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Aliases & Descriptionsfor DYNLRB2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions dynein, light chain, roadblock-type 21 2 Roadblock domain-containing protein 22 3 DNLC2B1 2 3 bithoraxoid-like protein2 ROBLD21 2 3 roadblock/LC7-like2 DNCL2B2 3 5 roadblock domain containing 22 dynein, cytoplasmic, light polypeptide 2B1 2 MGC620332 Dynein light chain 2B, cytoplasmic2 3 dynein light chain roadblock-type 22
Export aliases for DYNLRB2 gene to outside databases Previous GC identifers: GC16P079133 GC16P080574
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Summariesfor DYNLRB2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09 Function : Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules
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Genomic Viewsfor DYNLRB2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DYNLRB2 gene promoter: Cart-1 FOXO1a POU2F1 Cdc5 GATA-3 GATA-2 GATA-1 FOXO3a FOXO3b FOXO4 Other transcription factors Search SABiosciences Chromatin IP Primers for DYNLRB2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q23.3 Ensembl cytogenetic band: 16q23.2 HGNC cytogenetic band: 16q23.3 DYNLRB2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P066331: view genomic region
(about GC identifiers )
Start:
66,331,392 bp from pter
End:
66,341,090 bp from pter
Size:
9,699 bases
Orientation:
plus strand
1 alternative location : Chr 16+ 80,574,854-80,584,541
RefSeq DNA sequence: NC_000016.9 NT_010498.15
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Proteinsfor DYNLRB2 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09 (See
protein sequence )Recommended Name: Dynein light chain roadblock-type 2 Size : 96 amino acids; 10855 Da
Subunit : Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and anumber of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1
Subcellular location : Cytoplasm
Miscellaneous : Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patientsExplore the universe of human proteins at neXtProt for DYNLRB2: NX_Q8TF09
REFSEQ proteins: NP_570967.1 ENSEMBL proteins: ENSP00000342009 ENSP00000302936 Human Recombinant Proteins 3 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
DYNLRB2 for ontologies About GeneDecksing Antibodies for DYNLRB2: Assays for DYNLRB2:
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Protein
Domains/ Familiesfor DYNLRB2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DYNLRB2 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TF09 ProtoNet protein and cluster: Q8TF09
1 Blocks protein family : IPB004942 Roadblock/LC7 family UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09 Similarity : Belongs to the GAMAD family
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Gene Functionfor DYNLRB2 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09 Function : Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
DYNLRB2 for ontologies About GeneDecksing
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Pathways & Interactionsfor DYNLRB2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
DYNLRB2 for pathways About GeneDecksing 2 Millipore Pathways for DYNLRB2 SABiosciences Custom Pathway-Focused PCR Arrays for DYNLRB2 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNLRB2 5 Interacting proteins for DYNLRB2 (ENSP00000302936 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
About this table
DYNLRB2 for ontologies About GeneDecksing
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Drugs & Compoundsfor DYNLRB2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for DYNLRB2
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Transcriptsfor DYNLRB2 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for DYNLRB2 gene: NM_130897.1
Additional cDNA sequence: AF125108.1 BC035232.1 BC054892.1
5 DOTS entries : DT.97778290 DT.95154196 DT.100019166 DT.75196573 DT.120656292
24 AceView cDNA sequences :
AA435968 AA446298 BC054892 AI826656 BX340151 AI023522 BQ109457 AA446025 AI026825 AA769674 CD676360 AA719152 AA872500 BC035232 BI830575 AA961187 AA300900 NM_130897 AF125108 BM668600 AA928442 BP370813 AW959427 AL043981
highest scoring ESTs for DYNLRB2 :AA435968 AA446025 AA446298 AA719152 AA769674 AA872500 AF125108 AI023522 AI026825 AL043981 Unigene Cluster for DYNLRB2:
Dynein, light chain, roadblock-type 2 Hs.98849 [show with all ESTs ] Unigene Representative Sequence: BC035232 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB2 ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b SP1 :           -         SP2 :   -   -     -   -         SP3 :         -   -         SP4 :         -          
About this scheme ECgene alternative splicing isoforms for DYNLRB2 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000338542 ENST00000305904 (uc002ffo.2 uc002ffp.2 uc002ffq.2 )
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Expression for DYNLRB2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section DYNLRB2 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching DYNLRB2 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
47635_at2 , 3
U95-B
1
0.81
1.00
1.00
1.00
AA719152
0.80
1.00
0.91
1
238116_at2 , 3
U133-B
1
0.73
1.00
--
--
AW959427
0.80
1.00
0.91
1
238116_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
About this table
DYNLRB2 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGTATTAAAA SOURCE GeneReport for Unigene cluster: Hs.98849 UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09 Tissue specificity : High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderatein kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte
SABiosciences Custom PCR Arrays for DYNLRB2
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Orthologsfor DYNLRB2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for DYNLRB2 gene from 5/14 species (see all 14 )
About this table Species with no ortholog for DYNLRB2 ENSEMBL Gene Tree for DYNLRB2 (if available)
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Paralogsfor DYNLRB2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for DYNLRB2 gene DYNLRB1 2
DYNLRB2 for paralogs About GeneDecksing
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Genomic Variantsfor DYNLRB2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 16 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for DYNLRB2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DYNLRB2: --
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Disorders & Mutationsfor DYNLRB2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DYNLRB2 for disorders About GeneDecksing
OMIM: 607168 Human Genome Epidemiology (HuGE) Navigator: DYNLRB2 (2 documents) Export disorders and mutations for DYNLRB2 gene to outside databases
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Medical Newsfor DYNLRB2 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor DYNLRB2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 8 PubMed articles for DYNLRB2 gene integrated from 7 sources : (articles sorted by number of sources associating them with DYNLRB2) Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PubMed id 11750132) 1 , 2 , 3, 7 Jiang J.... Zhao S. (2001) Cytoplasmic dynein nomenclature. (PubMed id 16260502) 1 , 3 Pfister K.K....Vallee R.B. (2005) The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. (PubMed id 12077152) 1 , 2 Susalka S.J....Pfister K.K. (2002) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255) 1 Dastani Z....Genest J. (2010) Requirement of a dynein light chain in TGFbeta/Smad3 signaling. (PubMed id 19711352) 1 Jin Q....Mulder K.M. (2009) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801) 1 Gevaert K.... Vandekerckhove J. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DYNLRB2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DYNLRB2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DYNLRB2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DYNLRB2 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DYNLRB2 gene: Search GeneIP for patents involving DYNLRB2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DYNLRB2 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for DYNLRB2
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