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DMTF1 Gene

protein-coding GIFtS: 55

GC07P081392

cyclin D binding myb-like transcription factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
cyclin D binding myb-like transcription factor 1¹ ²		FLJ76054²
DMP1¹ ² ³		cyclin-D-binding Myb-like transcription factor 1²
hDMP1¹ ² ³		cyclin D-binding Myb-like protein 1²
DMTF¹ ²		OTTHUMP00000205131²
Cyclin-D-interacting Myb-like protein 1² ³		FLJ41265²
hDMTF1² ³		FLJ25188²
OTTHUMP00000205282²

External Ids:	HGNC: 14603¹	Entrez Gene: 9988²	Ensembl: ENSG00000135164⁷	UniProtKB: Q9Y222³

Export aliases for DMTF1 gene to outside databases

Previous GC identifers: GC07P085317 GC07P086379 GC07P086393 GC07P086426 GC07P086620 GC07P086781

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DMTF1:

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and

two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic

Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53

pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may

play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by

binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and

is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222

Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby

promoting TP53/p53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By

similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize

transcriptional activation by isoform 1

Gene Wiki entry for DMTF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DMTF1 gene promoter:
         p53   Nkx6-1   Sox9   YY1   E47   Elk-1   Cdc5   FAC1   Lmo2   MEF-2A
         Other transcription factors

Search SABiosciences Chromatin IP Primers for DMTF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DMTF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21 Ensembl cytogenetic band: 7q21.12 HGNC cytogenetic band: 7q21

DMTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DMTF1 gene location

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P081392: view genomic region (about GC identifiers)

Start:	81,392,670 bp from pter
End:	81,436,634 bp from pter
Size:	43,965 bases
Orientation:	plus strand

1 alternative location:

Chr7+ 86,781,677-86,825,648

RefSeq DNA sequence:

NC_000007.13 NT_007933.15 NT_079595.2

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222 (See protein sequence)

Recommended Name: Cyclin-D-binding Myb-like transcription factor 1

Size: 760 amino acids; 84471 Da

Subunit: Interacts with the D-type cyclins CCND1, CCND2 and CCND3 (By similarity). Interaction with D-type cyclins may

modulate transcriptional activation by this protein (By similarity)

Subcellular location: Nucleus

Developmental stage: Isoform 2 expression is down-regulated during myeloid differentiation, while the expression of

isoform 1 and isoform 3 remain constant

Sequence caution: Sequence=BAD92467.1; Type=Erroneous translation; Note=Wrong choice of frame;

Secondary accessions: B2RBE1 Q05C48 Q59G79 Q6IS13 Q969T2 Q9H2Z2 Q9H2Z3

Alternative splicing: 4 isoforms: Q9Y222-1 Q9Y222-2 Q9Y222-3 Q9Y222-4

Explore the universe of human proteins at neXtProt for DMTF1: NX_Q9Y222

Post-translational modifications:

Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the

cyclin-D1/CDK4 complex (By similarity)¹

REFSEQ proteins (3 alternative transcripts):

NP_001135798.1 NP_001135799.1 NP_066968.3

ENSEMBL proteins:

ENSP00000410288 ENSP00000378193 ENSP00000401129 ENSP00000411706 ENSP00000393472 ENSP00000407941

ENSP00000406384 ENSP00000416307 ENSP00000415910 ENSP00000412532 ENSP00000397490 ENSP00000416499

ENSP00000332171 ENSP00000413118 ENSP00000378192 ENSP00000415382 ENSP00000412734 ENSP00000396570

ENSP00000411908 ENSP00000393370 ENSP00000411858 ENSP00000389774 ENSP00000387712 ENSP00000413722

ENSP00000402627

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for DMTF1
	Novus Biologicals Protein for DMTF1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	10095122
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

About this table

DMTF1 for ontologies About GeneDecksing

Antibodies for DMTF1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DMTF1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for DMTF1
	Novus Biologicals Antibodies for DMTF1
	Browse antibodies at Epitomics

