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FZD6 Gene

protein-coding GIFtS: 62

GC08P099511

frizzled homolog 6 (Drosophila)
(Previous name: frizzled (Drosophila) homolog 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
frizzled homolog 6 (Drosophila)¹ ²		frizzled-6²
frizzled (Drosophila) homolog 6¹		seven transmembrane helix receptor²
Hfz6¹		HFZ6²
fz-6²		Fz-6³
FZ6²		hFz6³

External Ids:	HGNC: 4044¹	Entrez Gene: 8323²	Ensembl: ENSG00000164930⁷	UniProtKB: O60353³

Export aliases for FZD6 gene to outside databases

Previous GC identifers: GC08P103316 GC08P104379 GC08P103979 GC08P104267

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD6:

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are

receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a

cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family

members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative

regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic

transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript

variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FZD6 gene promoter:
         HNF-4alpha2   COUP-TF1   Meis-1   HOXA9B   Pax-2   Tal-1beta   E47   Cdc5   Tal-1   Nkx6-1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for FZD6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FZD6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3-q23.1 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3-q23.1

FZD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD6 gene location

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P099511: view genomic region (about GC identifiers)

Start:	99,511,909 bp from pter
End:	99,546,152 bp from pter
Size:	34,244 bases
Orientation:	plus strand

1 alternative location:

Chr8+ 104,310,661-104,345,094

RefSeq DNA sequence:

NC_000008.10 NT_008046.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353 (See protein sequence)

Recommended Name: Frizzled-6 precursor

Size: 706 amino acids; 79292 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q6N0A5 Q6P9C3 Q8WXR9

Explore the universe of human proteins at neXtProt for FZD6: NX_O60353

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001158087.1 NP_001158088.1 NP_003497.2

ENSEMBL proteins:

ENSP00000429055 ENSP00000428188 ENSP00000427733 ENSP00000351605 ENSP00000429528 ENSP00000428257

ENSP00000428301

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: FZD6
	GenScript Custom Purified and Recombinant Proteins Services for FZD6
	Novus Biologicals Protein for FZD6
	Novus Biologicals Lysate for FZD6
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	18029348
GO:0005887	integral to plasma membrane	ISS	15265686
GO:0016020	membrane	--	--
GO:0016327	apicolateral plasma membrane	IEA	--
GO:0045177	apical part of cell	IEA	--

About this table

FZD6 for ontologies About GeneDecksing

Antibodies for FZD6:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FZD6
	R&D Systems Antibodies for FZD6 (Frizzled-6)
	Cell Signaling Technology (CST) Antibodies for FZD6
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for FZD6
	Novus Biologicals Antibodies for FZD6
	Browse antibodies at Epitomics

Assays for FZD6:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FZD6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FZD6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZD6 for domains About GeneDecksing

4 InterPro domains/families:

IPR000539 Frizzled

IPR020067 Frizzled_dom

IPR015526 Frizzled-related

IPR017981 GPCR_2-like

Graphical View of Domain Structure for InterPro Entry O60353

ProtoNet protein and cluster: O60353

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Domain: Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity)

Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)

Similarity: Belongs to the G-protein coupled receptor Fz/Smo family

Similarity: Contains 1 FZ (frizzled) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FZD6 Sigma-Aldrich shRNA Panels and shRNA for FZD6
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): FZD6 OriGene shRNA RFP (see all 3): FZD6 OriGene basic RS shRNA (see all 3): FZD6 OriGene siRNA (see all 3): FZD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FZD6

miRNA:		Sigma-Aldrich microRNA Mimics for FZD6 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FZD6
		8/17 SABiosciences Assays for microRNAs that regulate FZD6 (see all 17):
		hsa-miR-607 hsa-miR-520e hsa-miR-301a hsa-miR-519a hsa-miR-372 hsa-miR-520d-3p hsa-miR-302b hsa-miR-130b

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): FZD6 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): FZD6 OriGene untagged cDNA clones in CMV expression vector: FZD6 OriGene 3'-UTR clone (see all 3): FZD6 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FZD6
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for FZD6

Genatlas biochemistry entry for FZD6:

Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT

receptor,expressed in various normal adult and fetal tissues,involved in signal transduction,activating Dishevelled

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	--	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	IPI	10347172
GO:0017147	Wnt-protein binding	ISS	15265686
GO:0042813	Wnt receptor activity	IDA	10347172

About this table

FZD6 for ontologies About GeneDecksing

Animal Models: 9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fzd6):

embryogenesis	hearing/vestibular/ear	lethality-prenatal/perinatal	limbs/digits/tail	nervous system
normal	reproductive system	skin/coat/nails	vision/eye

