
    Novus Biologicals Protein for DICER1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005793 ER-Golgi intermediate compartment IEA--
    GO:0005829 cytosol TAS--
    GO:0016442 RNA-induced silencing complex IDA15973356
    About this table

    DICER1 for ontologies           About GeneDecksing



    Antibodies for DICER1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DICER1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DICER1  (Dicer)
    Browse OriGene Antibodies
    GenScript Superior Antibodies for DICER1 
    Novus Biologicals Antibodies for DICER1
    Browse antibodies at Epitomics

    Assays for DICER1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DICER1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DICER1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DICER1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR001159 Ds-RNA-bd
     IPR003100 PAZ
     IPR000999 RNase_III
     IPR014720 dsRNA-bd-like

    Graphical View of Domain Structure for InterPro Entry Q9UPY3

    ProtoNet protein and cluster: Q9UPY3

    4 Blocks protein families:
    IPB000999 Ribonuclease III family
    IPB001159 Double-stranded RNA binding (DsRBD) domain
    IPB003100 Argonaute and Dicer protein
    IPB005034 Protein of unknown function DUF283


    UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3
    Similarity: Belongs to the helicase family. Dicer subfamily
    Similarity: Contains 1 Dicer dsRNA-binding fold domain
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 2 RNase III domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3
    Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex
    (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and
    TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs
    and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may
    subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs
    (siRNAs) which target the selective destruction of complementary RNAs
    Enzyme Number (IUBMB): EC 3.1.26.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for DICER1
    Sigma-Aldrich shRNA Panels and shRNA for DICER1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): DICER1
    OriGene shRNA RFP (see all 2): DICER1
    OriGene basic RS shRNA (see all 2): DICER1
    OriGene siRNA (see all 2): DICER1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DICER1 
    miRNA:Sigma-Aldrich microRNA Mimics for DICER1
    Sigma-Aldrich microRNA target validation systems for DICER1 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DICER1 
    8/39 SABiosciences Assays for microRNAs that regulate DICER1 (see all 39):
    hsa-miR-607 hsa-miR-29a hsa-miR-301a hsa-miR-192 hsa-miR-548m hsa-miR-1184 hsa-miR-298 hsa-miR-186

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for DICER1 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): DICER1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): DICER1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): DICER1
    OriGene 3'-UTR clone (see all 2): DICER1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DICER1 
    Sino Biological Human cDNA Clone for DICER1

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for DICER1 

    5/13 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 13):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding ----
    GO:0003723 RNA binding ----
    GO:0003725 double-stranded RNA binding IDA12411504
    About this table

    DICER1 for ontologies           About GeneDecksing

    Animal Models: 15/22 MGI mutant phenotypes (inferred from 15 alleles(MGI details for Dicer1) (see all 22):

    behavior/neurologicalcardiovascular systemcellularembryogenesisendocrine/exocrine gland
    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
    lethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tailliver/biliary systemno phenotypic analysis

    DICER1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for DICER1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DICER1

    5/206 Interacting proteins for DICER1 (Q9UPY31, 2 ENSP000003437453) via UniProtKB, MINT, and/or STRING (see all 206)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TARBP2Q156331, 2, ENSP000002669873EBI-395506,EBI-978581 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 STRING: ENSP00000266987
    EIF2C1Q9UL181, 2, ENSP000003623003EBI-395506,EBI-527363 MINT-6488488 MINT-6488791 STRING: ENSP00000362300
    EIF2C2Q9UKV81, 2EBI-395506,EBI-528269 MINT-6489217 MINT-6489539
    PIWIL1Q96J941EBI-395506,EBI-527417
    EEF1A1P681042MINT-6489217 MINT-6489539 MINT-6488488 MINT-6488791
    About this table

    5/13 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 13):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525 angiogenesis IEA--
    GO:0006396 RNA processing IEA--
    GO:0019827 stem cell maintenance IEA--
    GO:0030324 lung development IEA--
    GO:0030326 embryonic limb morphogenesis ----
    About this table

    DICER1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DICER1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for DICER1
    Sigma-Aldrich shRNA Panels and shRNA for DICER1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): DICER1
    OriGene shRNA RFP (see all 2): DICER1
    OriGene basic RS shRNA (see all 2): DICER1
    OriGene siRNA (see all 2): DICER1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DICER1 
    miRNA: Sigma-Aldrich microRNA Mimics for DICER1
    Sigma-Aldrich microRNA target validation systems for DICER1 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DICER1 
    8/39 SABiosciences Assays for microRNAs that regulate DICER1 (see all 39):
    hsa-miR-607 hsa-miR-29a hsa-miR-301a hsa-miR-192 hsa-miR-548m hsa-miR-1184 hsa-miR-298 hsa-miR-186
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): DICER1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): DICER1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): DICER1
    OriGene 3'-UTR Clone (see all 2): DICER1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DICER1 
    Primers: OriGene genome-wide validated SYBR primer pairs: DICER1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DICER1: PPH10383A

