Aliases &
Descriptions
for ENPP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ectonucleotide pyrophosphatase/phosphodiesterase 31 2 | | phosphodiesterase-I beta2 | | PDNP32 3 5 | | NPP32 | | B101 2 | | ectonucleotide pyrophosphatase/phosphodiesterase family member 32 | | gp130RB13-61 2 | | dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)2 | | PD-IBETA1 2 | | dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)2 | | CD203c1 2 | | OTTHUMP000000179012 | | Phosphodiesterase I/nucleotide pyrophosphatase 32 3 | | PD-Ibeta3 | | Phosphodiesterase I beta2 3 | | CD203c antigen3 | | E-NPP 32 3 | | |
Export aliases for ENPP3 gene to outside databasesPrevious GC identifers: GC06P131617 GC06M131805 GC06P131893 GC06P131939 GC06P132000 |
Summaries
for ENPP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ENPP3:
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellularnucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembraneproteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentarytract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The humanmRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus,basophils, and mast cells. (provided by RefSeq)
UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638Function: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars,and NAD (By similarity)
Gene Wiki entry for ENPP3 |
Genomic Views
for ENPP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ENPP3 gene promoter:
ISGF-3 c-Myb FOXL1 Sox9 Chx10 RORalpha1 RFX1 Nkx6-1 Cart-1 AREB6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ENPP3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ENPP3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q22ENPP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P129540: view genomic region
(about GC identifiers)
Start:
|
129,540,257 bp from pter |
End:
|
129,650,562 bp from pter |
Size:
|
110,306 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr6+ 131,949,582-132,068,553 |
RefSeq DNA sequence:- NC_000006.11 NT_025741.15
|
Proteins
for ENPP3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638 (See
protein sequence)Recommended Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Size: 875 amino acids; 100124 Da
Cofactor: Binds 2 divalent metal cations per subunit (Probable)
Subcellular location: Membrane; Single-pass type II membrane protein (Potential). Secreted. Note=Located to the apicalsurface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasmamembrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells
Sequence caution: Sequence=AAD05192.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5JTL3Explore the universe of human proteins at neXtProt for ENPP3: NX_O14638
Post-translational modifications:
N-glycosylation is necessary for correct trafficking to the apical surface, but is not the apical targeting signal (Bysimilarity)1
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity orvariability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bondconserved in both1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005012.2
ENSEMBL proteins: ENSP00000406261 ENSP00000350265 ENSP00000408642 ENSP00000399269 ENSP00000415589
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ENPP3 for ontologies About GeneDecksing
Antibodies for ENPP3:
Assays for ENPP3: |
Protein
Domains/
Families
for ENPP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ENPP3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O14638ProtoNet protein and cluster: O14638 2 Blocks protein families: IPB001212 Somatomedin B IPB002591 Type I phosphodiesterase/nucleotide pyrophosphatase
UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638Similarity: Belongs to the nucleotide pyrophosphatase/phosphodiesterase familySimilarity: Contains 2 SMB (somatomedin-B) domains |
Gene Function
for ENPP3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638Function: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars,and NAD (By similarity)Catalytic activity: Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of3'-hydroxy-terminated oligonucleotidesCatalytic activity: A dinucleotide + H(2)O = 2 mononucleotidesEnzyme regulation: At low concentrations of ATP, a phosphorylated active site intermediate is formed which inhibitsfurther ATP hydrolysisInduction: Up-regulated by stimulation by allergen or by cross-linking with IgE. The IgE-mediated activation isenhanced by tetradecanoyl phorbol acetate (TPA), a stimulator of the PKC pathway, and inhibited by the P13 kinaseinhibitors, LY294002 and wortmannin. Up-regulated in invasive bile duct cancers
5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0003824 | catalytic activity |
-- | -- | | GO:0004528 | phosphodiesterase I activity |
IEA | -- | | GO:0004551 | nucleotide diphosphatase activity |
IEA | -- | | GO:0005044 | scavenger receptor activity |
IEA | -- |
About this table
ENPP3 for ontologies About GeneDecksing
|
Pathways & Interactions
for ENPP3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
ENPP3 for pathways About GeneDecksing
1  Millipore Pathway for ENPP3
5/6  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for ENPP3 (see all 6)
5/6  Kegg Pathways (Kegg details for ENPP3) (see all 6):
SABiosciences Custom Pathway-Focused PCR Arrays for ENPP3
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ENPP3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENPP3
5/64 Interacting proteins for ENPP3 (ENSP000003502653 O146382) via UniProtKB, MINT, and/or STRING (see all 64)About this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
