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F10 Gene

protein-coding GIFtS: 66

GC13P094215

coagulation factor X
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
coagulation factor X¹ ²		factor Xa²
Stuart-Prower factor² ³		FXA²
FX²		EC 3.4.21.6³
OTTHUMP00000202678²		Stuart factor³
prothrombinase²

External Ids:	HGNC: 3528¹	Entrez Gene: 2159²	Ensembl: ENSG00000126218⁷	UniProtKB: P00742³

Export aliases for F10 gene to outside databases

Previous GC identifers: GC13P112387 GC13P108414 GC13P112863 GC13P111725 GC13P112825 GC13P113777

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F10:

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes

multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the

tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2

EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the

other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor

IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts

prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this

gene result in factor X deficiency, a hemorrhagic condition of variable severity. (provided by RefSeq)

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of

factor Va, calcium and phospholipid during blood clotting

Gene Wiki entry for F10 (Factor X)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the F10 gene promoter:
         NF-kappaB1   AP-1   ATF   HNF-4alpha2   c-Jun   c-Fos   COUP-TF1   POU2F1   CHOP-10   C/EBPalpha
         Other transcription factors

Search SABiosciences Chromatin IP Primers for F10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

F10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F10 gene location

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P094215: view genomic region (about GC identifiers)

Start:	94,215,823 bp from pter
End:	94,242,228 bp from pter
Size:	26,406 bases
Orientation:	plus strand

1 alternative location:

Chr13+ 113,777,128-113,803,843

RefSeq DNA sequence:

NC_000013.10 NT_027140.6

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742 (See protein sequence)

Recommended Name: Coagulation factor X precursor

Size: 488 amino acids; 54732 Da

Subunit: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held

together by 1 or more disulfide bonds

Subcellular location: Secreted

PDB structures from and Proteopedia :

1C5M (3D)

1EZQ (3D)

1F0R (3D)

1F0S (3D)

1FAX (3D)

1FJS (3D)

1FXY (3D)

1G2L (3D)

1G2M (3D)

1HCG (3D)

1IOE (3D)

1IQE (3D)

1IQF (3D)

1IQG (3D)

1IQH (3D)

1IQI (3D)

1IQJ (3D)

1IQK (3D)

1IQL (3D)

1IQM (3D)

1IQN (3D)

1KSN (3D)

1LPG (3D)

1LPK (3D)

1LPZ (3D)

1LQD (3D)

1MQ5 (3D)

1MQ6 (3D)

1MSX (3D)

1NFU (3D)

1NFW (3D)

1NFX (3D)

1NFY (3D)

1NL8 (3D)

1P0S (3D)

1V3X (3D)

1WU1 (3D)

1XKA (3D)

1XKB (3D)

1Z6E (3D)

2BMG (3D)

2BOH (3D)

2BOK (3D)

2BQ6 (3D)

2BQ7 (3D)

2BQW (3D)

2CJI (3D)

2D1J (3D)

2EI6 (3D)

2EI7 (3D)

2EI8 (3D)

2FZZ (3D)

2G00 (3D)

2GD4 (3D)

2H9E (3D)

2J2U (3D)

2J34 (3D)

2J38 (3D)

2J4I (3D)

2J94 (3D)

2J95 (3D)

2JKH (3D)

2P16 (3D)

2P3F (3D)

2P3T (3D)

2P3U (3D)

2P93 (3D)

2P94 (3D)

2P95 (3D)

2PHB (3D)

2PR3 (3D)

2Q1J (3D)

2RA0 (3D)

2UWL (3D)

2UWO (3D)

2UWP (3D)

2VH0 (3D)

2VH6 (3D)

2VVC (3D)

2VVU (3D)

2VVV (3D)

2VWL (3D)

2VWM (3D)

2VWN (3D)

2VWO (3D)

2W26 (3D)

2W3I (3D)

2W3K (3D)

2XBV (3D)

