FAU Gene
protein-coding GIFtS : 55
GC11M061214
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (Previous name: Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptionsfor FAU gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed1 2 FBR-MuSV-associated ubiquitously expressed2 Fub11 2 monoclonal nonspecific suppressor factor beta2 FLJ229861 2 FAU-encoded ubiquitin-like protein2 asr11 2 FAU12 MNSFbeta1 2 ribosomal protein S302 Fubi1 2 40S ribosomal protein S302 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed(fox derived)1 2 ubiquitin-like protein fubi and ribosomal protein S302 RPS301 2 ubiquitin-like-S30 fusion protein2
Export aliases for FAU gene to outside databases Previous GC identifers: GC11M067403 GC11M066569 GC11M065138 GC11M064663 GC11M064644 GC11M064888
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Summariesfor FAU gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FAU : This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. (provided by RefSeq) Gene Wiki entry for FAU
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Genomic Viewsfor FAU gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAU gene promoter: AP-1 IRF-1 Max1 Max c-Myc GR-alpha ATF c-Jun c-Fos GR-beta Other transcription factors Search SABiosciences Chromatin IP Primers for FAU Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FAU
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13 FAU Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M061214: view genomic region
(about GC identifiers )
Start:
61,214,736 bp from pter
End:
61,216,309 bp from pter
Size:
1,574 bases
Orientation:
minus strand
1 alternative location : Chr 11- 64,888,103-64,889,660
RefSeq DNA sequence: NC_000011.9 NT_167190.1
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Proteinsfor FAU gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: RS30_HUMAN, P62861 (See
protein sequence )Recommended Name: 40S ribosomal protein S30 Size : 59 amino acids; 6648 Da
Miscellaneous : This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-likeprotein
Sequence caution : Sequence=AAH33877.1; Type=Erroneous initiation; Sequence=AAQ87877.1; Type=Erroneous initiation;Sequence=BAB15515.1; Type=Erroneous initiation; Sequence=CAA46714.1; Type=Erroneous initiation; Sequence=CAA46716.1; Type=Erroneous initiation; Sequence=CAG46772.1; Type=Erroneous initiation;
Secondary accessions : Q05472 Q95261 Q9H5V4UniProtKB/Swiss-Prot: UBIM_HUMAN, P35544 (See
protein sequence )
Recommended Name: Ubiquitin-like protein FUBI Size : 74 amino acids; 7760 Da
Miscellaneous : This protein is synthesized with ribosomal S30 as its C-terminal extension
Secondary accessions : Q9H5V4Explore the universe of human proteins at neXtProt for FAU: NX_P35544 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_001988.1 ENSEMBL proteins: ENSP00000413848 ENSP00000411592 ENSP00000279259 Human Recombinant Proteins 5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6 ):
About this table
FAU for ontologies About GeneDecksing Antibodies for FAU: Assays for FAU:
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Protein
Domains/ Familiesfor FAU gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAU for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P62861 Graphical View of Domain Structure for InterPro Entry P35544 ProtoNet protein and cluster: P62861
UniProtKB/Swiss-Prot: RS30_HUMAN, P62861 Similarity : Belongs to the ribosomal protein S30e family
UniProtKB/Swiss-Prot: UBIM_HUMAN, P35544 Similarity : Belongs to the ubiquitin family
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Gene Functionfor FAU gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section Genatlas biochemistry entry for FAU :Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog 4 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
FAU for ontologies About GeneDecksing
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Pathways & Interactionsfor FAU gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
FAU for pathways About GeneDecksing 1 Kegg Pathway (Kegg details for FAU) : SABiosciences Custom Pathway-Focused PCR Arrays for FAU Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAU 5/113 Interacting proteins for FAU (P35544 2 ENSP00000279259 3 P62861 2 , 2 ) via UniProtKB, MINT, and/or STRING (see all 113 )About this table 5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10 ):
About this table
FAU for ontologies About GeneDecksing
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Drugs & Compoundsfor FAU gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
FAU for compounds About GeneDecksing Browse Tocris compounds for FAU 1 Novoseek chemical compound relationship for FAU gene
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
arsenite
54.2
1
10069470 (1)
About this table
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Transcriptsfor FAU gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for FAU gene: NM_001997.4
