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EIF2C1 Gene

protein-coding   GIFtS: 58

GC01P034466
eukaryotic translation initiation factor 2C, 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for EIF2C1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
eukaryotic translation initiation factor 2C, 11 2     Q992
AGO11 2 3     DKFZp686M131672
Putative RNA-binding protein Q992 3     protein argonaute-12
hAgo12 3     argonaute 12
eIF2C 12 3     Golgi Endoplasmic Reticulum protein 95 kDa2
eIF-2C 12 3     argonaute12
GERP952 5     Eukaryotic translation initiation factor 2C 13
EIF2C2 5     Argonaute13
OTTHUMP000000085182     

External Ids:    HGNC: 32621   Entrez Gene: 265232   Ensembl: ENSG000000928477   UniProtKB: Q9UL183   

Export aliases for EIF2C1 gene to outside databases

Previous GC identifers: GC01P036171 GC01P035391 GC01P035762 GC01P035776 GC01P036017 GC01P036107 GC01P036335


Summaries
for EIF2C1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EIF2C1:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded
protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in
short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related
family members including argonaute 3, and argonaute 4. (provided by RefSeq)

UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short
interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease
activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of
promoter regions which are complementary to bound short antigene RNAs (agRNAs)

Gene Wiki entry for EIF2C1

Genomic Views
for EIF2C1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF2C1 gene promoter:
         AP-1   MZF-1   SREBP-1c   SREBP-1b   SREBP-1a   Sox9   NRSF form 1   NRSF form 2   c-Myb   RREB-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for EIF2C1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for EIF2C1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

EIF2C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2C1 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P034466:  view genomic region     (about GC identifiers)

Start:
 34,466,263 bp from pter
End:
 34,506,900 bp from pter
Size:
 40,638 bases
Orientation:
 plus strand

1 alternative location:
Chr1+ 36,335,409-36,389,900     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

Proteins
for EIF2C1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18 (See protein sequence)
Recommended Name: Protein argonaute-1  
Size: 857 amino acids; 97214 Da
Subunit: Interacts with DDB1, DDX6, DDX20, DDX47, DHX9, DICER1, EIF2C2/AGO2, GEMIN4, ILF3, IMP8, MOV10, PRMT5, SART3,
TARBP2, TNRC6B and UPF1
Subcellular location: Cytoplasm, P-body
PDB structure from and Proteopedia :
1SI2 (3D)    1SI3 (3D)    
Secondary accessions: Q5TA57 Q6P4S0

Explore the universe of human proteins at neXtProt for EIF2C1: NX_Q9UL18 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_036331.1  

    ENSEMBL proteins: 
    ENSP00000362300 ENSP00000362302 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: EIF2C1
    GenScript Custom Purified and Recombinant Proteins Services for EIF2C1 
    Novus Biologicals Proteins for EIF2C1
    Novus Biologicals Lysate for EIF2C1
    Sino Biological Recombinant Protein for EIF2C1
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932 cytoplasmic mRNA processing body IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol TAS--
    About this table

    EIF2C1 for ontologies           About GeneDecksing



    Antibodies for EIF2C1: 
    Millipore Mono- and Polyclonal Antibodies for the study of EIF2C1
    Sigma-Aldrich Antibodies for EIF2C1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for EIF2C1  (Ago1)
    OriGene Antibodies: EIF2C1
    GenScript Custom Superior Antibodies Services for EIF2C1 
    Novus Biologicals Antibody for EIF2C1
    Browse antibodies at Epitomics

    Assays for EIF2C1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EIF2C1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for EIF2C1 

    Protein Domains/
    Families
    for EIF2C1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EIF2C1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR014811 DUF1785
     IPR003165 Piwi
     IPR003100 PAZ
     IPR012337 RNaseH-like

    Graphical View of Domain Structure for InterPro Entry Q9UL18

    ProtoNet protein and cluster: Q9UL18

    2 Blocks protein families:
    IPB003100 Argonaute and Dicer protein
    IPB003165 Stem cell self-renewal protein Piwi


    UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18
    Similarity: Belongs to the argonaute family. Ago subfamily
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 1 Piwi domain


    Gene Function
    for EIF2C1 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: AGO1_HUMAN, Q9UL18
    Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short
    interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease
    activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of
    promoter regions which are complementary to bound short antigene RNAs (agRNAs)

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for EIF2C1
    Sigma-Aldrich shRNA for EIF2C1
    OriGene 29mer shRNA kits in GFP-retroviral vector: EIF2C1
    OriGene shRNA RFP: EIF2C1
    OriGene basic RS shRNA: EIF2C1
    OriGene siRNA: EIF2C1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of EIF2C1 
    miRNA:Sigma-Aldrich microRNA Mimics for EIF2C1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of EIF2C1 
    8/44 SABiosciences Assays for microRNAs that regulate EIF2C1 (see all 44):
    hsa-miR-323-3p hsa-miR-1197 hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-105 hsa-miR-548l hsa-miR-1184

