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ENPP3 Gene

protein-coding   GIFtS: 60

GC06P129540
ectonucleotide pyrophosphatase/phosphodiesterase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PDNP3)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ectonucleotide pyrophosphatase/phosphodiesterase 31 2     phosphodiesterase-I beta2
PDNP32 3 5     NPP32
B101 2     ectonucleotide pyrophosphatase/phosphodiesterase family member 32
gp130RB13-61 2     dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)2
PD-IBETA1 2     dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)2
CD203c1 2     OTTHUMP000000179012
Phosphodiesterase I/nucleotide pyrophosphatase 32 3     PD-Ibeta3
Phosphodiesterase I beta2 3     CD203c antigen3
E-NPP 32 3     

External Ids:    HGNC: 33581   Entrez Gene: 51692   Ensembl: ENSG000001542697   UniProtKB: O146383   

Export aliases for ENPP3 gene to outside databases

Previous GC identifers: GC06P131617 GC06M131805 GC06P131893 GC06P131939 GC06P132000


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ENPP3:
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular
nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane
proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary
tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human
mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus,
basophils, and mast cells. (provided by RefSeq)

UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638
Function: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars,
and NAD (By similarity)

Gene Wiki entry for ENPP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENPP3 gene promoter:
         ISGF-3   c-Myb   FOXL1   Sox9   Chx10   RORalpha1   RFX1   Nkx6-1   Cart-1   AREB6   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ENPP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ENPP3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q22

ENPP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENPP3 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P129540:  view genomic region     (about GC identifiers)

Start:
129,540,257 bp from pter
End:
129,650,562 bp from pter
Size:
110,306 bases
Orientation:
plus strand

1 alternative location:
Chr6+ 131,949,582-132,068,553     
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638 (See protein sequence)
Recommended Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3  
Size: 875 amino acids; 100124 Da
Cofactor: Binds 2 divalent metal cations per subunit (Probable)
Subcellular location: Membrane; Single-pass type II membrane protein (Potential). Secreted. Note=Located to the apical
surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma
membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells
Sequence caution: Sequence=AAD05192.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5JTL3

Explore the universe of human proteins at neXtProt for ENPP3: NX_O14638 

Post-translational modifications:

  • N-glycosylation is necessary for correct trafficking to the apical surface, but is not the apical targeting signal (By
  • similarity)1
  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or
  • variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond
    conserved in both1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005012.2  

    ENSEMBL proteins: 
    ENSP00000406261 ENSP00000350265 ENSP00000408642 ENSP00000399269 ENSP00000415589 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ENPP3 
    Novus Biologicals Protein for ENPP3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005887 integral to plasma membrane TAS9344668
    GO:0016020 membrane IEA--
    GO:0048471 perinuclear region of cytoplasm IDA10513816
    About this table

    ENPP3 for ontologies           About GeneDecksing



    Antibodies for ENPP3: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ENPP3
    R&D Systems Antibodies for ENPP3 (ENPP-3/CD203c)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ENPP3 
    Novus Biologicals Antibodies for ENPP3
    Browse antibodies at Epitomics

    Assays for ENPP3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ENPP3 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ENPP3 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ENPP3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR002591 Phosphodiest/P_Trfase
     IPR001604 DNA/RNA_non-sp_Endonuclease
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR020821 Extracellular_endonuc_su_A
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry O14638

    ProtoNet protein and cluster: O14638

    2 Blocks protein families:
    IPB001212 Somatomedin B
    IPB002591 Type I phosphodiesterase/nucleotide pyrophosphatase


    UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638
    Similarity: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family
    Similarity: Contains 2 SMB (somatomedin-B) domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638
    Function: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars,
    and NAD (By similarity)
    Catalytic activity: Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of
    3'-hydroxy-terminated oligonucleotides
    Catalytic activity: A dinucleotide + H(2)O = 2 mononucleotides
    Enzyme regulation: At low concentrations of ATP, a phosphorylated active site intermediate is formed which inhibits
    further ATP hydrolysis
    Induction: Up-regulated by stimulation by allergen or by cross-linking with IgE. The IgE-mediated activation is
    enhanced by tetradecanoyl phorbol acetate (TPA), a stimulator of the PKC pathway, and inhibited by the P13 kinase
    inhibitors, LY294002 and wortmannin. Up-regulated in invasive bile duct cancers

