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DUSP6 Gene

protein-coding   GIFtS: 67

GC12M086807
dual specificity phosphatase 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for DUSP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
dual specificity phosphatase 61 2     MAP kinase phosphatase 32 3
PYST11 2 3 5     dual specificity protein phosphatase 62
MKP32 3 5     serine/threonine specific protein phosphatase2
MKP-31 3     EC 3.1.3.163
Mitogen-activated protein kinase phosphatase 32 3     EC 3.1.3.483
Dual specificity protein phosphatase PYST12 3     

External Ids:    HGNC: 30721   Entrez Gene: 18482   Ensembl: ENSG000001393187   UniProtKB: Q168283   

Export aliases for DUSP6 gene to outside databases

Previous GC identifers: GC12M089159 GC12M090189 GC12M089674 GC12M088244 GC12M089741


Summaries
for DUSP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUSP6:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.
They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),
which are associated with cellular proliferation and differentiation. Different members of the family of dual
specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution
and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This
gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and
unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
Function: Inactivates MAP kinases. Has a specificity for the ERK family

Gene Wiki entry for DUSP6

Genomic Views
for DUSP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP6 gene promoter:
         Elk-1   STAT1beta   STAT1alpha   STAT1   STAT3   GATA-1   GATA-3   GATA-2   RFX1   SRF   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DUSP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DUSP6 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22-q23   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q22-q23

DUSP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP6 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M086807:  view genomic region     (about GC identifiers)

Start:
 86,807,701 bp from pter
End:
 86,812,160 bp from pter
Size:
 4,460 bases
Orientation:
 minus strand

1 alternative location:
Chr12- 89,741,839-89,746,296     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

Proteins
for DUSP6 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 6  
Size: 381 amino acids; 42320 Da
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
1HZM (3D)    1MKP (3D)    
Secondary accessions: O75109 Q53Y75 Q9BSH6
Alternative splicing: 2 isoforms:  Q16828-1   Q16828-2   

Explore the universe of human proteins at neXtProt for DUSP6: NX_Q16828 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001937.2  NP_073143.2  


    ENSEMBL proteins: 
    ENSP00000279488 ENSP00000307835 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for DUSP6
    OriGene Purified Proteins (see all 2): DUSP6
    OriGene Protein Over-expression Lysate (see all 2): DUSP6
    GenScript Custom Purified and Recombinant Proteins Services for DUSP6 
    Novus Biologicals Protein for DUSP6
    Novus Biologicals Lysates for DUSP6
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654 nucleoplasm EXP17322878
    GO:0005737 cytoplasm IDA8670865
    About this table

    DUSP6 for ontologies           About GeneDecksing



    Antibodies for DUSP6: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DUSP6
    R&D Systems Antibodies for DUSP6 (MKP-3)
    Cell Signaling Technology (CST) Antibodies for DUSP6  (MKP3)
    OriGene Antibodies: DUSP6
    GenScript Custom Superior Antibodies Services for DUSP6 
    Novus Biologicals Antibodies for DUSP6
    Epitomics antibodies for DUSP6

    Assays for DUSP6: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DUSP6 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DUSP6 

    Protein Domains/
    Families
    for DUSP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DUSP6 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001763 Rhodanese-like
     IPR000387 Dual-sp/Tyr_phosphatase
     IPR014393 Dual_MAP_Kinase_Phosphatase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q16828

    ProtoNet protein and cluster: Q16828

    2 Blocks protein families:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Gene Function
    for DUSP6 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
    Function: Inactivates MAP kinases. Has a specificity for the ERK family
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Enzyme Numbers (IUBMB): EC 3.1.3.16  EC 3.1.3.48 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DUSP6
    Sigma-Aldrich shRNA Panels and shRNA for DUSP6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): DUSP6
    OriGene shRNA RFP (see all 2): DUSP6
    OriGene basic RS shRNA (see all 2): DUSP6
    OriGene siRNA (see all 2): DUSP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DUSP6 
    miRNA:Sigma-Aldrich microRNA Mimics for DUSP6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DUSP6 
    6 SABiosciences Assays for microRNAs that regulate DUSP6:
    hsa-miR-1178 hsa-miR-520d-5p hsa-miR-374b hsa-miR-145 hsa-miR-524-5p hsa-miR-374a