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: EIF2C1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: EIF2C1
    OriGene untagged cDNA clones in CMV expression vector: EIF2C1
    OriGene 3'-UTR clone: EIF2C1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: EIF2C1 
    Sino Biological Human cDNA Clone for EIF2C1

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for EIF2C1 

    Genatlas biochemistry entry for EIF2C1:
    eukaryotic initiation factor 2C1,ubiquitously expressed,putative accessory factor contributing to the formation of the
    ternary initiation complex made of E172,initiation Met-tRNA and GTP

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003723 RNA binding IEA--
    GO:0005515 protein binding IPI12526743
    About this table

    EIF2C1 for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Eif2c1):

    no phenotypic analysis

    EIF2C1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EIF2C1 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    EIF2C1 for pathways           About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  EIF2C1
        Regulation of eIF4 and p70S6K Signaling
    EIF2 Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for EIF2C1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for EIF2C1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF2C1

    5/188 Interacting proteins for EIF2C1 (ENSP000003623003 Q9UL181, 2) via UniProtKB, MINT, and/or STRING (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DICER1Q9UPY31, 2STRING: ENSP00000343745 EBI-527363,EBI-395506 MINT-6488488 MINT-6488791
    IPO8O153971EBI-527363,EBI-358808
    PRNPP041561EBI-527363,EBI-977302
    EIF2C2Q9UKV82MINT-6167681 MINT-6167695 MINT-6167661 MINT-6167702 MINT-6167688 MINT-6167709
    SART3Q150202MINT-6167588 MINT-6488590 MINT-6488488 MINT-6488791
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000956 nuclear-transcribed mRNA catabolic process IDA18771919
    GO:0006417 regulation of translation IEA--
    GO:0031047 gene silencing by RNA IEA--
    GO:0035278 negative regulation of translation involved in gene silencing by miRNA IDA18771919
    GO:0045449 regulation of transcription IEA--
    About this table

    EIF2C1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EIF2C1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF2C1


    Transcripts
    for EIF2C1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for EIF2C1
    Sigma-Aldrich shRNA for EIF2C1
    OriGene 29mer shRNA kits in GFP-retroviral vector: EIF2C1
    OriGene shRNA RFP: EIF2C1
    OriGene basic RS shRNA: EIF2C1
    OriGene siRNA: EIF2C1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of EIF2C1 
    miRNA: Sigma-Aldrich microRNA Mimics for EIF2C1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of EIF2C1 
    8/44 SABiosciences Assays for microRNAs that regulate EIF2C1 (see all 44):
    hsa-miR-323-3p hsa-miR-1197 hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-105 hsa-miR-548l hsa-miR-1184
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: EIF2C1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: EIF2C1
    OriGene untagged cDNA clones in CMV expression vector: EIF2C1
    OriGene 3'-UTR Clone: EIF2C1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: EIF2C1 
    Primers: OriGene genome-wide validated SYBR primer pairs: EIF2C1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for EIF2C1: PPH16729A

    REFSEQ mRNAs for EIF2C1 gene: 

    NM_012199.2  

    Additional cDNA sequence: 

    AF093097.1 AK000326.1 AK001622.1 AK002003.1 AK027611.1 AK314148.1 BC063275.1 CR936823.1 
    U92986.1 

    6 DOTS entries:

    DT.415593  DT.95279692  DT.91797251  DT.40108476  DT.95259083  DT.40226186 

    24/165 AceView cDNA sequences (see all 165):

    F03857 BG236359 BM794307 AA447772 AA699358 BQ425517 H88369 AA909793 
    AA453723 AI242569 F07607 BQ187004 BX953492 CK300071 AA477432 BI094423 
    H53427 BF438013 H88431 AU132504 BE467699 AA326718 AI251849 AF093097 

    highest scoring ESTs for EIF2C1:

    AA234651 AA453723 AA024743 AA024744 AA065244 AA065245 AA081632 AA150231 AA152289 AA295365 

    Unigene Cluster for EIF2C1:

    Eukaryotic translation initiation factor 2C, 1
    Hs.22867  [show with all ESTs]
    Unigene Representative Sequence: NM_012199


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373204(uc001bzk.2 uc001bzl.2 uc009vuy.2) ENST00000373206


    Expression
    for EIF2C1 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    EIF2C1 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching EIF2C1 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    53837_at2, 3 U95-B 1 0.88 1.00 0.51 1.17 AA234651 1.00 1.00 1.00 1
    47463_at2, 3 U95-B 1 0.81 1.00 0.00 0.85 AA453723 1.00 1.00 1.00 1
    87639_at2, 3 U95-E 1 0.50 1.00 0.86 1.00 AI971316 0.60 1.00 0.82 1
    88862_at2, 3 U95-D 1 0.44 1.00 0.83 0.99 W22173 0.80 1.00 0.91 1
    218287_s_at2, 3 U133-A 1 0.73 1.00 -- -- NM_012199 0.60 1.00 0.82 1
    222576_s_at2, 3 U133-B 1 0.64 1.00 -- -- AW071829 0.80 1.00 0.91 1
    218287_s_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    222576_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    EIF2C1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    EIF2C1 gene expression
    EIF2C1 gene electronic northern expression
    EIF2C1 gene sage expression
    About these images

