Aliases &
Descriptions
for FOXK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| forkhead box K11 2 | | FLJ149772 | | Myocyte nuclear factor2 3 | | FOXK1L2 | | MNF2 3 | | forkhead box protein K12 | | IMAGE:51644971 | | |
Export aliases for FOXK1 gene to outside databasesPrevious GC identifers: GC07U901483 GC07P004496 |
Summaries
for FOXK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a rolein myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiologicalstimuli (By similarity)
Gene Wiki entry for FOXK1 |
Genomic Views
for FOXK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXK1 gene promoter:
FOXO4 p53 FOXO1a STAT3 STAT5B ER-alpha STAT5A STAT1 STAT1alpha STAT1beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXK1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FOXK1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22FOXK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P004588: view genomic region
(about GC identifiers)
Start:
|
4,638,801 bp from pter |
End:
|
4,811,074 bp from pter |
Size:
|
172,274 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000007.13 NT_007819.17 NT_079592.2
|
Proteins
for FOXK1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037 (See
protein sequence)Recommended Name: Forkhead box protein K1 Size: 733 amino acids; 75457 Da
Subunit: Interacts with SIN3B to form a complex which represses transcription (By similarity)
Subcellular location: Nucleus (Probable)Alternative splicing: 2 isoforms: P85037-1 P85037-2 Explore the universe of human proteins at neXtProt for FOXK1: NX_P85037
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001032242.1
ENSEMBL proteins: ENSP00000394442 ENSP00000328720
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FOXK1 for ontologies About GeneDecksing
Antibodies for FOXK1:
Assays for FOXK1: |
Protein
Domains/
Families
for FOXK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXK1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P85037ProtoNet protein and cluster: P85037 UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037Similarity: Contains 1 FHA domainSimilarity: Contains 1 fork-head DNA-binding domain |
Gene Function
for FOXK1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a rolein myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiologicalstimuli (By similarity)
5/11 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 11): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000287 | magnesium ion binding |
ISS | -- | | GO:0003690 | double-stranded DNA binding |
ISS | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
ISS | -- | | GO:0003704 | specific RNA polymerase II transcription factor activity |
ISS | -- | | GO:0003705 | sequence-specific enhancer binding RNA polymerase II transcription factor activity |
ISS | -- |
About this table
FOXK1 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Foxk1):
FOXK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FOXK1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for FOXK1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXK1
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0007275 | multicellular organismal development |
-- | -- | | GO:0007389 | pattern specification process |
ISS | -- | | GO:0007517 | muscle organ development |
IEA | -- | | GO:0009790 | embryo development |
ISS | -- |
About this table
FOXK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FOXK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for FOXK1
|
Transcripts
for FOXK1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FOXK1 gene: NM_001037165.1 Additional cDNA sequence: AK022628.1 AK122663.1 AK302243.1 BC038434.1 BX538089.1 12 DOTS entries: DT.91666561 DT.443423 DT.309308 DT.95262466 DT.121048047 DT.95190633 DT.91808076 DT.100737927 DT.121048088 DT.121128834 DT.87015898 DT.97825583
 highest scoring ESTs for FOXK1:AA077540 AA078590 AA368166 AA405812 AA837313 AI085174 AL134029 AW007319 AW389254 AW504141 Unigene Cluster for FOXK1: Forkhead box K1 Hs.487393 [show with all ESTs]Unigene Representative Sequence: NM_001037165
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446823 ENST00000328914(uc003sna.1 uc003snb.1 uc003snc.1 uc003snd.1)
ENST00000496023 ENST00000460979
|
Expression
for FOXK1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FOXK1 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching FOXK1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 54973_at2, 3
|
U95-C |
2 |
0.75 |
0.92 |
0.56 |
0.47 |
AI125260 |
0.80 |
0.80 |
0.80 |
1 |
| 49183_at2, 3
|
U95-C |
2 |
0.50 |
0.60 |
0.18 |
1.35 |
AW007319 |
0.60 |
1.00 |
0.82 |
1 |
| 49186_g_at2, 3
|
U95-C |
2 |
0.38 |
0.62 |
0.54 |
1.35 |
AW007319 |
0.60 |
1.00 |
0.82 |
1 |
| 88823_at*2, 3
|
U95-E |
1 |
-- |
-- |
0.70 |
0.86 |
AA809282 |
0.20 |
1.00 |
0.72 |
1 |
| 230342_at2, 3
|
U133-B |
2 |
0.91 |
0.95 |
-- |
-- |
AI125260 |
0.80 |
0.80 |
0.80 |
1 |
| 226715_at2, 3
|
U133-B |
2 |
0.64 |
0.65 |
-- |
-- |
AW007319 |
0.60 |
1.00 |
0.82 |
1 |
| 230342_at2
|
U133Plus2 |
2 |
0.91 |
0.95 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 226715_at2
|
U133Plus2 |
2 |
0.64 |
0.65 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FOXK1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.487393
UniProtKB/Swiss-Prot: FOXK1_HUMAN, P85037Tissue specificity: Expressed both developing and adult tissues. In adults, significant expression is seen in tumors ofthe brain, colon and lymph node
SABiosciences Custom PCR Arrays for FOXK1
|
Orthologs
for FOXK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FOXK1 gene from 5/7 species (see all 7)
About this table Species with no ortholog for FOXK1
ENSEMBL Gene Tree for FOXK1 (if available) |
Paralogs
for FOXK1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for FOXK1 gene
- FOXJ12 FOXK22 KIAA04152
FOXK1 for paralogs About GeneDecksing
|
Genomic Variants
for FOXK1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FOXK1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FOXK1
1 CNV: 3662
2 Indels: 12904 47362 | | QIAGEN SeqTarget long-range PCR primers for resequencing FOXK1 |
|
Disorders & Mutations
for FOXK1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for FOXK1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FOXK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/26 PubMed articles for FOXK1 gene, integrated from 7 sources (see all 26):
(articles sorted by number of sources associating them with FOXK1)- Identification and characterization of human FOXK1 gene in silico. (PubMed id 15202027)1, 2, 3 Katoh M. and Katoh M. (2004)
- Identification and characterization of a novel human FOXK1 gene in silico. (PubMed id 15289879)1, 2, 7 Huang J.T. and Lee V. (2004)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for FOXK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOXK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXK1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FOXK1 gene:
Search GeneIP for patents involving FOXK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXK1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for FOXK1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for FOXK1 |
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