2XBW (3D)

2XBX (3D)

2XBY (3D)

2XC0 (3D)

2XC4 (3D)

2XC5 (3D)

3CEN (3D)

3CS7 (3D)

3ENS (3D)

3FFG (3D)

3HPT (3D)

3IIT (3D)

3K9X (3D)

3KL6 (3D)

3KQB (3D)

3KQC (3D)

3KQD (3D)

3KQE (3D)

3LIW (3D)

3M36 (3D)

3M37 (3D)

Secondary accessions: Q14340

Explore the universe of human proteins at neXtProt for F10: NX_P00742

Post-translational modifications:

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium¹

N- and O-glycosylated¹

The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic

pathway)¹

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF

domains¹

REFSEQ proteins: NP_000495.1

ENSEMBL proteins:

ENSP00000391786 ENSP00000387092 ENSP00000386320 ENSP00000364701 ENSP00000364709

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for F10 (Coagulation Factor X)
	Enzo Life Sciences proteins for F10
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: F10
	GenScript Custom Purified and Recombinant Proteins Services for F10
	Novus Biologicals Protein for F10
	Novus Biologicals Lysate for F10
	Sino Biological Recombinant Protein for F10
	Browse ProSpec Recombinant Proteins

5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005624	membrane fraction	IEA	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005792	microsome	IEA	--
GO:0005796	Golgi lumen	TAS	--

About this table

F10 for ontologies About GeneDecksing

Antibodies for F10:

	Millipore Mono- and Polyclonal Antibodies for the study of F10
	Sigma-Aldrich Antibodies for F10
	R&D Systems Antibodies for F10 (Coagulation Factor X)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for F10
	Novus Biologicals Antibody for F10
	Epitomics antibodies for F10

Assays for F10:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for F10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for F10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

F10 for domains About GeneDecksing

5/15 InterPro domains/families (see all 15):

IPR017857 Coagulation_fac_subgr_Gla_dom

IPR001314 Peptidase_S1A

IPR000742 EGF_3

IPR006209 EGF

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

Graphical View of Domain Structure for InterPro Entry P00742

ProtoNet protein and cluster: P00742

5/7 Blocks protein families (see all 7):

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB001438 Type II EGF-like signature

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain

Similarity: Contains 1 peptidase S1 domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of

factor Va, calcium and phospholipid during blood clotting

Catalytic activity: Selective cleavage of Arg- -Thr and then Arg- -Ile bonds in prothrombin to form thrombin

Enzyme Number (IUBMB): EC 3.4.21.6

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for F10 Sigma-Aldrich shRNA Panels and shRNA for F10
		OriGene 29mer shRNA kits in GFP-retroviral vector: F10 OriGene shRNA RFP: F10 OriGene basic RS shRNA: F10 OriGene siRNA: F10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of F10

miRNA:		Sigma-Aldrich microRNA Mimics for F10 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of F10
		Search SABiosciences for Assays for microRNAs that regulate F10

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: F10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: F10 OriGene untagged cDNA clones in CMV expression vector: F10 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for F10
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for F10

Genatlas biochemistry entry for F10:

coagulation factor X (Stuart Prower),vitamin K-dependent

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	IDA	17469850
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	18267072
GO:0005543	phospholipid binding	IDA	17469850

About this table

F10 for ontologies About GeneDecksing

Animal Models: 6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for F10):

cardiovascular system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging
reproductive system

F10 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

F10 for pathways About GeneDecksing

4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for F10

	Extrinsic Prothrombin Activation Pathway
	Intrinsic Prothrombin Activation Pathway
	TR/RXR Activation
	Coagulation System

