Aliases &
Descriptions
for FPR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| formyl peptide receptor 11 2 | | N-formylpeptide chemoattractant receptor2 3 | | FPR1 2 3 | | fMet-Leu-Phe receptor2 | | FMLP1 2 | | N-formyl peptide receptor3 | | fMLP receptor2 3 | | |
Export aliases for FPR1 gene to outside databasesPrevious GC identifers: GC19M052879 GC19M052610 GC19M056924 GC19M056940 GC19M052249 |
Summaries
for FPR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FPR1:
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupledreceptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms andis important in host defense and inflammation.
UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462Function: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors.Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein thatactivates a phosphatidylinositol-calcium second messenger system
 summary
for FPR1: The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower
expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are
involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil
chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of
degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and
cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been
implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity
is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more
complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered
on chromosome 19q13.3-13.4.
Gene Wiki entry for FPR1 (Formyl peptide receptor 1) |
Genomic Views
for FPR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FPR1 gene promoter:
AP-1 NF-kappaB1 FOXO4 FOXO1a STAT3 c-Fos c-Jun NF-kappaB ATF c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for FPR1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41FPR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M048579: view genomic region
(about GC identifiers)
Start:
|
48,579,824 bp from pter |
End:
|
48,585,911 bp from pter |
Size:
|
6,088 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 52,249,027-52,255,150 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for FPR1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462 (See
protein sequence)Recommended Name: fMet-Leu-Phe receptor Size: 350 amino acids; 38446 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q14939 Q7Z6A4 Q86U52 Q9NS48Explore the universe of human proteins at neXtProt for FPR1: NX_P21462
Post-translational modifications:
Phosphorylated; which is necessary for desensitization1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001180235.1 NP_002020.1
ENSEMBL proteins: ENSP00000302707
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FPR1 for ontologies About GeneDecksing
Antibodies for FPR1:
Assays for FPR1: |
Protein
Domains/
Families
for FPR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FPR1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21462ProtoNet protein and cluster: P21462 1 Blocks protein family: IPB000826 Formyl-methionyl peptide receptor signature
UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462Similarity: Belongs to the G-protein coupled receptor 1 family |
Gene Function
for FPR1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462Function: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors.Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein thatactivates a phosphatidylinositol-calcium second messenger system
Genatlas biochemistry entry for FPR1:formyl peptide (bacterial) receptor 1,mediating chemotaxis and inducing leukocyte activation,(formyl-Met-Leu-Phe),Gprotein coupled,secretin receptor superfamily3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
FPR1 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fpr1):
FPR1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FPR1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
FPR1 for pathways About GeneDecksing
2  Millipore Pathways for FPR1
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for FPR1
2  Kegg Pathways (Kegg details for FPR1):  | hsa04080 Neuroactive ligand-receptor interaction | | hsa05150 Staphylococcus aureus infection |
SABiosciences Pathway-Focused PCR Arrays including FPR1: PAHS-3009A PAHS-3803A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FPR1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FPR1
5/29 Interacting proteins for FPR1 (ENSP000003027073) via UniProtKB, MINT, and/or STRING (see all 29)About this table
5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7): About this table
FPR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FPR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
FPR1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for FPR1 |
Compounds for FPR1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| WKYMVm | FPR1, FPR2 and FPR3 receptor agonist | [187986-17-0] | | N-Formyl-Met-Leu-Phe | Endogenous FPR1 agonist | [59880-97-6] |
About this table
10/71  Novoseek chemical compound relationships for FPR1 gene (see all 71)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fmlp |
96.2 |
661 |
7619076 (8), 9850337 (8), 9178189 (7), 8756080 (7) (see all 99) |
| n-formylmethionyl-leucylphenylalanine |
91.2 |
62 |
8392932 (4), 1935939 (3), 2163872 (2), 7525325 (2) (see all 41) |
| cyclosporin h |
89.2 |
12 |
9727041 (3), 15494526 (1), 16549058 (1), 12370393 (1) (see all 8) |
| fr 901459 |
81.7 |
3 |
10908115 (1), 12361388 (1) |
| fnlpntl |
73.1 |
2 |
8756080 (1), 11369647 (1) |
| leukotriene b4 |
69 |
24 |
8241512 (2), 8756080 (2), 9845549 (1), 11135292 (1) (see all 13) |
| superoxide |
65.8 |
44 |
9178189 (3), 8136611 (3), 17692291 (3), 8225024 (2) (see all 29) |
| lxa4 |
62.8 |
7 |
