Aliases &
Descriptions
for FLII gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| flightless I homolog (Drosophila)1 2 | | MGC392651 2 | | FLIL1 2 3 | | flightless I (Drosophila) homolog1 | | FLI1 2 | | protein flightless-1 homolog2 | | Fli11 2 | | |
Export aliases for FLII gene to outside databasesPrevious GC identifers: GC17M018393 GC17M019740 GC17M018091 GC17M018348 GC17M018088 |
Summaries
for FLII gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FLII:
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-proteinprotein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and thestructural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region onchromosome 17. (provided by RefSeq)
UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045Function: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) andacts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonicdevelopment (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis andcell migration
Gene Wiki entry for FLII |
Genomic Views
for FLII gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FLII gene promoter:
Max1 c-Myc Max RFX1 c-Myb Egr-2 E47 Tal-1 AP-4 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for FLII
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FLII  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2FLII Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M017901: view genomic region
(about GC identifiers)
Start:
|
17,901,403 bp from pter |
End:
|
17,915,309 bp from pter |
Size:
|
13,907 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 18,148,150-18,162,056 |
RefSeq DNA sequence:- NC_000017.10 NT_010718.16
|
Proteins
for FLII gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045 (See
protein sequence)Recommended Name: Protein flightless-1 homolog Size: 1269 amino acids; 144751 Da
Subunit: Interacts with actin, ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2. Interacts with the nuclear receptors ESR1 andTHRB
Subcellular location: Nucleus (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton,centrosome (By similarity). Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS1, RHOAand CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity)Explore the universe of human proteins at neXtProt for FLII: NX_Q13045
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002009.1
ENSEMBL proteins: ENSP00000368763 ENSP00000324573
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FLII for ontologies About GeneDecksing
Antibodies for FLII:
Assays for FLII: |
Protein
Domains/
Families
for FLII gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FLII for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13045ProtoNet protein and cluster: Q13045 2 Blocks protein families: IPB001611 Leucine-rich repeat signature IPB007123 Gelsolin region
UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045Similarity: Contains 5 gelsolin-like repeatsSimilarity: Contains 15 LRR (leucine-rich) repeats |
Gene Function
for FLII gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045Function: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) andacts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonicdevelopment (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis andcell migration
Genatlas biochemistry entry for FLII:Drosophila flightless (fli) homolog 1,highly expressed in muscle,overlapping 3'end of LLGL1,constantly deleted inSmith-Magenis syndrome (SMCR),member of gelsolin and LRR family2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
FLII for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Flii):
FLII for phenotypes About GeneDecksing
|
Pathways & Interactions
for FLII gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for FLII
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FLII
3 Interacting proteins for FLII (ENSP000003245733 Q130451, 2) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
FLII for ontologies About GeneDecksing
|
Drugs & Compounds
for FLII gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
FLII for compounds About GeneDecksing
 Browse Tocris compounds for FLII
1  Novoseek chemical compound relationship for FLII gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
7.74 |
7 |
11580247 (3), 16780875 (2), 10998179 (1) |
About this table
|
Transcripts
for FLII gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FLII gene: NM_002018.2 Additional cDNA sequence: AB208864.1 AK295655.1 AK295814.1 AK297836.1 AK310400.1 BC001582.1 BC017030.2 BC021885.1 BC025300.1 U01184.1 24/28 DOTS entries (see all 28): DT.75169954 DT.95291769 DT.100843196 DT.95355701 DT.100843193 DT.95355238 DT.40117375 DT.100844998 DT.95355263 DT.100843188 DT.120997771 DT.100031398 DT.95355372 DT.95355377 DT.100031403 DT.95337867 DT.102834873 DT.120997717 DT.120997768 DT.91692009 DT.100843192 DT.95322594 DT.95355241 DT.95355374 24/573 AceView cDNA sequences (see all 573): BQ959310 AI400101 BE326238 BI824801 CB266971 BU149786 AI376185 BF063924 AA310928 BG576609 BE222407 AW000787 BX282359 BF061012 BI793233 BU542167 BM553383 CN483878 CD613719 CK429219 CD673662 BQ928494 BQ632289 BE468053
