Aliases &
Descriptions
for DYNLRB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| dynein, light chain, roadblock-type 11 2 | | BLP2 3 | | DNLC2A1 2 3 5 | | BITH2 3 | | ROBLD11 2 3 | | dynein light chain roadblock-type 12 | | DNCL2A2 3 5 | | roadblock domain containing 12 | | dynein, cytoplasmic, light polypeptide 2A1 2 | | dynein-associated protein HKM232 | | Roadblock domain-containing protein 12 3 | | Roadblock-12 | | Bithoraxoid-like protein2 3 | | cytoplasmic dynein light chain 2A2 | | Dynein light chain 2A, cytoplasmic2 3 | | ROBL/LC7-like 12 | | Dynein-associated protein Km232 3 | | |
Export aliases for DYNLRB1 gene to outside databasesPrevious GC identifers: GC20P032568 GC20P033104 |
Summaries
for DYNLRB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DYNLRB1:
This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable ofbinding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas,suggesting that this gene may be involved in tumor progression. (provided by RefSeq)
UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules
Gene Wiki entry for DYNLRB1 |
Genomic Views
for DYNLRB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DYNLRB1 gene promoter:
NF-kappaB1 NF-kappaB FOXJ2 (long isoform) GATA-1 Nkx3-1 v1 Nkx3-1 v2 Nkx3-1 v3 Nkx3-1 Nkx3-1 v4 Cdc5
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYNLRB1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DYNLRB1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.21DYNLRB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P029885: view genomic region
(about GC identifiers)
Start:
|
29,885,141 bp from pter |
End:
|
29,909,381 bp from pter |
Size:
|
24,241 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr20+ 33,104,214-33,128,762 |
RefSeq DNA sequence:- NC_000020.10 NT_011362.10
|
Proteins
for DYNLRB1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97 (See
protein sequence)Recommended Name: Dynein light chain roadblock-type 1 Size: 96 amino acids; 10922 Da
Subunit: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number ofnon-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains(LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves asa scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs binddirectly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNLRB2. Interacts withDYNC1I1 and DYNC1I2. Interacts with RAB6A isoform 1 (GTP-bound); the interaction is direct. Interacts with RAB6Aisoform 2 (GDP-bound); the interaction is direct. Interacts with RAB6B (GDP-bound)
Subcellular location: Cytoplasm
PDB structures from  and Proteopedia  :1Z09 (3D)
2B95 (3D)
2E8J (3D)
2HZ5 (3D)
Secondary accessions: B1AKR5 Q5TC72 Q96IV3 Q9NQM2Alternative splicing: 2 isoforms: Q9NP97-1 Q9NP97-2 (Additional isoforms seem to exist)Explore the universe of human proteins at neXtProt for DYNLRB1: NX_Q9NP97
REFSEQ proteins: NP_054902.1
ENSEMBL proteins: ENSP00000363979 ENSP00000349679 ENSP00000300469 ENSP00000409090
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
DYNLRB1 for ontologies About GeneDecksing
Antibodies for DYNLRB1:
Assays for DYNLRB1: |
Protein
Domains/
Families
for DYNLRB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DYNLRB1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NP97ProtoNet protein and cluster: Q9NP97 1 Blocks protein family: IPB004942 Roadblock/LC7 family
UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97Similarity: Belongs to the GAMAD family |
Gene Function
for DYNLRB1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
DYNLRB1 for ontologies About GeneDecksing
|
Pathways & Interactions
for DYNLRB1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
DYNLRB1 for pathways About GeneDecksing
2  Millipore Pathways for DYNLRB1
SABiosciences Custom Pathway-Focused PCR Arrays for DYNLRB1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNLRB1
5/12 Interacting proteins for DYNLRB1 (ENSP000003639793 Q9NP971, 2) via UniProtKB, MINT, and/or STRING (see all 12)About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
DYNLRB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DYNLRB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DYNLRB1
|
Transcripts