1910866 (3), 12410796 (2), 8376607 (1), 8527441 (1) |
| calcium |
62.4 |
117 |
1744114 (4), 9207244 (4), 9353293 (4), 1910866 (3) (see all 56) |
| cytochalasin |
60.6 |
1 |
8509449 (1) |
About this table
|
Transcripts
for FPR1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FPR1 gene (2 alternative transcripts): NM_001193306.1 NM_002029.3 Additional cDNA sequence: AK314935.1 BC005315.1 BT007429.1 CR617277.1 M37128.1 M60627.1 2 DOTS entries: DT.114544 DT.121504046 24/86 AceView cDNA sequences (see all 86): CR617277 NM_002029 M60627 BX283670 BQ637261 BT007429 BI518820 BG540422 AI394681 M60626 AL553297 CB528963 CD369350 CD369210 AI744388 AA425767 BM055345 BU741238 BG485087 CB993626 BV197143 AW051494 BI909107 M78084
 highest scoring ESTs for FPR1:BC005315 BF030509 BG483022 BG485087 BG540422 BG570426 BG745611 BI518820 BI835348 BI909107 Unigene Cluster for FPR1: Formyl peptide receptor 1 Hs.753 [show with all ESTs]Unigene Representative Sequence: BM924794
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304748(uc002pxq.2)
|
Expression
for FPR1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FPR1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching FPR1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36919_r_at2, 3
|
U95-A |
1 |
0.50 |
1.00 |
1.00 |
1.00 |
M60626 |
0.80 |
1.00 |
0.91 |
1 |
| 205119_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_002029 |
0.60 |
1.00 |
0.82 |
1 |
| 205118_at2, 3
|
U133-A |
1 |
0.27 |
1.00 |
-- |
-- |
M60626 |
0.80 |
1.00 |
0.91 |
1 |
| 205119_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 205118_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FPR1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGCCAGGACT
SOURCE GeneReport for Unigene cluster: Hs.753
Expression variation in blood from EXPOLDB for FPR1 UniProtKB/Swiss-Prot: FPR1_HUMAN, P21462Tissue specificity: Neutrophils
SABiosciences Expression via Pathway-Focused PCR Arrays including FPR1: PAHS-3009A PAHS-3803A
|
Orthologs
for FPR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FPR1 gene from 3 species
About this table Species with no ortholog for FPR1
ENSEMBL Gene Tree for FPR1 (if available) |
Paralogs
for FPR1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for FPR1 gene
- FPR32 C3AR12 C5AR12 GPR322 CMKLR12 FPR22 GPR32P2
FPR1 for paralogs About GeneDecksing
|
Genomic Variants
for FPR1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FPR1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FPR1
3 CNVs: 8875 34482 4085 | | QIAGEN SeqTarget long-range PCR primers for resequencing FPR1 |
|
Disorders & Mutations
for FPR1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FPR1 for disorders About GeneDecksing
OMIM: 136537
10/17 Novoseek disease relationships for FPR1 gene (see all 17)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| periodontitis juvenile |
67.3 |
3 |
11559706 (1), 10534074 (1), 11607790 (1) |
| leukemia basophilic |
56.9 |
6 |
19706734 (1), 17082621 (1), 20195765 (1), 11238659 (1) (see all 5) |
| malignant glioma |
45.7 |
11 |
17611713 (2), 15258259 (1), 19233142 (1), 19037090 (1) (see all 5) |
| glioblastoma |
44.3 |
43 |
19037090 (5), 17575160 (4), 18433988 (4), 15928303 (4) (see all 12) |
| inflammation |
39.7 |
13 |
8573582 (1), 9845549 (1), 14500740 (1), 16118363 (1) (see all 11) |
| bacterial infections |
35.1 |
7 |
15187149 (1), 15623572 (1), 11238229 (1), 18060741 (1) (see all 5) |
| glioma |
20.9 |
28 |
15928303 (4), 16516855 (4), 17520823 (3), 19233142 (2) (see all 8) |
| necrosis |
6.39 |
6 |
15147563 (1), 11238229 (1), 12747235 (1), 7518434 (1) (see all 6) |
| tuberculosis |
4.97 |
1 |
12869034 (1) |
| cancer |
0.493 |
1 |
2007248 (1) |
About this table
Human Gene Mutation Database (HGMD): FPR1
Genetic Association Database (GAD): FPR1
Human Genome Epidemiology (HuGE) Navigator: FPR1 (13 documents)
Export disorders and mutations for FPR1 gene to outside databases
|
Medical News
for FPR1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FPR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/365 PubMed articles for FPR1 gene, integrated from 7 sources (see all 365):
(articles sorted by number of sources associating them with FPR1)- Evaluation of human leukocyte N-formylpeptide recepto r (FPR1) SNPs in aggressive periodontitis patients. (PubMed id 12595898)1, 3, 4, 7 Zhang Y....Hart T.C. (2003)
- Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. (PubMed id 2161213)1, 2, 3 Boulay F.... Vignais P. (1990)
- Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 2, 7 Bao L.... Gerard C. (1992)
- Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression. (PubMed id 1445895)1, 2, 7 Perez H.D.... Andrews W.H. (1992)
- The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. (PubMed id 2176894)1, 2, 7 Boulay F.... Vignais P. (1990)
- Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. (PubMed id 10514456)1, 2, 7 Maestes D.C.... Prossnitz E.R. (1999)
- Sequence and organization of the human N-formyl peptide receptor- encoding gene. (PubMed id 8224916)1, 2, 7 Murphy P.M.... Ahuja S.K. (1993)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. (PubMed id 1712023)1, 2 Murphy P.M. and McDermott D. (1991)
|
External Searches for FPR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FPR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FPR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FPR1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FPR1 gene:
Search GeneIP for patents involving FPR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FPR1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Tocris compounds for FPR1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for FPR1 |
| |
|
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