Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



FKBP5 Gene

protein-coding   GIFtS: 63

GC06M035262
FK506 binding protein 5
(Previous name: FK506-binding protein 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
FK506 binding protein 51 2     FF1 antigen2 3
FKBP511 2 3 5     54 kDa progesterone receptor-associated immunophilin2 3
FKBP541 2 3     51 kDa FK506-binding protein 52
P541 2     OTTHUMP000000162682
PPIase1 2     peptidylprolyl cis-trans isomerase2
Ptg-101 2     peptidyl-prolyl cis-trans isomerase FKBP52
FK506-binding protein 51 3     MGC1110062
Androgen-regulated protein 62 3     rotamase2
FKBP-512 3     T-cell FK506-binding protein2
HSP90-binding immunophilin2 3     51 kDa FK506-binding protein3
AIG62 3     EC 5.2.1.83
51 kDa FKBP2 3     p543
PPIase FKBP52 3     Rotamase3
FKBP-52 3     

External Ids:    HGNC: 37211   Entrez Gene: 22892   Ensembl: ENSG000000960607   UniProtKB: Q134513   

Export aliases for FKBP5 gene to outside databases

Previous GC identifers: GC06M035543 GC06M035588 GC06M035649 GC06M035541


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FKBP5:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation
and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl
isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition.
It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa
heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative
splicing results in multiple transcript variants.(provided by RefSeq)

UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
Function: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FKBP5 gene promoter:
         NF-kappaB1   STAT5A   STAT5B   GR-alpha   GR-beta   NF-kappaB   POU2F2 (Oct-2.1)   Oct-B1   POU2F2C   POU2F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for FKBP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FKBP5 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

FKBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP5 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035262:  view genomic region     (about GC identifiers)

Start:
35,262,003 bp from pter
End:
35,414,145 bp from pter
Size:
152,143 bases
Orientation:
minus strand

1 alternative location:
Chr6- 35,541,362-35,696,358     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP5  
Size: 457 amino acids; 51212 Da
Subunit: Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the
complex when NR3C1 binds glucocorticoid
Subcellular location: Cytoplasm. Nucleus
PDB structures from and Proteopedia :
1KT0 (3D)    

Explore the universe of human proteins at neXtProt for FKBP5: NX_Q13451 

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001139247.1  NP_001139248.1  NP_001139249.1  NP_004108.1  


    ENSEMBL proteins: 
    ENSP00000349811 ENSP00000338160 ENSP00000362982 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for FKBP5
    OriGene Purified Protein: FKBP5
    OriGene Protein Over-expression Lysate: FKBP5
    GenScript Custom Purified and Recombinant Proteins Services for FKBP5 
    Novus Biologicals Proteins for FKBP5
    Novus Biologicals Lysates for FKBP5
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    FKBP5 for ontologies           About GeneDecksing



    Antibodies for FKBP5: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FKBP5
    R&D Systems Antibodies for FKBP5 (FKBP51)
    OriGene Antibodies: FKBP5
    GenScript Custom Superior Antibodies Services for FKBP5 
    Novus Biologicals Antibodies for FKBP5
    Browse antibodies at Epitomics

    Assays for FKBP5: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FKBP5 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FKBP5 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FKBP5 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011990 TPR-like_helical
     IPR023114 Elongated_TPR_rpt_dom
     IPR001440 TPR-1
     IPR001179 PPIase_FKBP
     IPR013026 TPR-contain

    Graphical View of Domain Structure for InterPro Entry Q13451

    ProtoNet protein and cluster: Q13451

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Similarity: Contains 2 PPIase FKBP-type domains
    Similarity: Contains 3 TPR repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Function: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by FK506 but not cyclosporin
    Induction: By androgen
    Enzyme Number (IUBMB): EC 5.2.1.8 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FKBP5
    Sigma-Aldrich shRNA for FKBP5
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): FKBP5
    OriGene shRNA RFP (see all 4): FKBP5
    OriGene basic RS shRNA (see all 4): FKBP5
    OriGene siRNA (see all 4): FKBP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FKBP5 
    miRNA:Sigma-Aldrich microRNA Mimics for FKBP5
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FKBP5 
    5 SABiosciences Assays for microRNAs that regulate FKBP5:
    hsa-miR-495 hsa-miR-544 hsa-miR-122 hsa-miR-571 hsa-miR-539

