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FCGR2A Gene

protein-coding GIFtS: 63

GC01P132800

Fc fragment of IgG, low affinity IIa, receptor (CD32)
(Previous names: Fc fragment of IgG, low affinity IIa, receptor for (CD32) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FCG2, FCGR2A1, FCGR2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
Fc fragment of IgG, low affinity IIa, receptor (CD32)¹ ²		low affinity immunoglobulin gamma Fc region receptor II-a²
IGFR2¹ ² ³ ⁵		fcRII-a²
CD32¹ ² ³ ⁵		FcGR²
CDw32¹ ² ³		Immunoglobulin G Fc receptor II²
CD32A¹ ²		FCGR2²
IgG Fc receptor II-a² ³		MGC30032²
Fc-gamma RII-a² ³		MGC23887²
FCGR2A1² ³		CD32 antigen³
FCG2² ³		FcRII-a³
Fc fragment of IgG, low affinity IIa, receptor for (CD32)¹		Fc-gamma-RIIa³
fc-gamma-RIIa²

External Ids:	HGNC: 3616¹	Entrez Gene: 2212²	Ensembl: ENSG00000143226⁷	UniProtKB: P12318³

Export aliases for FCGR2A gene to outside databases

Previous GC identifers: GC01P159191 GC01P157207 GC01P158252 GC01P158744 GC01P158743 GC01P158288 GC01P159741 GC01P161475

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FCGR2A:

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune

response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as

macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes.

Alternative splicing results in multiple transcript variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318

Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates

cellular responses against pathogens and soluble antigens

Gene Wiki entry for FCGR2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FCGR2A gene promoter:
         NF-1   p300   C/EBPbeta   Sox9   RP58   Pax-6   C/EBPalpha   Meis-1   GATA-1   STAT3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for FCGR2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23

FCGR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FCGR2A gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P132800: view genomic region (about GC identifiers)

Start:	132,800,353 bp from pter
End:	132,814,372 bp from pter
Size:	14,020 bases
Orientation:	plus strand

1 alternative location:

Chr1+ 161,475,220-161,493,803

RefSeq DNA sequence:

NC_000001.10 NT_004487.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318 (See protein sequence)

Recommended Name: Low affinity immunoglobulin gamma Fc region receptor II-a precursor

Size: 317 amino acids; 35001 Da

Subunit: Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function

Subcellular location: Cell membrane; Single-pass type I membrane protein

Sequence caution: Sequence=AAA35932.1; Type=Erroneous initiation;

PDB structures from and Proteopedia :

1FCG (3D)

1H9V (3D)

3D5O (3D)

Secondary accessions: Q8WUN1 Q8WW64

Alternative splicing: 2 isoforms: P12318-1 P12318-2

Explore the universe of human proteins at neXtProt for FCGR2A: NX_P12318

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001129691.1 NP_067674.2

ENSEMBL proteins:

ENSP00000271450 ENSP00000356949 ENSP00000393544

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for FCGR2A (Fc gamma RIIA/CD32a)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FCGR2A OriGene Protein Over-expression Lysate: FCGR2A
	GenScript Custom Purified and Recombinant Proteins Services for FCGR2A
	Novus Biologicals Protein for FCGR2A
	Novus Biologicals Lysate for FCGR2A
	Sino Biological Recombinant Protein for FCGR2A
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

FCGR2A for ontologies About GeneDecksing

Antibodies for FCGR2A:

	Millipore Mono- and Polyclonal Antibodies for the study of FCGR2A
	Sigma-Aldrich Antibodies for FCGR2A
	R&D Systems Antibodies for FCGR2A (Fc gamma RII/CD32, Fc gamma RIIA/CD32a)
	OriGene Antibodies (see all 11): FCGR2A
	GenScript Custom Superior Antibodies Services for FCGR2A
	Novus Biologicals Antibodies for FCGR2A
	Browse antibodies at Epitomics

Assays for FCGR2A:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FCGR2A
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FCGR2A for domains About GeneDecksing

3 InterPro domains/families:

IPR013783 Ig-like_fold

IPR007110 Ig-like

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P12318

ProtoNet protein and cluster: P12318

UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318

Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates

cellular responses against pathogens and soluble antigens

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FCGR2A Sigma-Aldrich shRNA for FCGR2A
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): FCGR2A OriGene shRNA RFP (see all 3): FCGR2A OriGene basic RS shRNA (see all 3): FCGR2A OriGene siRNA (see all 2): FCGR2A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FCGR2A

miRNA:		Sigma-Aldrich microRNA Mimics for FCGR2A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FCGR2A
		Search SABiosciences for Assays for microRNAs that regulate FCGR2A

