Aliases &
Descriptions
for FIBP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| fibroblast growth factor (acidic) intracellular binding protein1 2 | | FGFIBP1 2 | | aFGF intracellular-binding protein2 3 | | FGF-1 intracellular-binding protein2 3 | | acidic fibroblast growth factor intracellular-binding protein2 | | FIBP-12 |
Export aliases for FIBP gene to outside databasesPrevious GC identifers: GC11M068185 GC11M067333 GC11M065901 GC11M065426 GC11M065407 GC11M065651 |
Summaries
for FIBP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FIBP:
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesisor inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that bindsselectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenicaction of aFGF. Two transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq)
UniProtKB/Swiss-Prot: FIBP_HUMAN, O43427Function: May be involved in mitogenic function of FGF1
Gene Wiki entry for FIBP |
Genomic Views
for FIBP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FIBP gene promoter:
C/EBPalpha TBP p53 p300 STAT1alpha STAT1beta STAT1 SRF c-Jun Fra-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FIBP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FIBP  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1FIBP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M061977: view genomic region
(about GC identifiers)
Start:
|
61,977,728 bp from pter |
End:
|
61,982,391 bp from pter |
Size:
|
4,664 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr11- 65,651,211-65,656,010 |
RefSeq DNA sequence:- NC_000011.9 NT_167190.1
|
Proteins
for FIBP gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FIBP_HUMAN, O43427 (See
protein sequence)Recommended Name: Acidic fibroblast growth factor intracellular-binding protein Size: 364 amino acids; 41878 Da
Subunit: Binds to internalized FGF1
Subcellular location: Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmicmembranes, particularly of mitochondria
Secondary accessions: A8K0J7 Q27Q85 Q6IBQ3 Q9HD65Alternative splicing: 2 isoforms: O43427-1 O43427-2 Explore the universe of human proteins at neXtProt for FIBP: NX_O43427
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_004205.2 NP_942600.1
ENSEMBL proteins: ENSP00000350124 ENSP00000344572 ENSP00000395854 ENSP00000400354
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
FIBP for ontologies About GeneDecksing
Antibodies for FIBP:
Assays for FIBP: |
Protein
Domains/
Families
for FIBP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FIBP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O43427ProtoNet protein and cluster: O43427 1 Blocks protein family: IPB008614 Acidic fibroblast growth factor binding
|
Gene Function
for FIBP gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FIBP_HUMAN, O43427Function: May be involved in mitogenic function of FGF1
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
FIBP for ontologies About GeneDecksing
|
Pathways & Interactions
for FIBP gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for FIBP
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FIBP
5/7 Interacting proteins for FIBP (O434271, 2) via UniProtKB, MINT, and/or STRING (see all 7)About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
TAS | 9806903 |
About this table
FIBP for ontologies About GeneDecksing
|
Drugs & Compounds
for FIBP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
FIBP for compounds About GeneDecksing
 Browse Tocris compounds for FIBP
4  Novoseek chemical compound relationships for FIBP gene
About this table
|
Transcripts
for FIBP gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FIBP gene (2 alternative transcripts): NM_004214.4 NM_198897.1 Additional cDNA sequence: AF010187.2 AF171944.1 AF171945.1 AF171946.1 AF250391.1 AK223438.1 AK289562.1 AK293882.1 AK296571.1 AK299159.1 AK309974.1 AK315976.1 BC014388.2 BC017448.1 CR456749.1 CR590625.1 CR593925.1 CR604063.1 CR604159.1 CR611951.1 CR614878.1 CR619573.1 CR620055.1 CR622949.1 20 DOTS entries: DT.92463846 DT.101984337 DT.85105395 DT.92463842 DT.100031717 DT.100669892 DT.92463835 DT.100868533 DT.95272685 DT.95272682 DT.102822895 DT.100669894 DT.120708720 DT.100669895 DT.100669896 DT.87004196 DT.100669899 DT.120708701 DT.120708724 DT.92463845 24/423 AceView cDNA sequences (see all 423): CB216000 AF171946 BX441835 AF171944 CB126321 CA390812 BE263231 BM997620 BI838147 NM_198897 BP341910 BQ276278 BX332614 AA489891 CR611951 CR604159 BU731818 CD050233 AI341784 BM800099 BM083853 BM463393 BQ573972 BP346485
 highest scoring ESTs for FIBP:AF010187 AA248871 AA434539 AF171944 AF171945 AF171946 AF250391 AI815638 AU099522 AW000918 Unigene Cluster for FIBP: Fibroblast growth factor (acidic) intracellular binding protein Hs.7768 [show with all ESTs]Unigene Representative Sequence: BQ050043
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for FIBP (see all 13)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | |
About this scheme
ECgene alternative splicing isoforms for FIBP
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357519 ENST00000338369(uc009yqu.2 uc001ogd.2 uc001oge.2)
ENST00000426652(uc010roq.1 uc010ror.1) ENST00000442885
|
Expression
for FIBP gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FIBP expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching FIBP gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37361_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
0.90 |
0.94 |
AF010187 |
1.00 |
1.00 |
1.00 |
1 |
| 57259_at2, 3
|
U95-C |
1 |
0.38 |
1.00 |
0.95 |
1.06 |
AW000918 |
0.80 |
1.00 |
0.91 |
1 |
| 202041_s_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_004214 |
0.60 |
1.00 |
0.82 |
1 |
| 202041_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FIBP for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACTGAGGTGC
SOURCE GeneReport for Unigene cluster: Hs.7768
Expression variation in blood from EXPOLDB for FIBP UniProtKB/Swiss-Prot: FIBP_HUMAN, O43427Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Alsofound in placenta, liver and kidney
SABiosciences Custom PCR Arrays for FIBP
|
Orthologs
for FIBP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FIBP gene from 5/9 species (see all 9)
About this table Species with no ortholog for FIBP
ENSEMBL Gene Tree for FIBP (if available) |
Paralogs
for FIBP gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for FIBP gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FIBP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FIBP
1 CNV: 3855 | | QIAGEN SeqTarget long-range PCR primers for resequencing FIBP |
|
Disorders & Mutations
for FIBP gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FIBP for disorders About GeneDecksing
OMIM: 608296
8 Novoseek disease relationships for FIBP gene
About this table
Human Genome Epidemiology (HuGE) Navigator: FIBP (2 documents)
Export disorders and mutations for FIBP gene to outside databases
|
Medical News
for FIBP gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FIBP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/86 PubMed articles for FIBP gene, integrated from 7 sources (see all 86):
(articles sorted by number of sources associating them with FIBP)- Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. (PubMed id 9806903)1, 2, 3 Kolpakova E....Olsnes S. (1998)
- Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. (PubMed id 11104667)1, 2, 7 Kolpakova E.... Olsnes S. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Enhancement of fibroblast growth factor (FGF) activity by an FGF- binding protein. (PubMed id 11509569)1, 7 Tassi E.... Wellstein A. (2001)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Angiogenic factor expression in hepatic cirrhosis. (PubMed id 17497037)1 Giatromanolaki A....Sivridis E. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
|
External Searches for FIBP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FIBP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FIBP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FIBP gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/fibp/ |
|
| | |
About This Section
| Patent Information for FIBP gene:
Search GeneIP for patents involving FIBP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FIBP gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for FIBP |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for FIBP |
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