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DYRK1A Gene

protein-coding   GIFtS: 60

GC21P024215
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: DYRK1, DYRK, MNBH)
Products    

Aliases &
Descriptions
for DYRK1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section
Aliases & Descriptions
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A1 2     dual specificity tyrosine-phosphorylation-regulated kinase 1A2
MNBH2 3 5     DYRK12
MNB2 3 5     mnb protein kinase homolog hp862
Dual specificity YAK1-related kinase2 3     serine/threonine kinase MNB2
Protein kinase minibrain homolog2 3     MNB/DYRK protein kinase2
HP862 3     serine/threonine-specific protein kinase2
DYRK2 3     EC 2.7.12.13
hMNB2 3     dual-specificity tyrosine-Y-phosphorylation regulated kinase, EC 2.7.19
OTTHUMP000001090902     

External Ids:    HGNC: 30911   Entrez Gene: 18592   Ensembl: ENSG000001575407   UniProtKB: Q136273   

Export aliases for DYRK1A gene to outside databases

Previous GC identifers: GC21P035317 GC21P037659 GC21P037712 GC21P037660 GC21P037661 GC21P038739


Summaries
for DYRK1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DYRK1A:
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member
contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly
conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine
residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in
brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the
Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects
associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from
each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
(provided by RefSeq)

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
Function: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates
serine, threonine and tyrosine residues in its sequence and in exogenous substrates

Gene Wiki entry for DYRK1A

Genomic Views
for DYRK1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYRK1A gene promoter:
         AP-1   CREB   c-Jun   c-Fos   deltaCREB   FOXO1a   POU3F1   POU3F2   CUTL1   Bach1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DYRK1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DYRK1A 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13   Ensembl cytogenetic band:  21q22.13   HGNC cytogenetic band: 21q22.13
Nature(405: 311-319) cytogenetic band:   21q22.13
DYRK1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK1A gene location
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P024215:   GeneLoc Nature:405,311-319
Start:
 24,215,875 bp from pter       24,367,732 bp from centromere
End:
 24,363,782 bp from pter 24,464,002 bp from centromere
Size:
 147,908 bases 96,271 bases
Orientation:
 plus strand plus strand

1 alternative location:
Chr21+ 38,739,236-38,887,680     
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  

Whole chromosome sequencing:
cDNA sequence: D86550
genomic clones: pT1091 to pS165

Proteins
for DYRK1A gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A  
Size: 763 amino acids; 85584 Da
Subunit: Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9. Interacts with WDR68
Subcellular location: Nucleus speckle
Developmental stage: Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome
brain
PDB structure from and Proteopedia :
2VX3 (3D)    2WO6 (3D)    
Secondary accessions: O60769 Q92582 Q92810 Q9UNM5
Alternative splicing: 5 isoforms:  Q13627-1   Q13627-2   Q13627-3   Q13627-4   Q13627-5   (Additional isoforms seem to exist)

Explore the universe of human proteins at neXtProt for DYRK1A: NX_Q13627 

Post-translational modifications:

  • Autophosphorylated on tyrosine residues1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (4 alternative transcripts): 
    NP_001387.2  NP_567824.1  NP_569120.1  NP_569122.1  


    ENSEMBL proteins: 
    ENSP00000416089 ENSP00000381929 ENSP00000342690 ENSP00000407854 ENSP00000319032 ENSP00000381932 
    ENSP00000398483 ENSP00000340373 ENSP00000412912 ENSP00000412269 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant DYRK1A Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: DYRK1A
    GenScript Custom Purified and Recombinant Proteins Services for DYRK1A 
    Novus Biologicals Protein for DYRK1A
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus ISS--
    GO:0016607 nuclear speck ISS--
    About this table

    DYRK1A for ontologies           About GeneDecksing



    Antibodies for DYRK1A: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DYRK1A
    R&D Systems Antibodies for DYRK1A
    Cell Signaling Technology (CST) Antibodies for DYRK1A 
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for DYRK1A 
    Novus Biologicals Antibodies for DYRK1A
    Browse antibodies at Epitomics

    Assays for DYRK1A: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DYRK1A 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DYRK1A 

    Protein Domains/
    Families
    for DYRK1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DYRK1A for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR017442 Se/Thr_prot_kinase-like_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q13627

    ProtoNet protein and cluster: Q13627

    UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    Gene Function
    for DYRK1A gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
    Function: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates
    serine, threonine and tyrosine residues in its sequence and in exogenous substrates
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by RANBP9
    Enzyme Number (IUBMB): EC 2.7.12.1 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for DYRK1A
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DYRK1A
    Sigma-Aldrich shRNA Panels and shRNA for DYRK1A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): DYRK1A
    OriGene shRNA RFP (see all 5): DYRK1A
    OriGene basic RS shRNA (see all 5): DYRK1A
    OriGene siRNA (see all 5): DYRK1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DYRK1A 
    miRNA:Sigma-Aldrich microRNA Mimics for DYRK1A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DYRK1A 
    8/27 SABiosciences Assays for microRNAs that regulate DYRK1A (see all 27):
    hsa-miR-498 hsa-miR-217 hsa-miR-520d-5p hsa-miR-522 hsa-miR-485-3p hsa-miR-487a hsa-miR-557 hsa-miR-548a-3p