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ENPP3
    Sigma-Aldrich shRNA for ENPP3
    OriGene 29mer shRNA kits in GFP-retroviral vector: ENPP3
    OriGene shRNA RFP: ENPP3
    OriGene basic RS shRNA: ENPP3
    OriGene siRNA: ENPP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ENPP3 
    miRNA:Sigma-Aldrich microRNA Mimics for ENPP3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ENPP3 
    Search SABiosciences for Assays for microRNAs that regulate ENPP3

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ENPP3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ENPP3
    OriGene untagged cDNA clones in CMV expression vector: ENPP3
    OriGene 3'-UTR clone: ENPP3 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ENPP3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ENPP3 

    5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0003824 catalytic activity ----
    GO:0004528 phosphodiesterase I activity IEA--
    GO:0004551 nucleotide diphosphatase activity IEA--
    GO:0005044 scavenger receptor activity IEA--
    About this table

    ENPP3 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ENPP3 for pathways           About GeneDecksing

    1 Millipore Pathway for ENPP3
        NAD metabolism

    5/6 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  ENPP3 (see all 6)
        Riboflavin Metabolism
    Nicotinate and Nicotinamide Metabolism
    Pantothenate and CoA Biosynthesis
    Pyrimidine Metabolism
    Purine Metabolism

    5/6 Kegg Pathways  (Kegg details for ENPP3) (see all 6):
        hsa00230 Purine metabolism
    hsa00500 Starch and sucrose metabolism
    hsa00740 Riboflavin metabolism
    hsa00760 Nicotinate and nicotinamide metabolism
    hsa00770 Pantothenate and CoA biosynthesis

        SABiosciences Custom Pathway-Focused PCR Arrays for ENPP3 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ENPP3
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENPP3

    5/64 Interacting proteins for ENPP3 (ENSP000003502653 O146382) via UniProtKB, MINT, and/or STRING (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932MINT-7253566
    ACP1ENSP000002720673STRING: ENSP00000272067
    ACP2ENSP000002569973STRING: ENSP00000256997
    ADAENSP000003619653STRING: ENSP00000361965
    ADRBK1ENSP000003122623STRING: ENSP00000312262
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006796 phosphate metabolic process IDA10513816
    GO:0006955 immune response IEA--
    GO:0008152 metabolic process ----
    GO:0009143 nucleoside triphosphate catabolic process IDA10513816
    GO:0030505NOT inorganic diphosphate transport IDA10513816
    About this table

    ENPP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ENPP3 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENPP3
    3 Novoseek chemical compound relationships for ENPP3 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 65.1 17 19418203 (3), 16751009 (3), 16940746 (3), 11815741 (2) (see all 9)
    allergens 55.5 7 12403934 (2), 17275019 (1), 12956749 (1), 16918511 (1) (see all 5)
    wortmannin 39.1 1 17624239 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ENPP3
    Sigma-Aldrich shRNA for ENPP3
    OriGene 29mer shRNA kits in GFP-retroviral vector: ENPP3
    OriGene shRNA RFP: ENPP3
    OriGene basic RS shRNA: ENPP3
    OriGene siRNA: ENPP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ENPP3 
    miRNA: Sigma-Aldrich microRNA Mimics for ENPP3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ENPP3 
    Search SABiosciences for Assays for microRNAs that regulate ENPP3
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ENPP3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ENPP3
    OriGene untagged cDNA clones in CMV expression vector: ENPP3
    OriGene 3'-UTR Clone: ENPP3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ENPP3 
    Primers: OriGene genome-wide validated SYBR primer pairs: ENPP3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ENPP3: PPH15328A

    REFSEQ mRNAs for ENPP3 gene: 

    NM_005021.3  

    Additional cDNA sequence: 