    REFSEQ mRNAs for DICER1 gene (3 alternative transcripts): 

    NM_001195573.1  NM_030621.3  NM_177438.2  

    Additional cDNA sequence: 

    AB023145.2 AB028449.1 AF007142.1 AJ132261.2 AK001041.1 AK001827.1 AK002007.1 AK091094.1 
    AK091513.1 AL122105.1 AL832389.1 AY845867.1 AY845868.1 AY929254.1 AY929255.1 AY929256.1 
    BC046934.1 BC068591.1 BC150287.1 HM595745.1 

    14 DOTS entries:

    DT.317718  DT.95252847  DT.100816980  DT.97763171  DT.91823640  DT.95295120  DT.95266523  DT.95182023 
    DT.97823900  DT.100816977  DT.120779731  DT.120779673  DT.40293064  DT.99951130 

    24/320 AceView cDNA sequences (see all 320):

    BU507638 AA262488 BQ004539 BQ188480 AI886037 NM_030621 AA953139 BU689415 
    BF110900 BI712506 AA296802 BQ723760 AB023145 F03527 AI268132 AL707062 
    BM671458 AU119024 AW193662 BQ433107 AA743316 AI433026 AI249382 AU119116 

    highest scoring ESTs for DICER1:

    AB023145 AB028449 BC046934 BQ216141 AA044960 AA057340 AA069444 AA069472 AA091027 AA093761 

    Unigene Cluster for DICER1:

    Dicer 1, ribonuclease type III
    Hs.87889  [show with all ESTs]
    Unigene Representative Sequence: NM_177438


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DICER1 (see all 12)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                            -                                                                                                               
    SP2:              -     -     -     -     -     -                                                                                                               
    SP3:                                      -     -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32
    SP1:  -                                                                             -           -                 -         
    SP2:  -                                                                             -           -                 -         
    SP3:  -                                                                             -           -                 -         
    SP4:                                                  -                             -           -                 -         
    SP5:                                                                                                                        

    About this scheme

    ECgene alternative splicing isoforms for DICER1
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393063(uc001ydw.2 uc001yec.1) ENST00000343455(uc001ydy.1 uc010avh.1 uc001ydv.2 uc001ydx.2 uc001ydz.1 uc001yea.1 uc001yeb.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DICER1 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching DICER1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38764_at2, 3 U95-A 1 1.00 1.00 0.64 1.50 AF007142 0.60 1.00 0.82 1
    38765_at2, 3 U95-A 1 0.88 1.00 0.92 0.52 AB028449 0.80 1.00 0.91 1
    206061_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_030621 0.60 1.00 0.82 1
    212888_at2, 3 U133-A 1 0.82 1.00 -- -- BG109746 0.40 1.00 0.76 1
    213229_at2, 3 U133-A 1 0.73 1.00 -- -- BF590131 0.60 1.00 0.82 1
    216260_at2, 3 U133-A 1 0.55 1.00 -- -- AK001827 0.60 1.00 0.82 1
    206061_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212888_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    213229_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    216260_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    DICER1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DICER1 gene expression
    DICER1 gene electronic northern expression
    DICER1 gene sage expression
    About these images

    CGAP SAGE TAG: CTGCAGAAAT

    SOURCE GeneReport for Unigene cluster: Hs.87889

    Expression variation in blood from EXPOLDB for DICER1

    Primers: OriGene genome-wide validated SYBR primer pairs: DICER1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DICER1: PPH10383A
        SABiosciences Custom PCR Arrays for DICER1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for DICER1 gene from 5/14 species (see all 14)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    DICER11   -- dicer 1, ribonuclease type III 94.02(n)
    97.14(a)
    480426  XM_537547.2  XP_537547.2 
    chimpanzee
    (Pan troglodytes)
    DICER11   -- dicer 1, ribonuclease type III 99.79(n)
    99.9(a)
    453137  XM_001154199.1  XP_001154199.1 
    cow
    (Bos taurus)
    DICER11   -- dicer 1, ribonuclease type III 91.9(n)
    95.99(a)
    337871  NM_203359.1  NP_976235.1 
    rat
    (Rattus norvegicus)
    Dicer11   -- dicer 1, ribonuclease type III 89.67(n)
    93.74(a)
    299284  XM_001068155.1  XP_001068155.1 
    mouse
    (Mus musculus)
    Dicer11 , 5 12 (54.83 cM)5
    Dicer1, Dcr-1 homolog (Drosophila)1, 5 89.22(n)1
    93.28(a)1
    1921191  NM_148948.21  NP_683750.21 
     AB0814705  AF4308455  (see all 24)
    About this table        Species with no ortholog for DICER1