FZD6 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

FZD6 for pathways About GeneDecksing

2 Millipore Pathways for FZD6

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/13 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for FZD6 (see all 13)

	Colorectal Cancer Metastasis Signaling
	Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
	Ovarian Cancer Signaling
	Axonal Guidance Signaling
	Wnt/β-catenin Signaling

4 Kegg Pathways (Kegg details for FZD6):

	hsa04310 Wnt signaling pathway
	hsa04916 Melanogenesis
	hsa05200 Pathways in cancer
	hsa05217 Basal cell carcinoma

SABiosciences Pathway-Focused PCR Arrays including FZD6 (see all 4): PAHS-043A PAHS-047A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FZD6

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FZD6

5/49 Interacting proteins for FZD6 (ENSP00000351605³) via UniProtKB, MINT, and/or STRING (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FZD3	ENSP00000240093³	STRING: ENSP00000240093
WNT11	ENSP00000325526³	STRING: ENSP00000325526
WNT5A	ENSP00000264634³	STRING: ENSP00000264634
WNT6	ENSP00000233948³	STRING: ENSP00000233948
GNAS	ENSP00000302237³	STRING: ENSP00000302237

About this table

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001736	establishment of planar polarity	IEA	--
GO:0001843	neural tube closure	IEA	--
GO:0007166	cell surface receptor linked signaling pathway	--	--
GO:0007275	multicellular organismal development	IEA	--
GO:0035567	non-canonical Wnt receptor signaling pathway	IDA	14747478

About this table

FZD6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

FZD6 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZD6
2 PharmGKB drug compound relationships for FZD6 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FZD6 Sigma-Aldrich shRNA Panels and shRNA for FZD6
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): FZD6 OriGene shRNA RFP (see all 3): FZD6 OriGene basic RS shRNA (see all 3): FZD6 OriGene siRNA (see all 3): FZD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FZD6

miRNA:		Sigma-Aldrich microRNA Mimics for FZD6 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FZD6
		8/17 SABiosciences Assays for microRNAs that regulate FZD6 (see all 17):
		hsa-miR-607 hsa-miR-520e hsa-miR-301a hsa-miR-519a hsa-miR-372 hsa-miR-520d-3p hsa-miR-302b hsa-miR-130b

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): FZD6 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): FZD6 OriGene untagged cDNA clones in CMV expression vector: FZD6 OriGene 3'-UTR Clone (see all 3): FZD6 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for FZD6

Primers:		OriGene genome-wide validated SYBR primer pairs: FZD6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FZD6: PPH02402A

REFSEQ mRNAs for FZD6 gene (3 alternative transcripts):

NM_001164615.1 NM_001164616.1 NM_003506.3

Additional cDNA sequence:

AB012911.1 AB209734.1 AF072873.1 AK296824.1 AK299341.1 AK304092.1 AK313789.1 AK316544.1

BC036106.1 BC060836.1 BX538222.1 BX640609.1 CR623773.1

12 DOTS entries:

DT.95265004 DT.100687502 DT.313636 DT.101982634 DT.92043230 DT.99972645 DT.121479276 DT.121479296

DT.313638 DT.121479236 DT.121479264 DT.95265002

24/119 AceView cDNA sequences (see all 119):

AU131025 BX109942 NM_003506 CR623773 AW148330 BP351890 AI220799 CD644741

BU627239 N57630 AU131395 CA394506 CA413718 AA337236 BX640609 BF437445

BM995893 AI954576 BG570639 AI857747 D63299 AL558533 BX479752 BM955984

highest scoring ESTs for FZD6:

AB012911 AA064897 AA065217 AA319328 AA337236 AF072873 AW513314 AW590991 BC036106 BC060836

Unigene Cluster for FZD6:

Frizzled homolog 6 (Drosophila)

Hs.591863 [show with all ESTs]

Unigene Representative Sequence: BX538222

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FZD6

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10
SP1:
SP2:													-
SP3:			-		-

About this scheme

ECgene alternative splicing isoforms for FZD6
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000522566 ENST00000521195 ENST00000519011 ENST00000358755(uc003ylh.2 uc003yli.2 uc003ylj.2 uc011lhn.1 uc011lho.1 uc011lhp.1)

ENST00000523739 ENST00000523933 ENST00000522484

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FZD6 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching FZD6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34472_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.91	AB012911	1.00	1.00	1.00	1
47968_at²^{, 3}	U95-B	1	0.81	1.00	0.99	1.09	AA065217	0.80	1.00	0.91	1
203987_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003506	0.60	1.00	0.82	1
203987_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