    AK024899.1 AK226107.1 AK292903.1 AK296080.1 AK309080.1 AK310691.1 AK315893.1 DQ234347.1 
    EF560735.1 

    4 DOTS entries:

    DT.110060  DT.100742267  DT.121321943  DT.100742266 

    24/45 AceView cDNA sequences (see all 45):

    CF529367 AI539373 AL696295 BX098243 AI570172 BX482253 AI589225 NM_005021 
    AW293070 AA034097 AI872744 AK024899 AI862179 AL708614 AI190925 AA872930 
    AI300713 BE463716 AI765324 AI685421 AI758400 AI219273 AI200230 AU100145 

    highest scoring ESTs for ENPP3:

    AI765324 AA001826 AA002029 AA034097 AA527645 AA678335 AA813122 AA884920 AI190925 AI200230 

    Unigene Cluster for ENPP3:

    Ectonucleotide pyrophosphatase/phosphodiesterase 3
    Hs.486489  [show with all ESTs]
    Unigene Representative Sequence: NM_005021


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ENPP3

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:              -     -                 -                                                                                                                     
    SP2:              -     -                 -                                                                                                           -         
    SP3:                    -                                                                                                                                       
    SP4:              -                                                                                                                                             

    ExUns: 26 ^ 27 ^ 28a · 28b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        

    About this scheme

    ECgene alternative splicing isoforms for ENPP3
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414305(uc010kfp.1 uc003qcu.3 uc003qcv.2 uc010kfq.2)
    ENST00000357639 ENST00000423831 ENST00000494023 ENST00000427148 ENST00000470930
    ENST00000427707(uc011ecc.1 uc010kfn.1 uc010kfo.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ENPP3 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching ENPP3 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    89860_at2, 3 U95-E 1 0.81 1.00 1.00 1.00 AI765324 1.00 1.00 1.00 1
    232737_s_at2 U133-B 1 0.91 1.00 -- -- -- -- -- -- --
    222938_x_at2, 3 U133-B 1 0.91 1.00 -- -- AI685421 0.80 1.00 0.91 1
    219912_s_at*2, 3 U133-A 1 0.46 1.00 -- -- NM_005021 0.60 1.00 0.82 1
    232737_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    222938_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    219912_s_at*2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    ENPP3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ENPP3 gene expression
    ENPP3 gene electronic northern expression
    ENPP3 gene sage expression
    About these images

    CGAP SAGE TAG: CCACAGAAAG

    SOURCE GeneReport for Unigene cluster: Hs.486489

    UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638
    Tissue specificity: Expressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cells
    and their progenitors

    Primers: OriGene genome-wide validated SYBR primer pairs: ENPP3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ENPP3: PPH15328A
        SABiosciences Custom PCR Arrays for ENPP3 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ENPP3 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ENPP31   -- ectonucleotide pyrophosphatase/phosphodiesterase 3 87.18(n)
    85.92(a)
    474820  XM_532050.2  XP_532050.2 
    chimpanzee
    (Pan troglodytes)
    ENPP31   -- ectonucleotide pyrophosphatase/phosphodiesterase 3 99.54(n)
    99.31(a)
    463000  XM_001168720.1  XP_001168720.1 
    cow
    (Bos taurus)
    ENPP31   -- ectonucleotide pyrophosphatase/phosphodiesterase 3 85.96(n)
    81.92(a)
    529405  NM_001075923.1  NP_001069391.1 
    rat
    (Rattus norvegicus)
    Enpp31   -- ectonucleotide pyrophosphatase/phosphodiesterase 3 81.5(n)
    81.35(a)
    54410  NM_019370.1  NP_062243.1 
    mouse
    (Mus musculus)
    Enpp31 , 5 10 (12.26 cM)5
    ectonucleotide pyrophosphatase/phosphodiesterase 31, 5 81.86(n)1
    80.99(a)1
    2095581  NM_134005.11  NP_598766.11 
     AA8713955  AI8764385  (see all 17)
    About this table        Species with no ortholog for ENPP3

