Aliases &
Descriptions
for DTX2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| deltex homolog 2 (Drosophila)1 2 | | zinc ion binding protein2 | | RNF581 2 3 | | MGC710982 | | KIAA15282 3 5 | | protein deltex-22 | | RING finger protein 582 3 | | deltex22 | | hDTX22 3 | | OTTHUMP000002084152 | | deltex (Drosophila) homolog 21 | | Deltex23 |
Export aliases for DTX2 gene to outside databasesPrevious GC identifers: GC07P074626 GC07P075689 GC07P075703 GC07P075735 GC07P075928 GC07P076090 |
Summaries
for DTX2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DTX2:
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM)
UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broadspectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending onthe developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting thetranscriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that itmay regulate the Notch pathway via some ubiquitin ligase activity
Gene Wiki entry for DTX2 |
Genomic Views
for DTX2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DTX2 gene promoter:
ARP-1 c-Jun c-Fos Fra-1 JunB JunD AP-1 E47 Tal-1beta Tal-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DTX2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23DTX2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P071168: view genomic region
(about GC identifiers)
Start:
|
71,168,994 bp from pter |
End:
|
71,172,895 bp from pter |
Size:
|
3,902 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 76,090,972-76,151,394 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079595.2
|
Proteins
for DTX2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9 (See
protein sequence)Recommended Name: Protein deltex-2 Size: 622 amino acids; 67246 Da
Subunit: Homomultimer. May form a heteromultimer with other members of the Deltex family. Interacts with NOTCH1 (Bysimilarity)
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear
Sequence caution: Sequence=BAA96052.1; Type=Erroneous initiation;
Secondary accessions: Q6XM88 Q96H69 Q9H890 Q9P200Alternative splicing: 2 isoforms: Q86UW9-1 Q86UW9-2 Explore the universe of human proteins at neXtProt for DTX2: NX_Q86UW9
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001096064.1 NP_001096065.1 NP_001096066.1 NP_065943.2
ENSEMBL proteins: ENSP00000407398 ENSP00000409040 ENSP00000389231 ENSP00000322885 ENSP00000390881 ENSP00000397648 ENSP00000390218 ENSP00000415838 ENSP00000387894 ENSP00000411986 ENSP00000392114 ENSP00000407897 ENSP00000403342 ENSP00000399639 ENSP00000392545 ENSP00000393775 ENSP00000410892 ENSP00000305242
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
DTX2 for ontologies About GeneDecksing
Antibodies for DTX2:
Assays for DTX2: |
Protein
Domains/
Families
for DTX2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DTX2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86UW9ProtoNet protein and cluster: Q86UW9 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9Domain: The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitinligases (By similarity)Similarity: Belongs to the Deltex familySimilarity: Contains 1 RING-type zinc fingerSimilarity: Contains 2 WWE domains |
Gene Function
for DTX2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: DTX2_HUMAN, Q86UW9Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broadspectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending onthe developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting thetranscriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that itmay regulate the Notch pathway via some ubiquitin ligase activity
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
DTX2 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Dtx2):
DTX2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DTX2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
DTX2 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for DTX2
1  Kegg Pathway (Kegg details for DTX2):
SABiosciences Pathway-Focused PCR Array including DTX2: PAHS-405A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DTX2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DTX2
5/20 Interacting proteins for DTX2 (Q86UW91, 2 ENSP000003228853) via UniProtKB, MINT, and/or STRING (see all 20)About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007219 | Notch signaling pathway |
IEA | -- |
About this table
DTX2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DTX2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DTX2
|
Transcripts
for DTX2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DTX2 gene (4 alternative transcripts): NM_001102594.1 NM_001102595.1 NM_001102596.1 NM_020892.2 Additional cDNA sequence: AB040961.1 AK023924.1 AK026252.1 AK293226.1 AY225124.1 AY225125.1 BC008856.2 BC013192.1 BC018555.1 BC026059.2 BC064535.1 BC093079.1 CR604084.1 DQ010329.1 DQ082728.1 DQ082730.1 24 DOTS entries: DT.100682666 DT.92469716 DT.95192094 DT.95214454 DT.114138 DT.100810678 DT.40239991 DT.100810690 DT.100720557 DT.121099383 DT.121099330 DT.121099351 DT.121099373 DT.100810682 DT.100810684 DT.101987018 DT.121099342 DT.40224247 DT.102834853 DT.121124795 DT.91713744 DT.91880229 DT.95078662 DT.97860962 24/195 AceView cDNA sequences (see all 195): AY225124 BI333802 CB992094 CR604084 BI769881 CB993822 CB989696 BU145636 AW274887 BU616049 BI334999 AL561485 BU689947 AI001005 BQ102509 AI921688 AL555691 BE672481 BU542343 CB991425 AY225125 AA641548 BM977352 BQ086180
 highest scoring ESTs for DTX2:AI138834 AA134155 AA134156 AA284611 AA284881 AA398822 AA398969 AA398970 AA403082 AA411813 Unigene Cluster for DTX2: Deltex homolog 2 (Drosophila) Hs.187058 [show with all ESTs]Unigene Representative Sequence: NM_020892
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DTX2 (see all 17)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | |
About this scheme
ECgene alternative splicing isoforms for DTX2
18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000425780 ENST00000456590 ENST00000451769 ENST00000324432(uc011kgk.1 uc003uff.3 uc003ufg.3 uc003ufh.3 uc003ufl.1)
ENST00000492339 ENST00000495345 ENST00000457529 ENST00000446600 ENST00000413936
ENST00000423646 ENST00000438930 ENST00000430490 ENST00000442516 ENST00000423250
ENST00000429179 ENST00000435861 ENST00000472426 ENST00000446820
|
Expression
for DTX2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DTX2 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching DTX2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37977_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AI138834 |
1.00 |
1.00 |
1.00 |
1 |
| 215732_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AK023924 |
0.80 |
1.00 |
0.91 |
1 |
| 215732_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DTX2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.187058
Expression variation in blood from EXPOLDB for DTX2 SABiosciences Expression via Pathway-Focused PCR Array including DTX2: PAHS-405A
|
Orthologs
for DTX2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DTX2 gene from 5/9 species (see all 9)
About this table Species with no ortholog for DTX2
ENSEMBL Gene Tree for DTX2 (if available) |
Paralogs
for DTX2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DTX2 gene
- DTX12 DTX42 DTX3L2 DTX32
DTX2 for paralogs About GeneDecksing
|
Genomic Variants
for DTX2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DTX2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for DTX2
14 CNVs: 2700 64866 8569 8568 9060 94619 82040 22956 7646 9061 3686 39497 5241 36708
1 Indel: 33848
1 Inversion: 37295 | | QIAGEN SeqTarget long-range PCR primers for resequencing DTX2 |
|
Disorders & Mutations
for DTX2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DTX2 for disorders About GeneDecksing
OMIM: 613141
Export disorders and mutations for DTX2 gene to outside databases
|
Medical News
for DTX2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DTX2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/19 PubMed articles for DTX2 gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with DTX2)- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PubMed id 12670957)1, 2, 7 Takeyama K.... Shipp M.A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. (PubMed id 11564735)1, 2 Yamamoto N....Nakafuku M. (2001)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PubMed id 17286044)1, 7 Yi Z....Wu Z. (2006)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for DTX2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DTX2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DTX2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DTX2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DTX2 gene:
Search GeneIP for patents involving DTX2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DTX2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for DTX2 |
| | | | Search Tocris compounds for DTX2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for DTX2 |
| |
|
|
