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Aliases & Descriptionsfor DRAM2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions DNA-damage regulated autophagy modulator 21 2 MGC542891 2 Transmembrane protein 771 2 3 WWFQ1541 2 TMEM772 3 5 DNA damage-regulated autophagy modulator protein 22 PRO1801 2 damage regulated autophagy modulator 22 RP5-1180E21.11 2 OTTHUMP000000136852
Export aliases for DRAM2 gene to outside databases Previous GC identifers: GC01M111461 GC01M111659
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Summariesfor DRAM2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Function : Induces apoptotic cell death when co-expressed with DRAM1
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Genomic Viewsfor DRAM2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for DRAM2 Other transcription factors Search SABiosciences Chromatin IP Primers for DRAM2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DRAM2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3 DRAM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M109531: view genomic region
(about GC identifiers )
Start:
109,531,529 bp from pter
End:
109,554,409 bp from pter
Size:
22,881 bases
Orientation:
minus strand
1 alternative location : Chr 1- 111,659,955-111,682,825
RefSeq DNA sequence: NC_000001.10 NT_032977.9
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Proteinsfor DRAM2 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 (See
protein sequence )Recommended Name: DNA damage-regulated autophagy modulator protein 2 Size : 266 amino acids; 29766 Da
Subcellular location : Lysosome membrane; Multi-pass membrane protein
Sequence caution : Sequence=BAC11562.1; Type=Erroneous initiation;
Secondary accessions : B3SUG9 Q4VWF6 Q86VD3 Q8NBQ4Explore the universe of human proteins at neXtProt for DRAM2: NX_Q6UX65 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_848549.3 ENSEMBL proteins: ENSP00000286692 Human Recombinant Proteins 5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6 ):
About this table
DRAM2 for ontologies About GeneDecksing Antibodies for DRAM2: Assays for DRAM2:
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Protein
Domains/ Familiesfor DRAM2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DRAM2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6UX65 ProtoNet protein and cluster: Q6UX65
UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Similarity : Belongs to the DRAM/TMEM150 family
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Gene Functionfor DRAM2 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Function : Induces apoptotic cell death when co-expressed with DRAM1Induction : Not induced by TP53/p53 or TP73/p73
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Pathways & Interactionsfor DRAM2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for DRAM2 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DRAM2 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
About this table
DRAM2 for ontologies About GeneDecksing
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Drugs & Compoundsfor DRAM2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for DRAM2
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Transcriptsfor DRAM2 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for DRAM2 gene: NM_178454.4
Additional cDNA sequence: AK075350.1 AK092961.1 AK309557.1 AL833098.1 AY336747.1 AY358492.1 BC047025.1 BC091509.1 CR598225.1 CR602380.1 CR607093.1 CR613969.1 CR626576.1 EF710624.1
24/29 DOTS entries (see all 29 ): DT.100883773 DT.95155118 DT.208306 DT.102837002 DT.100883775 DT.100717399 DT.100705590 DT.100883777
DT.92447452 DT.100883780 DT.121409427 DT.100830893 DT.437327 DT.100883779 DT.95155125 DT.101964493 DT.121409467 DT.91740571 DT.92447467 DT.100883778 DT.121409305 DT.121409308 DT.121409332 DT.409117 24/257 AceView cDNA sequences (see all 257 ):
AY358492 BI964163 AI356184 BG258660 BM480151 AW675383 AA836572 AI088857 AA594963 CA431105 AI125040 AA812114 AV711819 AI026716 BG496936 BU621312 CD671123 BQ058466 AW068971 BQ642220 BI760611 AW104544 BM784358 AA748024 Unigene Cluster for DRAM2:
DNA-damage regulated autophagy modulator 2 Hs.485606 [show with all ESTs ] Unigene Representative Sequence: AK092961 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DRAM2 (see all 13 ) ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c SP1 :         -   -   -         -   -   -       -   -                   SP2 :         -   -   -         -   -   -   -   -   -   -                   SP3 :         -   -   -         -   -   -   -   -     -                   SP4 :         -             -   -   -   -   -   -   -                   SP5 :         -             -   -   -       -   -                  
About this scheme ECgene alternative splicing isoforms for DRAM2 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000463682 ENST00000490780 ENST00000462092 ENST00000286692 (uc001eae.3 )ENST00000477588 ENST00000480600 ENST00000477769 ENST00000461449 ENST00000484310 (uc001ead.3 uc009wfy.2 uc001eaf.3 )ENST00000496430
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Expression for DRAM2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section DRAM2 expression in normal and diseased human tissues 1 / 2
8 probe-sets matching DRAM2 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
45780_at2
U95-B
1
0.94
1.00
0.92
1.07
--
--
--
--
--
72478_at2
U95-D
1
0.44
1.00
0.97
0.98
--
--
--
--
--
58928_at2
U95-C
1
0.38
1.00
0.90
1.06
--
--
--
--
--
46424_at2
U95-B
1
0.38
1.00
0.92
0.89
--
--
--
--
--
225230_at2
U133-B
1
1.00
1.00
--
--
--
--
--
--
--
225228_at2
U133-B
1
0.64
1.00
--
--
--
--
--
--
--
225230_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
225228_at2
U133Plus2
1
0.64
1.00
--
--
--
--
--
--
--
About this table
DRAM2 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAAGAAGCCA SOURCE GeneReport for Unigene cluster: Hs.485606 UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Tissue specificity : Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highestlevels in placenta and heart. Not detected in brain or thymus
SABiosciences Custom PCR Arrays for DRAM2
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Orthologsfor DRAM2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for DRAM2 gene from 5/10 species (see all 10 )
About this table Species with no ortholog for DRAM2 ENSEMBL Gene Tree for DRAM2 (if available)
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Paralogsfor DRAM2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for DRAM2 gene TMEM150A 2 DRAM1 2 TMEM150C 2 TMEM150B 2
DRAM2 for paralogs About GeneDecksing
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Genomic Variantsfor DRAM2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 1 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for DRAM2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DRAM2: --
QIAGEN SeqTarget long-range PCR primers for resequencing DRAM2
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Disorders & Mutationsfor DRAM2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DRAM2 for disorders About GeneDecksing
OMIM: 613360 Human Genome Epidemiology (HuGE) Navigator: DRAM2 (1 document)Export disorders and mutations for DRAM2 gene to outside databases
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Medical Newsfor DRAM2 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor DRAM2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/11 PubMed articles for DRAM2 gene, integrated from 7 sources (see all 11 ): (articles sorted by number of sources associating them with DRAM2) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) Analysis of DRAM-related proteins reveals evolutionar ily conserved and divergent roles in the control of autophagy. (PubMed id 19556885) 1 , 2 O'Prey J....Ryan K.M. (2009) Reduced expression of DRAM2/TMEM77 in tumor cells int erferes with cell death. (PubMed id 19895784) 1 , 2 Park S.M....Park J. (2009) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743) 1 , 2 Otsuki T....Isogai T. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DRAM2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DRAM2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DRAM2 gene
(According to HUGE )
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Specialized Databases showing DRAM2 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DRAM2 gene: Search GeneIP for patents involving DRAM2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DRAM2 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for DRAM2
ELISAs and CLIAs for DRAM2
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