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DTX2 Gene

protein-coding   GIFtS: 55

GC07P071168
deltex homolog 2 (Drosophila)
(Previous name: deltex (Drosophila) homolog 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
deltex homolog 2 (Drosophila)1 2     zinc ion binding protein2
RNF581 2 3     MGC710982
KIAA15282 3 5     protein deltex-22
RING finger protein 582 3     deltex22
hDTX22 3     OTTHUMP000002084152
deltex (Drosophila) homolog 21     Deltex23

External Ids:    HGNC: 159731   Entrez Gene: 1138782   Ensembl: ENSG000000910737   UniProtKB: Q86UW93   

Export aliases for DTX2 gene to outside databases

Previous GC identifers: GC07P074626 GC07P075689 GC07P075703 GC07P075735 GC07P075928 GC07P076090


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DTX2:
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM)

UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad
spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on
the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the
transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it
may regulate the Notch pathway via some ubiquitin ligase activity

Gene Wiki entry for DTX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DTX2 gene promoter:
         ARP-1   c-Jun   c-Fos   Fra-1   JunB   JunD   AP-1   E47   Tal-1beta   Tal-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DTX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

DTX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DTX2 gene location

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P071168:  view genomic region     (about GC identifiers)

Start:
71,168,994 bp from pter
End:
71,172,895 bp from pter
Size:
3,902 bases
Orientation:
plus strand

1 alternative location:
Chr7+ 76,090,972-76,151,394     
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NT_079595.2  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9 (See protein sequence)
Recommended Name: Protein deltex-2  
Size: 622 amino acids; 67246 Da
Subunit: Homomultimer. May form a heteromultimer with other members of the Deltex family. Interacts with NOTCH1 (By
similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear
Sequence caution: Sequence=BAA96052.1; Type=Erroneous initiation;
Secondary accessions: Q6XM88 Q96H69 Q9H890 Q9P200
Alternative splicing: 2 isoforms:  Q86UW9-1   Q86UW9-2   

Explore the universe of human proteins at neXtProt for DTX2: NX_Q86UW9 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001096064.1  NP_001096065.1  NP_001096066.1  NP_065943.2  


    ENSEMBL proteins: 
    ENSP00000407398 ENSP00000409040 ENSP00000389231 ENSP00000322885 ENSP00000390881 ENSP00000397648 
    ENSP00000390218 ENSP00000415838 ENSP00000387894 ENSP00000411986 ENSP00000392114 ENSP00000407897 
    ENSP00000403342 ENSP00000399639 ENSP00000392545 ENSP00000393775 ENSP00000410892 ENSP00000305242 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for DTX2 
    Novus Biologicals Lysate for DTX2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    DTX2 for ontologies           About GeneDecksing



    Antibodies for DTX2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DTX2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DTX2 
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for DTX2 
    Novus Biologicals Antibodies for DTX2
    Browse antibodies at Epitomics

    Assays for DTX2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DTX2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DTX2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DTX2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001841 Znf_RING
     IPR004170 WWE-dom
     IPR018123 WWE-dom_subgr
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q86UW9

    ProtoNet protein and cluster: Q86UW9

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9
    Domain: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin
    ligases (By similarity)
    Similarity: Belongs to the Deltex family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 WWE domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9
    Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad
    spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on
    the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the
    transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it
    may regulate the Notch pathway via some ubiquitin ligase activity

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for DTX2
    Sigma-Aldrich shRNA Panels and shRNA for DTX2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): DTX2
    OriGene shRNA RFP (see all 5): DTX2
    OriGene basic RS shRNA (see all 5): DTX2
    OriGene siRNA (see all 4): DTX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DTX2 
    miRNA:Sigma-Aldrich microRNA Mimics for DTX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DTX2 
    8/10 SABiosciences Assays for microRNAs that regulate DTX2 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): DTX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): DTX2
    OriGene untagged cDNA clones in CMV expression vector (see all 4): DTX2
    OriGene 3'-UTR clone (see all 4): DTX2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DTX2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for DTX2 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16189514
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    DTX2 for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dtx2):

    immune system

    DTX2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    DTX2 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  DTX2
        Notch Signaling