Assays for DMTF1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DMTF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DMTF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DMTF1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR017877 MYB-like

IPR001005 SANT_DNA-bd

IPR009057 Homeodomain-like

IPR014778 Myb_DNA-bd

IPR012287 Homeodomain-rel

Graphical View of Domain Structure for InterPro Entry Q9Y222

ProtoNet protein and cluster: Q9Y222

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222

Similarity: Belongs to the DMTF1 family

Similarity: Contains 1 HTH myb-type DNA-binding domain

Similarity: Contains 2 Myb-like domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222

Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby

promoting TP53/p53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By

similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize

transcriptional activation by isoform 1

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for DMTF1 Sigma-Aldrich shRNA for DMTF1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): DMTF1 OriGene shRNA RFP (see all 6): DMTF1 OriGene basic RS shRNA (see all 6): DMTF1 OriGene siRNA (see all 5): DMTF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DMTF1

miRNA:		Sigma-Aldrich microRNA Mimics for DMTF1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DMTF1
		8/23 SABiosciences Assays for microRNAs that regulate DMTF1 (see all 23):
		hsa-miR-549 hsa-miR-520e hsa-miR-300 hsa-miR-1202 hsa-miR-15a hsa-miR-424 hsa-miR-548g hsa-miR-372

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): DMTF1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): DMTF1 OriGene untagged cDNA clones in CMV expression vector (see all 2): DMTF1 OriGene 3'-UTR clone (see all 3): DMTF1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for DMTF1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for DMTF1

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	10095122

About this table

DMTF1 for ontologies About GeneDecksing

Animal Models: 13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dmtf1):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	hematopoietic system
immune system	lethality-postnatal	life span-post-weaning/aging	nervous system	renal/urinary system
reproductive system	skin/coat/nails	tumorigenesis

DMTF1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for DMTF1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DMTF1

1 Interacting protein for DMTF1 (Q9Y222²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²	MINT-61915

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	10095122
GO:0007049	cell cycle	IEA	--

About this table

DMTF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DMTF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for DMTF1 Sigma-Aldrich shRNA for DMTF1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): DMTF1 OriGene shRNA RFP (see all 6): DMTF1 OriGene basic RS shRNA (see all 6): DMTF1 OriGene siRNA (see all 5): DMTF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DMTF1

miRNA:		Sigma-Aldrich microRNA Mimics for DMTF1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DMTF1
		8/23 SABiosciences Assays for microRNAs that regulate DMTF1 (see all 23):
		hsa-miR-549 hsa-miR-520e hsa-miR-300 hsa-miR-1202 hsa-miR-15a hsa-miR-424 hsa-miR-548g hsa-miR-372

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): DMTF1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): DMTF1 OriGene untagged cDNA clones in CMV expression vector (see all 2): DMTF1 OriGene 3'-UTR Clone (see all 3): DMTF1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for DMTF1

Primers:		OriGene genome-wide validated SYBR primer pairs: DMTF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for DMTF1: PPH11960A

REFSEQ mRNAs for DMTF1 gene (3 alternative transcripts):

NM_001142326.1 NM_001142327.1 NM_021145.3

Additional cDNA sequence:

AB209230.1 AF052102.1 AF084530.1 AF202144.1 AF202145.1 AK002073.1 AK057917.1 AK095828.1

AK123259.1 AK126664.1 AK295144.1 AK296211.1 AK314622.1 BC007418.2 BC007447.2 BC029370.1

BC070064.1

24/29 DOTS entries (see all 29):

DT.87015777 DT.87013858 DT.92438795 DT.436161 DT.92438790 DT.65284162 DT.95166826 DT.102843239

DT.407666 DT.100822911 DT.100822916 DT.40274110 DT.121059998 DT.102843241 DT.121060010 DT.121060067

DT.92405929 DT.100822910 DT.121059967 DT.121060054 DT.100822904 DT.121059994 DT.121060031 DT.407668

24/224 AceView cDNA sequences (see all 224):

