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FIZ1 Gene

protein-coding GIFtS: 42

GC19M052413

FLT3-interacting zinc finger 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
FLT3-interacting zinc finger 1¹ ²
ZNF798¹ ² ³
FLJ14768¹ ²
Zinc finger protein 798² ³
FLJ00416²
flt3-interacting zinc finger protein 1²

External Ids:	HGNC: 25917¹	Entrez Gene: 84922²	Ensembl: ENSG00000179943⁷	UniProtKB: Q96SL8³

Export aliases for FIZ1 gene to outside databases

Previous GC identifers: GC19M060795 GC19M056102

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FIZ1:

This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of

hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the

expression of rod-specific genes in retina. (provided by RefSeq)

UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8

Function: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated

transactivation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for FIZ1
Other transcription factors

Search SABiosciences Chromatin IP Primers for FIZ1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FIZ1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42

FIZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FIZ1 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M052413: view genomic region (about GC identifiers)

Start:	52,413,729 bp from pter
End:	52,421,887 bp from pter
Size:	8,159 bases
Orientation:	minus strand

1 alternative location:

Chr19- 56,102,738-56,110,893

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8 (See protein sequence)

Recommended Name: Flt3-interacting zinc finger protein 1

Size: 496 amino acids; 51996 Da

Subunit: Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent

manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR.

Interacts with NRL (By similarity)

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)

Sequence caution: Sequence=BAD18728.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: Q6ZMJ7

Explore the universe of human proteins at neXtProt for FIZ1: NX_Q96SL8

REFSEQ proteins: NP_116225.2

ENSEMBL proteins:

ENSP00000221665

Human Recombinant Proteins

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3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--

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FIZ1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FIZ1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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FIZ1 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96SL8

ProtoNet protein and cluster: Q96SL8

UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8

Similarity: Contains 11 C2H2-type zinc fingers

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8

Function: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated

transactivation (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FIZ1 Sigma-Aldrich shRNA for FIZ1
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miRNA:		Sigma-Aldrich microRNA Mimics for FIZ1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FIZ1
		3 SABiosciences Assays for microRNAs that regulate FIZ1:
		hsa-miR-513a-5p hsa-miR-220c hsa-miR-455-3p

Gene
Editing:

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Cell
Lines:

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5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0005102	receptor binding	ISS	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0009055	electron carrier activity	--	--

About this table

FIZ1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for FIZ1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FIZ1

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045449	regulation of transcription	IEA	--

About this table

FIZ1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FIZ1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for FIZ1 Sigma-Aldrich shRNA for FIZ1
		OriGene 29mer shRNA kits in GFP-retroviral vector: FIZ1 OriGene shRNA RFP: FIZ1 OriGene basic RS shRNA: FIZ1 OriGene siRNA: FIZ1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FIZ1

miRNA:		Sigma-Aldrich microRNA Mimics for FIZ1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FIZ1
		3 SABiosciences Assays for microRNAs that regulate FIZ1:
		hsa-miR-513a-5p hsa-miR-220c hsa-miR-455-3p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: FIZ1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FIZ1 OriGene untagged cDNA clones in CMV expression vector: FIZ1 OriGene 3'-UTR Clone: FIZ1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FIZ1

Primers:		OriGene genome-wide validated SYBR primer pairs: FIZ1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FIZ1: PPH11991A

REFSEQ mRNAs for FIZ1 gene:

NM_032836.2

Additional cDNA sequence:

AK027674.1 BC020368.1 BC132777.1 BC136512.1 CR596546.1

5 DOTS entries:

DT.403910 DT.95254954 DT.86846015 DT.121445746 DT.100739580

24/93 AceView cDNA sequences (see all 93):

F23452 AI096509 BM974765 BM663774 AW206984 AW614655 CR596546 AI990725

AI699699 C01696 CA841110 AW409891 AW275332 BM690768 BM692120 BC020368

BF594355 BU728526 BM479809 BG284147 AW206386 BX283241 BG765347 AA864884

highest scoring ESTs for FIZ1:

AI823365 AK027674 AA282742 AA864884 AI096509 AI123493 AI300604 AI569028 AI799934 AI990725

Unigene Cluster for FIZ1:

FLT3-interacting zinc finger 1

Hs.515617 [show with all ESTs]

Unigene Representative Sequence: NM_032836

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000221665(uc002qli.3 uc002qlj.3)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FIZ1 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching FIZ1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76611_at²^{, 3}	U95-E	1	1.00	1.00	0.78	1.14	AI096509	0.60	1.00	0.82	1
45908_at²^{, 3}	U95-B	1	0.50	1.00	0.19	0.86	AI823365	0.80	1.00	0.91	1
228663_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI096509	0.60	1.00	0.82	1
226967_at²^{, 3}	U133-B	1	0.36	1.00	--	--	BG231981	0.60	1.00	0.82	1
228663_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226967_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

About this table

FIZ1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

FIZ1 gene electronic northern expression

About these images

CGAP SAGE TAG: GAATGGGCTG

SOURCE GeneReport for Unigene cluster: Hs.515617

UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8

Tissue specificity: Widely expressed

Primers:		OriGene genome-wide validated SYBR primer pairs: FIZ1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FIZ1: PPH11991A