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): FCGR2A OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): FCGR2A OriGene untagged cDNA clones in CMV expression vector: FCGR2A OriGene 3'-UTR clone (see all 2): FCGR2A Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FCGR2A
		Sino Biological Human cDNA Clone for FCGR2A

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for FCGR2A

Genatlas biochemistry entry for FCGR2A:

immunoglobulin G,low affinity Fc receptor 2A (see IGFCR@),primarily expressed by cells of the myeloid lineage

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005515	protein binding	IPI	17785206
GO:0019864	IgG binding	IEA	--

About this table

FCGR2A for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fcgr3):

hematopoietic system

immune system

FCGR2A for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

FCGR2A for pathways About GeneDecksing

1 Millipore Pathway for FCGR2A

Selected targets of CREB1

5/7 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for FCGR2A (see all 7)

	B Cell Receptor Signaling
	Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
	Role of NFAT in Regulation of the Immune Response
	IL-10 Signaling
	Dendritic Cell Maturation

5 Kegg Pathways (Kegg details for FCGR2A):

	hsa04145 Phagosome
	hsa04666 Fc gamma R-mediated phagocytosis
	hsa05140 Leishmaniasis
	hsa05150 Staphylococcus aureus infection
	hsa05322 Systemic lupus erythematosus

SABiosciences Custom Pathway-Focused PCR Arrays for FCGR2A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FCGR2A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FCGR2A

5/6 Interacting proteins for FCGR2A (ENSP00000271450³ P12318^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRP	P02741¹	STRING: ENSP00000255030 EBI-1395970,EBI-1395983
SYK	P43405²	STRING: ENSP00000364898 MINT-8026703 MINT-8028878
APCS	ENSP00000255040³	STRING: ENSP00000255040
PIK3R1	ENSP00000274335³	STRING: ENSP00000274335
SPNS1	ENSP00000309945³	STRING: ENSP00000309945

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

FCGR2A for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FCGR2A
10/39 Novoseek chemical compound relationships for FCGR2A gene (see all 39)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
r 131	83	6	15004265 (4), 19026120 (1)
piceatannol	62.5	1	11344169 (1)
dihydrotachysterol	59.6	1	1532752 (1)
tyrosine	52.7	121	11141335 (4), 15130090 (4), 7521687 (4), 16169188 (3) (see all 43)
histidine	48.7	23	8772237 (2), 10675363 (1), 18165525 (1), 8555090 (1) (see all 15)
arginine	34.9	33	8772237 (3), 10675363 (1), 18165525 (1), 19232413 (1) (see all 15)
phenylalanine	33.5	4	11719384 (1), 9382867 (1), 10449433 (1), 12508114 (1)
wortmannin	28.7	1	12407113 (1)
rituximab	28.2	8	17324336 (3), 17650444 (1), 14563637 (1), 17594928 (1) (see all 5)
inositol	26.1	4	9525908 (1), 12773515 (1), 12832410 (1), 11741917 (1)

About this table

1 PharmGKB drug compound relationship for FCGR2A gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
heparin	CO PD FA GN	8555090

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FCGR2A Sigma-Aldrich shRNA for FCGR2A
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): FCGR2A OriGene shRNA RFP (see all 3): FCGR2A OriGene basic RS shRNA (see all 3): FCGR2A OriGene siRNA (see all 2): FCGR2A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FCGR2A

miRNA:		Sigma-Aldrich microRNA Mimics for FCGR2A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FCGR2A
		Search SABiosciences for Assays for microRNAs that regulate FCGR2A

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): FCGR2A OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): FCGR2A OriGene untagged cDNA clones in CMV expression vector: FCGR2A OriGene 3'-UTR Clone (see all 2): FCGR2A Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FCGR2A

Primers:		OriGene genome-wide validated SYBR primer pairs: FCGR2A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FCGR2A: PPH17649A

REFSEQ mRNAs for FCGR2A gene (2 alternative transcripts):

NM_001136219.1 NM_021642.3

Additional cDNA sequence:

AK225438.1 AK225601.1 AK226059.1 AK298657.1 AK298734.1 AK315225.1 BC019931.1 BC020823.1

CR593871.1 J03619.1 M28697.1 M31932.1 X62572.1 Y00644.1

18 DOTS entries:

DT.92449395 DT.97844847 DT.87077467 DT.121462482 DT.92449402 DT.95156082 DT.121462532 DT.121462586

DT.92449423 DT.95360629 DT.100057430 DT.100774280 DT.121462502 DT.121462594 DT.85104268 DT.87018412

DT.91650634 DT.91958909

24/509 AceView cDNA sequences (see all 509):