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    OriGene untagged cDNA clones in CMV expression vector: FKBP5
    OriGene 3'-UTR clone (see all 4): FKBP5 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for FKBP5 
    Sino Biological Human cDNA Clone for FKBP5

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for FKBP5 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515 protein binding IPI14743216
    GO:0005528 FK506 binding TAS9001212
    GO:0016853 isomerase activity IEA--
    GO:0031072 heat shock protein binding IPI9660753
    About this table

    FKBP5 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fkbp5):

    lethality-prenatal/perinatalnormalrenal/urinary system

    FKBP5 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    FKBP5 for pathways           About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  FKBP5
        NRF2-mediated Oxidative Stress Response
    Glucocorticoid Receptor Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for FKBP5 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FKBP5
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP5

    5 Interacting proteins for FKBP5 (Q134511, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151111, 2EBI-306914,EBI-81249 MINT-47952 MINT-48060
    IKBKEQ141642MINT-47961 MINT-48123
    MAP3K1Q132332MINT-48346 MINT-47977
    MAP3K7O433182MINT-48031 MINT-49248
    --O394742MINT-2841064
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457 protein folding IEA--
    About this table

    FKBP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    FKBP5 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FKBP5
    10/11 Novoseek chemical compound relationships for FKBP5 gene (see all 11)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 74.5 33 18326728 (3), 20023700 (3), 7693698 (3), 15089760 (2) (see all 19)
    steroid 60.9 12 11751894 (2), 1383226 (1), 15821585 (1), 20371398 (1) (see all 10)
    rapamycin 58.6 22 9658403 (3), 15878982 (2), 11089542 (1), 18320068 (1)
    molybdate 48.5 2 2303491 (1), 9183567 (1)
    progestin 48.2 9 12746298 (7)
    dexamethasone 47.8 18 18326728 (4), 11089542 (2), 12519866 (2), 16723223 (1) (see all 7)
    mifepristone 46.2 2 20371398 (1), 12746298 (1)
    cyclosporin a 42.8 8 20023700 (3), 11089542 (1), 12351405 (1), 12611898 (1)
    progesterone 41.7 8 7688746 (3), 8114727 (1), 7693698 (1), 9195978 (1) (see all 6)
    testosterone 36.5 18 20023700 (4), 15821585 (3), 19433513 (3), 12917209 (1) (see all 7)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FKBP5
    Sigma-Aldrich shRNA for FKBP5
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): FKBP5
    OriGene shRNA RFP (see all 4): FKBP5
    OriGene basic RS shRNA (see all 4): FKBP5
    OriGene siRNA (see all 4): FKBP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FKBP5 
    miRNA: Sigma-Aldrich microRNA Mimics for FKBP5
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FKBP5 
    5 SABiosciences Assays for microRNAs that regulate FKBP5:
    hsa-miR-495 hsa-miR-544 hsa-miR-122 hsa-miR-571 hsa-miR-539
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    OriGene untagged cDNA clones in CMV expression vector: FKBP5
    OriGene 3'-UTR Clone (see all 4): FKBP5 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for FKBP5 
    Primers: OriGene genome-wide validated SYBR primer pairs: FKBP5
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for FKBP5: PPH02277A

    REFSEQ mRNAs for FKBP5 gene (4 alternative transcripts): 

    NM_001145775.1  NM_001145776.1  NM_001145777.1  NM_004117.3  

    Additional cDNA sequence: 

    AB209893.1 AF194172.1 AK093304.1 AK222807.1 AK302704.1 AK303356.1 AK312422.1 AL122066.1 
    BC034770.1 BC042605.1 BC111050.1 BX647390.1 CR620368.1 HM245387.1 HM245388.1 HM245391.1 
    U42031.1 U71321.1 X97300.1 

    19 DOTS entries:

    DT.100810577  DT.217993  DT.100810576  DT.100036440  DT.100000254  DT.100810580  DT.91638670  DT.100801419 
    DT.121339202  DT.40227714  DT.95200204  DT.121339196  DT.121339252  DT.121339167  DT.121339223  DT.75120548 
    DT.95136421  DT.100755214  DT.121339249 

    24/336 AceView cDNA sequences (see all 336):

    AF194172 BX364564 AA789188 AA345703 X97300 BU688200 BP377824 CB217026 
    AJ715015 AI679222 BM705679 AL046952 AI220884 AL045832 AW082272 BM544497 
    U71321 AI700784 AA343895 AL122066 BU618549 CD244775 BP378260 BC042605 

    highest scoring ESTs for FKBP5:

    AA382675 AI753747 AL701450 AL701502 AW500704 BG392941 BG899577 BM546723 BM921807 BX470415 

    Unigene Cluster for FKBP5:

    FK506 binding protein 5
    Hs.407190  [show with all ESTs]
    Unigene Representative Sequence: NM_001145777


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP5 (see all 8)

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                    -     -           -     -     -     -     -     -     -     -                                                     -                     
    SP2:                                                        -     -     -     -     -                                                     -                     
    SP3:                          -           -     -     -     -     -     -     -     -                                                                           
    SP4:                                                        -     -                                                                                             
    SP5:                    -                                                                                                                                       

    ExUns: 20a · 20b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            

    About this scheme

    ECgene alternative splicing isoforms for FKBP5
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357266(uc011dte.1 uc003okx.2 uc011dtf.1) ENST00000337746(uc003oky.2)
    ENST00000373875(uc003okz.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    FKBP5 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching FKBP5 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    46271_at2, 3 U95-B 1 1.00 1.00 0.99 1.16 AI753747 0.80 1.00 0.91 1
    34721_at2, 3 U95-A 1 1.00 1.00 0.98 0.84 U42031 0.80 0.80 0.80 1
    204560_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004117 0.60 1.00 0.82 1
    224856_at2, 3 U133-B 1 1.00 1.00 -- -- W86302 0.40 1.00 0.76 1
    224840_at2, 3 U133-B 1 1.00 1.00 -- -- AI753747 0.80 1.00 0.91 1
    204560_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    224856_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    224840_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    FKBP5 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    FKBP5 gene expression
    FKBP5 gene electronic northern expression
    FKBP5 gene sage expression
    About these images

    CGAP SAGE TAG: GTTCCAGTGA

    SOURCE GeneReport for Unigene cluster: Hs.407190

    Expression variation in blood from EXPOLDB for FKBP5

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Tissue specificity: Widely expressed, enriched in testis compared to other tissues

    Primers: OriGene genome-wide validated SYBR primer pairs: FKBP5
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for FKBP5: PPH02277A
        SABiosciences Custom PCR Arrays for FKBP5 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for FKBP5 gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FKBP51   -- FK506 binding protein 5 92.4(n)
    95.39(a)
    481759  XM_538880.2  XP_538880.2 
    chimpanzee
    (Pan troglodytes)
    FKBP51   -- FK506 binding protein 5 99.93(n)
    99.78(a)
    462639  XM_001172411.1  XP_001172411.1 
    cow
    (Bos taurus)
    FKBP51   -- FK506 binding protein 5 93.8(n)
    97.18(a)
    535704  XM_615814.3  XP_615814.3 
    rat
    (Rattus norvegicus)
    Fkbp51   -- FK506 binding protein 5 86.26(n)
    91.45(a)
    361810  NM_001012174.1  NP_001012174.1 
    mouse
    (Mus musculus)
    Fkbp51 , 5 17 (14.66 cM)5
    FK506 binding protein 51, 5 84.58(n)1
    87.28(a)1
    142291  NM_010220.21  NP_034350.11 
     AK0041755  AK1593895  (see all 19)
    About this table        Species with no ortholog for FKBP5

    ENSEMBL Gene Tree for FKBP5 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for FKBP5 gene
    FKBP1A2  FKBP1C2  FKBP42  FKBP82  FKBP62  FKBP1B2  FKBP32  