ENPP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ENPP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
ENPP3 for compounds About GeneDecksing
 Browse Tocris compounds for ENPP3
3  Novoseek chemical compound relationships for ENPP3 gene
About this table
|
Transcripts
for ENPP3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ENPP3 gene: NM_005021.3 Additional cDNA sequence: AK024899.1 AK226107.1 AK292903.1 AK296080.1 AK309080.1 AK310691.1 AK315893.1 DQ234347.1 EF560735.1 4 DOTS entries: DT.110060 DT.100742267 DT.121321943 DT.100742266 24/45 AceView cDNA sequences (see all 45): CF529367 AI539373 AL696295 BX098243 AI570172 BX482253 AI589225 NM_005021 AW293070 AA034097 AI872744 AK024899 AI862179 AL708614 AI190925 AA872930 AI300713 BE463716 AI765324 AI685421 AI758400 AI219273 AI200230 AU100145
 highest scoring ESTs for ENPP3:AI765324 AA001826 AA002029 AA034097 AA527645 AA678335 AA813122 AA884920 AI190925 AI200230 Unigene Cluster for ENPP3: Ectonucleotide pyrophosphatase/phosphodiesterase 3 Hs.486489 [show with all ESTs]Unigene Representative Sequence: NM_005021
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ENPP3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|
|
| SP1: | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ENPP3
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000414305(uc010kfp.1 uc003qcu.3 uc003qcv.2 uc010kfq.2)
ENST00000357639 ENST00000423831 ENST00000494023 ENST00000427148 ENST00000470930
ENST00000427707(uc011ecc.1 uc010kfn.1 uc010kfo.1)
|
Expression
for ENPP3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ENPP3 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching ENPP3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 89860_at2, 3
|
U95-E |
1 |
0.81 |
1.00 |
1.00 |
1.00 |
AI765324 |
1.00 |
1.00 |
1.00 |
1 |
| 232737_s_at2
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 222938_x_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AI685421 |
0.80 |
1.00 |
0.91 |
1 |
| 219912_s_at*2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
NM_005021 |
0.60 |
1.00 |
0.82 |
1 |
| 232737_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 222938_x_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 219912_s_at*2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ENPP3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCACAGAAAG
SOURCE GeneReport for Unigene cluster: Hs.486489
UniProtKB/Swiss-Prot: ENPP3_HUMAN, O14638Tissue specificity: Expressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cellsand their progenitors
SABiosciences Custom PCR Arrays for ENPP3
|
Orthologs
for ENPP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ENPP3 gene from 5/9 species (see all 9)
About this table Species with no ortholog for ENPP3
ENSEMBL Gene Tree for ENPP3 (if available) |
Paralogs
for ENPP3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ENPP3 gene
- ENPP62 ENPP12 ENPP52 ENPP42 ENPP72 ENPP22
ENPP3 for paralogs About GeneDecksing
|
Genomic Variants
for ENPP3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ENPP3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for ENPP3
9 CNVs: 69603 94012 81590 94013 69604 94015 32838 94014 81589
1 Indel: 99708 | | QIAGEN SeqTarget long-range PCR primers for resequencing ENPP3 |
|
Disorders & Mutations
for ENPP3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ENPP3 for disorders About GeneDecksing
OMIM: 602182
5 Novoseek disease relationships for ENPP3 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: ENPP3 (1 document)
Export disorders and mutations for ENPP3 gene to outside databases
|
Medical News
for ENPP3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ENPP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/59 PubMed articles for ENPP3 gene, integrated from 7 sources (see all 59):
(articles sorted by number of sources associating them with ENPP3)- Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. (PubMed id 9344668)1, 2, 3, 7 Piao J.-H.... Sano K. (1997)
- Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E- NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases. (PubMed id 15072822)1, 2, 7 Yano Y.... Kasuga M. (2004)
- The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. (PubMed id 15031605)1, 2, 7 Buehring H.J.... Valent P. (2004)
- The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3. (PubMed id 11342463)1, 2, 7 Buehring H.J....Sano K. (2001)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- CD203c expression on human basophils is associated wi th asthma exacerbation. (PubMed id 20159259)1, 7 Ono E....Akiyama K. (2010)
- Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma. (PubMed id 14533006)1, 7 Yano Y....Kasuga M. (2003)
- Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy. (PubMed id 17275019)1, 7 Ocmant A....Schandene L. (2007)
- Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells. (PubMed id 10524196)1, 7 Andoh K.... Sano K. (1999)
- Inhibition of CD203c membrane up-regulation in human basophils by high dilutions of histamine: a controlled replication study. (PubMed id 19418203)1, 7 Chirumbolo S....Bellavite P. (2009)
|
External Searches for ENPP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ENPP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ENPP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ENPP3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ENPP3 gene:
Search GeneIP for patents involving ENPP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ENPP3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for ENPP3 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for ENPP3 |
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