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DRAM2 Gene

protein-coding   GIFtS: 42

GC01M109531
DNA-damage regulated autophagy modulator 2
(Previous name: transmembrane protein 77 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TMEM77)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
DNA-damage regulated autophagy modulator 21 2     MGC542891 2
Transmembrane protein 771 2 3     WWFQ1541 2
TMEM772 3 5     DNA damage-regulated autophagy modulator protein 22
PRO1801 2     damage regulated autophagy modulator 22
RP5-1180E21.11 2     OTTHUMP000000136852

External Ids:    HGNC: 287691   Entrez Gene: 1283382   Ensembl: ENSG000001561717   UniProtKB: Q6UX653   

Export aliases for DRAM2 gene to outside databases

Previous GC identifers: GC01M111461 GC01M111659


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65
Function: Induces apoptotic cell death when co-expressed with DRAM1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DRAM2
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DRAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DRAM2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

DRAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRAM2 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M109531:  view genomic region     (about GC identifiers)

Start:
109,531,529 bp from pter
End:
109,554,409 bp from pter
Size:
22,881 bases
Orientation:
minus strand

1 alternative location:
Chr1- 111,659,955-111,682,825     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 (See protein sequence)
Recommended Name: DNA damage-regulated autophagy modulator protein 2  
Size: 266 amino acids; 29766 Da
Subcellular location: Lysosome membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC11562.1; Type=Erroneous initiation;
Secondary accessions: B3SUG9 Q4VWF6 Q86VD3 Q8NBQ4

Explore the universe of human proteins at neXtProt for DRAM2: NX_Q6UX65 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_848549.3  

    ENSEMBL proteins: 
    ENSP00000286692 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for DRAM2 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764 lysosome IDA19895784
    GO:0005765 lysosomal membrane IEA--
    GO:0005794 Golgi apparatus IDA18029348
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    DRAM2 for ontologies           About GeneDecksing



    Antibodies for DRAM2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DRAM2
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    GenScript Custom Superior Antibodies Services for DRAM2 
    Browse antibodies at Epitomics

    Assays for DRAM2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DRAM2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DRAM2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DRAM2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019402 Frag1/DRAM/Sfk1

    Graphical View of Domain Structure for InterPro Entry Q6UX65

    ProtoNet protein and cluster: Q6UX65

    UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65
    Similarity: Belongs to the DRAM/TMEM150 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65
    Function: Induces apoptotic cell death when co-expressed with DRAM1
    Induction: Not induced by TP53/p53 or TP73/p73

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for DRAM2
    Sigma-Aldrich shRNA for DRAM2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): DRAM2
    OriGene shRNA RFP (see all 2): DRAM2
    OriGene basic RS shRNA (see all 2): DRAM2
    OriGene siRNA: DRAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DRAM2 
    miRNA:Sigma-Aldrich microRNA Mimics for DRAM2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DRAM2 
    Search SABiosciences for Assays for microRNAs that regulate DRAM2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DRAM2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DRAM2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): DRAM2
    OriGene 3'-UTR clone: DRAM2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DRAM2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for DRAM2 


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for DRAM2 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DRAM2

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915 apoptosis IEA--
    GO:0006917 induction of apoptosis IDA19895784
    About this table

    DRAM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DRAM2


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for DRAM2
    Sigma-Aldrich shRNA for DRAM2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): DRAM2
    OriGene shRNA RFP (see all 2): DRAM2
    OriGene basic RS shRNA (see all 2): DRAM2
    OriGene siRNA: DRAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DRAM2 
    miRNA: Sigma-Aldrich microRNA Mimics for DRAM2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DRAM2 
    Search SABiosciences for Assays for microRNAs that regulate DRAM2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DRAM2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DRAM2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): DRAM2
    OriGene 3'-UTR Clone: DRAM2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DRAM2 
    Primers: OriGene genome-wide validated SYBR primer pairs: DRAM2
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for DRAM2

    REFSEQ mRNAs for DRAM2 gene: 

    NM_178454.4  

    Additional cDNA sequence: 