 highest scoring ESTs for FLII:BC017030 BC025300 BE244601 BG716926 BI603669 BM452734 BM455575 BM473960 BM476936 BM559308 Unigene Cluster for FLII: Flightless I homolog (Drosophila) Hs.513984 [show with all ESTs]Unigene Representative Sequence: NM_002018
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FLII (see all 16)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | · | 25c | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · |
|---|
|
| SP1: | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for FLII
17 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493401 ENST00000461110(uc010vxp.1) ENST00000379450 ENST00000327031(uc002gsq.1 uc010cpy.1 uc002gsr.1 uc010vxn.1 uc010vxo.1 uc002gss.1)
ENST00000473425 ENST00000459958 ENST00000487693 ENST00000488221 ENST00000474265
ENST00000493600 ENST00000476369 ENST00000478416 ENST00000496727 ENST00000465046
ENST00000487369 ENST00000479175 ENST00000488932
|
Expression
for FLII gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FLII expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching FLII gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33133_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
0.90 |
0.95 |
U80184 |
0.20 |
1.00 |
0.72 |
1 |
| 88279_s_at2, 3
|
U95-E |
1 |
0.81 |
1.00 |
0.75 |
1.30 |
AI978629 |
0.40 |
1.00 |
0.76 |
1 |
| 88281_s_at2, 3
|
U95-E |
1 |
0.69 |
1.00 |
0.76 |
0.75 |
AA255598 |
0.40 |
1.00 |
0.76 |
1 |
| 222065_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AI830227 |
0.40 |
1.00 |
0.76 |
1 |
| 212025_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
BG421186 |
0.40 |
1.00 |
0.76 |
1 |
| 212024_x_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
U80184 |
0.20 |
1.00 |
0.72 |
1 |
| 222065_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212025_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212024_x_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FLII for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGCGGCCGCG
SOURCE GeneReport for Unigene cluster: Hs.513984
Expression variation in blood from EXPOLDB for FLII UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045Tissue specificity: Strongest expression in skeletal muscle with high expression also in the heart and lung
SABiosciences Custom PCR Arrays for FLII
|
Orthologs
for FLII gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FLII gene from 5/9 species (see all 9)
About this table Species with no ortholog for FLII
ENSEMBL Gene Tree for FLII (if available) |
Paralogs
for FLII gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for FLII gene
- SVIL2 VILL2 AVIL2 GSN2 SCIN2 CAPG2 VIL12
FLII for paralogs About GeneDecksing
|
Genomic Variants
for FLII gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FLII (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FLII
1 CNV: 30807
1 Inversion: 0495 | | QIAGEN SeqTarget long-range PCR primers for resequencing FLII |
|
Disorders & Mutations
for FLII gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FLII for disorders About GeneDecksing
OMIM: 600362
UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045
Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS) [MIM:182290]. It is a contiguous genedeletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findingsincludes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioralproblems
2 Novoseek disease relationships for FLII gene
About this table
Human Genome Epidemiology (HuGE) Navigator: FLII (2 documents)
Export disorders and mutations for FLII gene to outside databases
|
Medical News
for FLII gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FLII gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/60 PubMed articles for FLII gene, integrated from 7 sources (see all 60):
(articles sorted by number of sources associating them with FLII)- Identification of the binding partners for flightless I, a novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. (PubMed id 9525888)1, 2, 7 Liu Y.-T. and Yin H.L. (1998)
- Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. (PubMed id 9177775)1, 2, 7 Campbell H.D.... Lupski J.R. (1997)
- The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2. (PubMed id 7825574)1, 3, 7 Chen K.S....Lupski J.R. (1995)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. (PubMed id 14966289)1, 2 Lee Y.-H.... Stallcup M.R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. (PubMed id 10366446)1, 2 Fong K.S.K. and de Couet H.G. (1999)
|
External Searches for FLII gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FLII gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FLII gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FLII gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FLII gene:
Search GeneIP for patents involving FLII
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FLII gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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| | |
 |  |  |  | |
| |  | Search Tocris compounds for FLII |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for FLII |
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