    ENSEMBL Gene Tree for DICER1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DICER1 gene
    IFIH12  DHX582  DDX582  

    DICER1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/549 NCBI SNPs in DICER1 are shown (see all 549)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs130781,2
    C,F,H,95556747(+) CACTAT/ACAACT 2 -- ut3113Minor allele frequency- A:0.08NS EA NA WA 594
    rs10061571,2
    C,F,O,95560625(+) AAAGGA/GTATCT 2 -- int18Minor allele frequency- G:0.03NS EA NA WA 562
    rs10570351,2
    C,F,O,95554142(+) ACACGC/TGCTCA 2 -- ut31 ese315Minor allele frequency- N:0.00MN NS EA NA 1240
    rs10636081,2
    --95556384(-) TAGTTG/AATAAG 2 -- ut311Minor allele frequency- A:0.00MN 184
    rs10636091,2
    --95556371(-) GAATAG/AAAAGA 2 -- ut31 ese31Minor allele frequency- A:0.00MN 184
    rs11876521,2
    C,F,H,95555205(+) TTCCAT/CGAAGC 2 -- ut31 ese311Minor allele frequency- C:0.01NS EA NA WA 428
    rs11876531,2
    C,95558582(+) CATAAT/CAGAAT 2 -- int19Minor allele frequency- C:0.00NS EA NA WA 420
    rs11876541,2
    C,F,95561248(+) GAATTA/TAGAAG 2 -- int15Minor allele frequency- T:0.05NS EA 504
    rs11876551,2
    C,F,O,A,H,95565556(+) TGAAGC/TGGCTG 2 -- int122Minor allele frequency- N:0.00MN NS EA NA WA 1494
    rs12099041,2
    C,F,O,A,H,95563712(+) TTACGC/TTTTTT 2 -- int1 trp327Minor allele frequency- T:0.17NS EA NA MN WA 2316
    About this table

    HapMap Linkage Disequilibrium images for DICER1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for DICER1
         7 CNVs: 76711 5766 87334 76712 76709 76713 76710

    QIAGEN SeqTarget long-range PCR primers for resequencing DICER1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DICER1 for disorders           About GeneDecksing

    OMIM: 606241   disorders: 601200  

    UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3

  • Defects in DICER1 are a cause of pleuropulmonary blastoma (PPB) [MIM:601200]. PPB is a rare pediatric tumor of
  • the lung that arises during fetal lung development and is often part of an inherited cancer syndrome. PPBs contain
    both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined
    with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst
    walls and form a dense 'cambium' layer beneath the epithelial lining. In a subset of patients, overgrowth of the
    mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis

    Human Gene Mutation Database (HGMD): DICER1
    Human Genome Epidemiology (HuGE) Navigator: DICER1 (8 documents)

    Export disorders and mutations for DICER1 gene to outside databases


    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/145 PubMed articles for DICER1 gene, integrated from 7 sources (see all 145):
    (articles sorted by number of sources associating them with DICER1)
    1. Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. (PubMed id 10786632)1, 2, 3 Matsuda S....Hamaguchi M. (2000)
    2. Interaction of 5-lipoxygenase with cellular proteins. (PubMed id 10051563)1, 2, 3 Provost P.... Radmark O. (1999)
    3. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. (PubMed id 14749716)1, 2, 7 Tahbaz N....Hobman T.C. (2004)
    4. The role of PACT in the RNA silencing pathway. (PubMed id 16424907)1, 2, 7 Lee Y.... Kim V.N. (2006)
    5. DICER1 mutations in familial pleuropulmonary blastoma . (PubMed id 19556464)1, 2, 7 Hill D.A....Goodfellow P.J. (2009)
    6. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. (PubMed id 19219043)1, 2 Melo S.A.... Esteller M. (2009)
    7. In vitro reconstitution of the human RISC-loading complex. (PubMed id 18178619)1, 2 MacRae I.J....Doudna J.A. (2008)
    8. Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. (PubMed id 17452327)1, 2 Kok K.H.... Jin D.-Y. (2007)
    9. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    10. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. (PubMed id 15973356)1, 2 Chendrimada T.P.... Shiekhattar R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23405 HGNC: 17098 AceView: DICER1 Ensembl:ENSG00000100697 euGenes: HUgn23405
    ECgene: DICER1 H-InvDB: DICER1

    (According to HUGE)
    About This Section
    HUGE: KIAA0928

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Protein Spotlighthttp://www.expasy.org/spotlight/back_issues/sptlt087.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for DICER1 gene:
    Search GeneIP for patents involving DICER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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