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): DYRK1A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): DYRK1A
    OriGene untagged cDNA clones in CMV expression vector (see all 5): DYRK1A
    OriGene 3'-UTR clone (see all 4): DYRK1A 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DYRK1A 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for DYRK1A 

    Genatlas biochemistry entry for DYRK1A:
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1,Drosophila minibrain homolog Dres27,mouse homolog
    ubiquitously expressed at low levels in embryo,expressed in adult central nervous system -cortex,hippocampus,striatum
    and spinal cord) located in the Down syndrome critical region (DCR),involved in post-embryonic neurogenesis,putatively
    overexpressed in Down syndrome and involved in the learning defect and in hypotonia

    5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity TAS8975710
    GO:0004674 protein serine/threonine kinase activity ISS--
    GO:0004713 protein tyrosine kinase activity ISS--
    GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA9748265
    About this table

    DYRK1A for ontologies           About GeneDecksing

    Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dyrk1a):

    cardiovascular systemcraniofacialembryogenesisgrowth/sizelethality-postnatal
    lethality-prenatal/perinatalliver/biliary systemnervous system

    DYRK1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DYRK1A gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    DYRK1A for pathways           About GeneDecksing

    1 Millipore Pathway for DYRK1A
        Translation Regulation activity of EIF2

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  DYRK1A
        Inositol Phosphate Metabolism
    Nicotinate and Nicotinamide Metabolism
    Sonic Hedgehog Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for DYRK1A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DYRK1A
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DYRK1A

    5/22 Interacting proteins for DYRK1A (ENSP000003403733 Q136272) via UniProtKB, MINT, and/or STRING (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622582MINT-51046 MINT-51048 MINT-51047
    SFNP319472MINT-3975419
    YWHABP319462MINT-8007738
    YWHAGP619812MINT-50850
    MDM2ENSP000002581493STRING: ENSP00000258149
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation ISS--
    GO:0007399 nervous system development TAS8769099
    GO:0018108 peptidyl-tyrosine phosphorylation ISS--
    GO:0046777 protein autophosphorylation ISS--
    About this table

    DYRK1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for DYRK1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    DYRK1A for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for DYRK1A:
    Small Molecule - Inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DYRK1A
    10 Novoseek chemical compound relationships for DYRK1A gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 63.7 6 15780591 (1), 11828259 (1), 14990717 (1), 19016842 (1) (see all 6)
    serine 52.2 4 11828259 (1), 14990717 (1), 19801542 (1), 19796173 (1)
    tyrosine 49.9 47 17536841 (6), 19796173 (3), 12604362 (2), 19016842 (2) (see all 17)
    glycogen 40.2 1 11311121 (1)
    phosphotyrosine 21.3 10 17536841 (2)
    leucine 11.7 2 8975710 (1), 9070862 (1)
    arginine 8.37 4 10644696 (1), 14623875 (1), 11755526 (1)
    proline 3.33 2 11311121 (1)
    histidine 0 1 17536841 (1)
    alanine 0 2 10644696 (1), 12604362 (1)
    About this table



    Transcripts
    for DYRK1A gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for DYRK1A
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DYRK1A
    Sigma-Aldrich shRNA Panels and shRNA for DYRK1A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): DYRK1A
    OriGene shRNA RFP (see all 5): DYRK1A
    OriGene basic RS shRNA (see all 5): DYRK1A
    OriGene siRNA (see all 5): DYRK1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DYRK1A 
    miRNA: Sigma-Aldrich microRNA Mimics for DYRK1A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DYRK1A 
    8/27 SABiosciences Assays for microRNAs that regulate DYRK1A (see all 27):
    hsa-miR-498 hsa-miR-217 hsa-miR-520d-5p hsa-miR-522 hsa-miR-485-3p hsa-miR-487a hsa-miR-557 hsa-miR-548a-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): DYRK1A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): DYRK1A
    OriGene untagged cDNA clones in CMV expression vector (see all 5): DYRK1A
    OriGene 3'-UTR Clone (see all 4): DYRK1A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DYRK1A 
    Primers: OriGene genome-wide validated SYBR primer pairs: DYRK1A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DYRK1A: PPH09997A

    REFSEQ mRNAs for DYRK1A gene (4 alternative transcripts): 

    NM_001396.3  NM_101395.2  NM_130436.2  NM_130438.2  

    Additional cDNA sequence: 

