Aliases &
Descriptions
for FGL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| fibrinogen-like 21 2 | | pT491 2 3 | | T491 2 | | Fibrinogen-like protein 22 3 | | fibroleukin2 |
Export aliases for FGL2 gene to outside databasesPrevious GC identifers: GC07M075361 GC07M076423 GC07M076437 GC07M076470 GC07M076662 GC07M076822 |
Summaries
for FGL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FGL2:
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. Thecarboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein formsa tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologicfunctions at mucosal sites. (provided by RefSeq)
UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314Function: May play a role in physiologic lymphocyte functions at mucosal sites
Gene Wiki entry for FGL2 |
Genomic Views
for FGL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FGL2 gene promoter:
HNF-1A GR-alpha Nkx2-2 ISGF-3 CUTL1 FOXO4 oct-B2 oct-B3 POU2F1 POU2F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FGL2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23FGL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M071425: view genomic region
(about GC identifiers)
Start:
|
71,425,321 bp from pter |
End:
|
71,431,783 bp from pter |
Size:
|
6,463 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7- 76,822,688-76,829,143 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079595.2
|
Proteins
for FGL2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314 (See
protein sequence)Recommended Name: Fibroleukin precursor Size: 439 amino acids; 50229 Da
Subunit: Homotetramer; disulfide-linked
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for FGL2: NX_Q14314
REFSEQ proteins: NP_006673.1
ENSEMBL proteins: ENSP00000248598
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FGL2 for ontologies About GeneDecksing
Antibodies for FGL2:
Assays for FGL2: |
Protein
Domains/
Families
for FGL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FGL2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14314ProtoNet protein and cluster: Q14314 1 Blocks protein family: IPB002181 Fibrinogen
UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314Similarity: Contains 1 fibrinogen C-terminal domain |
Gene Function
for FGL2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314Function: May play a role in physiologic lymphocyte functions at mucosal sites
Genatlas biochemistry entry for FGL2:fibrinogen-like 2,expressed in T lymphocytes1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005102 | receptor binding |
IEA | -- |
About this table
FGL2 for ontologies About GeneDecksing
Animal Models: 5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fgl2):
FGL2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FGL2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
FGL2 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for FGL2
SABiosciences Custom Pathway-Focused PCR Arrays for FGL2
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FGL2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FGL2
5/6 Interacting proteins for FGL2 (ENSP000002485983) via UniProtKB, MINT, and/or STRING (see all 6)About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- |
About this table
FGL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FGL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
FGL2 for compounds About GeneDecksing
 Browse Tocris compounds for FGL2
3  Novoseek chemical compound relationships for FGL2 gene
About this table
|
Transcripts
for FGL2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FGL2 gene: NM_006682.2 Additional cDNA sequence: AK222999.1 AK310921.1 AK312672.1 BC017813.1 BC033820.1 BC073986.1 CR610336.1 CR626993.1 Z36531.1 9 DOTS entries: DT.100763829 DT.411270 DT.99966380 DT.121124933 DT.121124849 DT.100763827 DT.425175 DT.100690071 DT.91734133 24/89 AceView cDNA sequences (see all 89): BP348913 AL574274 BC033820 BC073986 BM724154 H64776 CD671192 AL550407 BU929217 CA394164 AU136637 CD369260 AW204815 BC017813 AW294447 AW611535 CA407168 CR610336 AI432401 BI835740 BX095475 AI493153 H64775 CB958136
 highest scoring ESTs for FGL2:Z36531 AI432401 AL550407 AL574274 AW466931 BC033820 BF896490 BF902394 BI760455 BI835740 Unigene Cluster for FGL2: Fibrinogen-like 2 Hs.520989 [show with all ESTs]Unigene Representative Sequence: NM_006682
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000248598(uc003ugb.2)
|
Expression
for FGL2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FGL2 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching FGL2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39593_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.99 |
