Aliases &
Descriptions
for DLG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| discs, large homolog 1 (Drosophila)1 2 | | OTTHUMP000002080722 | | SAP-971 2 3 | | presynaptic protein SAP972 | | SAP971 2 3 | | DKFZp781B04262 | | dJ1061C18.1.11 2 | | OTTHUMP000001651992 | | DLGH11 2 | | OTTHUMP000002080712 | | hdlg1 2 | | OTTHUMP000002080762 | | Synapse-associated protein 972 3 | | discs large homolog 12 | | discs, large (Drosophila) homolog 11 | | OTTHUMP000001652132 | | DKFZp761P08182 | | disks large homolog 12 | | OTTHUMP000001652122 | | hDlg3 |
Export aliases for DLG1 gene to outside databasesPrevious GC identifers: GC03M192736 GC03M197118 GC03M198177 GC03M198097 GC03M198259 GC03M196769 |
Summaries
for DLG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Function: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels,receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherensjunction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates theexcitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator ofKv1.5 channel
Gene Wiki entry for DLG1 |
Genomic Views
for DLG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DLG1 gene promoter:
NF-kappaB NF-kappaB1 YY1 C/EBPalpha CHOP-10 POU3F2 (N-Oct-5a) POU3F2 POU3F2 (N-Oct-5b) Pax-2 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for DLG1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DLG1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29DLG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M194068: view genomic region
(about GC identifiers)
Start:
|
194,068,872 bp from pter |
End:
|
194,324,699 bp from pter |
Size:
|
255,828 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr3- 196,769,431-197,026,171 |
RefSeq DNA sequence:- NC_000003.11 NT_029928.13
|
Proteins
for DLG1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959 (See
protein sequence)Recommended Name: Disks large homolog 1 Size: 904 amino acids; 100455 Da
Subunit: Homotetramer (Probable). Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3,DLGAP4 and MAP1A. May interact with HTR2A (By similarity). Interacts with LRFN1 (By similarity). Interacts through itsPDZ domains with GRIN2A, KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, KCND2, KCND3, GRIA1, GPR124 and GPR125. Interacts withKCNF1. Interacts with CAMK2 (by similarity). Interacts with cytoskeleton-associated proteins EPB41 and EZR. Found in acomplex with KCNA5 and CAV3. Found in a complex with APC and CTNNB1. Interacts with CDH1 through binding to PIK3R1.Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12. Interacts through its guanylatekinase-like domain with KIF13B. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Mayinteract with TJAP1. Interacts with TOPK and the HTLV-1 viral Tax and HPV-18 E6 papillomavirus (HPV) oncoproteins.Interacts with PTEN (By similarity). Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4
Subcellular location: Membrane; Peripheral membrane protein (By similarity). Basolateral cell membrane (By similarity).Endoplasmic reticulum membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynapticdensity (By similarity). Cell junction, synapse. Cell membrane, sarcolemma. Note=Colocalizes with EPB41 at regions ofintercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes.Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity)
PDB structures from  and Proteopedia  :1PDR (3D)
2OQS (3D)
2X7Z (3D)
Secondary accessions: A5YKK7 B7ZMM0 B9EIQ5 Q12958Alternative splicing: 7 isoforms: Q12959-1 Q12959-2 Q12959-3 Q12959-4 Q12959-5 Q12959-6 Q12959-7 Explore the universe of human proteins at neXtProt for DLG1: NX_Q12959
Post-translational modifications:
Phosphorylation of Ser-232 regulates association with GRIN2A. Isoform 2 is phosphorylated on Ser-698. Isoform 3 isphosphorylated on Ser-665 (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001091894.1 NP_004078.2
ENSEMBL proteins: ENSP00000345731 ENSP00000393771 ENSP00000390403 ENSP00000400169 ENSP00000350303 ENSP00000371228 ENSP00000321087 ENSP00000407531 ENSP00000398939 ENSP00000413238 ENSP00000391732 ENSP00000396658 ENSP00000376187 ENSP00000411278 ENSP00000396768 ENSP00000376186 ENSP00000412579 ENSP00000396474 ENSP00000376185 ENSP00000398702 ENSP00000414189 ENSP00000352997
Human Recombinant Proteins
5/16 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 16): About this table
DLG1 for ontologies About GeneDecksing
Antibodies for DLG1:
Assays for DLG1: |
Protein
Domains/
Families
for DLG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DLG1 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q12959ProtoNet protein and cluster: Q12959 3 Blocks protein families: IPB001452 SH3 domain signature IPB001478 PDZ/DHR/GLGF domain IPB008144 Guanylate kinase
