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FANCG Gene

protein-coding   GIFtS: 63

GC09M035030
Fanconi anemia, complementation group G
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: XRCC9)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
Fanconi anemia, complementation group G1 2     X-ray repair, complementing defective, in Chinese hamster, 92
XRCC92 3 5     X-ray repair complementing defective repair in Chinese hamster cells 92
FAG1 2     Fanconi anemia group G protein2
DNA repair protein XRCC92 3     Protein FACG3

External Ids:    HGNC: 35881   Entrez Gene: 21892   Ensembl: ENSG000002218297   UniProtKB: O152873   

Export aliases for FANCG gene to outside databases

Previous GC identifers: GC09M035386 GC09M035243 GC09M035063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FANCG:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2),
FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The
previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder
characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage,
and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity;
they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for
complementation group G. (provided by RefSeq)

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be
implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor
suppressor gene

Gene Wiki entry for FANCG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FANCG gene promoter:
         GATA-1   CREB   deltaCREB   GATA-3   GATA-2   NF-kappaB1   NF-kappaB   ATF6   PPAR-gamma2   PPAR-gamma1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for FANCG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FANCG 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

FANCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FANCG gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035030:  view genomic region     (about GC identifiers)

Start:
35,029,423 bp from pter
End:
35,035,601 bp from pter
Size:
6,179 bases
Orientation:
minus strand

1 alternative location:
Chr9- 35,073,832-35,080,013     
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287 (See protein sequence)
Recommended Name: Fanconi anemia group G protein  
Size: 622 amino acids; 68554 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and
FANCM. The complex is not found in FA patients
Subcellular location: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic

Explore the universe of human proteins at neXtProt for FANCG: NX_O15287 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004620.1  

    ENSEMBL proteins: 
    ENSP00000412793 ENSP00000409607 ENSP00000367910 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: FANCG
    GenScript Custom Purified and Recombinant Proteins Services for FANCG 
    Novus Biologicals Protein for FANCG
    Novus Biologicals Lysates for FANCG
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm TAS--
    GO:0005737 cytoplasm IEA--
    GO:0005739 mitochondrion IDA17060495
    About this table

    FANCG for ontologies           About GeneDecksing



    Antibodies for FANCG: 
    Millipore Mono- and Polyclonal Antibodies for the study of FANCG
    Sigma-Aldrich Antibodies for FANCG
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): FANCG
    GenScript Custom Superior Antibodies Services for FANCG 
    Novus Biologicals Antibodies for FANCG
    Epitomics antibodies for FANCG

    Assays for FANCG: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FANCG 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FANCG 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FANCG for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O15287

    ProtoNet protein and cluster: O15287

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
    Similarity: Contains 4 TPR repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
    Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be
    implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor
    suppressor gene

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for FANCG
    Sigma-Aldrich shRNA Panels and shRNA for FANCG
    OriGene 29mer shRNA kits in GFP-retroviral vector: FANCG
    OriGene shRNA RFP: FANCG
    OriGene basic RS shRNA: FANCG
    OriGene siRNA: FANCG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FANCG 
    miRNA:Sigma-Aldrich microRNA Mimics for FANCG
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FANCG 
    Search SABiosciences for Assays for microRNAs that regulate FANCG

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for FANCG 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: FANCG
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FANCG
    OriGene untagged cDNA clones in CMV expression vector: FANCG
    OriGene 3'-UTR clone: FANCG 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: FANCG 
    Sino Biological Human cDNA Clone for FANCG

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for FANCG 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684 damaged DNA binding TAS9806548
    GO:0004871 signal transducer activity ----
    GO:0005515 protein binding IPI16189514
    About this table

    FANCG for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fancg):

    cellularendocrine/exocrine glandno phenotypic analysisreproductive system

    FANCG for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    FANCG for pathways           About GeneDecksing

    1 Millipore Pathway for FANCG
        Meiosis

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  FANCG
        Hereditary Breast Cancer Signaling
    Role of BRCA1 in DNA Damage Response

        SABiosciences Pathway-Focused PCR Array including FANCG: PAHS-029A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FANCG
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FANCG

    5/23 Interacting proteins for FANCG (ENSP000003679103 O152871, 2) via UniProtKB, MINT, and/or STRING (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCAO153602STRING: ENSP00000373952 MINT-4789325 MINT-19441 MINT-19440 MINT-4789189 MINT-68475 MINT-19452 MINT-4789226 MINT-19444 MINT-19447
    ZBED1O960061, 2EBI-81610,EBI-740037 MINT-66922
    FANCLQ9NW382STRING: ENSP00000233741 MINT-4789189 MINT-4789226 MINT-4789325
    FANCFQ9NPI82STRING: ENSP00000330875 MINT-19449 MINT-19448
    FANCEQ9HB962STRING: ENSP00000229769 MINT-45827
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075 cell cycle checkpoint TAS9256465
    GO:0000160 two-component signal transduction system (phosphorelay) ----
    GO:0001541 ovarian follicle development IEA--
    GO:0006281 DNA repair TAS--
    GO:0006974 response to DNA damage stimulus ----
    About this table