1.03 |
AI432401 |
0.80 |
1.00 |
0.91 |
1 |
| 39591_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.94 |
1.03 |
Z36531 |
1.00 |
1.00 |
1.00 |
1 |
| 39592_r_at2, 3
|
U95-A |
2 |
0.94 |
0.84 |
0.79 |
0.63 |
Z36531 |
1.00 |
1.00 |
1.00 |
1 |
| 62189_at2, 3
|
U95-C |
1 |
0.50 |
1.00 |
0.96 |
1.33 |
AI440192 |
0.40 |
1.00 |
0.76 |
1 |
| 204834_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_006682 |
0.60 |
1.00 |
0.82 |
1 |
| 227265_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
AW135176 |
0.20 |
1.00 |
0.72 |
1 |
| 204834_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 227265_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FGL2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.520989
Expression variation in blood from EXPOLDB for FGL2 UniProtKB/Swiss-Prot: FGL2_HUMAN, Q14314Tissue specificity: Constitutively expressed in cytotoxic T-cells
SABiosciences Custom PCR Arrays for FGL2
|
Orthologs
for FGL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FGL2 gene from 5/10 species (see all 10)
About this table Species with no ortholog for FGL2
ENSEMBL Gene Tree for FGL2 (if available) |
Paralogs
for FGL2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for FGL2 gene
- FGG2 FGB2 FGL12
FGL2 for paralogs About GeneDecksing
|
Genomic Variants
for FGL2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FGL2
2 CNVs: 3686 47979 | | QIAGEN SeqTarget long-range PCR primers for resequencing FGL2 |
|
Disorders & Mutations
for FGL2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FGL2 for disorders About GeneDecksing
OMIM: 605351
10/13 Novoseek disease relationships for FGL2 gene (see all 13)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepatitis fulminant |
74.1 |
1 |
12752447 (1) |
| hepatic necrosis |
67 |
1 |
12594208 (1) |
| viral hepatitis |
66.7 |
15 |
12840059 (2), 16437596 (2), 18801734 (1), 15100314 (1) (see all 6) |
| hepatic failure fulminant |
58.5 |
9 |
19785959 (3), 12594208 (1) |
| hepatitis b chronic |
58.1 |
3 |
12840059 (2), 16437596 (1) |
| hepatitis |
54.4 |
6 |
12840059 (1), 19785959 (1), 12594208 (1), 15268797 (1) (see all 5) |
| thrombosis |
28.6 |
4 |
15100314 (4) |
| liver diseases |
24.7 |
1 |
12594208 (1) |
| hepatitis b |
22.6 |
11 |
16437596 (3), 18801734 (1), 15268797 (1) |
| necrosis |
22.3 |
3 |
10429765 (1), 19785959 (1) |
About this table
Genetic Association Database (GAD): FGL2
Human Genome Epidemiology (HuGE) Navigator: FGL2 (2 documents)
Export disorders and mutations for FGL2 gene to outside databases
|
Medical News
for FGL2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FGL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/41 PubMed articles for FGL2 gene, integrated from 7 sources (see all 41):
(articles sorted by number of sources associating them with FGL2)- Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PubMed id 7642106)1, 2, 3 Ruegg C. and Pytela R. (1995)
- Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. (PubMed id 9647217)1, 2, 7 Marazzi S.... Ruegg C. (1998)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Large-scale investigation of genomic markers for severe periodontitis. (PubMed id 15490304)1, 4 Suzuki A....Kamoi K. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The FGL2/fibroleukin prothrombinase is involved in al veolar macrophage activation in COPD through the MAPK pathway. (PubMed id 20438701)1, 7 Liu Y....Ning Q. (2010)
- Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection. (PubMed id 15905589)1, 7 Ning Q....Luo X. (2005)
- Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B. (PubMed id 16437596)1, 7 Zhu C.L....Ning Q. (2005)
- Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant. (PubMed id 11170750)1, 7 Yuwaraj S....Levy G.A. (2001)
- Hepatitis B virus-induced hFGL2 transcription is dependent on c-Ets-2 and MAPK signal pathway. (PubMed id 18801734)1, 7 Han M....Ning Q. (2008)
|
External Searches for FGL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FGL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FGL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FGL2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| SeattleSNPs | http://pga.gs.washington.edu/data/fgl2/ |
|
| | |
About This Section
| Patent Information for FGL2 gene:
Search GeneIP for patents involving FGL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FGL2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for FGL2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for FGL2 |
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