    ENSEMBL Gene Tree for ENPP3 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ENPP3 gene
    ENPP62  ENPP12  ENPP52  ENPP42  ENPP72  ENPP22  

    ENPP3 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/984 NCBI SNPs in ENPP3 are shown (see all 984)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs3649641,2
    --132013856(-) atataA/Ctatat 1 -- int10--------
    rs3654751,2
    C,F,O,A,132055621(-) CTTTCA/GTTAAA 1 -- int118Minor allele frequency- N:0.00NA EA NS 1212
    rs3786971,2
    C,F,O,H,132043349(-) AAAATA/TAGTTC 1 -- int114Minor allele frequency- T:0.04NS EA NA WA 646
    rs3900881,2
    C,H132018071(-) ttagcC/Tgggtg 1 -- int16Minor allele frequency- T:0.00NA WA 12
    rs4041791,2
    --132039888(-) AAAGCA/CGTAAG 1 -- int10--------
    rs4494411,2
    C,F,A,H,132041883(+) ggcccA/Ggctac 1 -- int18Minor allele frequency- G:0.45EA NA 226
    rs4536391,2
    C,F,O,H,132049657(+) CTTCCA/CTGTGA 1 -- int1 trp317Minor allele frequency- C:0.14NS EA NA WA 1064
    rs9587571,2
    H131973130(-) TCCCAT/CTGCTA 1 -- int18Minor allele frequency- C:0.00NA EA MN NS 836
    rs9587581,2
    --131973090(-) TTGGCA/CCTGCC 1 -- int10--------
    rs10542221,2
    H132068088(+) AAACCA/CCTATT 2 T P ref1 mis1 ese35Minor allele frequency- C:0.00MN NS EA 590
    About this table

    HapMap Linkage Disequilibrium images for ENPP3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for ENPP3
         9 CNVs: 69603 94012 81590 94013 69604 94015 32838 94014 81589
         1 Indel: 99708

    QIAGEN SeqTarget long-range PCR primers for resequencing ENPP3 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ENPP3 for disorders           About GeneDecksing

    OMIM: 602182

    5 Novoseek disease relationships for ENPP3 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    idiopathic urticaria 74.4 4 16751009 (4)
    allergy 60.5 19 18331364 (4), 17275019 (3), 12403934 (3), 15031605 (3) (see all 5)
    anaphylaxis 33.6 4 18331364 (2)
    tumors 0 5 15072822 (2), 14533006 (1)
    cancer 0 3 14533006 (2), 15072822 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: ENPP3 (1 document)

    Export disorders and mutations for ENPP3 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/59 PubMed articles for ENPP3 gene, integrated from 7 sources (see all 59):
    (articles sorted by number of sources associating them with ENPP3)
    1. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. (PubMed id 9344668)1, 2, 3, 7 Piao J.-H.... Sano K. (1997)
    2. Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E- NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases. (PubMed id 15072822)1, 2, 7 Yano Y.... Kasuga M. (2004)
    3. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. (PubMed id 15031605)1, 2, 7 Buehring H.J.... Valent P. (2004)
    4. The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3. (PubMed id 11342463)1, 2, 7 Buehring H.J....Sano K. (2001)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. CD203c expression on human basophils is associated wi th asthma exacerbation. (PubMed id 20159259)1, 7 Ono E....Akiyama K. (2010)
    7. Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma. (PubMed id 14533006)1, 7 Yano Y....Kasuga M. (2003)
    8. Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy. (PubMed id 17275019)1, 7 Ocmant A....Schandene L. (2007)
    9. Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells. (PubMed id 10524196)1, 7 Andoh K.... Sano K. (1999)
    10. Inhibition of CD203c membrane up-regulation in human basophils by high dilutions of histamine: a controlled replication study. (PubMed id 19418203)1, 7 Chirumbolo S....Bellavite P. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5169 HGNC: 3358 AceView: ENPP3 Ensembl:ENSG00000154269 euGenes: HUgn5169
    ECgene: ENPP3 Kegg: 5169 H-InvDB: ENPP3

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ENPP3 gene:
    Search GeneIP for patents involving ENPP3

    GeneCards and IP:
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