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FAM32A Gene

protein-coding GIFtS: 48

GC19P015867

family with sequence similarity 32, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
family with sequence similarity 32, member A¹ ²
DKFZP586O0120¹
hypothetical protein LOC26017²

External Ids:	HGNC: 24563¹	Entrez Gene: 26017²	Ensembl: ENSG00000105058⁷	UniProtKB: Q9Y421³

Export aliases for FAM32A gene to outside databases

Previous GC identifers: GC19P016157 GC19P016297

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for FAM32A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM32A gene promoter:
         CUTL1   POU3F2   Arnt   YY1   USF1   AREB6   STAT5A   FAC1   SREBP-1b   SREBP-1c
         Other transcription factors

Search SABiosciences Chromatin IP Primers for FAM32A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FAM32A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19pter-p13.3 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19pter-p13.3

FAM32A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM32A gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P015867: view genomic region (about GC identifiers)

Start:	15,867,006 bp from pter
End:	15,873,595 bp from pter
Size:	6,590 bases
Orientation:	plus strand

1 alternative location:

Chr19+ 16,296,234-16,302,855

RefSeq DNA sequence:

NC_000019.9 NT_011295.11

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421 (See protein sequence)

Recommended Name: Protein FAM32A

Size: 112 amino acids; 13178 Da

Secondary accessions: Q9BT02

Explore the universe of human proteins at neXtProt for FAM32A: NX_Q9Y421

REFSEQ proteins: NP_054796.1

ENSEMBL proteins:

ENSP00000263384

Human Recombinant Proteins

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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	11256614

About this table

FAM32A for ontologies About GeneDecksing

Antibodies for FAM32A:

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Assays for FAM32A:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for FAM32A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FAM32A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM32A for domains About GeneDecksing

1 InterPro domain/family:

IPR013865 DUF1754_euk

Graphical View of Domain Structure for InterPro Entry Q9Y421

ProtoNet protein and cluster: Q9Y421

1 Blocks protein family: IPB013865 Protein of unknown function DUF1754

UniProtKB/Swiss-Prot: FA32A_HUMAN, Q9Y421

Similarity: Belongs to the FAM32 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FAM32A Sigma-Aldrich shRNA for FAM32A
		OriGene 29mer shRNA kits in GFP-retroviral vector: FAM32A OriGene shRNA RFP: FAM32A OriGene basic RS shRNA: FAM32A OriGene siRNA: FAM32A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM32A

miRNA:		Sigma-Aldrich microRNA Mimics for FAM32A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM32A
		Search SABiosciences for Assays for microRNAs that regulate FAM32A

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FAM32A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FAM32A OriGene untagged cDNA clones in CMV expression vector: FAM32A OriGene 3'-UTR clone: FAM32A Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FAM32A
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for FAM32A

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

FAM32A for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for FAM32A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM32A

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

About this table

FAM32A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM32A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FAM32A Sigma-Aldrich shRNA for FAM32A
		OriGene 29mer shRNA kits in GFP-retroviral vector: FAM32A OriGene shRNA RFP: FAM32A OriGene basic RS shRNA: FAM32A OriGene siRNA: FAM32A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM32A

miRNA:		Sigma-Aldrich microRNA Mimics for FAM32A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM32A
		Search SABiosciences for Assays for microRNAs that regulate FAM32A

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FAM32A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FAM32A OriGene untagged cDNA clones in CMV expression vector: FAM32A OriGene 3'-UTR Clone: FAM32A Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FAM32A

Primers:		OriGene genome-wide validated SYBR primer pairs: FAM32A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FAM32A: PPH07262A

REFSEQ mRNAs for FAM32A gene:

NM_014077.2

Additional cDNA sequence:

AF151902.1 AK312058.1 AL050157.1 BC000639.1 BC004447.1 BC017286.1 CR594783.1 CR594996.1

CR597639.1 CR599994.1 CR601203.1 CR603364.1 CR603593.1 CR605955.1 CR606857.1 CR607046.1

CR608983.1 CR614913.1 CR621715.1 CR623049.1 CR625672.1 CR625808.1

12 DOTS entries:

DT.445450 DT.97864266 DT.95156694 DT.92445142 DT.100879214 DT.100879221 DT.92445137 DT.100668640

DT.100644856 DT.100879204 DT.100879210 DT.121452605

24/396 AceView cDNA sequences (see all 396):

BU174534 AI830295 BU541528 BI791496 BQ682046 BQ026557 CB163290 BM676484

BI767577 BQ897691 BG251372 CA430478 BQ683613 BG336060 CR625808 CR605955

AW054889 CF135104 BM547395 BI771412 Z38536 BM477755 Z42304 BG746838

highest scoring ESTs for FAM32A:

AL050157 AA100503 AA126668 AA127306 AA182015 AA199669 AA209328 AA401220 AA404232 AA478466

Unigene Cluster for FAM32A:

Family with sequence similarity 32, member A

Hs.631614 [show with all ESTs]

Unigene Representative Sequence: BM923512

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM32A

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	·	5d
SP1:
SP2:											-
SP3:											-
SP4:											-		-

