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FANCG Gene

protein-coding GIFtS: 63

GC09M035030

Fanconi anemia, complementation group G
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: XRCC9)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
Fanconi anemia, complementation group G¹ ²		X-ray repair, complementing defective, in Chinese hamster, 9²
XRCC9² ³ ⁵		X-ray repair complementing defective repair in Chinese hamster cells 9²
FAG¹ ²		Fanconi anemia group G protein²
DNA repair protein XRCC9² ³		Protein FACG³

External Ids:	HGNC: 3588¹	Entrez Gene: 2189²	Ensembl: ENSG00000221829⁷	UniProtKB: O15287³

Export aliases for FANCG gene to outside databases

Previous GC identifers: GC09M035386 GC09M035243 GC09M035063

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FANCG:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2),

FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The

previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder

characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage,

and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity;

they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for

complementation group G. (provided by RefSeq)

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287

Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be

implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor

suppressor gene

Gene Wiki entry for FANCG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FANCG gene promoter:
         GATA-1   CREB   deltaCREB   GATA-3   GATA-2   NF-kappaB1   NF-kappaB   ATF6   PPAR-gamma2   PPAR-gamma1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for FANCG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FANCG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13

FANCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FANCG gene location

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M035030: view genomic region (about GC identifiers)

Start:	35,029,423 bp from pter
End:	35,035,601 bp from pter
Size:	6,179 bases
Orientation:	minus strand

1 alternative location:

Chr9- 35,073,832-35,080,013

RefSeq DNA sequence:

NC_000009.11 NT_008413.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287 (See protein sequence)

Recommended Name: Fanconi anemia group G protein

Size: 622 amino acids; 68554 Da

Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and

FANCM. The complex is not found in FA patients

Subcellular location: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic

Explore the universe of human proteins at neXtProt for FANCG: NX_O15287

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004620.1

ENSEMBL proteins:

ENSP00000412793 ENSP00000409607 ENSP00000367910

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: FANCG
	GenScript Custom Purified and Recombinant Proteins Services for FANCG
	Novus Biologicals Protein for FANCG
	Novus Biologicals Lysates for FANCG
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IDA	17060495

About this table

FANCG for ontologies About GeneDecksing

Antibodies for FANCG:

	Millipore Mono- and Polyclonal Antibodies for the study of FANCG
	Sigma-Aldrich Antibodies for FANCG
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): FANCG
	GenScript Custom Superior Antibodies Services for FANCG
	Novus Biologicals Antibodies for FANCG
	Epitomics antibodies for FANCG

Assays for FANCG:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FANCG
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FANCG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FANCG for domains About GeneDecksing

2 InterPro domains/families:

IPR011990 TPR-like_helical

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry O15287

ProtoNet protein and cluster: O15287

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287

Similarity: Contains 4 TPR repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287

Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be

implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor

suppressor gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FANCG Sigma-Aldrich shRNA Panels and shRNA for FANCG
		OriGene 29mer shRNA kits in GFP-retroviral vector: FANCG OriGene shRNA RFP: FANCG OriGene basic RS shRNA: FANCG OriGene siRNA: FANCG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FANCG

miRNA:		Sigma-Aldrich microRNA Mimics for FANCG Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FANCG
		Search SABiosciences for Assays for microRNAs that regulate FANCG

Gene
Editing:

Sigma-Aldrich CompoZr Knockout ZFN for FANCG

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FANCG OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FANCG OriGene untagged cDNA clones in CMV expression vector: FANCG OriGene 3'-UTR clone: FANCG Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: FANCG
		Sino Biological Human cDNA Clone for FANCG

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for FANCG

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003684	damaged DNA binding	TAS	9806548
GO:0004871	signal transducer activity	--	--
GO:0005515	protein binding	IPI	16189514

About this table

FANCG for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fancg):

cellular

endocrine/exocrine gland

no phenotypic analysis

reproductive system

FANCG for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

FANCG for pathways About GeneDecksing

1 Millipore Pathway for FANCG

Meiosis

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for FANCG

	Hereditary Breast Cancer Signaling
	Role of BRCA1 in DNA Damage Response

SABiosciences Pathway-Focused PCR Array including FANCG: PAHS-029A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FANCG

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FANCG

5/23 Interacting proteins for FANCG (ENSP00000367910³ O15287^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FANCA	O15360²	STRING: ENSP00000373952 MINT-4789325 MINT-19441 MINT-19440 MINT-4789189 MINT-68475 MINT-19452 MINT-4789226 MINT-19444 MINT-19447
ZBED1	O96006¹^,²	EBI-81610,EBI-740037 MINT-66922
FANCL	Q9NW38²	STRING: ENSP00000233741 MINT-4789189 MINT-4789226 MINT-4789325
FANCF	Q9NPI8²	STRING: ENSP00000330875 MINT-19449 MINT-19448
FANCE	Q9HB96²	STRING: ENSP00000229769 MINT-45827

