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Aliases & Descriptionsfor FBXO44 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions F-box protein 441 2 FBX443 5 FBG31 2 3 5 OTTHUMP000000358962 FBX301 2 3 DKFZp781J08522 FBX6A2 3 5 F-box gene 32 Fbx441 2 OTTHUMP000000358942 Fbxo6a1 2 OTTHUMP000000022422 MGC141401 2 F-box only protein 442 F-box/G-domain protein 32 3 FBXO6A3 F-box protein FBX302 3
Export aliases for FBXO44 gene to outside databases Previous GC identifers: GC01P011423 GC01P011650 GC01P011714
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Summariesfor FBXO44 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FBXO44 : This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Four alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. (provided by RefSeq) UniProtKB/Swiss-Prot: FBX44_HUMAN, Q9H4M3 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
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Genomic Viewsfor FBXO44 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXO44 gene promoter: Nkx2-2 NF-1 RORalpha1 E2F-2 E2F-1 E2F-4 E2F E2F-3a E2F-5 GR-beta Other transcription factors Search SABiosciences Chromatin IP Primers for FBXO44 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FBXO44
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.21 FBXO44 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P010868: view genomic region
(about GC identifiers )
Start:
10,868,528 bp from pter
End:
10,877,542 bp from pter
Size:
9,015 bases
Orientation:
plus strand
1 alternative location : Chr 1+ 11,714,432-11,723,384
RefSeq DNA sequence: NC_000001.10 NT_021937.19
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Proteinsfor FBXO44 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: FBX44_HUMAN, Q9H4M3 (See
protein sequence )Recommended Name: F-box only protein 44 Size : 255 amino acids; 29747 Da
Subunit : Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1
Miscellaneous : In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to anyof the 200 glycans tested
Sequence caution : Sequence=CAI20210.1; Type=Erroneous gene model prediction; Sequence=CAI20213.1; Type=Erroneous genemodel prediction;
Secondary accessions : B3KNZ2 B7Z743 Q5TGX2 Q5TGX4 Q5TGX5 Q68DJ9 Q8WWY2Alternative splicing : 2 isoforms : Q9H4M3-1 Q9H4M3-2 Explore the universe of human proteins at neXtProt for FBXO44: NX_Q9H4M3
REFSEQ proteins (4 alternative transcripts):
NP_001014765.1 NP_149438.2 NP_904319.1 NP_904320.1 ENSEMBL proteins: ENSP00000365961 ENSP00000389820 ENSP00000251547 ENSP00000365959 ENSP00000251546 ENSP00000365951 ENSP00000365953 Human Recombinant Proteins 1 Gene Ontology (GO) cellular component term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0019005 SCF ubiquitin ligase complex
IDA 18203720
About this table
FBXO44 for ontologies About GeneDecksing Antibodies for FBXO44: Assays for FBXO44:
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Protein
Domains/ Familiesfor FBXO44 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FBXO44 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H4M3 ProtoNet protein and cluster: Q9H4M3
1 Blocks protein family : IPB007397 F-box associated region UniProtKB/Swiss-Prot: FBX44_HUMAN, Q9H4M3 Similarity : Contains 1 F-box domainSimilarity : Contains 1 FBA (F-box associated) domain
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Gene Functionfor FBXO44 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: FBX44_HUMAN, Q9H4M3 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
About this table
FBXO44 for ontologies About GeneDecksing
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Pathways & Interactionsfor FBXO44 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for FBXO44 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO44 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0030163 protein catabolic process
IEA --
About this table
FBXO44 for ontologies About GeneDecksing
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Drugs & Compoundsfor FBXO44 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for FBXO44
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Transcriptsfor FBXO44 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for FBXO44 gene (4 alternative transcripts): NM_001014765.1 NM_033182.5 NM_183412.2 NM_183413.2
Additional cDNA sequence: AK055344.1 AK293721.1 AK294053.1 AK296025.1 AK301418.1 AK316284.1 AK316347.1 AY007380.1 AY040878.1 BC007832.2 CR749368.1
14 DOTS entries : DT.453903 DT.98082938 DT.311266 DT.95325489 DT.434118 DT.95325483 DT.100028573 DT.91662213
DT.91803490 DT.97844355 DT.100728555 DT.121351652 DT.100832858 DT.95325478 24/128 AceView cDNA sequences (see all 128 ):
NM_183412 BI761677 BQ896294 AW817475 BP347458 BU164185 CB851742 BX093428 AA668575 CD723098 CD723040 BQ068245 BM479367 AA236229 NM_033182 AI879059 AL121209 NM_183413 AI935776 AY007380 BU164151 AI269945 CK820309 AW403656