    FKBP5 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1310 NCBI SNPs in FKBP5 are shown (see all 1310)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7343691,2
    C,F35544852(-) TGCCAG/AAAAAA 6 /Q syn1 ref17Minor allele frequency- A:0.01NA EA MN 584
    rs7370541,2
    C,F,A,H,35575487(-) AGCAGC/TGGCTG 4 -- int117Minor allele frequency- T:0.24NA NS EA WA 1203
    rs7474111,2
    C,F,A,35586373(+) gtctcG/Aaattc 4 -- int11Minor allele frequency- A:0.12NA 72
    rs7556581,2
    C,F,O,H,35549670(-) ACTCGG/ACAGTG 4 -- int1 ut3126Minor allele frequency- A:0.05NA EA MN NS 3558
    rs9432971,2
    C,F,35667860(-) agttaG/AgtcCT 1 -- int114Minor allele frequency- A:0.18NS EA NA WA 726
    rs9921051,2
    C,F,O,35555183(+) AAGTGA/CATCTT 4 -- int117Minor allele frequency- C:0.15NS EA NA WA 2472
    rs10039991,2
    --35544381(-) GCAGCC/TTTGAC 3 -- int10--------
    rs10438051,2
    C,F,A,35541432(-) TTTTTT/AAAAAA 3 -- ut31 trp310Minor allele frequency- A:0.18NS EA NA WA 632
    rs10809461,2
    --35637312(-) GTTCAA/GGAAAT 4 -- int10--------
    rs13209911,2
    --35562432(-) GTATAA/GAAAAC 4 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for FKBP5 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 29 variations for FKBP5
         15/25 CNVs (see all 25): 36516 51903 51906 31284 43539 81370 81368 44255 37752 31283 99504 93672 64485 81369 53613
         3 Indels: 93673 69487 60588
         1 Inversion: 37274

    QIAGEN SeqTarget long-range PCR primers for resequencing FKBP5 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FKBP5 for disorders           About GeneDecksing

    OMIM: 602623   disorders: 608516  

    6 Novoseek disease relationships for FKBP5 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    idiopathic myelofibrosis 66.9 4 15089760 (2), 12842707 (1), 12351405 (1)
    shock 37.4 7 15802496 (2), 10022435 (1), 11525247 (1), 9658403 (1) (see all 5)
    prostate cancer 30.8 7 15131019 (3), 15821585 (1), 20023700 (1)
    mammary tumor 19.4 2 12746298 (1)
    tumors 0 4 15131019 (2), 18320068 (1)
    cancer 0 4 19732725 (4)
    About this table

    1 PharmGKB disease relationship for FKBP5 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Human Gene Mutation Database (HGMD): FKBP5
    Genetic Association Database (GAD): FKBP5
    Human Genome Epidemiology (HuGE) Navigator: FKBP5 (27 documents)

    Export disorders and mutations for FKBP5 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/146 PubMed articles for FKBP5 gene, integrated from 7 sources (see all 146):
    (articles sorted by number of sources associating them with FKBP5)
    1. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. (PubMed id 9001212)1, 2, 3 Nair S.C.... Smith D.F. (1997)
    2. Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition. (PubMed id 9125197)1, 2, 7 Baughman G.... Bourgeois S. (1997)
    3. FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. (PubMed id 7693698)1, 2, 7 Smith D.F.... Deibel M.R. Jr. (1993)
    4. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. (PubMed id 15565110)1, 4 Binder E.B....Muller-Myhsok B. (2004)
    5. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. (PubMed id 12538866)1, 2 Sinars C.R.... Clardy J. (2003)
    8. Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis. (PubMed id 15089760)1, 7 Bock O....Kreipe H. (2004)
    9. FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. (PubMed id 18320068)1, 7 Jiang W....Mikkelsen T. (2008)
    10. The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. (PubMed id 12746298)1, 7 Hubler T.R....Scammell J.G. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2289 HGNC: 3721 AceView: FKBP5 Ensembl:ENSG00000096060 euGenes: HUgn2289
    ECgene: FKBP5 H-InvDB: FKBP5

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for FKBP5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for FKBP5 gene:
    Search GeneIP for patents involving FKBP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for FKBP5 Antibodies for FKBP5
     Super-pooled esiRNAs for FKBP5 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FKBP5 microRNA Mimics for FKBP5
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies for FKBP5 (FKBP51)   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FKBP5
     SeqTarget long-range PCR primers for resequencing FKBP5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FKBP5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FKBP5
     GenScript Custom Purified and Recombinant Proteins Services for FKBP5 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for FKBP5
     GenScript Custom Assay Services for FKBP5 GenScript Custom Superior Antibodies Services for FKBP5
     GenScript Custom overexpressing Cell Line Services for FKBP5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FKBP5 promoter
     Search Chromatin IP Primers for FKBP5
     RT2 qPCR Primer Assay for FKBP5
     GNC Network for FKBP5
     Assays for microRNAs that regulate FKBP5
     SABiosciences Custom PCR Arrays for FKBP5
     Search Tocris compounds for FKBP5
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for FKBP5
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for FKBP5
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for FKBP5
     Proteins for FKBP5
     Lysates for FKBP5
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for FKBP5
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    FKBP5 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4