FZD6 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

FZD6 gene electronic northern expression

About these images

CGAP SAGE TAG: ACCACCCATT

SOURCE GeneReport for Unigene cluster: Hs.591863

Expression variation in blood from EXPOLDB for FZD6

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Tissue specificity: Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus,

prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney

Primers:		OriGene genome-wide validated SYBR primer pairs: FZD6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for FZD6: PPH02402A

SABiosciences Expression via Pathway-Focused PCR Arrays including FZD6 (see all 4): PAHS-043A PAHS-047A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FZD6 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FZD6¹	--	frizzled homolog 6 (Drosophila)	91.22(n) 92.78(a)	403610 NM_001003065.1 NP_001003065.1
chimpanzee (Pan troglodytes)	FZD6¹	--	frizzled homolog 6 (Drosophila)	99.58(n) 99.29(a)	464327 XM_001156717.1 XP_001156717.1
cow (Bos taurus)	FZD6¹	--	frizzled homolog 6 (Drosophila)	90.56(n) 90.79(a)	445418 XM_863880.2 XP_868973.2
rat (Rattus norvegicus)	Fzd6¹	--	frizzled homolog 6 (Drosophila)	84.37(n) 85.8(a)	282581 XM_343230.3 XP_343231.3
mouse (Mus musculus)	Fzd6^{1 , 5}	15 (15.22 cM)⁵	frizzled homolog 6 (Drosophila)^{1, 5}	83.48(n)¹ 84.19(a)¹	14368¹ NM_008056.2¹ NP_032082.2¹ AA869784⁵ AK088399⁵ (see all 13)

About this table Species with no ortholog for FZD6

ENSEMBL Gene Tree for FZD6 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FZD6 gene

FZD3² FZD10² FZD1² FZD8² FZD5² FZD9² FZD2² FZD7²

FZD4²

FZD6 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs703808^1,2	C,F,H,	104320928(-)	`AGATAT/CGGGAA`	2	--	int¹		18	NS EA NA WA	982
rs703809^1,2	C,F,H,	104321313(-)	`gcacaC/Tcaaag`	2	--	int¹		11	NS EA NA WA	504
rs703810^1,2	C,F,O,	104333838(-)	`ATGCCA/GTAACC`	2	--	int¹		16	NS EA NA WA	1390
rs827524^1,2	--	104310388(+)	`TAACCA/GTCATT`	2	--	ng5¹		4	EA NA MN	242
rs827525^1,2	C,H,	104311476(+)	`CAGGTG/TCCCGG`	2	--	int¹		9	MN NA WA	270
rs827526^1,2	C,F,O,	104311523(+)	`TGGGGC/AGCGGG`	2	--	int¹		11	MN NS NA EA WA	832
rs827527^1,2	C,F,O,H,	104311714(+)	`GAAAAG/TCGAGA`	2	--	int¹		12	MN NS EA NA WA	686
rs827528^1,2	C,F,O,A,	104312432(+)	`GATGTA/G/TTGAAA`	9	M V L	ref¹ mis¹		18	MN NA NS EA WA	1218
rs827529^1,2	C,H,	104313605(+)	`TTCATT/GAATCA`	2	--	int¹		8	NA WA	86
rs827530^1,2	C,F,A,	104314709(+)	`ACCCCA/CGAACC`	2	--	int¹		12	NS EA NA WA	638

About this table

HapMap Linkage Disequilibrium images for FZD6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FZD6: --

QIAGEN SeqTarget long-range PCR primers for resequencing FZD6

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FZD6 for disorders About GeneDecksing

OMIM: 603409

1 PharmGKB disease relationship for FZD6 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

About this table

Human Genome Epidemiology (HuGE) Navigator: FZD6 (2 documents)
Tumor Gene Database (TGDB): FZD6

Export disorders and mutations for FZD6 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/19 PubMed articles for FZD6 gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with FZD6)

Molecular cloning of human frizzled-6. (PubMed id 9480858)^{1, 2, 3, 7} Tokuhara M.... Katoh M. (1998)
The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. (PubMed id 14747478)^{1, 3} Golan T....Gazit A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)¹ Yerges L.M....Zmuda J.M. (2009)
Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PubMed id 19543507)¹ Kim J.G....Moon S.Y. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway. (PubMed id 19034702)¹ Miyakoshi T....Osamura R.Y. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. (PubMed id 17516841)¹ Sirchia R. and Luparello C. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8323	HGNC: 4044	AceView: FZD6	Ensembl:ENSG00000164930	euGenes: HUgn8323
ECgene: FZD6	Kegg: 8323	H-InvDB: FZD6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for FZD6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FZD6 gene
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