    1 Kegg Pathway  (Kegg details for DTX2):
        hsa04330 Notch signaling pathway

        SABiosciences Pathway-Focused PCR Array including DTX2: PAHS-405A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DTX2
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTX2

    5/20 Interacting proteins for DTX2 (Q86UW91, 2 ENSP000003228853) via UniProtKB, MINT, and/or STRING (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D4Q9Y2X81, 2EBI-740376,EBI-745527 MINT-67411
    HPCAL1P372352MINT-67483
    HPCAL4Q9UM192MINT-66565
    NCALDP616012MINT-67559
    NCS1P621662MINT-66973
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219 Notch signaling pathway IEA--
    About this table

    DTX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DTX2


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for DTX2
    Sigma-Aldrich shRNA Panels and shRNA for DTX2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): DTX2
    OriGene shRNA RFP (see all 5): DTX2
    OriGene basic RS shRNA (see all 5): DTX2
    OriGene siRNA (see all 4): DTX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DTX2 
    miRNA: Sigma-Aldrich microRNA Mimics for DTX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DTX2 
    8/10 SABiosciences Assays for microRNAs that regulate DTX2 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): DTX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): DTX2
    OriGene untagged cDNA clones in CMV expression vector (see all 4): DTX2
    OriGene 3'-UTR Clone (see all 4): DTX2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DTX2 
    Primers: OriGene genome-wide validated SYBR primer pairs: DTX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DTX2: PPH10410A

    REFSEQ mRNAs for DTX2 gene (4 alternative transcripts): 

    NM_001102594.1  NM_001102595.1  NM_001102596.1  NM_020892.2  

    Additional cDNA sequence: 

    AB040961.1 AK023924.1 AK026252.1 AK293226.1 AY225124.1 AY225125.1 BC008856.2 BC013192.1 
    BC018555.1 BC026059.2 BC064535.1 BC093079.1 CR604084.1 DQ010329.1 DQ082728.1 DQ082730.1 

    24 DOTS entries:

    DT.100682666  DT.92469716  DT.95192094  DT.95214454  DT.114138  DT.100810678  DT.40239991  DT.100810690 
    DT.100720557  DT.121099383  DT.121099330  DT.121099351  DT.121099373  DT.100810682  DT.100810684  DT.101987018 
    DT.121099342  DT.40224247  DT.102834853  DT.121124795  DT.91713744  DT.91880229  DT.95078662  DT.97860962 

    24/195 AceView cDNA sequences (see all 195):

    AY225124 BI333802 CB992094 CR604084 BI769881 CB993822 CB989696 BU145636 
    AW274887 BU616049 BI334999 AL561485 BU689947 AI001005 BQ102509 AI921688 
    AL555691 BE672481 BU542343 CB991425 AY225125 AA641548 BM977352 BQ086180 

    highest scoring ESTs for DTX2:

    AI138834 AA134155 AA134156 AA284611 AA284881 AA398822 AA398969 AA398970 AA403082 AA411813 

    Unigene Cluster for DTX2:

    Deltex homolog 2 (Drosophila)
    Hs.187058  [show with all ESTs]
    Unigene Representative Sequence: NM_020892


    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DTX2 (see all 17)

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a ·
    SP1:                                                                                                                                                        -   
    SP2:                                -                 -     -     -     -     -     -     -                                                                     
    SP3:                                -                 -     -     -     -                 -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                        -   

    ExUns: 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:        -                                 

    About this scheme

    ECgene alternative splicing isoforms for DTX2
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000425780 ENST00000456590 ENST00000451769 ENST00000324432(uc011kgk.1 uc003uff.3 uc003ufg.3 uc003ufh.3 uc003ufl.1)
    ENST00000492339 ENST00000495345 ENST00000457529 ENST00000446600 ENST00000413936
    ENST00000423646 ENST00000438930 ENST00000430490 ENST00000442516 ENST00000423250
    ENST00000429179 ENST00000435861 ENST00000472426 ENST00000446820

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DTX2 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching DTX2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37977_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AI138834 1.00 1.00 1.00 1
    215732_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK023924 0.80 1.00 0.91 1
    215732_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    DTX2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DTX2 gene expression
    DTX2 gene electronic northern expression
    DTX2 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.187058