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): DUSP6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): DUSP6
    OriGene untagged cDNA clones in CMV expression vector (see all 3): DUSP6
    OriGene 3'-UTR clone (see all 2): DUSP6 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): DUSP6 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for DUSP6 

    Genatlas biochemistry entry for DUSP6:
    dual specificity (tyr/thr) phosphatase 6,including two transcripts,ubiquitously expressed,involved in signal
    transduction altered in pancreatic ductal carcinogenesis

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721 phosphoprotein phosphatase activity ----
    GO:0004725 protein tyrosine phosphatase activity EXP17322878
    GO:0005515 protein binding IEA--
    GO:0008138 protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016787 hydrolase activity IEA--
    About this table

    DUSP6 for ontologies           About GeneDecksing

    Animal Models: 11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dusp6):

    cardiovascular systemcellularcraniofacialgrowth/sizehearing/vestibular/ear
    hematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatallimbs/digits/tail
    skeleton

    DUSP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DUSP6 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    DUSP6 for pathways           About GeneDecksing

    1 Millipore Pathway for DUSP6
        Signal transduction Erk Interactions- Inhibition of Erk

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  DUSP6
        cAMP-mediated Signaling
    ERK/MAPK Signaling
    G-Protein Coupled Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for DUSP6
        MAPK/Erk in Growth and Differentiation

    1 Kegg Pathway  (Kegg details for DUSP6):
        hsa04010 MAPK signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including DUSP6: PAHS-040A PAHS-045A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DUSP6
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP6

    5/23 Interacting proteins for DUSP6 (ENSP000002794883 Q168282) via UniProtKB, MINT, and/or STRING (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502MINT-66931
    TEX11Q8IYF32MINT-67633
    MAPK7ENSP000002996123STRING: ENSP00000299612
    MAPK1ENSP000002158323STRING: ENSP00000215832
    MAPK3ENSP000002630253STRING: ENSP00000263025
    About this table

    5/19 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 19):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188 inactivation of MAPK activity IDA8670865
    GO:0001933 negative regulation of protein phosphorylation IEA--
    GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006470 protein dephosphorylation ----
    GO:0014070 response to organic cyclic substance IEA--
    About this table

    DUSP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUSP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    DUSP6 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP6
    10/12 Novoseek chemical compound relationships for DUSP6 gene (see all 12)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 80.3 1 10085148 (1)
    phosphothreonine 54 2 9596579 (1)
    dmso 29.7 2 17459723 (1), 10702230 (1)
    tyrosine 29.5 5 15240129 (1), 8626780 (1), 16834321 (1)
    phosphotyrosine 24.6 2 9596579 (1)
    pd 98,059 20 1 16740736 (1)
    phenylephrine 10.9 1 10085148 (1)
    h2o2 1.73 2 16834321 (1), 18632752 (1)
    cysteine 1.4 6 16834321 (4), 15541888 (1)
    oxygen 0 3 18245669 (1), 12840032 (1), 18632752 (1)
    About this table



    Transcripts
    for DUSP6 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DUSP6
    Sigma-Aldrich shRNA Panels and shRNA for DUSP6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): DUSP6
    OriGene shRNA RFP (see all 2): DUSP6
    OriGene basic RS shRNA (see all 2): DUSP6
    OriGene siRNA (see all 2): DUSP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DUSP6 
    miRNA: Sigma-Aldrich microRNA Mimics for DUSP6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DUSP6 
    6 SABiosciences Assays for microRNAs that regulate DUSP6:
    hsa-miR-1178 hsa-miR-520d-5p hsa-miR-374b hsa-miR-145 hsa-miR-524-5p hsa-miR-374a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): DUSP6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): DUSP6
    OriGene untagged cDNA clones in CMV expression vector (see all 3): DUSP6
    OriGene 3'-UTR Clone (see all 2): DUSP6 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): DUSP6 
    Primers: OriGene genome-wide validated SYBR primer pairs: DUSP6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DUSP6: PPH02573A