AA405066 AW083059 CB269960 BX281436 BF057846 AW027430 BC007418 AF202144

AA251377 NM_021145 BE205814 AI538206 BX643599 BX102382 BQ224002 AA251625

CA950096 CA447940 AK123259 BI753203 AU138152 BX479606 BM722130 AF052102

highest scoring ESTs for DMTF1:

AF052102 AA026305 AA027139 AA047217 AA165286 AA165287 AA205698 AA205699 AA251377 AA340636

Unigene Cluster for DMTF1:

Cyclin D binding myb-like transcription factor 1

Hs.196129 [show with all ESTs]

Unigene Representative Sequence: AK126664

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for DMTF1 (see all 22)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13a	·
SP1:
SP2:							-		-		-		-		-		-		-						-
SP3:							-		-		-		-		-		-		-
SP4:							-						-		-		-		-						-
SP5:							-		-				-		-		-		-						-

ExUns:	13b	^	14	^	15	^	16a	·	16b	·	16c	^	17	^	18a	·	18b	·	18c	^	19a	·	19b	·	19c	^	20	^	21a	·	21b	·	21c	^	22	^	23a	·	23b	·	23c	^	24a	·	24b
SP1:							-		-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DMTF1
18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):

ENST00000454008 ENST00000394703 ENST00000480982 ENST00000446796 ENST00000456266

ENST00000424462(uc003uil.2) ENST00000412139(uc003uim.1 uc003uin.2)

ENST00000420131 ENST00000430405 ENST00000414194 ENST00000432937 ENST00000453049

ENST00000425705 ENST00000331242(uc003uih.2 uc011khb.1) ENST00000488352

ENST00000428819 ENST00000394702 ENST00000432366

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

DMTF1 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching DMTF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41808_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.25	AF052102	1.00	1.00	1.00	1
80303_at²^{, 3}	U95-E	1	0.94	1.00	0.92	0.75	AI609561	0.80	1.00	0.91	1
203301_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021145	0.60	1.00	0.82	1
203301_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

DMTF1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

DMTF1 gene electronic northern expression

About these images

CGAP SAGE TAG: ACCATTTATT

SOURCE GeneReport for Unigene cluster: Hs.196129

Expression variation in blood from EXPOLDB for DMTF1

UniProtKB/Swiss-Prot: DMTF1_HUMAN, Q9Y222

Tissue specificity: Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and

small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS

including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the

predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral

blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell

types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion,

strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs

in tumors which retain wild-type CDKN2A/ARF and TP53/p53 loci. Hemizygous gene deletion has also been observed in

leukemic blasts from patients with abnormalities of the long arm of chromosome 7

Primers:		OriGene genome-wide validated SYBR primer pairs: DMTF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for DMTF1: PPH11960A

SABiosciences Custom PCR Arrays for DMTF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DMTF1 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DMTF1¹	--	cyclin D binding myb-like transcription factor 1	94.6(n) 97.1(a)	475217 XM_854526.1 XP_859619.1
chimpanzee (Pan troglodytes)	DMTF1¹	--	cyclin D binding myb-like transcription factor 1	99.74(n) 99.74(a)	472434 XM_001162041.1 XP_001162041.1
cow (Bos taurus)	DMTF1¹	--	cyclin D binding myb-like transcription factor 1	93.72(n) 95.65(a)	539676 XM_864821.2 XP_869914.1
rat (Rattus norvegicus)	Dmtf1¹	--	cyclin D binding myb-like transcription factor 1	88.07(n) 89.13(a)	114485 NM_053693.1 NP_446145.1
mouse (Mus musculus)	Dmtf1^{1 , 5}	5 (3.69 cM)⁵	cyclin D binding myb-like transcription factor 1^{1, 5}	91.75(n)¹ 95(a)¹	23857¹ NM_011806.2¹ NP_035936.2¹ AA387375⁵ AI642025⁵ (see all 25)

