Aliases &
Descriptions
for FGF21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| fibroblast growth factor 211 2 | | FGF-212 3 |
Export aliases for FGF21 gene to outside databasesPrevious GC identifers: GC19P049818 GC19P049626 GC19P053934 GC19P053950 GC19P053951 GC19P049259 |
Summaries
for FGF21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FGF21:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possessbroad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonicdevelopment, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factorhas not yet been determined. (provided by RefSeq)
UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1Function: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB
Gene Wiki entry for FGF21 |
Genomic Views
for FGF21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FGF21 gene promoter:
STAT5B C/EBPalpha p300 PPAR-gamma1 PPAR-gamma2 p53 STAT3 ATF MRF-2 Sp1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FGF21
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1-qter Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.1-qterFGF21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P045638: view genomic region
(about GC identifiers)
Start:
|
45,638,191 bp from pter |
End:
|
45,640,357 bp from pter |
Size:
|
2,167 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 49,259,344-49,261,580 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for FGF21 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1 (See
protein sequence)Recommended Name: Fibroblast growth factor 21 precursor Size: 209 amino acids; 22300 Da
Subunit: Interacts (via C-terminus) with KLB; this interaction is direct
Subcellular location: Secreted (Potential)
Secondary accessions: Q8N683Explore the universe of human proteins at neXtProt for FGF21: NX_Q9NSA1
REFSEQ proteins: NP_061986.1
ENSEMBL proteins: ENSP00000222157
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FGF21 for ontologies About GeneDecksing
Antibodies for FGF21:
Assays for FGF21: |
Protein
Domains/
Families
for FGF21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FGF21 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NSA1ProtoNet protein and cluster: Q9NSA1 2 Blocks protein families: IPB002209 Heparin binding growth factor family signature IPB002348 IL1/HBGF family signature
UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1Similarity: Belongs to the heparin-binding growth factors family |
Gene Function
for FGF21 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FGF21_HUMAN, Q9NSA1Function: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
FGF21 for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Fgf21):
FGF21 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FGF21 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
FGF21 for pathways About GeneDecksing
4  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for FGF21
4  Kegg Pathways (Kegg details for FGF21):
SABiosciences Custom Pathway-Focused PCR Arrays for FGF21
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FGF21
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGF21
5/30 Interacting proteins for FGF21 (ENSP000002221573) via UniProtKB, MINT, and/or STRING (see all 30)About this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
FGF21 for ontologies About GeneDecksing
|
Drugs & Compounds
for FGF21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
FGF21 for compounds About GeneDecksing
 Browse Tocris compounds for FGF21
2  Novoseek chemical compound relationships for FGF21 gene
About this table
|
Transcripts
for FGF21 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FGF21 gene: NM_019113.2 Additional cDNA sequence: AB021975.1 AY359086.1 BC018404.1 1 DOTS entry: DT.92037354 4 AceView cDNA sequences: NM_019113 AB021975 AY359086 BC018404
 highest scoring ESTs for FGF21:AB021975 AY359086 BC018404 NM_019113 BE785063 CV024964 CR746717 BF874051 Unigene Cluster for FGF21: Fibroblast growth factor 21 Hs.283015 [show with all ESTs]Unigene Representative Sequence: BC018404
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000222157(uc002pkn.1 uc002pko.1)
|
Expression
for FGF21 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FGF21 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching FGF21 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 221433_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_019113 |
0.60 |
1.00 |
0.82 |
1 |
| 221433_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTGGGACCTT
SOURCE GeneReport for Unigene cluster: Hs.283015
SABiosciences Custom PCR Arrays for FGF21
|
Orthologs
for FGF21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FGF21 gene from 4 species
About this table Species with no ortholog for FGF21
ENSEMBL Gene Tree for FGF21 (if available) |
Paralogs
for FGF21 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for FGF21 gene
- FGF192 FGF232
FGF21 for paralogs About GeneDecksing
|
Genomic Variants
for FGF21 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FGF21 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FGF21
2 CNVs: 5107 32261 | | QIAGEN SeqTarget long-range PCR primers for resequencing FGF21 |
|
Disorders & Mutations
for FGF21 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FGF21 for disorders About GeneDecksing
OMIM: 609436
1 Novoseek disease relationship for FGF21 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| niddm |
16.1 |
1 |
19528204 (1), 18460341 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: FGF21 (1 document)
Export disorders and mutations for FGF21 gene to outside databases
|
Medical News
for FGF21 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FGF21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/49 PubMed articles for FGF21 gene, integrated from 7 sources (see all 49):
(articles sorted by number of sources associating them with FGF21)- Identification of a novel FGF, FGF-21, preferentially expressed in the liver. (PubMed id 10858549)1, 2, 3 Nishimura T.... Itoh N. (2000)
- Different roles of N- and C- termini in the functional activity of FGF21. (PubMed id 19117008)1, 2, 7 Micanovic R.... Kharitonenkov A. (2009)
- C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. (PubMed id 18829467)1, 2 Wu X....Li Y. (2008)
- Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. (PubMed id 17623664)1, 2 Kurosu H....Kuro-o M. (2007)
- FGF-21 as a novel metabolic regulator. (PubMed id 15902306)1, 2 Kharitonenkov A.... Shanafelt A.B. (2005)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Serum fibroblast growth factor 21 levels in gestation al diabetes mellitus in relation to insulin resistance and dyslipidemia. (PubMed id 19699495)1, 7 Stein S....Fasshauer M. (2010)
- Fibroblast growth factor-21 may mediate growth hormon e resistance in anorexia nervosa. (PubMed id 19926712)1, 7 Fazeli P.K....Klibanski A. (2010)
- Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivit y in Chinese subjects. (PubMed id 19318452)1, 7 Li H....Jia W. (2009)
|
External Searches for FGF21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FGF21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FGF21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGF21 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FGF21 gene:
Search GeneIP for patents involving FGF21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FGF21 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for FGF21 |
| |  |  |  |  | | | | | | Recombinant Protein for FGF21 |
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 | | | ELISAs and CLIAs for FGF21 |
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