    REFSEQ mRNAs for DUSP6 gene (2 alternative transcripts): 

    NM_001946.2  NM_022652.2  

    Additional cDNA sequence: 

    AB013382.1 AB013602.1 AB451265.1 AB451393.1 AK091753.1 AK222882.1 BC003143.1 BC003562.1 
    BC005047.1 BC037236.1 BT006895.1 CR593797.1 X93920.1 

    11 DOTS entries:

    DT.318611  DT.95131012  DT.100030226  DT.100798052  DT.92043785  DT.100798054  DT.100798057  DT.107281 
    DT.100798056  DT.100728521  DT.121191240 

    24/401 AceView cDNA sequences (see all 401):

    BU789040 AI085452 BQ001889 AW088518 AI192556 AI573117 AW290904 R62605 
    AA768101 CB306809 AA776489 AA405450 AI092872 BM918436 CB114320 AU131653 
    AU131995 CB137963 AU125568 H24634 BU184358 BQ082125 F12663 CR593797 

    highest scoring ESTs for DUSP6:

    AB013382 AA313210 AB013602 AL598733 AU120524 AV647942 AV658608 BC003143 BC003562 BC005047 

    Unigene Cluster for DUSP6:

    Dual specificity phosphatase 6
    Hs.298654  [show with all ESTs]
    Unigene Representative Sequence: BC037236


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP6

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                                -     -                                 
    SP2:                                      -                                 
    SP3:                                                                        
    SP4:                                -     -     -                           
    SP5:                                                                        

    About this scheme

    ECgene alternative splicing isoforms for DUSP6
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279488(uc001tay.2) ENST00000308385(uc001taz.2)

    Expression
    for DUSP6 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DUSP6 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching DUSP6 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41193_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB013382 1.00 1.00 1.00 1
    208892_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC003143 0.80 1.00 0.91 1
    208893_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC005047 0.80 1.00 0.91 1
    208891_at2, 3 U133-A 1 0.46 1.00 -- -- BC003143 0.80 1.00 0.91 1
    208892_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    208893_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    208891_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    DUSP6 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DUSP6 gene expression
    DUSP6 gene electronic northern expression
    DUSP6 gene sage expression
    About these images

    CGAP SAGE TAG: GGTACCCATT

    SOURCE GeneReport for Unigene cluster: Hs.298654

    Expression variation in blood from EXPOLDB for DUSP6

    Primers: OriGene genome-wide validated SYBR primer pairs: DUSP6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DUSP6: PPH02573A
        SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP6: PAHS-040A PAHS-045A 


    Orthologs
    for DUSP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for DUSP6 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 DUSP61   -- dual specificity phosphatase 6 93.88(n)
    99.74(a)    		 482594  XM_847148.1  XP_852241.1 
    chimpanzee
    (Pan troglodytes)    		 DUSP61   -- dual specificity phosphatase 6 99.65(n)
    99.74(a)    		 452115  XM_001165821.1  XP_001165821.1 
    cow
    (Bos taurus)    		 DUSP61   -- dual specificity phosphatase 6 94.4(n)
    99.21(a)    		 515310  NM_001046195.1  NP_001039660.1 
    rat
    (Rattus norvegicus)    		 Dusp61   -- dual specificity phosphatase 6 91.6(n)
    98.69(a)    		 116663  NM_053883.2  NP_446335.1 
    mouse
    (Mus musculus)    		 Dusp61 , 5 10 (51.13 cM)5
    		 dual specificity phosphatase 61, 5 90.64(n)1
    98.16(a)1    		 676031  NM_026268.21  NP_080544.11 
     AI8442005  AI8455845  (see all 18)
    About this table        Species with no ortholog for DUSP6

    ENSEMBL Gene Tree for DUSP6 (if available)

    Paralogs
    for DUSP6 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DUSP6 gene
    DUSP92  C20orf572  DUSP102  DUSP82  DUSP222  DUSP162  DUSP72  