AL543318 CR623806 CA428215 F05222 CD367627 U87569 U87562 AW451471

BM717638 BF445810 BG622254 CR607206 X51758 U87571 CA428150 CR593201

NM_001002275 AU098758 CD368312 AI735695 AI523174 BC031992 BQ718336 CR617159

highest scoring ESTs for FCGR2A:

R80546 M31932 BF089284 BF868457 BP426009 DQ892037 DQ895228 F35804 R23183 X68090

Unigene Cluster for FCGR2A:

Fc fragment of IgG, low affinity IIa, receptor (CD32)

Hs.352642 [show with all ESTs]

Unigene Representative Sequence: NM_001136219

GeneLoc Exon Structure

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000271450(uc001gan.2 uc001gam.2) ENST00000367972 ENST00000467654

ENST00000473080 ENST00000497474 ENST00000482233 ENST00000467525(uc001gao.2)

ENST00000471026 ENST00000483665 ENST00000461298 ENST00000459885 ENST00000486608

ENST00000491841 ENST00000429333

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FCGR2A expression in normal and diseased human tissues

¹ / ² / ³

7 probe-sets matching FCGR2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37688_f_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.07	M31932	0.80	0.67	0.74	1
37689_s_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.13	X68090	0.20	1.00	0.72	1
34665_g_at²^{, 3}	U95-A	3	1.00	0.33	0.92	0.84	X62573	0.20	0.11	0.16	3
203561_at²^{, 3}	U133-A	2	0.91	0.90	--	--	NM_021642	0.40	0.44	0.42	1
203561_at²	U133Plus2	2	0.91	0.90	--	--	--	--	--	--	--
1565674_at²	U133Plus2	2	0.36	0.75	--	--	--	--	--	--	--
1565673_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

FCGR2A for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

FCGR2A gene electronic northern expression

About these images

CGAP SAGE TAG: TAAGTCTATA

SOURCE GeneReport for Unigene cluster: Hs.352642

Expression variation in blood from EXPOLDB for FCGR2A

UniProtKB/Swiss-Prot: FCG2A_HUMAN, P12318

Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets

Primers:		OriGene genome-wide validated SYBR primer pairs: FCGR2A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FCGR2A: PPH17649A

SABiosciences Custom PCR Arrays for FCGR2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FCGR2A gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	FCGR2A¹	--	Fc fragment of IgG, low affinity IIa, receptor (CD32)	99.05(n) 97.47(a)	450194 NM_001009077.1 NP_001009077.1
rat (Rattus norvegicus)	Fcgr3¹	--	Fc receptor, IgG, low affinity III	64(n) 48.8(a)	116591 NM_053843.2 NP_446295.2
mouse (Mus musculus)	Fcgr3^{1 , 5}	1 (78.80 cM)⁵	Fc receptor, IgG, low affinity III^{1, 5}	71.84(n)¹ 60.68(a)¹	14131¹ NM_010188.4¹ NP_034318.1¹ AF197930⁵ AK077227⁵ (see all 32)

About this table Species with no ortholog for FCGR2A

ENSEMBL Gene Tree for FCGR2A (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FCGR2A gene

FCGR1B² FCGR2B² FCGR3A² FCRLB² FCGR3B² FCER1A² FCGR1A²

FCGR2A for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs12721^1,2	F	161489053(+)	`CAAATA/GACTGA`	2	--	ut3¹ ese³		1		MN	188
rs13878^1,2	C,F,A,H,	161487964(+)	`GGTCAT/CACTCT`	2	--	ut3¹		5		MN NA	508
rs368433^1,2	C,F,A,H	161484210(-)	`tttgaA/Gtaaga`	2	--	int¹		5		MN NS EA	602
rs368660^1,2	C,F,A	161487487(-)	`tcaaaG/Atggaa`	2	--	int¹		5		MN NA	326
rs368999^1,2	A	161487092(-)	`ttcaaC/GcATTT`	2	--	int¹		0	--	--	--	--
rs373579^1,2	C,F,A,	161483484(-)	`CCCCAT/CGGGCC`	2	--	int¹		5		MN NS EA	588
rs373611^1,2	C,A,H	161483856(-)	`aggccT/Cgggtg`	2	--	int¹		5		MN NS EA	600
rs374681^1,2	C,F,A,H	161486615(-)	`agtttC/Ttagtg`	2	--	int¹		4		NS EA	366
rs383958^1,2	C,F,A,H	161483579(-)	`GGACTG/ACTGAC`	2	--	int¹		6		MN NS EA NA	592
rs384517^1,2	C,A,H	161485837(-)	`attctC/Tattta`	2	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for FCGR2A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for FCGR2A
9 CNVs: 6791 3316 2329 65090 4258 8335 31666 65089 22934