    CGAP SAGE TAG: GATGGGGAAA

    SOURCE GeneReport for Unigene cluster: Hs.22867
    Primers: OriGene genome-wide validated SYBR primer pairs: EIF2C1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for EIF2C1: PPH16729A
        SABiosciences Custom PCR Arrays for EIF2C1 


    Orthologs
    for EIF2C1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for EIF2C1 gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 EIF2C11   -- eukaryotic translation initiation factor 2C, 1 95.64(n)
    100(a)    		 475337  XM_532563.2  XP_532563.2 
    chimpanzee
    (Pan troglodytes)    		 EIF2C11   -- eukaryotic translation initiation factor 2C, 1 99.81(n)
    100(a)    		 456747  XM_513312.2  XP_513312.2 
    cow
    (Bos taurus)    		 EIF2C11   -- eukaryotic translation initiation factor 2C, 1 95.33(n)
    99.88(a)    		 522972  XM_601262.3  XP_601262.3 
    rat
    (Rattus norvegicus)    		 Eif2c11   -- eukaryotic translation initiation factor 2C, 1 93.39(n)
    99.88(a)    		 313594  XM_233544.4  XP_233544.3 
    mouse
    (Mus musculus)    		 Eif2c11 , 5 4 (60.76 cM)5
    		 eukaryotic translation initiation factor 2C, 11, 5 93.31(n)1
    99.53(a)1    		 2365111  NM_153403.11  NP_700452.11 
     AB0814715  AK0809545  (see all 12)
    About this table        Species with no ortholog for EIF2C1

    ENSEMBL Gene Tree for EIF2C1 (if available)

    Paralogs
    for EIF2C1 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for EIF2C1 gene
    PIWIL42  PIWIL22  PIWIL12  EIF2C22  EIF2C42  PIWIL32  EIF2C32  

    EIF2C1 for paralogs           About GeneDecksing



    Genomic Variants
    for EIF2C1 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/281 NCBI SNPs in EIF2C1 are shown (see all 281)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs5814591,2
    		C,F,O,A,36375110(+) TTGCCC/TGGAGT 1 -- int114Minor allele frequency- T:0.45MN NS EA NA WA 1145
    rs5950551,2
    		C,F,O,A,H,36380133(-) AAAGAG/AAGACA 1 -- int1 trp314Minor allele frequency- A:0.45MN NS EA NA WA 1238
    rs5959611,2
    		C,F,O,A,H,36367780(+) CACCTA/GGGCGC 1 -- int111Minor allele frequency- G:0.44EA NA MN NS WA 728
    rs6196131,2
    		--36378770(-) ggtggC/Tgggcg 1 -- int10--------
    rs6205441,2
    		--36362100(+) aggatC/Tacagg 1 -- int10--------
    rs6209561,2
    		C,A,36362162(-) atggcG/Aaaacc 1 -- int11Minor allele frequency- A:0.50WA 2
    rs6274011,2
    		C,F36382741(+) GAATTT/CACCTA 1 -- int15Minor allele frequency- C:0.31MN NS EA 596
    rs6368321,2
    		C,F,A,36363475(+) ctcctG/Aaaaga 1 -- int112Minor allele frequency- A:0.49NS EA NA WA 844
    rs6440951,2
    		C,F,A,H,36363172(-) tgctgG/Agatta 1 -- int12Minor allele frequency- A:0.13NA WA 74
    rs6453781,2
    		--36363451(+) actatC/Gtgatt 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for EIF2C1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EIF2C1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing EIF2C1 

    Disorders & Mutations
    for EIF2C1 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EIF2C1 for disorders           About GeneDecksing

    OMIM: 606228

    Human Genome Epidemiology (HuGE) Navigator: EIF2C1 (9 documents)

    Export disorders and mutations for EIF2C1 gene to outside databases

    Medical News
    for EIF2C1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for EIF2C1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/59 PubMed articles for EIF2C1 gene, integrated from 7 sources (see all 59):
    (articles sorted by number of sources associating them with EIF2C1)
    1. Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. (PubMed id 10534406)1, 2, 3 Koesters R....Briner J. (1999)
    2. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. (PubMed id 16756390)1, 2, 7 Chu C.-Y. and Rana T.M. (2006)
    3. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 2 Weinmann L.... Meister G. (2009)
    4. Importance of translation and nonnucleolytic ago proteins for on- target RNA interference. (PubMed id 18771919)1, 2 Wu L.... Belasco J.G. (2008)
    5. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (2007)
    6. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. (PubMed id 16936728)1, 2 Janowski B.A.... Corey D.R. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. (PubMed id 15152257)1, 2 Ma J.-B.... Patel D.J. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Identification of eight members of the Argonaute family in the human genome. (PubMed id 12906857)1, 3 Sasaki T.... Shimizu N. (2003)

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    Genome Databases showing EIF2C1 gene

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    Entrez Gene: 26523 HGNC: 3262 AceView: EIF2C1 Ensembl:ENSG00000092847 euGenes: HUgn26523
    ECgene: EIF2C1 H-InvDB: EIF2C1

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