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FAM71D Gene

protein-coding GIFtS: 36

GC14P047825

family with sequence similarity 71, member D
(Previous name: chromosome 14 open reading frame 54 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C14orf54)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
family with sequence similarity 71, member D¹ ²
C14orf54² ³
chromosome 14 open reading frame 54¹
hypothetical protein LOC161142²
FLJ36130²

External Ids:	HGNC: 20101¹	Entrez Gene: 161142²	Ensembl: ENSG00000172717⁷	UniProtKB: Q8N9W8³

Export aliases for FAM71D gene to outside databases

Previous GC identifers: GC14P066726 GC14P067656

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for FAM71D
Other transcription factors

Search SABiosciences Chromatin IP Primers for FAM71D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q23.3

FAM71D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM71D gene location

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P047825: view genomic region (about GC identifiers)

Start:	47,825,458 bp from pter
End:	47,864,638 bp from pter
Size:	39,181 bases
Orientation:	plus strand

1 alternative location:

Chr14+ 67,656,146-67,695,267

RefSeq DNA sequence:

NC_000014.8 NT_026437.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FA71D_HUMAN, Q8N9W8 (See protein sequence)

Recommended Name: Protein FAM71D

Size: 422 amino acids; 47076 Da

Secondary accessions: Q86VN4

Alternative splicing: 2 isoforms: Q8N9W8-1 Q8N9W8-2

Explore the universe of human proteins at neXtProt for FAM71D: NX_Q8N9W8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_775797.2
Human Recombinant Proteins

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Assays for FAM71D:

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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FAM71D
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM71D for domains About GeneDecksing

1 InterPro domain/family:

IPR022168 DUF3699

Graphical View of Domain Structure for InterPro Entry Q8N9W8

ProtoNet protein and cluster: Q8N9W8

UniProtKB/Swiss-Prot: FA71D_HUMAN, Q8N9W8

Similarity: Belongs to the FAM71 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for FAM71D Sigma-Aldrich shRNA for FAM71D
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): FAM71D OriGene shRNA RFP (see all 2): FAM71D OriGene basic RS shRNA (see all 2): FAM71D OriGene siRNA (see all 2): FAM71D
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM71D

miRNA:		Sigma-Aldrich microRNA Mimics for FAM71D Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM71D
		1 SABiosciences Assays for microRNA that regulate FAM71D:
		hsa-miR-1244

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector: FAM71D OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FAM71D OriGene untagged cDNA clones in CMV expression vector: FAM71D Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for FAM71D

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for FAM71D

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM71D

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM71D

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for FAM71D Sigma-Aldrich shRNA for FAM71D
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): FAM71D OriGene shRNA RFP (see all 2): FAM71D OriGene basic RS shRNA (see all 2): FAM71D OriGene siRNA (see all 2): FAM71D
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM71D

miRNA:		Sigma-Aldrich microRNA Mimics for FAM71D Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM71D
		1 SABiosciences Assays for microRNA that regulate FAM71D:
		hsa-miR-1244

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FAM71D OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FAM71D OriGene untagged cDNA clones in CMV expression vector: FAM71D Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FAM71D

Primers:		OriGene genome-wide validated SYBR primer pairs: FAM71D Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FAM71D: PPH19605A

REFSEQ mRNAs for FAM71D gene:

NM_173526.3

Additional cDNA sequence:

AK093449.1 AK302154.1 BC037380.1 BC050401.1

7 DOTS entries:

DT.75199969 DT.100039443 DT.100743925 DT.100674146 DT.416381 DT.100680917 DT.120773233

20 AceView cDNA sequences:

AA718918 AI191975 AX748134 BC050401 BC037380 BI832052 NM_173526 AK093449

AI699453 BU101741 AA399527 AA398093 BI826576 BI831380 CD244027 AI956014

BM908047 AI925089 BF881294 AA831479

Unigene Cluster for FAM71D:

Family with sequence similarity 71, member D

Hs.412818 [show with all ESTs]

Unigene Representative Sequence: NM_173526

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM71D

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for FAM71D
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000311864(uc001xja.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FAM71D expression in normal and diseased human tissues

¹ / ²

1 probe-set matching FAM71D gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1552839_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

FAM71D gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.412818

Primers:		OriGene genome-wide validated SYBR primer pairs: FAM71D Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FAM71D: PPH19605A

SABiosciences Custom PCR Arrays for FAM71D

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM71D gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC480359¹	--	hypothetical LOC480359	82.85(n) 73.37(a)	480359 XM_537483.2 XP_537483.2
chimpanzee (Pan troglodytes)	LOC735597¹	--	similar to C14orf54 protein	98.75(n) 97.25(a)	735597 XM_001135797.1 XP_001135797.1
cow (Bos taurus)	C10H14orf54¹	--	family with sequence similarity 71, member D ortholog	81.54(n) 70.26(a)	618905 NM_001046625.1 NP_001040090.1
rat (Rattus norvegicus)	Fam71d¹	--	family with sequence similarity 71, member D	73.61(n) 62.8(a)	366671 NM_001017469.1 NP_001017469.1
mouse (Mus musculus)	Fam71d^{1 , 5}	12 (35.51 cM)⁵	family with sequence similarity 71, member D^{1, 5}	74.87(n)¹ 61.78(a)¹	70897¹ NM_027597.3¹ NP_081873.2¹ AB473726⁵ AK014851⁵ (see all 10)

About this table Species with no ortholog for FAM71D

ENSEMBL Gene Tree for FAM71D (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs877956^1,2	C,F	67693733(-)	`AATCAT/CTGTAA`	1	--	int¹		6		NA EA NS	522
rs1881035^1,2	C,F,A,	67692698(+)	`TGCGCA/GTGCGC`	1	--	int¹		3		NA EA WA	162
rs1918484^1,2	C,F,	67684731(-)	`acactG/Attgca`	1	--	int¹		4		NA WA	144
rs2025207^1,2	H	67694990(-)	`CTTTTC/TTTCTT`	1	--	int¹ trp³		4		NS EA	406
rs2025208^1,2	C,A,H	67689872(-)	`aggcaG/Tggtgg`	1	--	int¹		1		WA	2
rs2025209^1,2	C,	67689778(-)	`gattgC/Tgccac`	1	--	int¹		0	--	--	--	--
rs4454895^1,2	C	67694987(+)	`ATCAAG/AAAGAA`	1	--	int¹ trp³		4		NS EA	406
rs5809333^1,2	--	67692651(+)	`tgtgt-/GTGTGT gtgtg`	1	--	int¹		0	--	--	--	--
rs6573755^1,2	C,F,A,	67654476(+)	`GTGCCG/TTTGCT`	1	--	ng5¹		5		EA NS WA	388
rs6573758^1,2	C,F,A,	67667906(+)	`ctcggA/Gaggct`	1	--	int¹		2		NA WA	74

About this table

HapMap Linkage Disequilibrium images for FAM71D (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM71D
1 CNV: 8772

Search QIAGEN SeqTarget long-range PCR primers for resequencing for FAM71D

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

5 PubMed articles for FAM71D gene integrated from 7 sources:
(articles sorted by number of sources associating them with FAM71D)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 161142	HGNC: 20101	AceView: C14orf54	Ensembl:ENSG00000172717	euGenes: HUgn161142
ECgene: FAM71D	H-InvDB: FAM71D

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for FAM71D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for FAM71D gene:
Search GeneIP for patents involving FAM71D

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FAM71D
	Search QIAGEN SeqTarget long-range PCR primers for resequencing for FAM71D
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FAM71D

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FAM71D Gene

protein-coding GIFtS: 36

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FAM71D Gene

protein-coding GIFtS: 36

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