QIAGEN SeqTarget long-range PCR primers for resequencing FCGR2A

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FCGR2A for disorders About GeneDecksing

OMIM: 146790

10/41 Novoseek disease relationships for FCGR2A gene (see all 41)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lupus erythematosus systemic	63.1	21	11561111 (2), 12215902 (2), 10413210 (1), 12215903 (1) (see all 18)
nephritis	59.5	8	15004265 (4), 11263776 (1), 11480843 (1)
lupus nephritis	56.7	10	15004265 (3), 11237133 (2), 8636449 (2), 11229467 (1) (see all 6)
autoimmune diseases	51.2	8	16200626 (2), 16221721 (1), 10882671 (1), 19030019 (1) (see all 7)
thrombocytopenia	46.4	18	10201963 (3), 11480843 (2), 11434690 (1), 11588041 (1) (see all 13)
rheumatoid arthritis	39.4	10	16221721 (1), 19030019 (1), 16084773 (1), 12734884 (1) (see all 8)
meningococcal diseases	34.7	5	7930726 (1), 11812402 (1), 9798027 (1), 15243816 (1)
purpura thrombocytopenic	33.8	3	18485087 (1)
malaria falciparum	30.5	5	19284648 (2), 18194515 (1), 17587350 (1)
autoimmunity	28.2	3	16200626 (2), 10675363 (1)

About this table

2 PharmGKB disease relationships for FCGR2A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872
heparin-induced thrombocytopenia	CO PD FA GN	8555090

About this table

Human Gene Mutation Database (HGMD): FCGR2A
Genetic Association Database (GAD): FCGR2A
Human Genome Epidemiology (HuGE) Navigator: FCGR2A (213 documents)

Export disorders and mutations for FCGR2A gene to outside databases

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/527 PubMed articles for FCGR2A gene, integrated from 7 sources (see all 527):
(articles sorted by number of sources associating them with FCGR2A)

Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG. (PubMed id 10397151)^{1, 2, 7} Powell M.S.... Hogarth P.M. (1999)
FcgammaRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients. (PubMed id 11480843)^{1, 4, 7} Yun H.R....Kim S.Y. (2001)
The FcgammaRIIa polymorphism in children with atopic diseases. (PubMed id 14976391)^{1, 4, 7} Pawlik A....Gawronska-Szklarz B. (2004)
FcgammaRIIa polymorphism in Japanese patients with systemic lupus erythematosus. (PubMed id 11237133)^{1, 4, 7} Sato H....Dohi K. (2001)
Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study. (PubMed id 15583733)^{1, 4, 7} van der Meer I.M....de Maat M.P. (2004)
Platelet FcgammaRIIA His131Arg polymorphism and platelet function: antibodies to platelet-bound fibrinogen induce platelet activation. (PubMed id 12871511)^{1, 4, 7} Chen J....Bray P.F. (2003)
Low-binding alleles of Fcgamma receptor types IIA and IIIA are inherited independently and are associated with systemic lupus erythematosus in Hispanic patients. (PubMed id 11229467)^{1, 4, 7} Zuniga R....Salmon J.E. (2001)
Fc gamma RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients. (PubMed id 15004265)^{1, 4, 7} Bazilio A.P....Monteiro R.C. (2004)
Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. (PubMed id 11561111)^{1, 4, 7} Villarreal J....Poulton K. (2001)
Influence of FcgammaRIIA and MBL polymorphisms on severe acute respiratory syndrome. (PubMed id 16185324)^{1, 4, 7} Yuan F.F....Sullivan J.S. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2212	HGNC: 3616	AceView: HSPA6andFCGR2A	Ensembl:ENSG00000143226	euGenes: HUgn2212
ECgene: FCGR2A	Kegg: 2212	H-InvDB: FCGR2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for FCGR2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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FCGR2A Gene

protein-coding GIFtS: 63

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FCGR2A (Gene Symbol)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
IGFR2
CD32
CDw32
CD32A
IgG Fc receptor II-a
Fc-gamma RII-a
FCGR2A1
FCG2
Fc fragment of IgG, low affinity IIa, receptor for (CD32)
fc-gamma-RIIa
low affinity immunoglobulin gamma Fc region receptor II-a
fcRII-a
FcGR
Immunoglobulin G Fc receptor II
FCGR2
MGC30032
MGC23887
CD32 antigen
FcRII-a
Fc-gamma-RIIa

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FCGR2A Gene

protein-coding GIFtS: 63

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