for DYNLRB1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DYNLRB1 gene: NM_014183.2 Additional cDNA sequence: AF132750.1 AF161511.1 AF165516.1 AF178431.1 AK026864.1 AK294214.1 AY026513.1 BC002481.1 BC007223.2 CR596463.1 CR600460.1 CR624938.1 CR626029.1 21 DOTS entries: DT.100038015 DT.452007 DT.100795433 DT.95369365 DT.100795437 DT.92453938 DT.403148 DT.92453929 DT.95369369 DT.100795431 DT.120810789 DT.95369367 DT.100038013 DT.100795435 DT.40240199 DT.40316790 DT.87016853 DT.95361597 DT.95369368 DT.95369371 DT.91941391 24/670 AceView cDNA sequences (see all 670): AA398454 CD672468 AI077737 H63783 AW327452 AI041699 BC007223 R25185 AA719579 R77472 BG577096 BM708016 BU726444 BG059838 BQ001615 CD675456 BU619291 T95290 BQ630963 BU185217 BE905565 BM670714 AA293684 BI868702
 highest scoring ESTs for DYNLRB1:AA843531 AA027843 AA027908 AA037164 AA074220 AA074324 AA074365 AA083589 AA130842 AA130847 Unigene Cluster for DYNLRB1: Dynein, light chain, roadblock-type 1 Hs.728192 [show with all ESTs]Unigene Representative Sequence: BC007223
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB1 (see all 10)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DYNLRB1
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000480759 ENST00000374846 ENST00000357156(uc002xal.2 uc002xam.2 uc002xan.2)
ENST00000300469(uc002xao.2) ENST00000417166(uc010zuk.1)
|
Expression
for DYNLRB1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DYNLRB1 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching DYNLRB1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 48776_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AA843531 |
1.00 |
1.00 |
1.00 |
1 |
| 217918_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_014183 |
0.60 |
1.00 |
0.82 |
1 |
| 217917_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_014183 |
0.60 |
1.00 |
0.82 |
1 |
| 217918_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217917_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1554568_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1565611_at*2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DYNLRB1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCAGTCGCTT
SOURCE GeneReport for Unigene cluster: Hs.728192
UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97Tissue specificity: High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle andkidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64%hepatocellular carcinoma (HCC) patients
SABiosciences Custom PCR Arrays for DYNLRB1
|
Orthologs
for DYNLRB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DYNLRB1 gene from 5/9 species (see all 9)
About this table Species with no ortholog for DYNLRB1
ENSEMBL Gene Tree for DYNLRB1 (if available) |
Paralogs
for DYNLRB1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DYNLRB1 gene
- DYNLRB22
DYNLRB1 for paralogs About GeneDecksing
Pseudogenes
- 3 related pseudogenes
|
Genomic Variants
for DYNLRB1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 20 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DYNLRB1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for DYNLRB1
5 Indels: 42475 12178 40448 46091 26815 | | QIAGEN SeqTarget long-range PCR primers for resequencing DYNLRB1 |
|
Disorders & Mutations
for DYNLRB1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DYNLRB1 for disorders About GeneDecksing
OMIM: 607167
Export disorders and mutations for DYNLRB1 gene to outside databases
|
Medical News
for DYNLRB1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DYNLRB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/23 PubMed articles for DYNLRB1 gene, integrated from 7 sources (see all 23):
(articles sorted by number of sources associating them with DYNLRB1)- Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PubMed id 11750132)1, 2, 3, 7 Jiang J.... Zhao S. (2001)
- Rab6 family proteins interact with the dynein light chain protein DYNLRB1. (PubMed id 18044744)1, 2 Wanschers B.F.J.... Fransen J. (2008)
- Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74. (PubMed id 16970917)1, 2 Liu J.F....Liang D.C. (2006)
- Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. (PubMed id 12077152)1, 2 Susalka S.J....Pfister K.K. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
|
External Searches for DYNLRB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DYNLRB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYNLRB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYNLRB1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DYNLRB1 gene:
Search GeneIP for patents involving DYNLRB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYNLRB1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for DYNLRB1 |
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