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FCER2 Gene

protein-coding GIFtS: 63

GC19M007423

Fc fragment of IgE, low affinity II, receptor for (CD23)
(Previous names: Fc fragment of IgE, low affinity II, receptor for (CD23A) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CD23A, FCE2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
Fc fragment of IgE, low affinity II, receptor for (CD23)¹ ²		CD23A² ³
CLEC4J¹ ² ³ ⁵		BLAST-2² ³
CD23¹ ² ⁵		IGEBF² ³
FCE2² ³ ⁵		Fc fragment of IgE, low affinity II, receptor for (CD23A)¹
Immunoglobulin E-binding factor² ³		fc-epsilon-RII²
Lymphocyte IgE receptor² ³		low affinity immunoglobulin epsilon Fc receptor²
C-type lectin domain family 4 member J² ³		C-type lectin domain family 4, member J²
CD23 antigen² ³		Fc-epsilon-RII³

External Ids:	HGNC: 3612¹	Entrez Gene: 2208²	Ensembl: ENSG00000104921⁷	UniProtKB: P06734³

Export aliases for FCER2 gene to outside databases

Previous GC identifers: GC19M007712 GC19M007858 GC19M007648 GC19M007659

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCER2:

The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the

low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth

factor.(supplied by OMIM)

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734

Function: This receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells

(it is a B-cell-specific antigen)

Gene Wiki entry for FCER2 (CD23)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FCER2 gene promoter:
         GATA-3   c-Rel   RelA   NF-kappaB   NF-kappaB1   NF-kappaB2   NF-1   POU2F1   AREB6   ARP-1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for FCER2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3

FCER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCER2 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M007423: view genomic region (about GC identifiers)

Start:	7,423,283 bp from pter
End:	7,436,591 bp from pter
Size:	13,309 bases
Orientation:	minus strand

1 alternative location:

Chr19- 7,753,663-7,766,997

RefSeq DNA sequence:

NC_000019.9 NT_077812.2

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734 (See protein sequence)

Recommended Name: Low affinity immunoglobulin epsilon Fc receptor

Size: 321 amino acids; 36469 Da

Subcellular location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble

excreted form

Miscellaneous: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity

receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes

PDB structures from and Proteopedia :

1HLI (3D)

1KJE (3D)

1T8C (3D)

1T8D (3D)

2H2R (3D)

2H2T (3D)

Alternative splicing: 2 isoforms: P06734-1 P06734-2

Explore the universe of human proteins at neXtProt for FCER2: NX_P06734

Post-translational modifications:

N- and O-glycosylated¹

REFSEQ proteins: NP_001993.2

ENSEMBL proteins:

ENSP00000377758 ENSP00000353178 ENSP00000264072

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for FCER2 (CD23/Fc epsilon RII)
	Enzo Life Sciences proteins for FCER2
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: FCER2
	GenScript Custom Purified and Recombinant Proteins Services for FCER2
	Novus Biologicals Protein for FCER2
	Novus Biologicals Lysates for FCER2
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FCER2

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	2529542
GO:0009897	external side of plasma membrane	IEA	--

About this table

FCER2 for ontologies About GeneDecksing

Antibodies for FCER2:

	Millipore Mono- and Polyclonal Antibodies for the study of FCER2
	Sigma-Aldrich Antibodies for FCER2
	R&D Systems Antibodies for FCER2 (CD23/Fc epsilon RII)
	OriGene Antibodies (see all 2): FCER2
	GenScript Custom Superior Antibodies Services for FCER2
	Novus Biologicals Antibodies for FCER2
	Epitomics antibodies for FCER2

Assays for FCER2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FCER2 (CD23/Fc epsilon RII)
	GenScript Custom Assay Services for FCER2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FCER2 for domains About GeneDecksing

5 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

IPR002353 AntifreezeII

Graphical View of Domain Structure for InterPro Entry P06734

ProtoNet protein and cluster: P06734

1 Blocks protein family: IPB002353 Type II antifreeze protein signature

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734

Similarity: Contains 1 C-type lectin domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FCER2_HUMAN, P06734