    AB015282.1 AB015283.1 AB015284.1 AF108830.1 AJ001870.1 AJ001871.1 AK301752.1 BC030515.1 
    BC045802.1 BC065184.1 D85759.1 D86550.1 U52373.1 U58496.1 Z25423.1 

    9 DOTS entries:

    DT.97806866  DT.100791954  DT.449194  DT.92438592  DT.75101238  DT.121141919  DT.121141927  DT.92044861 
    DT.92438591 

    24/287 AceView cDNA sequences (see all 287):

    AU119258 AA887600 NM_101395 NM_001396 AI174919 CB134205 BI495555 AA866036 
    BI753541 AB015283 AI478511 BM975913 NM_130437 AW573170 BG165287 F04034 
    AA687255 AI424886 AI391600 BE790930 BM722758 CD557221 AA932861 W93238 

    highest scoring ESTs for DYRK1A:

    D86550 U52373 U58496 AA279906 AA306050 AA322447 AA331181 AA337593 AA342261 AA497079 

    Unigene Cluster for DYRK1A:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
    Hs.368240  [show with all ESTs]
    Unigene Representative Sequence: NM_130436


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1A (see all 6)

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:                                -                                                                                       
    SP2:                                                        -                                                     -         
    SP3:                                                                                                              -         
    SP4:                          -     -                       -                                                               
    SP5:                          -     -     -                 -                                                               

    About this scheme

    ECgene alternative splicing isoforms for DYRK1A
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451934 ENST00000498351 ENST00000398956 ENST00000338785(uc002ywg.1 uc002ywh.1 uc002ywi.2 uc002ywk.2 uc002ywl.2 uc002ywm.2 uc011aei.1)
    ENST00000455387 ENST00000321219 ENST00000398960 ENST00000455097(uc010gno.1)
    ENST00000339659(uc002ywj.2) ENST00000446708 ENST00000462274 ENST00000426672


    Expression
    for DYRK1A gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DYRK1A expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching DYRK1A gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36947_s_at2, 3 U95-A 1 1.00 1.00 -0.12 0.16 U58496 1.00 1.00 1.00 1
    827_s_at2, 3 U95-A 1 1.00 1.00 -0.08 0.15 U52373 1.00 1.00 1.00 1
    36946_at2, 3 U95-A 1 1.00 1.00 0.97 1.01 D86550 1.00 1.00 1.00 1
    1512_at2, 3 U95-A 1 1.00 1.00 0.98 0.99 D86550 1.00 1.00 1.00 1
    211541_s_at2, 3 U133-A 1 1.00 1.00 -- -- U52373 1.00 1.00 1.00 1
    211079_s_at2, 3 U133-A 1 1.00 1.00 -- -- Z25423 0.40 1.00 0.76 1
    209033_s_at2, 3 U133-A 1 1.00 1.00 -- -- D86550 1.00 1.00 1.00 1
    211541_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    211079_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    209033_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    DYRK1A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DYRK1A gene expression
    DYRK1A gene electronic northern expression
    DYRK1A gene sage expression
    About these images

    CGAP SAGE TAG: CGGTCTTATG

    SOURCE GeneReport for Unigene cluster: Hs.368240

    Expression variation in blood from EXPOLDB for DYRK1A

    UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
    Tissue specificity: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney

    Primers: OriGene genome-wide validated SYBR primer pairs: DYRK1A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DYRK1A: PPH09997A
        SABiosciences Custom PCR Arrays for DYRK1A 


    Orthologs
    for DYRK1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for DYRK1A gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 DYRK1A1   -- dual-specificity tyrosine-(Y)-phosphorylation regulated more 96.19(n)
    99.54(a)    		 487755  XM_844487.1  XP_849580.1 
    chimpanzee
    (Pan troglodytes)    		 DYRK1A1   -- dual-specificity tyrosine-(Y)-phosphorylation regulated more 99.65(n)
    100(a)    		 458545  XM_514894.2  XP_514894.2 
    cow
    (Bos taurus)    		 DYRK1A1   -- dual-specificity tyrosine-(Y)-phosphorylation regulated more 95.54(n)
    99.61(a)    		 532989  XM_612233.3  XP_612233.2 
    rat
    (Rattus norvegicus)    		 Dyrk1a1   -- dual-specificity tyrosine-(Y)-phosphorylation regulated more 94.28(n)
    99.61(a)    		 25255  NM_012791.1  NP_036923.1 
    mouse
    (Mus musculus)    		 Dyrk1a1 , 5 16 (55.30 cM)5
    		 dual-specificity tyrosine-(Y)-phosphorylation regulated more1, 5 93.93(n)1
    99.21(a)1    		 135481  NM_007890.11  NP_031916.11 
     AK0097885  AK0478455  (see all 26)
    About this table        Species with no ortholog for DYRK1A