SABiosciences Custom PCR Arrays for FIZ1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FIZ1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FIZ1¹	--	FLT3-interacting zinc finger 1	88.06(n) 92.16(a)	484292 XM_541407.2 XP_541407.2
chimpanzee (Pan troglodytes)	FIZ1¹	--	FLT3-interacting zinc finger 1	99.4(n) 99.8(a)	456307 XM_512915.2 XP_512915.2
cow (Bos taurus)	FIZ1¹	--	FLT3-interacting zinc finger 1	89.93(n) 93.33(a)	789631 XM_001256328.1 XP_001256329.1
rat (Rattus norvegicus)	Fiz1¹	--	FLT3-interacting zinc finger 1	80.52(n) 87.37(a)	292584 XM_218199.4 XP_218199.4
mouse (Mus musculus)	Fiz1^{1 , 5}	7 (2.90 cM)⁵	Flt3 interacting zinc finger protein 1^{1, 5}	80.67(n)¹ 87.91(a)¹	23877¹ NM_011813.2¹ NP_035943.2¹ AF126746⁵ AF126747⁵ (see all 28)

About this table Species with no ortholog for FIZ1

ENSEMBL Gene Tree for FIZ1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs310463^1,2	--	56106012(-)	`gatctC/Tggctc`	1	--	int¹		0	--	--	--	--
rs310468^1,2	C,F	56102453(-)	`tagccA/Gggtgt`	1	--	ng3¹		8		EA NA WA	72
rs2287792^1,2	H	56104920(-)	`CGCCAG/ACACCG`	2	/Q	syn¹ ref¹		5		EA NS	1156
rs7247236^1,2	C,A,	56104136(+)	`GGCGGC/TCGCCG`	2	T A	ref¹ mis¹		2		NA	4
rs10403432^1,2	--	56104524(+)	`CAGGCC/TTGCGC`	2	Q	syn¹ ref¹		0	--	--	--	--
rs10403462^1,2	C,	56104560(+)	`TCGTGG/CGTCAG`	2	/T	syn¹ ref¹		2		NA	4
rs10411640^1,2	C,F,A,H,	56105161(+)	`CTCTGC/TTTGGG`	1	--	int¹		8		NS EA NA WA	428
rs10451452^1,2	C,F,H,	56106221(+)	`TACAGG/CCCTTA`	1	--	int¹		16		NS EA NA WA	948
rs11469855^1,2	--	56103615(+)	`GGACC-/CTGTTTG`	1	--	ut3¹		0	--	--	--	--
rs12609355^1,2	C,F,H	56105932(+)	`gtggcG/Aggcgc`	1	--	int¹		4		NA WA	14

About this table

HapMap Linkage Disequilibrium images for FIZ1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FIZ1: --

QIAGEN SeqTarget long-range PCR primers for resequencing FIZ1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FIZ1 for disorders About GeneDecksing

OMIM: 609133

Export disorders and mutations for FIZ1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

7 PubMed articles for FIZ1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with FIZ1)

Interaction of retinal bZIP transcription factor NRL with Flt3- interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. (PubMed id 12566383)^{1, 2, 3, 7} Mitton K.P.... Swaroop A. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro. (PubMed id 17141759)¹ Mali R.S....Mitton K.P. (2007)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)² Yu L.-R.... Veenstra T.D. (2007)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. (PubMed id 10409713)¹ Wolf I. and Rohrschneider L.R. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84922	HGNC: 25917	AceView: FLJ14768	Ensembl:ENSG00000179943	euGenes: HUgn84922
ECgene: FIZ1	H-InvDB: FIZ1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for FIZ1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for FIZ1 gene:
Search GeneIP for patents involving FIZ1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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FIZ1 Gene

protein-coding GIFtS: 42

Aliases &
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for FIZ1 gene

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Proteins
for FIZ1 gene

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for FIZ1 gene

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Pathways & Interactions
for FIZ1 gene

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FIZ1 Gene

protein-coding GIFtS: 42

Aliases & Descriptionsfor FIZ1 gene

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Gene Functionfor FIZ1 gene

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Expression for FIZ1 gene

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Genome Databases showing FIZ1 gene

Other Databases showing FIZ1 gene

Specialized Databases showing FIZ1 gene

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Aliases &
Descriptions
for FIZ1 gene

Summaries
for FIZ1 gene

Genomic Views
for FIZ1 gene

Proteins
for FIZ1 gene

Protein Domains/
Families
for FIZ1 gene

Gene Function
for FIZ1 gene

Pathways & Interactions
for FIZ1 gene

Drugs & Compounds
for FIZ1 gene

Transcripts
for FIZ1 gene

Expression
for FIZ1 gene

Orthologs
for FIZ1 gene

Paralogs
for FIZ1 gene

Genomic Variants
for FIZ1 gene

Disorders & Mutations
for FIZ1 gene

Medical News
for FIZ1 gene

Publications
for FIZ1 gene

Intellectual Property
for FIZ1 gene

Products
for FIZ1 gene