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Domain: The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 bindingsite mediating association to membranes in polarized and non-polarized cellsDomain: The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27domain that binds CASK and DLG2Domain: The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable ofbinding several SH3 domains and also moderates the level of protein oligomerizationSimilarity: Belongs to the MAGUK familySimilarity: Contains 1 guanylate kinase-like domainSimilarity: Contains 1 L27 domainSimilarity: Contains 3 PDZ (DHR) domainsSimilarity: Contains 1 SH3 domain |
Gene Function
for DLG1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Function: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels,receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherensjunction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates theexcitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator ofKv1.5 channel
Genatlas biochemistry entry for DLG1:Drosophila tumor suppressor gene,discs large (Dlg) homolog 1,involved in coupling the cytoskeleton to the cell membrane5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9): About this table
DLG1 for ontologies About GeneDecksing
Animal Models: 15/17 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Dlg1) (see all 17):
DLG1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DLG1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
DLG1 for pathways About GeneDecksing
2  Millipore Pathways for DLG1
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for DLG1
1  Kegg Pathway (Kegg details for DLG1):  | hsa04660 T cell receptor signaling pathway |
SABiosciences Custom Pathway-Focused PCR Arrays for DLG1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DLG1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLG1
5/44 Interacting proteins for DLG1 (ENSP000003457313 Q129591, 2) via UniProtKB, MINT, and/or STRING (see all 44)About this table
5/31 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 31): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001657 | ureteric bud development |
-- | -- | | GO:0001658 | branching involved in ureteric bud morphogenesis |
-- | -- | | GO:0001771 | immunological synapse formation |
-- | -- | | GO:0001935 | endothelial cell proliferation |
IDA | 14699157 | | GO:0002088 | lens development in camera-type eye |
-- | -- |
About this table
DLG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DLG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
DLG1 for compounds About GeneDecksing
 Browse Tocris compounds for DLG1
10/14  Novoseek chemical compound relationships for DLG1 gene (see all 14)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| guanylate |
85.6 |
41 |
9523702 (3), 8938729 (2), 9286858 (2), 11723125 (1) (see all 29) |
| nmda |
53.5 |
13 |
15929985 (2), 16957582 (1), 18233995 (1), 17156128 (1) (see all 10) |
| glutamate |
52.3 |
19 |
18665322 (3), 15044483 (2), 10939335 (1), 15657400 (1) (see all 13) |
| threonine |
33.9 |
5 |
10779557 (1), 14699157 (1), 9326658 (1), 10646847 (1) |
| valine |
22.4 |
1 |
9326658 (1) |
| kainate |
19.7 |
4 |
11279111 (3), 18665322 (1) |
| alanine |
18.5 |
2 |
17069616 (1), 16466689 (1) |
| phosphatidylinositol |
17.5 |
1 |
17314165 (1) |
| potassium |
14.9 |
8 |
15277200 (2), 11709425 (1), 9341123 (1), 18004877 (1) (see all 6) |
| leucine |
8.47 |
1 |
9326658 (1) |
About this table
|
Transcripts
for DLG1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DLG1 gene (2 alternative transcripts): NM_001098424.1 NM_004087.2 Additional cDNA sequence: AB209536.1 AK293967.1 AK294772.1 AK294855.1 AK304280.1 AK310596.1 AK310893.1 AK311129.1 AL831922.1 BC015560.2 BC028486.1 BC037916.1 BC042118.1 BC140841.1 BC144651.1 EF553524.1 U13896.1 U13897.1 21 DOTS entries: DT.100770590 DT.455821 DT.86846298 DT.100687155 DT.95376452 DT.40251208 DT.120905530 DT.306676 DT.40216836 DT.75134794 DT.92046140 DT.100704315 DT.40204665 DT.92434289 DT.100025509 DT.40293013 DT.65288186 DT.91862824 DT.91984033 DT.92051255 DT.92434290 24/228 AceView cDNA sequences (see all 228): BQ433661 AA442049 AA436612 AA287392 AW296142 AI203869 BF445872 AA825909 BX645639 AI864248 N41990 AI144496 AA283948 U13896 BG164149 BX480920 AI815004 AA252522 AI934918 AA868467 BM728664 BP357364 CB146301 AI016834
 highest scoring ESTs for DLG1:U13896 U13897 AA281170 AA480937 AF063561 AI110686 AL698274 AU127322 AU134840 AU135910 Unigene Cluster for DLG1: Discs, large homolog 1 (Drosophila) Hs.292549 [show with all ESTs]Unigene Representative Sequence: NM_004087
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DLG1 (see all 12)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DLG1
18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31): ENST00000346964(uc003fxn.3) ENST00000436682 ENST00000412364 ENST00000434148
ENST00000357674(uc011bue.1) ENST00000381807 ENST00000314062(uc011bud.1)
ENST00000469371 ENST00000419354 ENST00000452595(uc010ian.2) ENST00000422288
ENST00000448528 ENST00000443183 ENST00000392382 ENST00000450955 ENST00000475394
ENST00000470629 ENST00000419227(uc011buf.1)
