Aliases &
Descriptions
for DIP2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| DIP2 disco-interacting protein 2 homolog B (Drosophila)1 2 | | KIAA14631 2 3 5 | | disco-interacting protein 2 homolog B2 | | MGC1040052 | | DIP2 homolog B3 |
Export aliases for DIP2B gene to outside databasesPrevious GC identifers: GC12U900523 GC12P049187 GC12P050898 |
Summaries
for DIP2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DIP2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DIP2B gene promoter:
Arnt XBP-1 SREBP-1a SREBP-1c SREBP-1b Pax-2 Meis-1 MEF-2A YY1 SRY
Other transcription factors
Search SABiosciences Chromatin IP Primers for DIP2B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DIP2B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12DIP2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P047931: view genomic region
(about GC identifiers)
Start:
|
47,931,402 bp from pter |
End:
|
48,175,180 bp from pter |
Size:
|
243,779 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 50,898,768-51,142,450 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for DIP2B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DIP2B_HUMAN, Q9P265 (See
protein sequence)Recommended Name: Disco-interacting protein 2 homolog B Size: 1576 amino acids; 171492 Da
Sequence caution: Sequence=BAC05025.1; Type=Erroneous initiation;
Secondary accessions: Q6B011 Q8N1L5 Q8NB38Alternative splicing: 2 isoforms: Q9P265-1 Q9P265-2 Explore the universe of human proteins at neXtProt for DIP2B: NX_Q9P265
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_775873.2
ENSEMBL proteins: ENSP00000301180 ENSP00000404446
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
DIP2B for ontologies About GeneDecksing
Antibodies for DIP2B:
Assays for DIP2B: |
Protein
Domains/
Families
for DIP2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DIP2B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P265ProtoNet protein and cluster: Q9P265 1 Blocks protein family: IPB000873 AMP-binding signature
UniProtKB/Swiss-Prot: DIP2B_HUMAN, Q9P265Similarity: Belongs to the DIP2 family |
Gene Function
for DIP2B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
IEA | -- | | GO:0008134 | transcription factor binding |
IEA | -- |
About this table
DIP2B for ontologies About GeneDecksing
|
Pathways & Interactions
for DIP2B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for DIP2B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DIP2B
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
-- | -- |
About this table
DIP2B for ontologies About GeneDecksing
|
Drugs & Compounds
for DIP2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DIP2B
|
Transcripts
for DIP2B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DIP2B gene: NM_173602.2 Additional cDNA sequence: AB040896.2 AK091597.1 AK097369.1 AK126758.1 BC007671.2 BC030156.2 BC071796.1 BC075027.2 BX537905.1 9 DOTS entries: DT.453171 DT.100748733 DT.40241585 DT.113339 DT.75148856 DT.91707153 DT.91763204 DT.92022520 DT.91763201
 highest scoring ESTs for DIP2B:AW044580 AA005009 AA005057 AA028940 AA028941 AA057073 AA069478 AA069766 AA126141 AA216099 Unigene Cluster for DIP2B: DIP2 disco-interacting protein 2 homolog B (Drosophila) Hs.505516 [show with all ESTs]Unigene Representative Sequence: NM_173602
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for DIP2B
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DIP2B
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000301180(uc001rwv.2 uc009zlt.2) ENST00000455310(uc001rwu.2 uc009zls.1)
|
Expression
for DIP2B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DIP2B expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching DIP2B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 46842_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.94 |
0.79 |
AW044580 |
0.80 |
0.88 |
0.84 |
1 |
| 57097_at2, 3
|
U95-B |
1 |
0.50 |
1.00 |
0.94 |
1.19 |
AL042612 |
0.60 |
1.00 |
0.82 |
1 |
| 53338_at2, 3
|
U95-B |
1 |
0.44 |
1.00 |
-0.12 |
1.03 |
AA252762 |
0.40 |
1.00 |
0.76 |
1 |
| 1553271_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DIP2B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTACTTGTCC
SOURCE GeneReport for Unigene cluster: Hs.505516
UniProtKB/Swiss-Prot: DIP2B_HUMAN, Q9P265Tissue specificity: Moderately expressed in adult brain, placenta, skeletal muscle, heart, kidney, pancreas, lung,spleen and colon. Expression was weaker in adult liver, kidney, spleen, and ovary, and in fetal brain and liver. Inthe brain, it is expressed in the cerebral cortex; the frontal, parietal, occipital and temporal lobes; theparacentral gyrus; the pons; the corpus callosum and the hippocampus. Highest expression levels in the brain werefound in the cerebral cortex and the frontal and parietal lobes
SABiosciences Custom PCR Arrays for DIP2B
|
Orthologs
for DIP2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DIP2B gene from 5/8 species (see all 8)
About this table Species with no ortholog for DIP2B
ENSEMBL Gene Tree for DIP2B (if available) |
Paralogs
for DIP2B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DIP2B gene
- DIP2C2 DIP2A2
DIP2B for paralogs About GeneDecksing
|
Genomic Variants
for DIP2B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DIP2B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for DIP2B
5 CNVs: 66220 43397 86374 61241 76035 | | QIAGEN SeqTarget long-range PCR primers for resequencing DIP2B |
|
Disorders & Mutations
for DIP2B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DIP2B for disorders About GeneDecksing
OMIM: 611379 disorders: 136630 Human Gene Mutation Database (HGMD): DIP2B
Human Genome Epidemiology (HuGE) Navigator: DIP2B (1 document)
Export disorders and mutations for DIP2B gene to outside databases
|
Medical News
for DIP2B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DIP2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/14 PubMed articles for DIP2B gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with DIP2B)- CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. (PubMed id 17236128)1, 2 Winnepenninckx B.... Kooy R.F. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for DIP2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DIP2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DIP2B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DIP2B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DIP2B gene:
Search GeneIP for patents involving DIP2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DIP2B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for DIP2B |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for DIP2B |
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