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FAM120AOS Gene

protein-coding GIFtS: 34

GC09M065886

family with sequence similarity 120A opposite strand
(Previous name: chromosome 9 open reading frame 10 opposite strand )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C9orf10OS)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
family with sequence similarity 120A opposite strand¹ ²
C9orf10OS² ³
chromosome 9 open reading frame 10 opposite strand¹
FLJ31534²
putative FAM120A opposite strand protein²

External Ids:	HGNC: 23389¹	Entrez Gene: 158293²	Ensembl: ENSG00000188938⁷	UniProtKB: Q5T036³

Export aliases for FAM120AOS gene to outside databases

Previous GC identifers: GC09M095242 GC09M096208

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM120AOS gene promoter:
         MIF-1   RFX1   ATF6   NF-E2   NF-E2 p45   AP-4   Arnt   AhR   ISGF-3   FOXL1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for FAM120AOS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FAM120AOS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.31 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q22.32

FAM120AOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM120AOS gene location

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M065886: view genomic region (about GC identifiers)

Start:	65,886,320 bp from pter
End:	65,893,143 bp from pter
Size:	6,824 bases
Orientation:	minus strand

1 alternative location:

Chr9- 96,208,776-96,215,874

RefSeq DNA sequence:

NC_000009.11 NT_008470.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: F120S_HUMAN, Q5T036 (See protein sequence)

Recommended Name: Putative FAM120A opposite strand protein

Size: 256 amino acids; 27929 Da

Caution: Product of a dubious gene prediction

Secondary accessions: A6NN20

Explore the universe of human proteins at neXtProt for FAM120AOS: NX_Q5T036

REFSEQ proteins: NP_942138.2

ENSEMBL proteins:

ENSP00000429212 ENSP00000364561 ENSP00000364558 ENSP00000416978 ENSP00000414298

Human Recombinant Proteins

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Antibodies for FAM120AOS:

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	Browse antibodies at Epitomics

Assays for FAM120AOS:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FAM120AOS
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5T036

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FAM120AOS Sigma-Aldrich shRNA for FAM120AOS
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): FAM120AOS OriGene shRNA RFP (see all 2): FAM120AOS OriGene basic RS shRNA (see all 2): FAM120AOS OriGene siRNA: FAM120AOS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM120AOS

miRNA:		Sigma-Aldrich microRNA Mimics for FAM120AOS Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM120AOS
		Search SABiosciences for Assays for microRNAs that regulate FAM120AOS

Gene
Editing:

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		OriGene GFP tagged cDNA clones in CMV expression vector: FAM120AOS OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FAM120AOS OriGene untagged cDNA clones in CMV expression vector: FAM120AOS OriGene 3'-UTR clone: FAM120AOS Browse MicroRNA Expression Plasmids
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Cell
Lines:

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(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for FAM120AOS

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM120AOS

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM120AOS

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FAM120AOS Sigma-Aldrich shRNA for FAM120AOS
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): FAM120AOS OriGene shRNA RFP (see all 2): FAM120AOS OriGene basic RS shRNA (see all 2): FAM120AOS OriGene siRNA: FAM120AOS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM120AOS

miRNA:		Sigma-Aldrich microRNA Mimics for FAM120AOS Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM120AOS
		Search SABiosciences for Assays for microRNAs that regulate FAM120AOS

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FAM120AOS OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FAM120AOS OriGene untagged cDNA clones in CMV expression vector: FAM120AOS OriGene 3'-UTR Clone: FAM120AOS Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FAM120AOS

Primers:		OriGene genome-wide validated SYBR primer pairs: FAM120AOS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FAM120AOS: PPH17459A

REFSEQ mRNAs for FAM120AOS gene:

NM_198841.2

Additional cDNA sequence:

AK093641.1 BC015241.2 BC068089.1

18 DOTS entries:

DT.100782234 DT.445599 DT.91939154 DT.97844655 DT.100027381 DT.95136928 DT.100844983 DT.121189003

DT.99926936 DT.110215 DT.417217 DT.95279271 DT.100782235 DT.121189006 DT.449081 DT.95279304

DT.100653920 DT.95279275

24/277 AceView cDNA sequences (see all 277):

AA954210 BM718922 AI690123 BC037551 AI819330 AA548164 AI198510 BE467518

BX501487 BU429261 BU687126 AI379998 AI458697 CA310955 AA495932 AW261850

AI383193 CA422837 CK823247 AW778742 CB131876 BG621088 AI223244 CA394323

highest scoring ESTs for FAM120AOS:

AI091434 AI093622 AI738623 AI762285 AI817853 AI857644 AI951697 AI951702 AK056096 AW024466

Unigene Clusters for FAM120AOS:

Family with sequence similarity 120A opposite strand

Hs.350364 [show with all ESTs], Hs.709859 [show with all ESTs]