1 Kegg Pathway (Kegg details for F10):

hsa04610 Complement and coagulation cascades

SABiosciences Custom Pathway-Focused PCR Arrays for F10

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for F10

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for F10

5/20 Interacting proteins for F10 (P00742^{1, 2} ENSP00000364709³) via UniProtKB, MINT, and/or STRING (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F13A1	ENSP00000264870³	STRING: ENSP00000264870
F13B	ENSP00000356382³	STRING: ENSP00000356382
F9	ENSP00000218099³	STRING: ENSP00000218099
FGA	ENSP00000306361³	STRING: ENSP00000306361
FGB	ENSP00000306099³	STRING: ENSP00000306099

About this table

5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0007597	blood coagulation, intrinsic pathway	TAS	--
GO:0007598	blood coagulation, extrinsic pathway	EXP	7598447
GO:0017187	peptidyl-glutamic acid carboxylation	TAS	--

About this table

F10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

F10 for compounds About GeneDecksing

Sigma-Aldrich Small Molecules for F10:

Small Molecule - Inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for F10
10/115 Novoseek chemical compound relationships for F10 gene (see all 115)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rivaroxaban	94.4	125	17938768 (3), 18307374 (3), 20139357 (3), 17595891 (3) (see all 77)
fondaparinux	94.3	179	12871328 (3), 15744699 (3), 15171960 (2), 12501872 (2) (see all 99)
apixaban	91.7	42	19851712 (5), 18315548 (3), 17868430 (2), 18393142 (1) (see all 29)
heparin	88.8	634	12871328 (6), 11009624 (5), 9642241 (5), 19967150 (5) (see all 99)
heparin pentasaccharide	88.6	11	12353073 (2), 11854268 (1), 14532267 (1), 12871328 (1) (see all 8)
dabigatran etexilate	86.4	16	19601856 (1), 19550318 (1), 18473863 (1), 19803538 (1) (see all 13)
otamixaban	83	12	17139573 (3), 17178269 (2), 16493482 (2), 19717184 (1) (see all 8)
hirudin	82.4	65	12883328 (3), 7740455 (3), 8218854 (2), 2096492 (2) (see all 42)
antistasin	82.1	23	7740449 (2), 9804761 (2), 8218854 (2), 1990979 (2) (see all 12)
gamma-carboxyglutamic acid	81.4	47	8226763 (4), 17387172 (3), 9780208 (2), 8355279 (1) (see all 19)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for F10 Sigma-Aldrich shRNA Panels and shRNA for F10
		OriGene 29mer shRNA kits in GFP-retroviral vector: F10 OriGene shRNA RFP: F10 OriGene basic RS shRNA: F10 OriGene siRNA: F10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of F10

miRNA:		Sigma-Aldrich microRNA Mimics for F10 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of F10
		Search SABiosciences for Assays for microRNAs that regulate F10

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: F10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: F10 OriGene untagged cDNA clones in CMV expression vector: F10 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for F10

Primers:		OriGene genome-wide validated SYBR primer pairs: F10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for F10: PPH17879A

REFSEQ mRNAs for F10 gene:

NM_000504.3

Additional cDNA sequence:

AK310772.1 AK310775.1 AK313798.1 BC040125.1 BC046125.1 CR603372.1 CR607773.1 CR623031.1

K01886.1 K03194.1 M22613.1 M57285.1

3 DOTS entries:

DT.313355 DT.100676340 DT.120780844

24/72 AceView cDNA sequences (see all 72):

BU849949 BM709916 BP339855 NM_000504 M22613 CB162539 CR603372 CD013940

BU846186 CD676150 CR607773 BC046125 BM987312 K01886 CB158437 M57285

CD518821 CR623031 CD014138 BQ018853 BQ027447 BC040125 CA444781 CB116661

highest scoring ESTs for F10:

AA484793 AA554502 AA635569 AA635577 AA724725 AA970666 AI033477 AI052362 AI160870 AI192868

Unigene Cluster for F10:

Coagulation factor X

Hs.361463 [show with all ESTs]

Unigene Representative Sequence: BC040125

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for F10 (see all 6)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c
SP1:									-						-						-
SP2:									-						-		-				-
SP3:									-						-
SP4:															-						-						-
SP5:																					-

