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Aliases & Descriptionsfor FAM58A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions family with sequence similarity 58, member A1 2 OTTHUMP000000259362 MGC297291 2 OTTHUMP000000259322 STAR2 5 cyclin-M2 OTTHUMP000000259372 cyclin-related protein FAM58A2 cyclin M2 Cyclin-M3
Export aliases for FAM58A gene to outside databases Previous GC identifers: GC0XM152375 GC0XM152506 GC0XM152854
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Summariesfor FAM58A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FAM58A : Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq) UniProtKB/Swiss-Prot: FA58A_HUMAN, Q8N1B3 Function : May have a role in cell proliferation
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Genomic Viewsfor FAM58A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM58A gene promoter: RFX1 ZID CUTL1 RP58 FOXF2 HNF-1A ISGF-3 FOXO4 FOXO1a GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for FAM58A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FAM58A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28 FAM58A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM141511: view genomic region
(about GC identifiers )
Start:
141,511,974 bp from pter
End:
141,519,982 bp from pter
Size:
8,009 bases
Orientation:
minus strand
1 alternative location : Chr X- 152,853,377-152,864,707
RefSeq DNA sequence: NC_000023.10 NT_167198.1
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Proteinsfor FAM58A gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: FA58A_HUMAN, Q8N1B3 (See
protein sequence )Recommended Name: Cyclin-related protein FAM58A Size : 248 amino acids; 28369 Da
Subunit : Interacts with SALL1
Sequence caution : Sequence=AAH01909.4; Type=Erroneous initiation; Sequence=AAH07232.4; Type=Erroneous initiation;Sequence=AAH32121.1; Type=Erroneous initiation; Sequence=AAH71851.1; Type=Erroneous initiation;
Secondary accessions : Q2I380 Q330J9 Q96IU5 Q9BUU1Alternative splicing : 2 isoforms : Q8N1B3-1 Q8N1B3-2 Explore the universe of human proteins at neXtProt for FAM58A: NX_Q8N1B3
REFSEQ proteins (2 alternative transcripts):
NP_001124469.1 NP_689487.2 ENSEMBL proteins: ENSP00000359192 ENSP00000359194 ENSP00000359190 ENSP00000412865 ENSP00000384396 ENSP00000391173 ENSP00000377422 ENSP00000276345 ENSP00000402949 Human Recombinant Proteins Antibodies for FAM58A: Assays for FAM58A:
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Protein
Domains/ Familiesfor FAM58A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM58A for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N1B3 ProtoNet protein and cluster: Q8N1B3
UniProtKB/Swiss-Prot: FA58A_HUMAN, Q8N1B3 Similarity : Belongs to the cyclin family. Cyclin-like FAM58 subfamily
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Gene Functionfor FAM58A gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: FA58A_HUMAN, Q8N1B3 Function : May have a role in cell proliferation
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
About this table
FAM58A for ontologies About GeneDecksing
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Pathways & Interactionsfor FAM58A gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for FAM58A Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM58A
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Drugs & Compoundsfor FAM58A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for FAM58A
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Transcriptsfor FAM58A gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for FAM58A gene (2 alternative transcripts): NM_001130997.1 NM_152274.3
Additional cDNA sequence: AY445048.1 BC001909.1 BC007232.1 BC032121.2 BC071851.1 CR591949.1 CR604685.1 CR609517.1 CR623450.1 DQ323993.1
9 DOTS entries : DT.403010 DT.100754240 DT.97844703 DT.121316730 DT.121316755 DT.95285215 DT.75102854 DT.91764825
DT.95285212 24/149 AceView cDNA sequences (see all 149 ):
CF529592 BQ669511 BU634035 CA307663 CB529466 AI368788 CD674841 CR604685 AI559684 AW079353 AW675396 AI564254 BU685137 AW009759 BE646636 BQ670735 BC071851 AW613907 BQ052733 BU628409 CR591949 CF529839 BM708687 BM785505
highest scoring ESTs for FAM58A :AW630663 BC001909 BC007232 BC032121 BC071851 BF568109 BG337452 BG680566 BG820886 BG820887 Unigene Cluster for FAM58A:
Family with sequence similarity 58, member A Hs.496943 [show with all ESTs ] Unigene Representative Sequence: BM473242 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM58A ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e SP1 :                 -           SP2 :                 -           SP3 :                           SP4 :   -   -   -                     SP5 :             -     -          
About this scheme ECgene alternative splicing isoforms for FAM58A 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000465867 ENST00000370173 ENST00000370175 (uc011myr.1 uc011mys.1 uc010nug.2 )ENST00000370171 ENST00000429336 ENST00000406277 ENST00000428722 ENST00000470284 ENST00000393837 ENST00000482182 ENST00000276345 ENST00000440428
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Expression for FAM58A gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section FAM58A expression in normal and diseased human tissues 1 / 2 / 3
4 probe-sets matching FAM58A gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
90281_f_at2 , 3
U95-E
3
1.00
0.94
0.95
0.94
AI148734
0.60
1.00
0.82
1
89612_at2 , 3
U95-E
3
1.00
0.83
0.62
1.06
AI971714
0.60
1.00
0.82
1
226466_s_at2 , 3
U133-B
4
1.00
0.83
--
--
AL544688
0.40
1.00
0.76
1
226466_s_at2
U133Plus2
4
1.00
0.83
--
--
--
--
--
--
--
About this table
FAM58A for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.496943 SABiosciences Custom PCR Arrays for FAM58A
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Orthologsfor FAM58A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for FAM58A gene from 5/11 species (see all 11 )
About this table Species with no ortholog for FAM58A ENSEMBL Gene Tree for FAM58A (if available)
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Paralogsfor FAM58A gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for FAM58A gene CCNL2 2 CCNT2 2 CCNK 2 CCNC 2 CCNL1 2 CCNT1 2
FAM58A for paralogs About GeneDecksing
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Genomic Variantsfor FAM58A gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr X pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for FAM58A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FAM58A: --
QIAGEN SeqTarget long-range PCR primers for resequencing FAM58A
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Disorders & Mutationsfor FAM58A gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM58A for disorders About GeneDecksing
OMIM: 300708 disorders : 300707 UniProtKB/Swiss-Prot: FA58A_HUMAN, Q8N1B3
Defects in FAM58A are the cause of toe syndactyly, telecanthus, and anogenital and renal malformations (STAR) [MIM:300707]; also known as STAR syndrome or syndactyly with renal and anogenital malformations Human Gene Mutation Database (HGMD) : FAM58A Export disorders and mutations for FAM58A gene to outside databases
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Medical Newsfor FAM58A gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor FAM58A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 8 PubMed articles for FAM58A gene integrated from 7 sources : (articles sorted by number of sources associating them with FAM58A) Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations. (PubMed id 18297069) 1 , 2 , 3 Unger S....Kohlhase J. (2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330) 2 Gauci S....Mohammed S. (2009) Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182) 1 Kim J.M....Kim N.S. (2006) The LIFEdb database in 2006. (PubMed id 16381901) 1 Mehrle A....Wiemann S. (2006) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 1 Wiemann S....Poustka A. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) DNA cloning using in vitro site-specific recombination. (PubMed id 11076863) 1 Hartley J.L....Brasch M.A. (2000)
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External Searches for FAM58A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM58A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM58A gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM58A gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for FAM58A gene: Search GeneIP for patents involving FAM58A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM58A gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for FAM58A
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