Aliases &
Descriptions
for FZD7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| frizzled homolog 7 (Drosophila)1 2 | | Frizzled, drosophila, homolog of, 72 | | FzE31 2 3 | | fz-72 | | hFz72 3 | | frizzled-72 | | frizzled (Drosophila) homolog 71 | | Fz-73 |
Export aliases for FZD7 gene to outside databasesPrevious GC identifers: GC02P201116 GC02P201623 GC02P202863 GC02P203101 GC02P202724 GC02P202607 |
Summaries
for FZD7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FZD7:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signalingproteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-richextracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail witha PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediatedsignals in poorly differentiated human esophageal carcinomas. (provided by RefSeq)
UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signalingpathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation ofbeta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has beenseen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integratedin the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathwaysseem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission ofpolarity information during tissue morphogenesis and/or in differentiated tissues
Gene Wiki entry for FZD7 |
Genomic Views
for FZD7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FZD7 gene promoter:
HNF-4alpha2 COUP-TF1 RSRFC4 NF-E2 p45 NF-E2 GATA-1 PPAR-gamma2 PPAR-gamma1 CP1A NF-Y
Other transcription factors
Search SABiosciences Chromatin IP Primers for FZD7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FZD7  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33FZD7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P194748: view genomic region
(about GC identifiers)
Start:
|
194,748,666 bp from pter |
End:
|
194,752,510 bp from pter |
Size:
|
3,845 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr2+ 202,899,310-202,903,160 |
RefSeq DNA sequence:- NC_000002.11 NT_005403.17
|
Proteins
for FZD7 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084 (See
protein sequence)Recommended Name: Frizzled-7 precursor Size: 574 amino acids; 63620 Da
Subunit: Interacts with MAGI3 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O94816 Q53S59 Q96B74Explore the universe of human proteins at neXtProt for FZD7: NX_O75084
REFSEQ proteins: NP_003498.1
ENSEMBL proteins: ENSP00000286201
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
FZD7 for ontologies About GeneDecksing
Antibodies for FZD7:
Assays for FZD7: |
Protein
Domains/
Families
for FZD7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FZD7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75084ProtoNet protein and cluster: O75084 1 Blocks protein family: IPB000539 Frizzled protein signature
UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084Domain: Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity)Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)Similarity: Belongs to the G-protein coupled receptor Fz/Smo familySimilarity: Contains 1 FZ (frizzled) domain |
Gene Function
for FZD7 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signalingpathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation ofbeta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has beenseen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integratedin the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathwaysseem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission ofpolarity information during tissue morphogenesis and/or in differentiated tissues
Genatlas biochemistry entry for FZD7:Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNTreceptor,expressed in fetal kidney and adult skeletal muscle,heart,brain and placenta5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
FZD7 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Fzd7):
FZD7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FZD7 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
FZD7 for pathways About GeneDecksing
2  Millipore Pathways for FZD7
5/14  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for FZD7 (see all 14)
4  Kegg Pathways (Kegg details for FZD7):
SABiosciences Pathway-Focused PCR Arrays including FZD7 (see all 5): PAHS-043A PAHS-047A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FZD7
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZD7
5/46 Interacting proteins for FZD7 (ENSP000002862013 O750842) via UniProtKB, MINT, and/or STRING (see all 46)About this table
5/20 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 20): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007166 | cell surface receptor linked signaling pathway |
-- | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0010812 | negative regulation of cell-substrate adhesion |
IMP | 18156211 | | GO:0014834 | satellite cell maintenance involved in skeletal muscle regeneration |
-- | -- | | GO:0019827 | stem cell maintenance |
IMP | 18681827 |
About this table
FZD7 for ontologies About GeneDecksing
|
Drugs & Compounds
for FZD7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
FZD7 for compounds About GeneDecksing
 Browse Tocris compounds for FZD7
1  Novoseek chemical compound relationship for FZD7 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leucine |
37.1 |
3 |
15870913 (2) |
About this table
|
Transcripts
for FZD7 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for FZD7 gene: NM_003507.1 Additional cDNA sequence: AB010881.1 AB017365.1 AL110146.1 BC015915.1 1 DOTS entry: DT.445208 24/124 AceView cDNA sequences (see all 124): BM978276 BU931818 BM992571 AI002187 BQ002052 AA903072 CA425516 N69049 BF109383 BC015915 AI189384 AW072200 NM_003507 AB017365 AI129705 AA612575 BQ021995 AA938994 W00697 AA778339 BF434722 W52682 BI767816 CB158179
 highest scoring ESTs for FZD7:AB017365 AA218955 AA322982 AA582269 AA612575 AA648616 AA730381 AA778339 AA826516 AA834126 Unigene Cluster for FZD7: Frizzled homolog 7 (Drosophila) Hs.173859 [show with all ESTs]Unigene Representative Sequence: AB017365
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000286201(uc002uyw.1)
|
Expression
for FZD7 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| FZD7 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching FZD7 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33222_at2, 3
|
U95-A |
1 |
0.44 |
1.00 |
1.00 |
1.00 |
AB017365 |
1.00 |
0.90 |
0.95 |
1 |
| 203705_s_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
AI333651 |
0.80 |
1.00 |
0.91 |
1 |
| 203705_s_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
FZD7 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TACAGATCAC
SOURCE GeneReport for Unigene cluster: Hs.173859
Expression variation in blood from EXPOLDB for FZD7 UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart,brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas
SABiosciences Expression via Pathway-Focused PCR Arrays including FZD7 (see all 5): PAHS-043A PAHS-047A
|
Orthologs
for FZD7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FZD7 gene from 5/9 species (see all 9)
About this table Species with no ortholog for FZD7
ENSEMBL Gene Tree for FZD7 (if available) |
Paralogs
for FZD7 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for FZD7 gene
- FZD32 FZD102 FZD12 FZD82 FZD52 FZD92 FZD22 FZD42
- FZD62
FZD7 for paralogs About GeneDecksing
|
Genomic Variants
for FZD7 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for FZD7 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FZD7
1 CNV: 68222 | | QIAGEN SeqTarget long-range PCR primers for resequencing FZD7 |
|
Disorders & Mutations
for FZD7 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FZD7 for disorders About GeneDecksing
OMIM: 603410
2 Novoseek disease relationships for FZD7 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: FZD7 (8 documents)
Tumor Gene Database (TGDB): FZD7
Export disorders and mutations for FZD7 gene to outside databases
|
Medical News
for FZD7 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for FZD7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/37 PubMed articles for FZD7 gene, integrated from 7 sources (see all 37):
(articles sorted by number of sources associating them with FZD7)- A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2, 3, 7 Tanaka S.... Sugimachi K. (1998)
- Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 7 Sagara N.... Katoh M. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Down-regulation of frizzled-7 expression decreases su rvival, invasion and metastatic capabilities of colon cancer cells. (PubMed id 19773752)1, 7 Ueno K....Hinoda Y. (2009)
- Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. (PubMed id 18313787)1, 7 Kim M....Wands J.R. (2008)
- Frizzled-7 as a potential therapeutic target in colorectal cancer. (PubMed id 18592008)1, 7 Ueno K....Hinoda Y. (2008)
- Variable FZD7 expression in colorectal cancers indica tes regulation by the tumour microenvironment. (PubMed id 19655379)1 Vincan E....Spaderna S. (2010)
- Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
|
External Searches for FZD7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FZD7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FZD7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FZD7 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FZD7 gene:
Search GeneIP for patents involving FZD7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FZD7 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for FZD7 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for FZD7 |
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