About this scheme

ECgene alternative splicing isoforms for F10
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000418726(uc010agq.1) ENST00000483537 ENST00000409306 ENST00000498455

ENST00000410083 ENST00000477269 ENST00000375551(uc001vsy.2) ENST00000375559(uc001vsx.2 uc001vsz.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

F10 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching F10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39979_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L29433	0.20	1.00	0.72	1
205620_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_000504	0.60	1.00	0.82	1
205620_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

F10 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: CCCCGGAGGT

SOURCE GeneReport for Unigene cluster: Hs.361463

Expression variation in blood from EXPOLDB for F10

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Tissue specificity: Plasma; synthesized in the liver

Primers:		OriGene genome-wide validated SYBR primer pairs: F10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for F10: PPH17879A

SABiosciences Custom PCR Arrays for F10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F10 gene from 5/10 species (see all 10)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F10¹	--	coagulation factor X	77.22(n) 74.63(a)	476993 XM_850853.1 XP_855946.1
chimpanzee (Pan troglodytes)	F10¹	--	coagulation factor X	99.52(n) 100(a)	452679 XM_509746.2 XP_509746.2
cow (Bos taurus)	F10¹	--	coagulation factor X	77.25(n) 72.29(a)	790178 XM_001256721.1 XP_001256722.1
rat (Rattus norvegicus)	F10¹	--	coagulation factor X	77.31(n) 75.69(a)	29243 NM_017143.2 NP_058839.1
mouse (Mus musculus)	F10^{1 , 5}	8 (5.73 cM)⁵	coagulation factor X^{1, 5}	77.97(n)¹ 77.54(a)¹	14058¹ NM_007972.3¹ NP_031998.3¹ AF087644⁵ AJ222677⁵ (see all 14)

About this table Species with no ortholog for F10

ENSEMBL Gene Tree for F10 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F10 gene

PAMR1² PROZ² F9² F2² PROC² F7²

F10 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs5958^1,2	H	113795213(+)	`GAGCCA/GACGTG`	1	--	int¹		5	MN NS EA	456
rs5959^1,2	--	113801797(+)	`AGATTC/TGAAGG`	2	F	ref¹ syn¹ ese³		1	MN	36
rs5960^1,2	C,F,O,A,	113801737(+)	`GGAACT/CATTCT`	2	/T	ref¹ syn¹		36	MN EA NS NA WA	4162
rs5961^1,2	C,F,	113783785(+)	`GAGCAG/CGCCAA`	2	/H /Q	mis¹ ref¹ ese³		14	MN NA NS EA WA	1322
rs5962^1,2	C,F,	113795261(+)	`GACAAC/TGGGGA`	2	N	ref¹ syn¹ ese³		10	MN NS EA NA	948
rs5963^1,2	F	113777188(+)	`TGCACC/ATCGTC`	2	/I /L	mis¹ ref¹ ese³		2	MN	292
rs473598^1,2	C,F,A,H,	113801189(+)	`CTGGCG/AGGTAG`	1	--	int¹		24	NS NA EA WA	1340
rs473950^1,2	C,F,H,	113788954(+)	`ggacaA/Gagcca`	1	--	int¹		10	NS NA WA	144
rs474671^1,2	C,F,	113776218(+)	`AGTGCT/CGTGGG`	1	--	ng5¹		16	EA NA NS	1016
rs474810^1,2	C,F,A,	113780910(+)	`TAGGGT/CAGCAG`	1	--	int¹		21	NS EA NA	1842

About this table

HapMap Linkage Disequilibrium images for F10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for F10
5 CNVs: 76521 9723 4819 87067 87068
2 Indels: 87069 25168

