Aliases &
Descriptions
for FGF13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| fibroblast growth factor 131 2 | | FHF-22 3 | | FHF21 2 3 | | FGF-132 3 | | FGF21 2 5 | | OTTHUMP000000241472 | | Fibroblast growth factor homologous factor 22 3 | | OTTHUMP000000241452 |
Export aliases for FGF13 gene to outside databasesPrevious GC identifers: GC0XM132285 GC0XM134559 GC0XM135658 GC0XM136419 GC0XM137439 GC0XM137541 GC0XM137713 |
Summaries
for FGF13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FGF13:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possessbroad mitogenic and cell survival activities, and are involved in a variety of biological processes, includingembryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located ina region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possiblecandidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mentalretardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcriptvariants encoding different isoforms with different N-termini. (provided by RefSeq)
UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913Function: Probably involved in nervous system development and function
Gene Wiki entry for FGF13 |
Genomic Views
for FGF13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FGF13 gene promoter:
Cart-1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha CHOP-10 Pbx1a SRF CUTL1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FGF13
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FGF13  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq27.1 HGNC cytogenetic band: Xq26.3FGF13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM126980: view genomic region
(about GC identifiers)
Start:
|
126,980,049 bp from pter |
End:
|
127,553,217 bp from pter |
Size:
|
573,169 bases |
Orientation:
|
minus strand |
1 alternative location:
| ChrX- 137,713,735-138,304,939 |
RefSeq DNA sequence:- NC_000023.10 NT_011786.16
|
Proteins
for FGF13 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913 (See
protein sequence)Recommended Name: Fibroblast growth factor 13 Size: 245 amino acids; 27564 Da
PDB structures from  and Proteopedia  :3HBW (3D)
Secondary accessions: B1AK18 O95830Alternative splicing: 2 isoforms: Q92913-1 Q92913-2 Explore the universe of human proteins at neXtProt for FGF13: NX_Q92913
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (6 alternative transcripts):
NP_001132970.1 NP_001132972.1 NP_001132973.1 NP_001132974.1 NP_004105.1 NP_378668.1
ENSEMBL proteins: ENSP00000322390 ENSP00000303391 ENSP00000396198 ENSP00000406916 ENSP00000411999 ENSP00000388688 ENSP00000359635 ENSP00000409276
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FGF13 for ontologies About GeneDecksing
Antibodies for FGF13:
Assays for FGF13: |
Protein
Domains/
Families
for FGF13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FGF13 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92913ProtoNet protein and cluster: Q92913 2 Blocks protein families: IPB002209 Heparin binding growth factor family signature IPB002348 IL1/HBGF family signature
UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913Similarity: Belongs to the heparin-binding growth factors family |
Gene Function
for FGF13 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913Function: Probably involved in nervous system development and function
Genatlas biochemistry entry for FGF13:fibroblast growth homologous factor 13,expressed principally in the nervous system and skeletal muscle with twoalternatively spliced isoforms3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
FGF13 for ontologies About GeneDecksing
|
Pathways & Interactions
for FGF13 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
FGF13 for pathways About GeneDecksing
4  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for FGF13
4  Kegg Pathways (Kegg details for FGF13):
SABiosciences Pathway-Focused PCR Arrays including FGF13 (see all 3): PAHS-041A PAHS-072A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FGF13
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FGF13
5/31 Interacting proteins for FGF13 (Q929131 ENSP000003596353) via UniProtKB, MINT, and/or STRING (see all 31)About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
FGF13 for ontologies About GeneDecksing
|
Drugs & Compounds
for FGF13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for FGF13
|
Transcripts