Function: This receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells

(it is a B-cell-specific antigen)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FCER2 Sigma-Aldrich shRNA for FCER2
		OriGene 29mer shRNA kits in GFP-retroviral vector: FCER2 OriGene shRNA RFP: FCER2 OriGene basic RS shRNA: FCER2 OriGene siRNA: FCER2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FCER2

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FCER2
		Search SABiosciences for Assays for microRNAs that regulate FCER2

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FCER2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FCER2 OriGene untagged cDNA clones in CMV expression vector: FCER2 OriGene 3'-UTR clone: FCER2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FCER2
		Sino Biological Human cDNA Clone for FCER2

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for FCER2

Genatlas biochemistry entry for FCER2:

immunoglobulin E,low affinity Fc receptor

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005178	integrin binding	TAS	2529542
GO:0005488	binding	IEA	--
GO:0005529	sugar binding	IEA	--
GO:0019863	IgE binding	IEA	--

About this table

FCER2 for ontologies About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fcer2a):

digestive/alimentary

hematopoietic system

immune system

FCER2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

FCER2 for pathways About GeneDecksing

3 Millipore Pathways for FCER2

	Immune response IL-4 signaling pathway
	Apoptosis and survival APRIL and BAFF signaling
	Metalloproteases in connective tissue degradation

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for FCER2

	CD40 Signaling
	IL-4 Signaling

1 Kegg Pathway (Kegg details for FCER2):

hsa04640 Hematopoietic cell lineage

SABiosciences Pathway-Focused PCR Arrays including FCER2: PAHS-055A PAHS-406A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FCER2

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FCER2

5/7 Interacting proteins for FCER2 (ENSP00000264072³) via UniProtKB, MINT, and/or STRING (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FYN	ENSP00000357656³	STRING: ENSP00000357656
STAT6	ENSP00000300134³	STRING: ENSP00000300134
BCL6	ENSP00000232014³	STRING: ENSP00000232014
EGR2	ENSP00000242480³	STRING: ENSP00000242480
IRF4	ENSP00000370343³	STRING: ENSP00000370343

About this table

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	IEA	--
GO:0051000	positive regulation of nitric-oxide synthase activity	IDA	7544003
GO:0051712	positive regulation of killing of cells of another organism	IDA	7544003
GO:0051773	positive regulation of nitric-oxide synthase 2 biosynthetic process	IDA	7544003

About this table

FCER2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

FCER2 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FCER2
10/47 Novoseek chemical compound relationships for FCER2 gene (see all 47)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
batimastat	44.8	12	9464810 (4), 9834082 (2), 9677315 (1)
allergens	42.3	2	1477031 (1), 9036969 (1)
cefadroxil	34.7	2	2143009 (1), 8309718 (1)
fenoterol	34.3	1	7600375 (1)
pdtc	26.5	1	12872985 (1)
ionomycin	24.5	4	1709049 (1), 9162220 (1), 9174602 (1), 10363788 (1)
nedocromil sodium	23.7	3	1334783 (3)
tunicamycin	17.5	2	1386872 (1)
neopterin	17.5	1	8104879 (1)
genistein	16.8	6	9250823 (2), 8186375 (1), 11202232 (1), 8242759 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FCER2 Sigma-Aldrich shRNA for FCER2
		OriGene 29mer shRNA kits in GFP-retroviral vector: FCER2 OriGene shRNA RFP: FCER2 OriGene basic RS shRNA: FCER2 OriGene siRNA: FCER2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FCER2

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FCER2
		Search SABiosciences for Assays for microRNAs that regulate FCER2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FCER2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FCER2 OriGene untagged cDNA clones in CMV expression vector: FCER2 OriGene 3'-UTR Clone: FCER2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FCER2

Primers:		OriGene genome-wide validated SYBR primer pairs: FCER2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FCER2: PPH00839A

REFSEQ mRNAs for FCER2 gene:

NM_002002.4

Additional cDNA sequence:

AK223207.1 AK310071.1 AK310707.1 BC014108.2 BC027879.1 BC062591.1 BC064417.1 M14766.1

M15059.1 X04772.1

6 DOTS entries:

DT.40217556 DT.100742549 DT.97781460 DT.95086505 DT.95162895 DT.95251779

24/39 AceView cDNA sequences (see all 39):

BI524037 BC014108 NM_002002 BC062591 BC064417 BC027879 AW401362 M14766

M15059 BI767247 AW448907 BM008470 BI832853 BP338917 BQ711965 BF891578

BV202551 X04772 BI907608 BM920436 BQ712620 AI936513 BG755883 AI494545

highest scoring ESTs for FCER2:

M15059 BC014108 BC062591 BC064417 BF664254 BI832853 BI907608 BI910113 BM920436 M14766

Unigene Cluster for FCER2:

Fc fragment of IgE, low affinity II, receptor for (CD23)

Hs.465778 [show with all ESTs]

Unigene Representative Sequence: BC027879

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FCER2 (see all 6)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12
SP1:							-						-		-		-
SP2:							-						-		-		-
SP3:													-		-		-								-
SP4:							-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for FCER2
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394208 ENST00000360067 ENST00000346664(uc010xjs.1 uc002mhn.2 uc010xjt.1 uc002mhm.2 uc010dvo.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FCER2 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching FCER2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34960_g_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.15	M15059	1.00	1.00	1.00	1
34959_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.87	M15059	1.00	1.00	1.00	1
206759_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002002	0.60	1.00	0.82	1
206760_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002002	0.60	1.00	0.82	1
206759_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206760_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

FCER2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

FCER2 gene electronic northern expression

About these images

CGAP SAGE TAG: GATACAGCCA

SOURCE GeneReport for Unigene cluster: Hs.465778

Expression variation in blood from EXPOLDB for FCER2

Primers:		OriGene genome-wide validated SYBR primer pairs: FCER2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FCER2: PPH00839A

SABiosciences Expression via Pathway-Focused PCR Arrays including FCER2: PAHS-055A PAHS-406A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FCER2 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	FCER2¹	--	Fc fragment of IgE, low affinity II, receptor for (CD23)	76.04(n) 66.32(a)	407106 XM_592551.3 XP_592551.3
rat (Rattus norvegicus)	Fcer2¹	--	Fc fragment of IgE, low affinity II, receptor for (CD23)	70.13(n) 58.44(a)	171075 NM_001033924.1 NP_001029096.1
mouse (Mus musculus)	Fcer2a^{1 , 5}	8 (1.92 cM)⁵	Fc receptor, IgE, low affinity II, alpha polypeptide^{1, 5}	70.78(n)¹ 58.12(a)¹	14128¹ NM_013517.2¹ NP_038545.1¹ AC087183⁵ AK080159⁵ (see all 20)

About this table Species with no ortholog for FCER2

ENSEMBL Gene Tree for FCER2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FCER2 gene

CLEC10A² CD207² ASGR1² ASGR2² CLEC4M² CD209² CLEC4F²

FCER2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs889182^1,2	C,F,O,A,	7765266(+)	`TCTTCA/GGATTC`	1	--	int¹		13		NA EA WA	5568
rs1042428^1,2	--	7755406(-)	`ATCAAC/TTTCCA`	2	N	syn¹ ref¹		0	--	--	--	--
rs1042429^1,2	F	7755083(-)	`AAGGGG/AGAGTT`	2	/G	syn¹ ref¹ trp³		1		MN	184
rs1990975^1,2	C,F,O,A,H,	7766274(+)	`CTTCTA/C/G/T CCTGG`	1	--	int¹		22		NA NS EA MN WA	5640
rs2228137^1,2	C,F,H,	7763248(-)	`CTGCCC/TGGAAC`	2	R W	ref¹ mis¹		19		MN NS EA NA WA	5556
rs2228138^1,2	C,F,	7755056(-)	`AGCCAC/TGTGGA`	2	H	ref¹ syn¹ ese³		7		MN NA EA WA	1132
rs2229229^1,2	--	7755074(-)	`TTTATC/TTGGGT`	2	I	ref¹ syn¹ ese³		1		MN	26
rs2229230^1,2	C,F	7754226(-)	`TTCTGC/TGACCG`	2	C	ref¹ syn¹ ese³		4		MN NA	186
rs2277989^1,2	C,F,A,	7761812(+)	`GAGTCA/C/G/T ACAAG`	1	--	int¹		17		EA NS NA WA	3472
rs2277990^1,2	C,F,	7755745(-)	`GCTTCT/CGGCCA`	1	--	int¹		2		NA WA	74