|
Expression
for DLG1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DLG1 expression in normal and diseased human tissues
1 / 2 / 3 16 probe-sets matching DLG1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 40065_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.71 |
0.66 |
U13896 |
1.00 |
1.00 |
1.00 |
1 |
| 40246_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
0.74 |
0.93 |
U13897 |
1.00 |
1.00 |
1.00 |
1 |
| 73606_at*2, 3
|
U95-E |
1 |
0.31 |
1.00 |
0.77 |
0.75 |
AW022793 |
0.20 |
1.00 |
0.72 |
1 |
| 50699_at*2, 3
|
U95-C |
1 |
-- |
-- |
0.75 |
1.72 |
AA777604 |
0.20 |
1.00 |
0.72 |
1 |
| 202515_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
BG251175 |
0.40 |
1.00 |
0.76 |
1 |
| 217208_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 202516_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_004087 |
0.60 |
1.00 |
0.82 |
1 |
| 202514_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AW139131 |
0.20 |
1.00 |
0.72 |
1 |
| 215988_s_at2
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230229_at*2, 3
|
U133-B |
1 |
0.27 |
1.00 |
-- |
-- |
AI692879 |
0.40 |
1.00 |
0.76 |
1 |
| 202515_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217208_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 202516_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 202514_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215988_s_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230229_at*2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DLG1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.292549
Expression variation in blood from EXPOLDB for DLG1 UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Tissue specificity: Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts,cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expressionprofiles
SABiosciences Custom PCR Arrays for DLG1
|
Orthologs
for DLG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DLG1 gene from 5/12 species (see all 12)
About this table Species with no ortholog for DLG1
ENSEMBL Gene Tree for DLG1 (if available) |
Paralogs
for DLG1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DLG1 gene
- DLG32 DLG22 DLG42 GUK12
DLG1 for paralogs About GeneDecksing
|
Genomic Variants
for DLG1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DLG1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for DLG1
11 CNVs: 36126 9465 29732 3473 31141 0043 59130 98594 68562 98593 53339
2 Inversions: 37243 0568 | | QIAGEN SeqTarget long-range PCR primers for resequencing DLG1 |
|
Disorders & Mutations
for DLG1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DLG1 for disorders About GeneDecksing
OMIM: 601014
7 Novoseek disease relationships for DLG1 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: DLG1 (6 documents)
Export disorders and mutations for DLG1 gene to outside databases
|
Medical News
for DLG1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DLG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/205 PubMed articles for DLG1 gene, integrated from 7 sources (see all 205):
(articles sorted by number of sources associating them with DLG1)- Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. (PubMed id 7937897)1, 2, 3 Lue R.A.... Chishti A.H. (1994)
- Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. (PubMed id 19213956)1, 2, 7 El-Haou S.... Hatem S.N. (2009)
- Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. (PubMed id 15021905)1, 2, 7 Yamamoto Y.... Takai Y. (2004)
- Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. (PubMed id 14699157)1, 2, 7 Laprise P.... Rivard N. (2004)
- Protein 4.1-mediated membrane targeting of human discs large in epithelial cells. (PubMed id 12807908)1, 2, 7 Hanada T.... Chishti A.H. (2003)
- The distribution and function of alternatively spliced insertions in hDlg. (PubMed id 11723125)1, 2, 7 McLaughlin M.... Viel A. (2002)
- Characterization of PDZ-binding kinase, a mitotic kinase. (PubMed id 10779557)1, 2, 7 Gaudet S.... Lue R.A. (2000)
- Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain. (PubMed id 8922391)1, 2, 7 Lue R.A.... Branton D. (1996)
- GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PubMed id 10859302)1, 2, 7 Hanada T.... Chishti A.H. (2000)
- The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. (PubMed id 10656683)1, 2, 7 Ishidate T.... Akiyama T. (2000)
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External Searches for DLG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DLG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DLG1 gene
(According to HUGE)
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Specialized Databases showing DLG1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for DLG1 gene:
Search GeneIP for patents involving DLG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DLG1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
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