    ENSEMBL Gene Tree for DYRK1A (if available)

    Paralogs
    for DYRK1A gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DYRK1A gene
    HIPK12  HIPK32  HIPK42  HIPK22  DYRK1B2  

    DYRK1A for paralogs           About GeneDecksing



    Genomic Variants
    for DYRK1A gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1470 NCBI SNPs in DYRK1A are shown (see all 1470)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 21 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs77201,2
    		C,F,A,38887206(+) TAAACC/TGATAT 5 -- ut31 ese311Minor allele frequency- T:0.21MN NA NS EA 1186
    rs9287631,2
    		C,F,O,A,H,38850640(+) TTGCAA/GTATGT 4 -- int119Minor allele frequency- G:0.10NA EA MN NS WA 889
    rs9287641,2
    		C,F,O,A,38827730(+) TAAATA/GATGGT 4 -- int118Minor allele frequency- G:0.40NA EA MN NS WA 1275
    rs10102651,2
    		C,38795562(+) TCTTCT/CGAGCT 4 -- int1 trp311Minor allele frequency- C:0.00MN NS EA NA WA 604
    rs10242941,2
    		C,F,O,A,H,38859427(+) TGAATT/CTCTAC 4 -- int124Minor allele frequency- C:0.46NS EA NA WA 1371
    rs10497531,2
    		--38845020(+) TCTGTC/TCGGCT 10 V syn1 ref1 ese30--------
    rs10497541,2
    		--38845035(+) CCGTCA/GTTTTC 10 S ref1 syn11Minor allele frequency- G:0.00MN 184
    rs10497551,2
    		--38845038(+) TCATTT/CTCATT 10 /F syn1 ref11Minor allele frequency- C:0.00MN 184
    rs10497561,2
    		H38845070(+) GGCTGG/CACAGA 10 /A /G mis1 ref14Minor allele frequency- C:0.00NS EA 406
    rs10497571,2
    		--38845083(+) CCCCAT/CTCACA 10 /H syn1 ref11Minor allele frequency- C:0.00MN 184
    About this table

    HapMap Linkage Disequilibrium images for DYRK1A (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DYRK1A: --

    QIAGEN SeqTarget long-range PCR primers for resequencing DYRK1A 

    Disorders & Mutations
    for DYRK1A gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DYRK1A for disorders           About GeneDecksing

    OMIM: 600855

    6 Novoseek disease relationships for DYRK1A gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 86 67 12618396 (4), 15694837 (3), 10812554 (3), 12814361 (2) (see all 33)
    mental retardation 71.7 8 15906374 (1), 16959772 (1), 9918863 (1), 11877424 (1) (see all 8)
    trisomy 45.4 7 11555628 (1), 16554754 (1), 19242551 (1)
    memory impairment 41.3 4 17696169 (1), 17536841 (1)
    alzheimers disease 37.6 8 19995442 (2), 18696092 (1), 17135279 (1), 19665384 (1) (see all 5)
    neuropathology 36.6 1 12618396 (1)
    About this table

    Human Gene Mutation Database (HGMD): DYRK1A
    Human Genome Epidemiology (HuGE) Navigator: DYRK1A (2 documents)

    Export disorders and mutations for DYRK1A gene to outside databases

    Medical News
    for DYRK1A gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for DYRK1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/141 PubMed articles for DYRK1A gene, integrated from 7 sources (see all 141):
    (articles sorted by number of sources associating them with DYRK1A)
    1. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'. (PubMed id 8975710)1, 2, 7 Song W.J....Kurnit D.W. (1996)
    2. Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. (PubMed id 10329007)1, 2, 7 Guimera J.... Pritchard M.A. (1999)
    3. Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2. (PubMed id 9284911)1, 3, 7 Guimera J....Estivill X. (1997)
    4. Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21. (PubMed id 8769099)1, 2, 7 Shindoh N....Shimizu N. (1996)
    5. A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. (PubMed id 8872470)1, 2, 7 Guimera J.... Pritchard M.A. (1996)
    6. Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. (PubMed id 9037601)1, 2, 7 Ohira M....Ohki M. (1997)
    7. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. (PubMed id 14593110)1, 2 Skurat A.V. and Dietrich A.D. (2004)
    10. Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran- binding protein M. (PubMed id 14500717)1, 2 Zou Y.... Friedman E. (2003)

    External Searches for DYRK1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DYRK1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1859 HGNC: 3091 AceView: DYRK1A Ensembl:ENSG00000157540 euGenes: HUgn1859
    ECgene: DYRK1A H-InvDB: DYRK1A

    Other Databases showing DYRK1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DYRK1A gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for DYRK1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for DYRK1A gene:
    Search GeneIP for patents involving DYRK1A

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    Products
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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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