for FGF13 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FGF13 gene (6 alternative transcripts): NM_001139498.1 NM_001139500.1 NM_001139501.1 NM_001139502.1 NM_004114.3 NM_033642.2 Additional cDNA sequence: AF100143.1 AF100144.1 AF108756.1 AF199612.1 AF199613.1 AK289960.1 AK297545.1 AK303685.1 AK316170.1 BC012347.1 BC034340.1 U66198.1 7 DOTS entries: DT.212776 DT.452448 DT.91718659 DT.91687058 DT.100033629 DT.95116819 DT.95234959 24/94 AceView cDNA sequences (see all 94): BM973803 AI629013 BU148846 AA814496 AW014749 Z40861 NM_033642 BM556968 BQ672978 AA927011 BU735762 Z45127 BE671440 BX332670 AA427817 U66198 W23426 AF108756 AU117815 BQ068644 BG704624 BI089753 BM903538 AI078287
 highest scoring ESTs for FGF13:AW014749 AA427960 AA449030 AF100144 AA427817 AA449747 AA621470 AA661813 AA814496 AA927011 Unigene Cluster for FGF13: Fibroblast growth factor 13 Hs.6540 [show with all ESTs]Unigene Representative Sequence: NM_004114
GeneLoc Exon Structure
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000315930(uc004fam.2) ENST00000305414(uc004fan.2 uc011mwk.1)
ENST00000436198 ENST00000455663 ENST00000448673 ENST00000421460 ENST00000370603
ENST00000441825(uc011mwi.1 uc004faq.2 uc004far.2 uc011mwj.1)
|
Expression
for FGF13 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FGF13 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching FGF13 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36232_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.69 |
0.42 |
U66198 |
0.80 |
0.80 |
0.80 |
1 |
| 46600_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.94 |
1.36 |
AW014749 |
0.80 |
1.00 |
0.91 |
1 |
| 468_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.86 |
0.68 |
U66198 |
0.80 |
0.80 |
0.80 |
1 |
| 205110_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_004114 |
0.60 |
1.00 |
0.82 |
1 |
| 205110_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FGF13 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TACAGGCAGT
SOURCE GeneReport for Unigene cluster: Hs.6540
Expression variation in blood from EXPOLDB for FGF13 UniProtKB/Swiss-Prot: FGF13_HUMAN, Q92913Tissue specificity: Nervous system
SABiosciences Expression via Pathway-Focused PCR Arrays including FGF13 (see all 3): PAHS-041A PAHS-072A
|
Orthologs
for FGF13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FGF13 gene from 5/8 species (see all 8)
About this table Species with no ortholog for FGF13
ENSEMBL Gene Tree for FGF13 (if available) |
Paralogs
for FGF13 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for FGF13 gene
- FGF122 FGF52 FGF112 FGF42 FGF62 FGF142
FGF13 for paralogs About GeneDecksing
|
Genomic Variants
for FGF13 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr X pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FGF13 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for FGF13
3 CNVs: 83772 97007 97006
7 Indels: 41240 41795 103283 41239 83773 62983 47770 | | QIAGEN SeqTarget long-range PCR primers for resequencing FGF13 |
|
Disorders & Mutations
for FGF13 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FGF13 for disorders About GeneDecksing
OMIM: 300070
1  Novoseek disease relationship for FGF13 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: FGF13 (1 document)
Export disorders and mutations for FGF13 gene to outside databases
|
Medical News
for FGF13 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FGF13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/30 PubMed articles for FGF13 gene, integrated from 7 sources (see all 30):
(articles sorted by number of sources associating them with FGF13)- Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PubMed id 8790420)1, 2, 3 Smallwood P.M.... Nathans J. (1996)
- Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. (PubMed id 10071193)1, 2, 7 Gecz J.... Mulley J.C. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of a novel member of the fibroblast growth factor family. (PubMed id 9751161)1, 7 Greene J.M....Alderson R.F. (1998)
- Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats. (PubMed id 9914447)1, 7 Yao D.L....Antonaccio M. (1999)
- Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Functional phylogeny relates LET-756 to fibroblast growth factor 9. (PubMed id 15199049)1 Popovici C....Roubin R. (2004)
- Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. (PubMed id 15282281)1 Wittmack E.K....Dib-Hajj S.D. (2004)
- Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties. (PubMed id 12496262)1 Facchiano A....Capogrossi M.C. (2003)
|
External Searches for FGF13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FGF13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FGF13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGF13 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FGF13 gene:
Search GeneIP for patents involving FGF13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FGF13 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for FGF13 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for FGF13 |
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