Unigene Representative Sequences: NM_198841, AK093641

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM120AOS (see all 8)

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f
SP1:											-		-
SP2:													-
SP3:													-		-
SP4:			-		-		-		-		-		-						-
SP5:											-		-						-

About this scheme

ECgene alternative splicing isoforms for FAM120AOS
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000520470 ENST00000476484 ENST00000483149 ENST00000523407 ENST00000375412(uc004ats.3 uc004att.3 uc004atu.3)

ENST00000520403 ENST00000428152 ENST00000375409 ENST00000428378 ENST00000483056

ENST00000479094(uc004atn.3 uc004ato.3) ENST00000423591(uc004atm.2 uc004atp.3 uc004atq.3 uc004atr.3)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FAM120AOS expression in normal and diseased human tissues

¹ / ² / ³

8 probe-sets matching FAM120AOS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45325_at²^{, 3}	U95-B	1	0.88	1.00	0.50	1.27	W28364	0.60	1.00	0.82	1
76824_at²^{, 3}	U95-E	1	0.69	1.00	0.69	0.71	AI091434	1.00	1.00	1.00	1
90405_at²^{, 3}	U95-D	1	0.31	1.00	0.70	1.02	N30215	0.80	1.00	0.91	1
225395_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI309997	0.60	1.00	0.82	1
230308_at²^{, 3}	U133-B	1	0.55	1.00	--	--	AI091434	1.00	1.00	1.00	1
225395_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230308_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--
1558761_a_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

About this table

FAM120AOS for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

FAM120AOS gene electronic northern expression

About these images

CGAP SAGE TAG: GAGGGCCTTC TGCTGTTCAT

SOURCE GeneReport for Unigene clusters: Hs.350364 Hs.709859

Primers:		OriGene genome-wide validated SYBR primer pairs: FAM120AOS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FAM120AOS: PPH17459A

SABiosciences Custom PCR Arrays for FAM120AOS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM120AOS gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	C030044B11Rik⁵	13 (25.04 cM)	RIKEN cDNA C030044B11 gene	--	CJ174269

About this table Species with no ortholog for FAM120AOS

ENSEMBL Gene Tree for FAM120AOS (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1331589^1,2	C,	96210057(+)	`AGTCCG/AAATAT`	1	--	int¹		1		NA	2
rs7862998^1,2	C,	96212066(+)	`cccggG/CcGCAC`	1	--	int¹		1		NA	2
rs7863115^1,2	C,	96212096(+)	`AAAAGC/TAAGAG`	1	--	int¹		0	--	--	--	--
rs9696476^1,2	C	96208379(+)	`GTTCCA/CCCCTA`	1	--	ng3¹		0	--	--	--	--
rs10667664^1,2	--	96211784(+)	`ttttt-/TTttttt`	1	--	int¹ trp³		0	--	--	--	--
rs10674558^1,2	C	96211795(+)	`TTTTTTT/-GAGAT`	1	--	int¹		1		NA	2
rs10821128^1,2	C,F,A,	96209943(+)	`TTTCTT/CTGAGA`	2	/K /E	ref¹ mis¹ ese³		16		NS EA NA	1350
rs11791719^1,2	H	96211967(+)	`gttttA/Cccatg`	1	--	int¹		0	--	--	--	--
rs13284310^1,2	--	96210904(+)	`tttttA/Tatttt`	1	--	int¹		0	--	--	--	--
rs13284315^1,2	--	96210911(+)	`tttttA/Tatttt`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for FAM120AOS (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM120AOS: --

QIAGEN SeqTarget long-range PCR primers for resequencing FAM120AOS

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

4 PubMed articles for FAM120AOS gene integrated from 7 sources:
(articles sorted by number of sources associating them with FAM120AOS)

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. (PubMed id 14585507)^{1, 3} Holden S. and Raymond F.L. (2003)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 158293	HGNC: 23389	AceView: C9orf10OS	Ensembl:ENSG00000188938	euGenes: HUgn158293
ECgene: FAM120AOS	H-InvDB: FAM120AOS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for FAM120AOS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for FAM120AOS gene:
Search GeneIP for patents involving FAM120AOS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM120AOS
	SeqTarget long-range PCR primers for resequencing FAM120AOS
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FAM120AOS
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM120AOS

	GenScript Custom Purified and Recombinant Proteins Services for FAM120AOS		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for FAM120AOS
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FAM120AOS Gene

protein-coding GIFtS: 34

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FAM120AOS Gene

protein-coding GIFtS: 34

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Expression
for FAM120AOS gene

Orthologs
for FAM120AOS gene

Paralogs
for FAM120AOS gene

Genomic Variants
for FAM120AOS gene

Disorders & Mutations
for FAM120AOS gene

Medical News
for FAM120AOS gene

Publications
for FAM120AOS gene

Intellectual Property
for FAM120AOS gene

Products
for FAM120AOS gene