QIAGEN SeqTarget long-range PCR primers for resequencing F10

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

F10 for disorders About GeneDecksing

OMIM: 227600

10/85 Novoseek disease relationships for F10 gene (see all 85)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
factor x deficiency	81	3	9799000 (1), 8449937 (1), 15569527 (1)
thromboembolism	80.6	54	16409461 (2), 19485937 (2), 16241946 (2), 14650860 (2) (see all 44)
scott syndrome	76.1	5	1730083 (2), 9054648 (1), 19408196 (1), 11421293 (1)
thrombosis	76	71	10604970 (2), 11554940 (2), 12829728 (2), 15338955 (2) (see all 54)
deep vein thrombosis	71.1	8	15091002 (1), 15554723 (1), 8029801 (1), 12750119 (1) (see all 8)
arterial thrombosis	69.2	17	10813384 (1), 11177336 (1), 11342132 (1), 17729190 (1) (see all 14)
bleeding	67.9	53	11554940 (2), 19598069 (2), 12829728 (2), 14633255 (2) (see all 44)
venous thrombosis	62.8	25	11434677 (3), 9241747 (2), 9336303 (1), 10813384 (1) (see all 14)
coagulopathy	62.1	15	11554940 (2), 19598069 (2), 14995986 (1), 12161341 (1) (see all 11)
hemophilia a	60.9	3	2130929 (1), 14717973 (1), 16409469 (1)

About this table

Genatlas disease: F10

bleeding diathesis (FX deficiency)

Human Gene Mutation Database (HGMD): F10
Human Genome Epidemiology (HuGE) Navigator: F10 (15 documents)

Export disorders and mutations for F10 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/1499 PubMed articles for F10 gene, integrated from 7 sources (see all 1499):
(articles sorted by number of sources associating them with F10)

Structural basis for chemical inhibition of human blood coagulation factor Xa. (PubMed id 9618463)^{1, 2, 7} Kamata K.... Kim S.H. (1998)
Structure of human des(1-45) factor Xa at 2.2-A resolution. (PubMed id 8355279)^{1, 2, 7} Padmanabhan K.... Kisiel W. (1993)
Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. (PubMed id 1902434)^{1, 2, 7} Messier T.L.... Church W.R. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{1, 2} Cargill M....Lander E.S. (1999)
Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X. (PubMed id 8243461)^{1, 2} Inoue K. and Morita T. (1993)
Cloning and characterization of the 5' end (exon 1) of the gene encoding human factor X. (PubMed id 2612918)^{1, 2} Jagadeeswaran P.... Lyman G. (1989)
Isolation and characterization of human blood-coagulation factor X cDNA. (PubMed id 3011603)^{1, 2} Kaul R.K.... Jagadeeswaran P. (1986)
Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C. (PubMed id 3768336)^{1, 2} Leytus S.P.... Davie E.W. (1986)
Characterization of an almost full-length cDNA coding for human blood coagulation factor X. (PubMed id 2582420)^{1, 2} Fung M.R.... McGillivray R.T.A. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2159	HGNC: 3528	AceView: F10	Ensembl:ENSG00000126218	euGenes: HUgn2159
ECgene: F10	Kegg: 2159	H-InvDB: F10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Factor_X
SeattleSNPs	http://pga.gs.washington.edu/data/f10/

Intellectual Property for F10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for F10 gene:
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GeneCards and IP:
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protein-coding GIFtS: 66

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PT PROLONGED
Pregnancy loss
Hemorrhagic diseases
sepsis
Herpes Simplex
SCOTT SYNDROME
Acute myocardial infarction
coagulopathy
allergy
Endocarditis
Myocardial Ischemia
Antithrombin III Deficiency
Factor VII Deficiency
Ischemia
Breast Cancer
Edema
Deep vein thrombosis
Antiphospholipid Syndrome
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platelet disorder
Asthma
Amyloidosis
Cancer
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BLEEDING TENDENCY
Cancer Lung
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stasis
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restenosis
BLADDER CARCINOMA
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STROKE
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Pulmonary Embolism
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F10 Gene

protein-coding GIFtS: 66

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