Additional cDNA sequence: AK026639.1 BC033877.1 CR541974.1 CR619116.1 X65923.1
24/28 DOTS entries (see all 28 ): DT.97761874 DT.100714868 DT.95316561 DT.101987486 DT.95174284 DT.91687819 DT.100727645 DT.95172595
DT.91772688 DT.87005531 DT.95172592 DT.120709024 DT.100714838 DT.100714864 DT.101987963 DT.120709010 DT.91772689 DT.97761870 DT.100714859 DT.101987166 DT.120709129 DT.91772658 DT.120709040 DT.120709046 24/1565 AceView cDNA sequences (see all 1565 ):
BE389674 BQ677803 AA863182 BM990881 AW474187 F27333 AA374599 AI538619 AI339108 BG170051 AA147734 BM928583 CB529070 AJ710877 AA593124 BM687802 AA055838 H75844 AW614512 BQ065034 BM874034 NM_001997 AA488673 AA328305
highest scoring ESTs for FAU :X65923 AA093836 AA113966 AA179223 AA226561 AA303247 AA305574 AA311237 AA319554 AA319801 Unigene Cluster for FAU:
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed Hs.387208 [show with all ESTs ] Unigene Representative Sequence: BM911491 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000434372 ENST00000455731 ENST00000279259 (uc001ocy.1 uc001ocx.2 )
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Expression for FAU gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section FAU expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching FAU gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
31955_at2 , 3
U95-A
3
0.88
0.89
1.00
1.00
X65923
1.00
1.00
1.00
1
200019_s_at2 , 3
U133-B
2
1.00
0.95
--
--
NM_001997
0.60
1.00
0.82
1
200019_s_at2
U133Plus2
2
1.00
0.95
--
--
--
--
--
--
--
About this table
FAU for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTTCCCTGGC SOURCE GeneReport for Unigene cluster: Hs.387208 Expression variation in blood from EXPOLDB for FAU
SABiosciences Custom PCR Arrays for FAU
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Orthologsfor FAU gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for FAU gene from 5/17 species (see all 17 )
About this table Species with no ortholog for FAU ENSEMBL Gene Tree for FAU (if available)
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Paralogsfor FAU gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for FAU gene LOC100291851 2
FAU for paralogs About GeneDecksing
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Genomic Variantsfor FAU gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 11 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for FAU (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FAU: --
QIAGEN SeqTarget long-range PCR primers for resequencing FAU
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Disorders & Mutationsfor FAU gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAU for disorders About GeneDecksing
OMIM: 134690 3 Novoseek disease relationships for FAU gene
About this table Export disorders and mutations for FAU gene to outside databases
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Medical Newsfor FAU gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor FAU gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/27 PubMed articles for FAU gene, integrated from 7 sources (see all 27 ): (articles sorted by number of sources associating them with FAU) Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. (PubMed id 1326960) 1 , 2 , 7 Kas K.... Merregaert J. (1992) fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. (PubMed id 8395683) 1 , 2 , 7 Michiels L....Merregaert J. (1993) Assignment of the human FAU gene to a subregion of chromosome 11q13. (PubMed id 8406491) 1 , 3, 7 Kas K....Larsson C. (1993) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PubMed id 19671159) 1 , 7 Pickard M.R....Williams G.T. (2009) fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. (PubMed id 12660817) 1 , 7 Rossman T.G....Komissarova E.V. (2003) FAU regulates carboplatin resistance in ovarian cance r. (PubMed id 19830698) 1 Moss E.L....Williams G.T. (2010) Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811) 2 Taylor T.D....Sakaki Y. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005)
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External Searches for FAU gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAU gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAU gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAU gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
ATLAS Chromosomes in Cancer entry for FAU Genetics and Cytogenetics in Oncology and Haematology NIEHS-SNPs http://egp.gs.washington.edu/data/fau/ NIEHS-SNPs http://egp.gs.washington.edu/data/fau/
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About This Section Patent Information for FAU gene: Search GeneIP for patents involving FAU GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAU gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for FAU
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