Aliases &
Descriptions
for DNAJB8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| DnaJ (Hsp40) homolog, subfamily B, member 81 2 | | MGC338841 2 | | OTTHUMP000002162442 | | DJ62 | | dnaJ homolog subfamily B member 82 | | DnaJ homolog, subfamily B, member 82 |
Export aliases for DNAJB8 gene to outside databasesPrevious GC identifers: GC03M129502 GC03M129663 GC03M128181 |
Summaries
for DNAJB8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DNAJB8:
DNAJB8 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperoneactivity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid Jdomain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 (PubMed 11147971)).(supplied by OMIM)
|
Genomic Views
for DNAJB8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJB8 gene promoter:
GATA-1 GATA-2 GATA-3 PPAR-gamma1 PPAR-gamma2 p300 HNF-4alpha2 COUP-TF1 RP58 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJB8
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.3DNAJB8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M125565: view genomic region
(about GC identifiers)
Start:
|
125,565,305 bp from pter |
End:
|
125,570,109 bp from pter |
Size:
|
4,805 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr3- 128,181,282-128,186,091 |
RefSeq DNA sequence:- NC_000003.11 NT_005612.16
|
Proteins
for DNAJB8 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DNJB8_HUMAN, Q8NHS0 (See
protein sequence)Recommended Name: DnaJ homolog subfamily B member 8 Size: 232 amino acids; 25686 Da
PDB structures from  and Proteopedia  :2DMX (3D)
Explore the universe of human proteins at neXtProt for DNAJB8: NX_Q8NHS0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_699161.1
ENSEMBL proteins: ENSP00000417418 ENSP00000316053
Human Recombinant Proteins
Antibodies for DNAJB8:
Assays for DNAJB8: |
Protein
Domains/
Families
for DNAJB8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJB8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NHS0ProtoNet protein and cluster: Q8NHS0 UniProtKB/Swiss-Prot: DNJB8_HUMAN, Q8NHS0Similarity: Contains 1 J domain |
Gene Function
for DNAJB8 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031072 | heat shock protein binding |
IEA | -- | | GO:0051082 | unfolded protein binding |
IEA | -- |
About this table
DNAJB8 for ontologies About GeneDecksing
|
Pathways & Interactions
for DNAJB8 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
DNAJB8 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for DNAJB8
SABiosciences Pathway-Focused PCR Array including DNAJB8: PAHS-076A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DNAJB8
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJB8
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- |
About this table
DNAJB8 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAJB8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DNAJB8
|
Transcripts
for DNAJB8 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DNAJB8 gene: NM_153330.2 Additional cDNA sequence: AK125946.1 AK126068.1 BC029521.1 BC050288.1 2 DOTS entries: DT.101979932 DT.305206 21 AceView cDNA sequences: AK126068 NM_153330 AI188219 BI830574 BQ429043 BX094760 AI638044 BI829319 AI219830 BI559505 BC029521 BI463059 BI825879 AK125946 BI560900 BC050288 BI825930 AA453366 AA453265 AA983750 BE041576
 highest scoring ESTs for DNAJB8:AI638044 AK125946 BC050288 AA453265 AA453366 AA983750 AI188219 AI219830 AK126068 BC029521 Unigene Cluster for DNAJB8: DnaJ (Hsp40) homolog, subfamily B, member 8 Hs.518241 [show with all ESTs]Unigene Representative Sequence: AK125946
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB8
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DNAJB8
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000469083 ENST00000319153(uc003ekk.1)
|
Expression
for DNAJB8 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DNAJB8 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching DNAJB8 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 49836_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AI638044 |
0.80 |
1.00 |
0.91 |
1 |
| 237284_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AI188219 |
0.60 |
1.00 |
0.82 |
1 |
| 237284_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DNAJB8 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.518241
SABiosciences Expression via Pathway-Focused PCR Array including DNAJB8: PAHS-076A
|
Orthologs
for DNAJB8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DNAJB8 gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
DNAJB81 |
-- |
DnaJ (Hsp40) homolog, subfamily B, member 8 |
86.35(n)
88.36(a) |
609460 XM_846718.1 XP_851811.1 |
chimpanzee
(Pan troglodytes) |
DNAJB81 |
-- |
DnaJ (Hsp40) homolog, subfamily B, member 8 |
99.28(n)
98.71(a) |
470916 XM_526299.2 XP_526299.1 |
cow
(Bos taurus) |
DNAJB81 |
-- |
DnaJ (Hsp40) homolog, subfamily B, member 8 |
85.14(n)
87.01(a) |
518674 XM_596872.2 XP_596872.2 |
rat
(Rattus norvegicus) |
Dnajb81 |
-- |
DnaJ (Hsp40) homolog, subfamily B, member 8 |
79.13(n)
87.39(a) |
500253 XM_575601.2 XP_575601.1 |
mouse
(Mus musculus) |
Dnajb81 , 5 |
6 (39.25 cM)5
|
DnaJ (Hsp40) homolog, subfamily B, member 81, 5 |
77.73(n)1
84.07(a)1 |
566911 NM_019964.11 NP_064348.11
AB0288565 AI3263135 (see all 9) |
About this table Species with no ortholog for DNAJB8
ENSEMBL Gene Tree for DNAJB8 (if available) |
Paralogs
for DNAJB8 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DNAJB8 gene
- DNAJB12 DNAJB42 DNAJB72 DNAJB52 DNAJB132 DNAJB22 DNAJB62
DNAJB8 for paralogs About GeneDecksing
|
Genomic Variants
for DNAJB8 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DNAJB8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DNAJB8
1 CNV: 3447 | | QIAGEN SeqTarget long-range PCR primers for resequencing DNAJB8 |
|
Disorders & Mutations
for DNAJB8 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJB8 for disorders About GeneDecksing
OMIM: 611337
Export disorders and mutations for DNAJB8 gene to outside databases
|
Medical News
for DNAJB8 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DNAJB8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
5 PubMed articles for DNAJB8 gene integrated from 7 sources:
(articles sorted by number of sources associating them with DNAJB8)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A DNAJB chaperone subfamily with HDAC-dependent activ ities suppresses toxic protein aggregation. (PubMed id 20159555)1 Hageman J....Kampinga H.H. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1 Ohtsuka K. and Hata M. (2000)
|
External Searches for DNAJB8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNAJB8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJB8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJB8 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DNAJB8 gene:
Search GeneIP for patents involving DNAJB8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJB8 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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