About this table Species with no ortholog for DMTF1

ENSEMBL Gene Tree for DMTF1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DMTF1 gene

TTF1²

DMTF1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs16627^1,2	F	86788727(-)	`AAAATTCTC/- TCTAT`	3	--	int¹		4		EU NA EA	342
rs740303^1,2	--	86822762(+)	`ACAGTT/GCTTCC`	3	--	int¹		4		NA EA MN	436
rs765968^1,2	C,F,O,A,H,	86794724(+)	`TTTCAA/GTATGA`	3	--	int¹		19		NA EA WA	2389
rs973044^1,2	C,F,A,	86800180(+)	`tGTATG/ATATGT`	3	--	int¹		14		NS EA NA	1148
rs1058972^1,2	C,F,O,A,H,	86789426(-)	`GTAGAA/GTAGAA`	3	--	int¹		18		MN NS EA NA WA	1250
rs1139643^1,2	--	86822669(-)	`TCTGGC/GGATAA`	6	S	ref¹ syn¹		0	--	--	--	--
rs1139644^1,2	--	86822668(-)	`CTGGGG/TATAAA`	9	S	fra¹ ref¹		0	--	--	--	--
rs1139645^1,2	--	86822662(-)	`ATAAAA/GCATGA`	6	A V	ref¹ mis¹		0	--	--	--	--
rs1558049^1,2	H	86820284(+)	`CTACCG/ATTGAC`	6	/I /V	mis¹ ref¹ ese³		8		NA EA MN NS	842
rs1558050^1,2	C,F,O,A,H,	86820459(+)	`TGGTAA/GACTAA`	3	--	int¹		24		NS EA NA WA	1546

About this table

HapMap Linkage Disequilibrium images for DMTF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DMTF1
1 CNV: 0106

QIAGEN SeqTarget long-range PCR primers for resequencing DMTF1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DMTF1 for disorders About GeneDecksing

OMIM: 608491

1 Novoseek disease relationship for DMTF1 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	22.3	14	17237816 (3), 19816943 (3), 18598225 (2), 17546045 (1) (see all 7)

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Genetic Association Database (GAD): DMTF1
Human Genome Epidemiology (HuGE) Navigator: DMTF1 (2 documents)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/25 PubMed articles for DMTF1 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with DMTF1)

Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). (PubMed id 10095122)^{1, 2, 3, 7} Bodner S.M.... Look A.T. (1999)
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. (PubMed id 17936562)^{1, 2, 7} Mallakin A....Inoue K. (2007)
Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. (PubMed id 12917399)^{1, 2, 7} Tschan M.P.... Torbett B.E. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Single nucleotide polymorphisms in breast cancer. (PubMed id 15010895)^{1, 4} Forsti A....Kumar R. (2004)
Dmp1 and tumor suppression. (PubMed id 17237816)^{1, 7} Inoue K....Frazier D.P. (2007)
Role of DMP1 and its future in lung cancer diagnostics. (PubMed id 18598225)^{1, 7} Sugiyama T....Inoue K. (2008)
Meta-analysis of genome-wide association data of bipo lar disorder and major depressive disorder. (PubMed id 20351715)¹ Liu Y....Sullivan P.F. (2010)
Emerging roles of DMP1 in lung cancer. (PubMed id 18559489)¹ Inoue K....Frazier D.P. (2008)
The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. (PubMed id 17972942)¹ Tschan M.P....Tobler A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9988	HGNC: 14603	AceView: DMTF1	Ensembl:ENSG00000135164	euGenes: HUgn9988
ECgene: DMTF1	H-InvDB: DMTF1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for DMTF1	Genetics and Cytogenetics in Oncology and Haematology

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Patent Information for DMTF1 gene:
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