About this table

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	9256465
GO:0000160	two-component signal transduction system (phosphorelay)	--	--
GO:0001541	ovarian follicle development	IEA	--
GO:0006281	DNA repair	TAS	--
GO:0006974	response to DNA damage stimulus	--	--

About this table

FANCG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

FANCG for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FANCG
6 Novoseek chemical compound relationships for FANCG gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mitomycin c	79.7	13	12637330 (2), 10567393 (2), 11756225 (2), 12915460 (1) (see all 7)
diepoxybutane	67.7	2	12637330 (1)
cisplatin	26.7	1	9256465 (1)
leucine	14.5	2	11050007 (1), 11093276 (1)
alanine	1.72	1	10567393 (1)
h2o2	0	1	15138265 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FANCG Sigma-Aldrich shRNA Panels and shRNA for FANCG
		OriGene 29mer shRNA kits in GFP-retroviral vector: FANCG OriGene shRNA RFP: FANCG OriGene basic RS shRNA: FANCG OriGene siRNA: FANCG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FANCG

miRNA:		Sigma-Aldrich microRNA Mimics for FANCG Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FANCG
		Search SABiosciences for Assays for microRNAs that regulate FANCG

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FANCG OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FANCG OriGene untagged cDNA clones in CMV expression vector: FANCG OriGene 3'-UTR Clone: FANCG Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: FANCG

Primers:		OriGene genome-wide validated SYBR primer pairs: FANCG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FANCG: PPH20387A

REFSEQ mRNAs for FANCG gene:

NM_004629.1

Additional cDNA sequence:

AJ007669.1 AK293427.1 AK311348.1 AK312987.1 BC000032.2 BC011623.2 BT009813.1 CR592637.1

U70310.1

16 DOTS entries:

DT.115886 DT.100781895 DT.100781893 DT.100781892 DT.95280820 DT.121145912 DT.91969485 DT.95280823

DT.121145915 DT.121145920 DT.95280822 DT.100781883 DT.102838808 DT.95280830 DT.121145935 DT.95280831

24/197 AceView cDNA sequences (see all 197):

CA390704 AA233751 AA426567 U70310 BQ881362 AA340034 BQ898789 BP364172

CF529400 AL701956 BM716105 NM_004629 BM551902 T33509 BI760648 BM045080

AA598979 BC011623 AA814381 BC000032 BU192683 AW955161 BM051787 T35916

highest scoring ESTs for FANCG:

AJ007669 AA180512 AL559559 AL701956 AL711298 AU125366 AU130696 BC000032 BC011623 BE255777

Unigene Cluster for FANCG:

Fanconi anemia, complementation group G

Hs.591084 [show with all ESTs]

Unigene Representative Sequence: AJ007669

GeneLoc Exon Structure

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000474894 ENST00000425676(uc003zwa.1) ENST00000448890 ENST00000378643(uc003zwb.1 uc010mkj.1 uc011lot.1)

ENST00000461149 ENST00000476212 ENST00000462124 ENST00000481254

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FANCG expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching FANCG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37584_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AJ007669	1.00	1.00	1.00	1
203564_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004629	0.60	1.00	0.82	1
203564_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

FANCG for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

FANCG gene electronic northern expression

About these images

CGAP SAGE TAG: AAGATGCTCT

SOURCE GeneReport for Unigene cluster: Hs.591084

Expression variation in blood from EXPOLDB for FANCG

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287

Tissue specificity: Highly expressed in testis and thymus. Found in lymphoblasts

Primers:		OriGene genome-wide validated SYBR primer pairs: FANCG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FANCG: PPH20387A

SABiosciences Expression via Pathway-Focused PCR Array including FANCG: PAHS-029A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FANCG gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FANCG¹	--	Fanconi anemia, complementation group G	85.32(n) 81.08(a)	611887 XM_849610.1 XP_854703.1
chimpanzee (Pan troglodytes)	FANCG¹	--	Fanconi anemia, complementation group G	99.52(n) 99.36(a)	465067 XM_001165190.1 XP_001165190.1
cow (Bos taurus)	FANCG¹	--	Fanconi anemia, complementation group G	85.4(n) 80.17(a)	615352 XM_867138.2 XP_872231.2
rat (Rattus norvegicus)	Fancg¹	--	Fanconi anemia, complementation group G	79.37(n) 72.58(a)	691105 XM_001076851.1 XP_001076851.1
mouse (Mus musculus)	Fancg^{1 , 5}	4 (22.97 cM)⁵	Fanconi anemia, complementation group G^{1, 5}	79.42(n)¹ 73.56(a)¹	60534¹ NM_053081.1¹ NP_444311.1¹ AF112439⁵ AF406951⁵ (see all 15)