    FANCG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    FANCG for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FANCG
    6 Novoseek chemical compound relationships for FANCG gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 79.7 13 12637330 (2), 10567393 (2), 11756225 (2), 12915460 (1) (see all 7)
    diepoxybutane 67.7 2 12637330 (1)
    cisplatin 26.7 1 9256465 (1)
    leucine 14.5 2 11050007 (1), 11093276 (1)
    alanine 1.72 1 10567393 (1)
    h2o2 0 1 15138265 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for FANCG
    Sigma-Aldrich shRNA Panels and shRNA for FANCG
    OriGene 29mer shRNA kits in GFP-retroviral vector: FANCG
    OriGene shRNA RFP: FANCG
    OriGene basic RS shRNA: FANCG
    OriGene siRNA: FANCG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FANCG 
    miRNA: Sigma-Aldrich microRNA Mimics for FANCG
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FANCG 
    Search SABiosciences for Assays for microRNAs that regulate FANCG
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: FANCG
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FANCG
    OriGene untagged cDNA clones in CMV expression vector: FANCG
    OriGene 3'-UTR Clone: FANCG 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: FANCG 
    Primers: OriGene genome-wide validated SYBR primer pairs: FANCG
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for FANCG: PPH20387A

    REFSEQ mRNAs for FANCG gene: 

    NM_004629.1  

    Additional cDNA sequence: 

    AJ007669.1 AK293427.1 AK311348.1 AK312987.1 BC000032.2 BC011623.2 BT009813.1 CR592637.1 
    U70310.1 

    16 DOTS entries:

    DT.115886  DT.100781895  DT.100781893  DT.100781892  DT.95280820  DT.121145912  DT.91969485  DT.95280823 
    DT.121145915  DT.121145920  DT.95280822  DT.100781883  DT.102838808  DT.95280830  DT.121145935  DT.95280831 

    24/197 AceView cDNA sequences (see all 197):

    CA390704 AA233751 AA426567 U70310 BQ881362 AA340034 BQ898789 BP364172 
    CF529400 AL701956 BM716105 NM_004629 BM551902 T33509 BI760648 BM045080 
    AA598979 BC011623 AA814381 BC000032 BU192683 AW955161 BM051787 T35916 

    highest scoring ESTs for FANCG:

    AJ007669 AA180512 AL559559 AL701956 AL711298 AU125366 AU130696 BC000032 BC011623 BE255777 

    Unigene Cluster for FANCG:

    Fanconi anemia, complementation group G
    Hs.591084  [show with all ESTs]
    Unigene Representative Sequence: AJ007669


    GeneLoc Exon Structure

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474894 ENST00000425676(uc003zwa.1) ENST00000448890 ENST00000378643(uc003zwb.1 uc010mkj.1 uc011lot.1)
    ENST00000461149 ENST00000476212 ENST00000462124 ENST00000481254

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    FANCG expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching FANCG gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37584_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AJ007669 1.00 1.00 1.00 1
    203564_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004629 0.60 1.00 0.82 1
    203564_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    FANCG for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    FANCG gene expression
    FANCG gene electronic northern expression
    FANCG gene sage expression
    About these images

    CGAP SAGE TAG: AAGATGCTCT

    SOURCE GeneReport for Unigene cluster: Hs.591084

    Expression variation in blood from EXPOLDB for FANCG

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
    Tissue specificity: Highly expressed in testis and thymus. Found in lymphoblasts

    Primers: OriGene genome-wide validated SYBR primer pairs: FANCG
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for FANCG: PPH20387A
        SABiosciences Expression via Pathway-Focused PCR Array including FANCG: PAHS-029A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for FANCG gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FANCG1   -- Fanconi anemia, complementation group G 85.32(n)
    81.08(a)
    611887  XM_849610.1  XP_854703.1 
    chimpanzee
    (Pan troglodytes)
    FANCG1   -- Fanconi anemia, complementation group G 99.52(n)
    99.36(a)
    465067  XM_001165190.1  XP_001165190.1 
    cow
    (Bos taurus)
    FANCG1   -- Fanconi anemia, complementation group G 85.4(n)
    80.17(a)
    615352  XM_867138.2  XP_872231.2 
    rat
    (Rattus norvegicus)
    Fancg1   -- Fanconi anemia, complementation group G 79.37(n)
    72.58(a)
    691105  XM_001076851.1  XP_001076851.1 
    mouse
    (Mus musculus)
    Fancg1 , 5 4 (22.97 cM)5
    Fanconi anemia, complementation group G1, 5 79.42(n)1
    73.56(a)1
    605341  NM_053081.11  NP_444311.11 
     AF1124395  AF4069515  (see all 15)
    About this table        Species with no ortholog for FANCG