About this scheme

ECgene alternative splicing isoforms for FAM32A
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000263384(uc002ndt.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FAM32A expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching FAM32A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34833_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL050157	1.00	0.90	0.95	1
201863_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014077	0.60	1.00	0.82	1
201863_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

FAM32A for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

FAM32A gene electronic northern expression

About these images

CGAP SAGE TAG: GTGGCCTGCA

SOURCE GeneReport for Unigene cluster: Hs.631614

Expression variation in blood from EXPOLDB for FAM32A

Primers:		OriGene genome-wide validated SYBR primer pairs: FAM32A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FAM32A: PPH07262A

SABiosciences Custom PCR Arrays for FAM32A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM32A gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC480644¹	--	similar to family with sequence similarity 32, member A, like less	93.45(n) 99.11(a)	480644 XM_537763.2 XP_537763.2
chimpanzee (Pan troglodytes)	LOC455808¹	--	similar to CGI-144 protein	99.7(n) 100(a)	455808 XM_512465.2 XP_512465.2
cow (Bos taurus)	LOC789844¹	--	similar to mCG125076	88.89(n) 88.29(a)	789844 XM_001255244.1 XP_001255245.1
rat (Rattus norvegicus)	Fam32a¹	--	family with sequence similarity 32, member A	89.58(n) 98.21(a)	498600 XM_573878.2 XP_573878.1
mouse (Mus musculus)	Fam32a⁵ 2510049I19Rik¹	8 (34.90 cM)⁵	family with sequence similarity 32, member A⁵ RIKEN cDNA 2510049I19 gene¹	88.69(n)¹ 97.32(a)¹	67922¹ NM_026455.3¹ NP_080731.1¹ AB041658⁵ AI842858⁵ (see all 23)

About this table Species with no ortholog for FAM32A

ENSEMBL Gene Tree for FAM32A (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

4 related pseudogenes

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs206231^1,2	C,F,O,A,H,	16301312(-)	`AGACAC/TGGAGG`	1	--	int¹		19	MN EA NA NS WA	1044
rs285233^1,2	C,F,A,	16300299(-)	`AACTCG/AAAGGA`	1	--	int¹		19	EA NA MN NS	1464
rs285234^1,2	C,F,O,A,	16300190(-)	`GAAAGA/GAAGGA`	1	--	int¹ trp³		8	NS EA NA WA	610
rs285235^1,2	C,F,A	16299952(-)	`GGAGGG/CTGAGG`	1	--	int¹		6	EA NA WA	148
rs285236^1,2	C,F,A,H,	16299174(-)	`cctgcG/Aatcct`	1	--	int¹		13	NS EA NA WA	554
rs285237^1,2	C,F,A,	16299126(-)	`gcccaG/Acccaa`	1	--	int¹		9	NS EA NA WA	632
rs366657^1,2	C,F,O,	16296711(+)	`TGCTGT/AACGTG`	1	--	int¹		4	MN NA	326
rs421193^1,2	C,F,A,	16295673(+)	`gaaggC/Acgaag`	1	--	ng5¹		5	NA EA WA	214
rs430186^1,2	C,A	16297171(+)	`cctccA/Ggggtt`	1	--	int¹		6	NA WA	12
rs434180^1,2	C,F,	16296771(+)	`CCCCGC/TTGGCC`	1	--	int¹		5	MN NS EA	602

About this table

HapMap Linkage Disequilibrium images for FAM32A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM32A: --

QIAGEN SeqTarget long-range PCR primers for resequencing FAM32A

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM32A for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: FAM32A (2 documents)

Export disorders and mutations for FAM32A gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/12 PubMed articles for FAM32A gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with FAM32A)

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.H....Lin W. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26017	HGNC: 24563	AceView: FAM32A	Ensembl:ENSG00000105058	euGenes: HUgn26017
ECgene: FAM32A	H-InvDB: FAM32A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for FAM32A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for FAM32A gene:
Search GeneIP for patents involving FAM32A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM32A
	SeqTarget long-range PCR primers for resequencing FAM32A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FAM32A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM32A

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ELISAs and CLIAs for FAM32A

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FAM32A Gene

protein-coding GIFtS: 48

Aliases &
Descriptions
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Proteins
for FAM32A gene

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for FAM32A gene

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Drugs & Compounds
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FAM32A Gene

protein-coding GIFtS: 48

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Genome Databases showing FAM32A gene

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Specialized Databases showing FAM32A gene

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Aliases &
Descriptions
for FAM32A gene

Summaries
for FAM32A gene

Genomic Views
for FAM32A gene

Proteins
for FAM32A gene

Protein Domains/
Families
for FAM32A gene

Gene Function
for FAM32A gene

Pathways & Interactions
for FAM32A gene

Drugs & Compounds
for FAM32A gene

Transcripts
for FAM32A gene

Expression
for FAM32A gene

Orthologs
for FAM32A gene

Paralogs
for FAM32A gene

Genomic Variants
for FAM32A gene

Disorders & Mutations
for FAM32A gene

Medical News
for FAM32A gene

Publications
for FAM32A gene

Intellectual Property
for FAM32A gene

Products
for FAM32A gene