    AK075350.1 AK092961.1 AK309557.1 AL833098.1 AY336747.1 AY358492.1 BC047025.1 BC091509.1 
    CR598225.1 CR602380.1 CR607093.1 CR613969.1 CR626576.1 EF710624.1 

    24/29 DOTS entries (see all 29):

    DT.100883773  DT.95155118  DT.208306  DT.102837002  DT.100883775  DT.100717399  DT.100705590  DT.100883777 
    DT.92447452  DT.100883780  DT.121409427  DT.100830893  DT.437327  DT.100883779  DT.95155125  DT.101964493 
    DT.121409467  DT.91740571  DT.92447467  DT.100883778  DT.121409305  DT.121409308  DT.121409332  DT.409117 

    24/257 AceView cDNA sequences (see all 257):

    AY358492 BI964163 AI356184 BG258660 BM480151 AW675383 AA836572 AI088857 
    AA594963 CA431105 AI125040 AA812114 AV711819 AI026716 BG496936 BU621312 
    CD671123 BQ058466 AW068971 BQ642220 BI760611 AW104544 BM784358 AA748024 

    Unigene Cluster for DRAM2:

    DNA-damage regulated autophagy modulator 2
    Hs.485606  [show with all ESTs]
    Unigene Representative Sequence: AK092961


    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DRAM2 (see all 13)

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                          -     -     -                       -     -     -                 -     -                                                   
    SP2:                          -     -     -                       -     -     -     -     -     -     -                                                   
    SP3:                          -     -     -                       -     -     -     -     -           -                                                   
    SP4:                          -                                   -     -     -     -     -     -     -                                                   
    SP5:                          -                                   -     -     -                 -     -                                                   

    About this scheme

    ECgene alternative splicing isoforms for DRAM2
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463682 ENST00000490780 ENST00000462092 ENST00000286692(uc001eae.3)
    ENST00000477588 ENST00000480600 ENST00000477769 ENST00000461449 ENST00000484310(uc001ead.3 uc009wfy.2 uc001eaf.3)
    ENST00000496430

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DRAM2 expression in normal and diseased human tissues

    1  / 2

    8 probe-sets matching DRAM2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    45780_at2 U95-B 1 0.94 1.00 0.92 1.07 -- -- -- -- --
    72478_at2 U95-D 1 0.44 1.00 0.97 0.98 -- -- -- -- --
    58928_at2 U95-C 1 0.38 1.00 0.90 1.06 -- -- -- -- --
    46424_at2 U95-B 1 0.38 1.00 0.92 0.89 -- -- -- -- --
    225230_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --
    225228_at2 U133-B 1 0.64 1.00 -- -- -- -- -- -- --
    225230_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    225228_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    DRAM2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DRAM2 gene expression
    DRAM2 gene electronic northern expression
    DRAM2 gene sage expression
    About these images

    CGAP SAGE TAG: AAAGAAGCCA

    SOURCE GeneReport for Unigene cluster: Hs.485606

    UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65
    Tissue specificity: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest
    levels in placenta and heart. Not detected in brain or thymus

    Primers: OriGene genome-wide validated SYBR primer pairs: DRAM2
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for DRAM2
        SABiosciences Custom PCR Arrays for DRAM2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for DRAM2 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TMEM771   -- transmembrane protein 77 91.6(n)
    91.35(a)
    479905  XM_537031.2  XP_537031.2 
    chimpanzee
    (Pan troglodytes)
    TMEM771   -- transmembrane protein 77 99.75(n)
    99.62(a)
    457117  XM_001162049.1  XP_001162049.1 
    cow
    (Bos taurus)
    TMEM771   -- transmembrane protein 77 92.36(n)
    89.85(a)
    767922  NM_001076996.1  NP_001070464.1 
    rat
    (Rattus norvegicus)
    Tmem771   -- transmembrane protein 77 87.67(n)
    85.66(a)
    362011  NM_001025018.1  NP_001020189.1 
    mouse
    (Mus musculus)
    Dram25
    Tmem771
    3 (46.50 cM)5
    VDNA-damage regulated autophagy modulator 25
    transmembrane protein 771
    88.18(n)1
    86.04(a)1
    671711  NM_026013.21  NP_080289.11 
     AI6476675  AI8454635  (see all 13)
    About this table        Species with no ortholog for DRAM2