    DUSP6 for paralogs           About GeneDecksing



    Genomic Variants
    for DUSP6 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/69 NCBI SNPs in DUSP6 are shown (see all 69)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs107441,2
    		C,F,O,A,89741904(-) AGTTTA/TGAGCT 2 -- ut31 ese310Minor allele frequency- T:0.33MN NS EA NA WA 916
    rs7040731,2
    		C,F,A,89741711(-) TAGAAC/TGTTTT 2 -- ng3115Minor allele frequency- T:0.22MN NS EA NA WA 1160
    rs7040741,2
    		C,F,A,89742731(-) GGTAGA/GACCAA 2 -- ut3114Minor allele frequency- G:0.21MN NA NS EA WA 870
    rs7040751,2
    		C,89743223(-) AACGAA/C/TGCCTA 6 E D mis1 syn1 ref110MN NA EA WA 490
    rs7040761,2
    		C,F,A,H,89743921(-) GATGCG/TGTGAT 2 -- int113Minor allele frequency- T:0.20NA NS EA WA 686
    rs7040771,2
    		C,F,A,H,89743936(+) AACTGG/CATAAC 2 -- int17Minor allele frequency- C:0.06NA WA 270
    rs7040781,2
    		C,F,A,H,89744246(+) GAACAT/GTAGAG 2 -- int111Minor allele frequency- G:0.05EA NA 1992
    rs7040791,2
    		A,89745186(+) TAGAAA/GGAAAC 2 -- int11Minor allele frequency- G:0.00MN 184
    rs7697001,2
    		C,F,A,89743614(-) TCTGGT/CATTCA 2 -- int115Minor allele frequency- C:0.10EA NA NS WA 2354
    rs7697011,2
    		C,F,A,89743589(+) TGGGTG/ACATTC 2 -- int112Minor allele frequency- A:0.18NA EA WA 632
    About this table

    HapMap Linkage Disequilibrium images for DUSP6 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DUSP6: --

    QIAGEN SeqTarget long-range PCR primers for resequencing DUSP6 

    Disorders & Mutations
    for DUSP6 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DUSP6 for disorders           About GeneDecksing

    OMIM: 602748

    2 Novoseek disease relationships for DUSP6 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 21.1 14 15832194 (3), 18771677 (1), 15240129 (1), 18694935 (1) (see all 8)
    breast cancer 0 2 16740736 (2)
    About this table

    1 PharmGKB disease relationship for DUSP6 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
    About this table

    Genetic Association Database (GAD): DUSP6
    Human Genome Epidemiology (HuGE) Navigator: DUSP6 (4 documents)

    Export disorders and mutations for DUSP6 gene to outside databases

    Medical News
    for DUSP6 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for DUSP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/115 PubMed articles for DUSP6 gene, integrated from 7 sources (see all 115):
    (articles sorted by number of sources associating them with DUSP6)
    1. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PubMed id 8626780)1, 3, 7 Muda M....Arkinstall S. (1996)
    2. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3, 7 Smith A....Ashworth A. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation. (PubMed id 10048930)1, 2 Stewart A.E.... McDonald N.Q. (1999)
    5. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. (PubMed id 9858808)1, 2 Furukawa T....Horii A. (1998)
    6. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. (PubMed id 8670865)1, 2 Groom L.A.... Keyse S.M. (1996)
    7. Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. (PubMed id 18771677)1, 7 Zeliadt N.A....Wattenberg E.V. (2008)
    8. Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3. (PubMed id 19091959)1, 7 Whetzel A.M....Hedrick C.C. (2009)
    9. Intramolecular dephosphorylation of ERK by MKP3. (PubMed id 14690430)1, 7 Kim Y....Denu J.M. (2003)
    10. Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation. (PubMed id 19106095)1, 7 Jurek A....Lennartsson J. (2009)

    External Searches for DUSP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DUSP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1848 HGNC: 3072 AceView: DUSP6 Ensembl:ENSG00000139318 euGenes: HUgn1848
    ECgene: DUSP6 Kegg: 1848 H-InvDB: DUSP6

    Other Databases showing DUSP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUSP6 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for DUSP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for DUSP6 gene:
    Search GeneIP for patents involving DUSP6

    GeneCards and IP:
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    Products
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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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