    ENSEMBL Gene Tree for FANCG (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/79 NCBI SNPs in FANCG are shown (see all 79)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs5040821,2
    C,F,O,35079361(+) CCATCG/TGTTGG 1 -- int133Minor allele frequency- T:0.41NA MN WA EA CA CSAM NS 2826
    rs5540981,2
    C,F,A,35077441(+) CCTCCC/TCGTCT 1 -- int118Minor allele frequency- T:0.31NS EA NA WA 1456
    rs5840401,2
    C,F,A,H35080830(+) gcctgC/Tgatcc 1 -- ng516Minor allele frequency- T:0.25NS NA 190
    rs5871181,2
    C,F,O,A,35074917(+) AAGTAT/CACATA 1 -- int121Minor allele frequency- C:0.25NA NS EA 1638
    rs5956551,2
    C,A,H,35081095(+) aaaaaA/Gaaaag 1 -- ng513Minor allele frequency- G:0.12NA 8
    rs10439571,2
    --35076998(-) GTGTAC/TACAGC 2 Y ref1 syn11Minor allele frequency- T:0.00MN 184
    rs22378571,2
    C,F,35076755(+) CTGCTA/GTTGTG 2 T I ref1 mis121Minor allele frequency- T:0.00MN NA NS EA WA 1912
    rs49869391,2
    C,F,35075969(+) GCTCCG/AAGCTA 2 /S /L ref1 mis122Minor allele frequency- A:0.04MN NS EA NA 2336
    rs49869401,2
    C,F,A35076517(-) TACTGC/TCACCA 2 P S ref1 mis115Minor allele frequency- A:0.00MN NS EA 1596
    rs70297881,2
    C,35080733(+) aatttA/Taaaaa 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for FANCG (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FANCG: --

    QIAGEN SeqTarget long-range PCR primers for resequencing FANCG 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FANCG for disorders           About GeneDecksing

    OMIM: 602956

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287

  • Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal
  • recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a
    predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to
    DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair

    10/12 Novoseek disease relationships for FANCG gene (see all 12)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 96.8 19 12552564 (2), 11050007 (1), 15299017 (1), 19102630 (1) (see all 17)
    cancer 47.5 2 12351379 (1), 19861535 (1)
    anemia 43.5 5 16643430 (1), 12915460 (1), 11093276 (1), 12001267 (1)
    t-all 36.1 2 10994546 (1)
    pancreatic cancer 33.2 11 14726700 (5), 15277238 (1), 15107617 (1), 12750283 (1) (see all 5)
    hnscc 32.8 2 17409780 (1), 16466850 (1)
    chromosomal aberrations 20.7 2 9256465 (1), 17097336 (1)
    somatic mutations 19.1 2 14726700 (1), 12750283 (1)
    carcinoma squamous cell 15.2 1 16982972 (1)
    breast cancer 13.9 2 14695169 (1)
    About this table

    Genatlas disease: FANCG
    Fanconi anemia,autosomal recessive,complementation group G,characterized by progressive bone marrow failure
    (pancytopenia),often associated with skeletal abnormalities and an increased cancer risk and with spontaneous
    chromosomal breakage exacerbated by exposure to DNA cross-linking agents

    GeneTests: FANCG
    Fanconi Anemia

    Locus Specific Mutation Databases (LSDB): FANCG
    Human Gene Mutation Database (HGMD): FANCG
    Genetic Association Database (GAD): FANCG
    Human Genome Epidemiology (HuGE) Navigator: FANCG (14 documents)

    Export disorders and mutations for FANCG gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/127 PubMed articles for FANCG gene, integrated from 7 sources (see all 127):
    (articles sorted by number of sources associating them with FANCG)
    1. The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. (PubMed id 9256465)1, 2, 3, 7 Liu N.... Thompson L.H. (1997)
    2. Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9. (PubMed id 11093276)1, 2, 7 Demuth I.... Digweed M. (2000)
    3. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. (PubMed id 10373536)1, 2, 7 Garcia-Higuera I.... D'Andrea A.D. (1999)
    4. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 4 Zienolddiny S....Haugen A. (2006)
    5. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (PubMed id 16116422)1, 2 Meetei A.R....Wang W. (2005)
    6. X-linked inheritance of Fanconi anemia complementation group B. (PubMed id 15502827)1, 2 Meetei A.R....Joenje H. (2004)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. (PubMed id 12724401)1, 2 Meetei A.R.... Wang W. (2003)
    10. The Fanconi anaemia group G gene FANCG is identical with XRCC9. (PubMed id 9806548)1, 2 De Winter J.P.... Joenje H. (1998)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2189 HGNC: 3588 AceView: FANCG Ensembl:ENSG00000221829 euGenes: HUgn2189
    ECgene: FANCG H-InvDB: FANCG

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for FANCG Genetics and Cytogenetics in Oncology and Haematology
    Fanconi Anemia Mutation Databasehttp://www.rockefeller.edu/fanconi/mutate/jumpg.html
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FANCG
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fancg/

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