    ENSEMBL Gene Tree for DRAM2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DRAM2 gene
    TMEM150A2  DRAM12  TMEM150C2  TMEM150B2  

    DRAM2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/210 NCBI SNPs in DRAM2 are shown (see all 210)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs110021,2
    C,F,A,H,111660540(-) AAGTCA/GAAAGA 1 -- ut31 ese311Minor allele frequency- G:0.25MN NS EA NA WA 772
    rs1827321,2
    C,F,A,H,111676597(-) GAGGAT/AGAGAA 1 -- int116Minor allele frequency- A:0.40NS EA NA WA 774
    rs3259131,2
    C,F,O,111659501(+) TTATTC/TCTTGA 1 -- ng3110Minor allele frequency- T:0.05MN NA NS EA 904
    rs3259141,2
    C,F,O,111659997(+) CCCAAA/CCTTCT 1 -- ut3121Minor allele frequency- C:0.07EA NA NS 3250
    rs3259161,2
    C,F,O,A,H,111661413(-) GCACAA/GTATTA 1 -- int116Minor allele frequency- G:0.39MN EA NA NS WA 1032
    rs3259171,2
    C,F,O,A,111661528(+) AGTGAT/CGGGAA 1 -- int111Minor allele frequency- C:0.25NS EA NA WA 654
    rs3259181,2
    C,F,111662723(+) CAGTGG/ATACTG 1 -- int122Minor allele frequency- A:0.29EA MN NA NS WA 3207
    rs3259191,2
    C,F,A,111662952(-) ATATGG/AAATTC 1 -- int110Minor allele frequency- A:0.27MN EA NA WA 1828
    rs3259201,2
    C,F,O,A,H,111663488(-) TTTAAA/GCTGAG 1 -- int19Minor allele frequency- G:0.25NA EA WA 358
    rs3259211,2
    C,F,O,111664343(-) CTTATT/CGCTGT 1 -- int120Minor allele frequency- C:0.29NS EA NA WA 1618
    About this table

    HapMap Linkage Disequilibrium images for DRAM2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DRAM2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing DRAM2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DRAM2 for disorders           About GeneDecksing

    OMIM: 613360

    Human Genome Epidemiology (HuGE) Navigator: DRAM2 (1 document)

    Export disorders and mutations for DRAM2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/11 PubMed articles for DRAM2 gene, integrated from 7 sources (see all 11):
    (articles sorted by number of sources associating them with DRAM2)
    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. Analysis of DRAM-related proteins reveals evolutionar ily conserved and divergent roles in the control of autophagy. (PubMed id 19556885)1, 2 O'Prey J....Ryan K.M. (2009)
    3. Reduced expression of DRAM2/TMEM77 in tumor cells int erferes with cell death. (PubMed id 19895784)1, 2 Park S.M....Park J. (2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 128338 HGNC: 28769 AceView: MGC54289 Ensembl:ENSG00000156171 euGenes: HUgn128338
    ECgene: DRAM2 H-InvDB: DRAM2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for DRAM2 gene:
    Search GeneIP for patents involving DRAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for DRAM2 Antibodies for DRAM2
     Super-pooled esiRNAs for DRAM2 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for DRAM2 microRNA Mimics for DRAM2
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
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     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DRAM2
     SeqTarget long-range PCR primers for resequencing DRAM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DRAM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DRAM2
     GenScript Custom Purified and Recombinant Proteins Services for DRAM2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for DRAM2
     GenScript Custom Assay Services for DRAM2 GenScript Custom Superior Antibodies Services for DRAM2
     GenScript Custom overexpressing Cell Line Services for DRAM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for DRAM2
     Search Chromatin IP Primers for DRAM2
     Search RT2 qPCR Primer Assays for DRAM2
     Search GNC Networks for DRAM2
     Search for Assays for microRNAs that regulate DRAM2
     SABiosciences Custom PCR Arrays for DRAM2
     Search Tocris compounds for DRAM2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for DRAM2
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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