About this table Species with no ortholog for FANCG

ENSEMBL Gene Tree for FANCG (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs504082^1,2	C,F,O,	35079361(+)	`CCATCG/TGTTGG`	1	--	int¹		33		NA MN WA EA CA CSAM NS	2826
rs554098^1,2	C,F,A,	35077441(+)	`CCTCCC/TCGTCT`	1	--	int¹		18		NS EA NA WA	1456
rs584040^1,2	C,F,A,H	35080830(+)	`gcctgC/Tgatcc`	1	--	ng5¹		6		NS NA	190
rs587118^1,2	C,F,O,A,	35074917(+)	`AAGTAT/CACATA`	1	--	int¹		21		NA NS EA	1638
rs595655^1,2	C,A,H,	35081095(+)	`aaaaaA/Gaaaag`	1	--	ng5¹		3		NA	8
rs1043957^1,2	--	35076998(-)	`GTGTAC/TACAGC`	2	Y	ref¹ syn¹		1		MN	184
rs2237857^1,2	C,F,	35076755(+)	`CTGCTA/GTTGTG`	2	T I	ref¹ mis¹		21		MN NA NS EA WA	1912
rs4986939^1,2	C,F,	35075969(+)	`GCTCCG/AAGCTA`	2	/S /L	ref¹ mis¹		22		MN NS EA NA	2336
rs4986940^1,2	C,F,A	35076517(-)	`TACTGC/TCACCA`	2	P S	ref¹ mis¹		15		MN NS EA	1596
rs7029788^1,2	C,	35080733(+)	`aatttA/Taaaaa`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for FANCG (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FANCG: --

QIAGEN SeqTarget long-range PCR primers for resequencing FANCG

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FANCG for disorders About GeneDecksing

OMIM: 602956

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287

Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal

recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a

predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to

DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair

10/12 Novoseek disease relationships for FANCG gene (see all 12)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fanconis anemia	96.8	19	12552564 (2), 11050007 (1), 15299017 (1), 19102630 (1) (see all 17)
cancer	47.5	2	12351379 (1), 19861535 (1)
anemia	43.5	5	16643430 (1), 12915460 (1), 11093276 (1), 12001267 (1)
t-all	36.1	2	10994546 (1)
pancreatic cancer	33.2	11	14726700 (5), 15277238 (1), 15107617 (1), 12750283 (1) (see all 5)
hnscc	32.8	2	17409780 (1), 16466850 (1)
chromosomal aberrations	20.7	2	9256465 (1), 17097336 (1)
somatic mutations	19.1	2	14726700 (1), 12750283 (1)
carcinoma squamous cell	15.2	1	16982972 (1)
breast cancer	13.9	2	14695169 (1)

About this table

Genatlas disease: FANCG

Fanconi anemia,autosomal recessive,complementation group G,characterized by progressive bone marrow failure

(pancytopenia),often associated with skeletal abnormalities and an increased cancer risk and with spontaneous

chromosomal breakage exacerbated by exposure to DNA cross-linking agents

GeneTests: FANCG

Fanconi Anemia

Locus Specific Mutation Databases (LSDB): FANCG
Human Gene Mutation Database (HGMD): FANCG
Genetic Association Database (GAD): FANCG
Human Genome Epidemiology (HuGE) Navigator: FANCG (14 documents)

Export disorders and mutations for FANCG gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/127 PubMed articles for FANCG gene, integrated from 7 sources (see all 127):
(articles sorted by number of sources associating them with FANCG)

The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. (PubMed id 9256465)^{1, 2, 3, 7} Liu N.... Thompson L.H. (1997)
Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9. (PubMed id 11093276)^{1, 2, 7} Demuth I.... Digweed M. (2000)
Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. (PubMed id 10373536)^{1, 2, 7} Garcia-Higuera I.... D'Andrea A.D. (1999)
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)^{1, 4} Zienolddiny S....Haugen A. (2006)
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (PubMed id 16116422)^{1, 2} Meetei A.R....Wang W. (2005)
X-linked inheritance of Fanconi anemia complementation group B. (PubMed id 15502827)^{1, 2} Meetei A.R....Joenje H. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. (PubMed id 12724401)^{1, 2} Meetei A.R.... Wang W. (2003)
The Fanconi anaemia group G gene FANCG is identical with XRCC9. (PubMed id 9806548)^{1, 2} De Winter J.P.... Joenje H. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2189	HGNC: 3588	AceView: FANCG	Ensembl:ENSG00000221829	euGenes: HUgn2189
ECgene: FANCG	H-InvDB: FANCG

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for FANCG	Genetics and Cytogenetics in Oncology and Haematology
Fanconi Anemia Mutation Database	http://www.rockefeller.edu/fanconi/mutate/jumpg.html
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FANCG
NIEHS-SNPs	http://egp.gs.washington.edu/data/fancg/

Intellectual Property for FANCG gene
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Patent Information for FANCG gene:
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GeneCards and IP:
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