Aliases &
Descriptions
for FOXD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| forkhead box D11 2 | | FREAC-42 3 | | FREAC41 2 3 | | forkhead box protein D12 | | FKHL82 3 5 | | forkhead-like 82 | | Forkhead-related protein FKHL82 3 | | Forkhead, drosophila, homolog-like 82 | | Forkhead-related transcription factor 42 3 | | forkhead-related activator 42 |
Export aliases for FOXD1 gene to outside databasesPrevious GC identifers: GC05M071547 GC05M072975 GC05M072780 GC05M072826 GC05M072777 GC05M072743 |
Summaries
for FOXD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FOXD1:
This intronless gene belongs to the forkhead family of transcription factors which is characterized by a distinctforkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in tumorformation. (provided by RefSeq)
UniProtKB/Swiss-Prot: FOXD1_HUMAN, Q16676Function: Transcription factor required for formation of positional identity in the developing retina, regionalizationof the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly (By similarity)
|
Genomic Views
for FOXD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXD1 gene promoter:
NF-kappaB1 FOXO1a FOXO4 NF-kappaB C/EBPalpha POU2F2B POU2F2C POU2F1 POU2F2 oct-B3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXD1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q12-q13 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q12-q13FOXD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M067947: view genomic region
(about GC identifiers)
Start:
|
67,947,569 bp from pter |
End:
|
67,949,821 bp from pter |
Size:
|
2,253 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr5- 72,742,083-72,744,352 |
RefSeq DNA sequence:- NC_000005.9 NT_006713.15
|
Proteins
for FOXD1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FOXD1_HUMAN, Q16676 (See
protein sequence)Recommended Name: Forkhead box protein D1 Size: 465 amino acids; 46140 Da
Subcellular location: Nucleus
Secondary accessions: Q12949Explore the universe of human proteins at neXtProt for FOXD1: NX_Q16676
REFSEQ proteins: NP_004463.1
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FOXD1 for ontologies About GeneDecksing
Antibodies for FOXD1:
Assays for FOXD1: |
Protein
Domains/
Families
for FOXD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXD1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q16676ProtoNet protein and cluster: Q16676 UniProtKB/Swiss-Prot: FOXD1_HUMAN, Q16676Similarity: Contains 1 fork-head DNA-binding domain |
Gene Function
for FOXD1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FOXD1_HUMAN, Q16676Function: Transcription factor required for formation of positional identity in the developing retina, regionalizationof the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly (By similarity)
Genatlas biochemistry entry for FOXD1:transcription factor-like 8,with a Drosophila homeo forkhead DNA binding domain homolog,kidney expressed (involved inkidney development)5/11 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 11): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IDA | 7957066 | | GO:0003690 | double-stranded DNA binding |
ISS | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
ISS | -- | | GO:0003704 | specific RNA polymerase II transcription factor activity |
ISS | -- | | GO:0003705 | sequence-specific enhancer binding RNA polymerase II transcription factor activity |
ISS | -- |
About this table
FOXD1 for ontologies About GeneDecksing
Animal Models: 8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Foxd1):
FOXD1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FOXD1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for FOXD1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXD1
5/24 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 24): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0001658 | branching involved in ureteric bud morphogenesis |
ISS | -- | | GO:0001755 | neural crest cell migration |
ISS | -- | | GO:0001822 | kidney development |
ISS | -- | | GO:0007389 | pattern specification process |
ISS | -- |
About this table
FOXD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for FOXD1
|
Transcripts
for FOXD1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FOXD1 gene: NM_004472.2 Additional cDNA sequence: U13222.1 U59832.1 2 DOTS entries: DT.113053 DT.95264588 24/25 AceView cDNA sequences (see all 25): U13222 AW022278 AA724254 BU728193 AA885070 AI739311 BU621287 BM929966 CB112634 AA341525 AA977269 BV204581 AI823914 BM999901 U59832 CB149239 BM706862 AI073371 BG121021 AI818164 NM_004472 AA778677 BI495774 W46229
 highest scoring ESTs for FOXD1:U13222 U59832 AA341525 AA724254 AA778677 AA885070 AA977269 AI073371 AI818164 AI823914 Unigene Cluster for FOXD1: Forkhead box D1 Hs.519385 [show with all ESTs]Unigene Representative Sequence: NM_004472
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000499003 ENST00000328926(uc003kcp.2)
|
Expression
for FOXD1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FOXD1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching FOXD1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33203_s_at2, 3
|
U95-A |
2 |
0.50 |
0.54 |
1.00 |
1.00 |
U59831 |
0.20 |
1.00 |
0.72 |
1 |
| 206307_s_at2, 3
|
U133-A |
2 |
0.46 |
0.50 |
-- |
-- |
NM_004472 |
0.60 |
1.00 |
0.82 |
1 |
| 206307_s_at2
|
U133Plus2 |
2 |
0.46 |
0.50 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FOXD1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTACACAAG
SOURCE GeneReport for Unigene cluster: Hs.519385
Expression variation in blood from EXPOLDB for FOXD1 SABiosciences Custom PCR Arrays for FOXD1
|
Orthologs
for FOXD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FOXD1 gene from 5/8 species (see all 8)
About this table Species with no ortholog for FOXD1
ENSEMBL Gene Tree for FOXD1 (if available) |
Paralogs
for FOXD1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for FOXD1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 5 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FOXD1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FOXD1
2 CNVs: 64230 80956 |
Disorders & Mutations
for FOXD1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOXD1 for disorders About GeneDecksing
OMIM: 601091
Export disorders and mutations for FOXD1 gene to outside databases
|
Medical News
for FOXD1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FOXD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
4 PubMed articles for FOXD1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with FOXD1)- Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PubMed id 7957066)1, 2, 3 Pierrou S....Carlsson P. (1994)
- Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53. (PubMed id 8702877)1, 2 Ernstsson S.... Enerbaeck S. (1996)
- Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). (PubMed id 8825632)1, 3 Larsson C....Carlsson P. (1995)
- Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta. (PubMed id 15716278)1, 7 Berg D.T....Grinnell B.W. (2005)
|
External Searches for FOXD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXD1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FOXD1 gene:
Search GeneIP for patents involving FOXD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXD1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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