    Expression variation in blood from EXPOLDB for DTX2

    Primers: OriGene genome-wide validated SYBR primer pairs: DTX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DTX2: PPH10410A
        SABiosciences Expression via Pathway-Focused PCR Array including DTX2: PAHS-405A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for DTX2 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    DTX21   -- deltex homolog 2 (Drosophila) 88.3(n)
    91.75(a)
    479723  XM_536849.2  XP_536849.2 
    chimpanzee
    (Pan troglodytes)
    DTX21   -- deltex homolog 2 (Drosophila) 97.99(n)
    96.35(a)
    747633  XM_001157724.1  XP_001157724.1 
    cow
    (Bos taurus)
    DTX21   -- deltex homolog 2 (Drosophila) 87.76(n)
    91.26(a)
    532767  NM_001017945.1  NP_001017945.1 
    rat
    (Rattus norvegicus)
    Dtx21   -- deltex 2 homolog (Drosophila) 84.57(n)
    85.76(a)
    304591  XM_347157.3  XP_347158.2 
    mouse
    (Mus musculus)
    Dtx21 , 5 5 (75.64 cM)5
    deltex 2 homolog (Drosophila)1, 5 84.49(n)1
    85.74(a)1
    741981  NM_023742.11  NP_076231.11 
     AA4084155  AA7625225  (see all 20)
    About this table        Species with no ortholog for DTX2

    ENSEMBL Gene Tree for DTX2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DTX2 gene
    DTX12  DTX42  DTX3L2  DTX32  

    DTX2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/270 NCBI SNPs in DTX2 are shown (see all 270)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs73981,2
    C,F,A,76135134(+) GCTTAA/GGATGC 4 -- ut31 ese313Minor allele frequency- N:0.00EA MN NA NS WA 2418
    rs10109331,2
    --76134819(+) CGCAAC/TATTAC 8 N ref1 syn13Minor allele frequency- T:0.00NA MN 348
    rs10516461,2
    --76135223(+) GAGTAA/GAGACT 4 -- ut31 ese30--------
    rs10550941,2
    F76104245(-) TCGCCA/GCAAAT 3 -- int11Minor allele frequency- G:0.40MN 184
    rs14653141,2
    C,A,H,76134203(-) TGGTGC/ATGGCC 4 -- int17Minor allele frequency- A:0.24MN NA EA WA 400
    rs15488231,2
    --76134943(-) CACCAA/GAGGCG 4 -- ut31 ese30--------
    rs16165631,2
    C,A76098742(-) acagaG/Atgaga 3 -- int11Minor allele frequency- A:0.00NA 2
    rs16213191,2
    C76128917(-) GCCCAG/CTGCCA 4 -- int11Minor allele frequency- C:0.50NA 2
    rs16278951,2
    C,A,H,76111296(-) ggctcA/Gagcct 4 -- int12Minor allele frequency- G:0.25NA 4
    rs16281991,2
    C76110568(-) cgagaT/Ctgcgc 4 -- int11Minor allele frequency- C:0.00NA 2
    About this table

    HapMap Linkage Disequilibrium images for DTX2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for DTX2
         14 CNVs: 2700 64866 8569 8568 9060 94619 82040 22956 7646 9061 3686 39497 5241 36708
         1 Indel: 33848
         1 Inversion: 37295

    QIAGEN SeqTarget long-range PCR primers for resequencing DTX2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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    DTX2 for disorders           About GeneDecksing

    OMIM: 613141


    Export disorders and mutations for DTX2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/19 PubMed articles for DTX2 gene, integrated from 7 sources (see all 19):
    (articles sorted by number of sources associating them with DTX2)
    1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 7 Takeyama K.... Shipp M.A. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. (PubMed id 11564735)1, 2 Yamamoto N....Nakafuku M. (2001)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    7. cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PubMed id 17286044)1, 7 Yi Z....Wu Z. (2006)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 113878 HGNC: 15973 AceView: DTX2 Ensembl:ENSG00000091073 euGenes: HUgn113878
    ECgene: DTX2 Kegg: 113878 H-InvDB: DTX2

    (According to HUGE)
    About This Section
    HUGE: KIAA1528

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for DTX2 gene:
    Search GeneIP for patents involving DTX2

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