highest scoring ESTs for FBXO44 :H15358 AA236229 AA236295 AA236298 AA325410 AA339322 AA350582 AA482646 AA668575 AI221722 Unigene Cluster for FBXO44:
F-box protein 44 Hs.556006 [show with all ESTs ] Unigene Representative Sequence: CR749368 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO44 (see all 6 ) ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 SP1 :                           -         SP2 :       -   -         -   -                 SP3 :                 -   -         -         SP4 :                                   SP5 :                                  
About this scheme ECgene alternative splicing isoforms for FBXO44 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000376770 (uc010oaq.1 uc001ask.2 uc001asm.2 uc001asl.2 uc001asn.2 uc010oar.1 uc010oas.1 )ENST00000425796 ENST00000471895 ENST00000251547 ENST00000376768 ENST00000475435 ENST00000251546 ENST00000376760 ENST00000376762
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Expression for FBXO44 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section FBXO44 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching FBXO44 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
46603_at2 , 3
U95-B
1
0.69
1.00
1.00
1.00
H15358
1.00
1.00
1.00
1
223517_at2 , 3
U133-B
1
0.73
1.00
--
--
AV722616
0.80
1.00
0.91
1
223517_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
About this table
FBXO44 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAGCCAAATA SOURCE GeneReport for Unigene cluster: Hs.556006 UniProtKB/Swiss-Prot: FBX44_HUMAN, Q9H4M3 Tissue specificity : Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver
SABiosciences Custom PCR Arrays for FBXO44
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Orthologsfor FBXO44 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for FBXO44 gene from 4 species
About this table Species with no ortholog for FBXO44 ENSEMBL Gene Tree for FBXO44 (if available)
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Paralogsfor FBXO44 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for FBXO44 gene FBXO6 2 FBXO27 2 FBXO2 2 NCCRP1 2
FBXO44 for paralogs About GeneDecksing
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Genomic Variantsfor FBXO44 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 1 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for FBXO44 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FBXO44: --
QIAGEN SeqTarget long-range PCR primers for resequencing FBXO44
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Disorders & Mutationsfor FBXO44 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FBXO44 for disorders About GeneDecksing
OMIM: 609111 Export disorders and mutations for FBXO44 gene to outside databases
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Medical Newsfor FBXO44 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor FBXO44 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/13 PubMed articles for FBXO44 gene, integrated from 7 sources (see all 13 ): (articles sorted by number of sources associating them with FBXO44) A new subfamily of structurally related human F-box proteins. (PubMed id 12383498) 1 , 2 , 3, 7 Ilyin G.P....Guguen-Guillouzo C. (2002) Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720) 1 , 2 , 7 Glenn K.A.... Paulson H.L. (2008) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Crystallization and preliminary X-ray characterizatio n of the Skp1-Fbg3 complex. (PubMed id 20057081) 1 Kumanomidou T....Yamane T. (2010) Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732) 1 Sowa M.E....Harper J.W. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277) 1 Jin J....Harper J.W. (2004)
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External Searches for FBXO44 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FBXO44 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FBXO44 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FBXO44 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
Functional Glycomics Gateway - Glycan Binding http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Fusion_411
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About This Section Patent Information for FBXO44 gene: Search GeneIP for patents involving FBXO44 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FBXO44 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for FBXO44
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Orthologs for FBXO44
Paralogs for FBXO44
Pathways/Interactions for FBXO44
Products for FBXO44
Proteins for FBXO44
Publications for FBXO44
Search Box for FBXO44
Summaries for FBXO44
Transcripts for FBXO44
Variants for FBXO44
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