About this table

HapMap Linkage Disequilibrium images for FCER2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FCER2
5 CNVs: 73308 73307 8863 89053 78054
6 Indels: 89054 78055 78056 61669 60273 89052

QIAGEN SeqTarget long-range PCR primers for resequencing FCER2

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FCER2 for disorders About GeneDecksing

OMIM: 151445

10/59 Novoseek disease relationships for FCER2 gene (see all 59)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphocytic leukemia chronic b-cell	72.4	11	10052715 (2), 15621797 (2), 7517747 (1), 1717071 (1) (see all 9)
leukemia lymphocytic chronic	67.5	17	11064465 (3), 2137545 (2), 8332446 (2), 1532590 (2) (see all 10)
lymphoma small lymphocytic	66.8	3	8058704 (1), 16540722 (1), 10478136 (1)
leukaemia lymphocytic	65.3	17	9508354 (2), 10233382 (2), 7873388 (2), 10713330 (1) (see all 13)
dermatitis atopic	64.6	24	1531123 (4), 9543080 (3), 8453305 (2), 8785171 (2) (see all 15)
leukemia eosinophilic	61.9	2	8589271 (1), 9620595 (1)
asthma allergic	56.3	10	9450145 (3), 1334783 (1), 7653734 (1), 1401914 (1) (see all 7)
chronic conjunctivitis	55.2	2	9191610 (1), 9154386 (1)
burkitt lymphoma	54.8	2	9036969 (1), 1354347 (1)
lymphoma	52.3	22	11211615 (3), 10478136 (3), 8058704 (2), 9508354 (2) (see all 14)

About this table

Human Gene Mutation Database (HGMD): FCER2
Human Genome Epidemiology (HuGE) Navigator: FCER2 (15 documents)

Export disorders and mutations for FCER2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/497 PubMed articles for FCER2 gene, integrated from 7 sources (see all 497):
(articles sorted by number of sources associating them with FCER2)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models. (PubMed id 8745401)^{1, 2} Bajorath J. and Aruffo A. (1996)
Modeling of the lectin-homology domains of the human and murine low- affinity Fc epsilon receptor (Fc epsilon RII/CD23). (PubMed id 8142907)^{1, 2} Padlan E.A. and Helm B.A. (1993)
Partial characterization of natural and recombinant human soluble CD23. (PubMed id 1417742)^{1, 2} Rose K.... Bonnefoy J.-Y. (1992)
Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression. (PubMed id 2972386)^{1, 2} Yokota A.... Kishimoto T. (1988)
Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. (PubMed id 3034567)^{1, 2} Luedin C.... Delespesse G. (1987)
Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins. (PubMed id 2949326)^{1, 2} Ikuta K.... Yodoi J. (1987)
Molecular structure of human lymphocyte receptor for immunoglobulin E. (PubMed id 2877743)^{1, 2} Kikutani H.... Kishimoto T. (1986)
Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases. (PubMed id 9680363)^{1, 7} Gu B....Wiley J.S. (1998)
Pax-5 is a key regulator of the B cell-restricted expression of the CD23a isoform. (PubMed id 12731041)^{1, 7} Visan I....Tony H.P. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2208	HGNC: 3612	AceView: FCER2	Ensembl:ENSG00000104921	euGenes: HUgn2208
ECgene: FCER2	Kegg: 2208	H-InvDB: FCER2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_221

Intellectual Property for FCER2 gene
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Patent Information for FCER2 gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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FCER2 Gene

protein-coding GIFtS: 63

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