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FZD7 Gene

protein-coding   GIFtS: 63

GC02P194748
frizzled homolog 7 (Drosophila)
(Previous name: frizzled (Drosophila) homolog 7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
frizzled homolog 7 (Drosophila)1 2     Frizzled, drosophila, homolog of, 72
FzE31 2 3     fz-72
hFz72 3     frizzled-72
frizzled (Drosophila) homolog 71     Fz-73

External Ids:    HGNC: 40451   Entrez Gene: 83242   Ensembl: ENSG000001557607   UniProtKB: O750843   

Export aliases for FZD7 gene to outside databases

Previous GC identifers: GC02P201116 GC02P201623 GC02P202863 GC02P203101 GC02P202724 GC02P202607


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD7:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling
proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich
extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with
a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated
signals in poorly differentiated human esophageal carcinomas. (provided by RefSeq)

UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD7 gene promoter:
         HNF-4alpha2   COUP-TF1   RSRFC4   NF-E2 p45   NF-E2   GATA-1   PPAR-gamma2   PPAR-gamma1   CP1A   NF-Y   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for FZD7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for FZD7 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

FZD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD7 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P194748:  view genomic region     (about GC identifiers)

Start:
194,748,666 bp from pter
End:
194,752,510 bp from pter
Size:
3,845 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 202,899,310-202,903,160     
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084 (See protein sequence)
Recommended Name: Frizzled-7 precursor  
Size: 574 amino acids; 63620 Da
Subunit: Interacts with MAGI3 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O94816 Q53S59 Q96B74

Explore the universe of human proteins at neXtProt for FZD7: NX_O75084 

REFSEQ proteins: NP_003498.1  

ENSEMBL proteins: 
ENSP00000286201 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
R&D Systems Recombinant & Natural Proteins for FZD7 (Frizzled-7)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: FZD7
GenScript Custom Purified and Recombinant Proteins Services for FZD7 
Novus Biologicals Proteins for FZD7
Novus Biologicals Lysate for FZD7
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IDA11256614
GO:0016020 membrane ----
GO:0016021 integral to membrane TAS9707618
About this table

FZD7 for ontologies           About GeneDecksing



Antibodies for FZD7: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for FZD7
R&D Systems Antibodies for FZD7 (Frizzled-7)
OriGene Antibodies: FZD7
GenScript Custom Superior Antibodies Services for FZD7 
Novus Biologicals Antibodies for FZD7
Browse antibodies at Epitomics

Assays for FZD7: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for FZD7 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for FZD7 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZD7 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR000539 Frizzled
 IPR020067 Frizzled_dom
 IPR015526 Frizzled-related
 IPR017981 GPCR_2-like

Graphical View of Domain Structure for InterPro Entry O75084

ProtoNet protein and cluster: O75084

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
Domain: Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity)
Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
Similarity: Contains 1 FZ (frizzled) domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
polarity information during tissue morphogenesis and/or in differentiated tissues

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FZD7
Sigma-Aldrich shRNA Panels and shRNA for FZD7
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): FZD7
OriGene shRNA RFP (see all 2): FZD7
OriGene basic RS shRNA (see all 2): FZD7
OriGene siRNA (see all 2): FZD7
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FZD7 
miRNA:Sigma-Aldrich microRNA Mimics for FZD7
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FZD7 
8/18 SABiosciences Assays for microRNAs that regulate FZD7 (see all 18):
hsa-miR-142-5p hsa-miR-548j hsa-miR-520d-5p hsa-miR-548i hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-613

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: FZD7
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FZD7
OriGene untagged cDNA clones in CMV expression vector (see all 2): FZD7
OriGene 3'-UTR clone: FZD7 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: FZD7 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for FZD7 

Genatlas biochemistry entry for FZD7:
Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT
receptor,expressed in fetal kidney and adult skeletal muscle,heart,brain and placenta

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0004888 transmembrane receptor activity ----
GO:0004930 G-protein coupled receptor activity IEA--
GO:0005515 protein binding ----
GO:0017147 Wnt-protein binding IPI18313787
GO:0030165 PDZ domain binding IPI18256285
About this table

FZD7 for ontologies           About GeneDecksing

Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fzd7):

no phenotypic analysis

FZD7 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


FZD7 for pathways           About GeneDecksing

2 Millipore Pathways for FZD7
    Transcription Androgen Receptor nuclear signaling
Translation Non-genomic (rapid) action of Androgen Receptor

5/14 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  FZD7 (see all 14)
    Factors Promoting Cardiogenesis in Vertebrates
Colorectal Cancer Metastasis Signaling
Axonal Guidance Signaling
Basal Cell Carcinoma Signaling
Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza

4 Kegg Pathways  (Kegg details for FZD7):
    hsa04310 Wnt signaling pathway
hsa04916 Melanogenesis
hsa05200 Pathways in cancer
hsa05217 Basal cell carcinoma

    SABiosciences Pathway-Focused PCR Arrays including FZD7 (see all 5): PAHS-043A PAHS-047A  

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for FZD7
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZD7

5/46 Interacting proteins for FZD7 (ENSP000002862013 O750842) via UniProtKB, MINT, and/or STRING (see all 46)
InteractantInteraction Details
GeneCardExternal ID(s)
UBQLN1Q9UMX02MINT-66943
UBQLN4Q9NRR52MINT-2864936
SDC4ENSP000003618183STRING: ENSP00000361818
DVL1L1ENSP000003681663STRING: ENSP00000368166
DVL2ENSP000000053403STRING: ENSP00000005340
About this table

5/20 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 20):

GO IDQualified GO termEvidencePubMed IDs
GO:0007166 cell surface receptor linked signaling pathway ----
GO:0007275 multicellular organismal development IEA--
GO:0010812 negative regulation of cell-substrate adhesion IMP18156211
GO:0014834 satellite cell maintenance involved in skeletal muscle regeneration ----
GO:0019827 stem cell maintenance IMP18681827
About this table

FZD7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

FZD7 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZD7
1 Novoseek chemical compound relationship for FZD7 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leucine 37.1 3 15870913 (2)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for FZD7
Sigma-Aldrich shRNA Panels and shRNA for FZD7
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): FZD7
OriGene shRNA RFP (see all 2): FZD7
OriGene basic RS shRNA (see all 2): FZD7
OriGene siRNA (see all 2): FZD7
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of FZD7 
miRNA: Sigma-Aldrich microRNA Mimics for FZD7
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of FZD7 
8/18 SABiosciences Assays for microRNAs that regulate FZD7 (see all 18):
hsa-miR-142-5p hsa-miR-548j hsa-miR-520d-5p hsa-miR-548i hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-613
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: FZD7
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: FZD7
OriGene untagged cDNA clones in CMV expression vector (see all 2): FZD7
OriGene 3'-UTR Clone: FZD7 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: FZD7 
Primers: OriGene genome-wide validated SYBR primer pairs: FZD7
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for FZD7: PPH02420A

REFSEQ mRNAs for FZD7 gene: 

NM_003507.1  

Additional cDNA sequence: 

AB010881.1 AB017365.1 AL110146.1 BC015915.1 

1 DOTS entry:

DT.445208 

24/124 AceView cDNA sequences (see all 124):

BM978276 BU931818 BM992571 AI002187 BQ002052 AA903072 CA425516 N69049 
BF109383 BC015915 AI189384 AW072200 NM_003507 AB017365 AI129705 AA612575 
BQ021995 AA938994 W00697 AA778339 BF434722 W52682 BI767816 CB158179 

highest scoring ESTs for FZD7:

AB017365 AA218955 AA322982 AA582269 AA612575 AA648616 AA730381 AA778339 AA826516 AA834126 

Unigene Cluster for FZD7:

Frizzled homolog 7 (Drosophila)
Hs.173859  [show with all ESTs]
Unigene Representative Sequence: AB017365


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000286201(uc002uyw.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

FZD7 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching FZD7 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
33222_at2, 3 U95-A 1 0.44 1.00 1.00 1.00 AB017365 1.00 0.90 0.95 1
203705_s_at2, 3 U133-A 1 0.46 1.00 -- -- AI333651 0.80 1.00 0.91 1
203705_s_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
About this table

FZD7 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
FZD7 gene expression
FZD7 gene electronic northern expression
FZD7 gene sage expression
About these images

CGAP SAGE TAG: TACAGATCAC

SOURCE GeneReport for Unigene cluster: Hs.173859

Expression variation in blood from EXPOLDB for FZD7

UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart,
brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas

Primers: OriGene genome-wide validated SYBR primer pairs: FZD7
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for FZD7: PPH02420A
    SABiosciences Expression via Pathway-Focused PCR Arrays including FZD7 (see all 5): PAHS-043A PAHS-047A  


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FZD7 gene from 5/9 species (see all 9)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
FZD71   -- frizzled homolog 7 (Drosophila) 93.55(n)
98.08(a)
488478  XM_545599.2  XP_545599.2 
chimpanzee
(Pan troglodytes)
FZD71   -- frizzled homolog 7 (Drosophila) 99.65(n)
100(a)
459881  XM_516034.2  XP_516034.2 
cow
(Bos taurus)
FZD71   -- frizzled homolog 7 (Drosophila) 92.92(n)
97.04(a)
524255  XM_602576.3  XP_602576.3 
mouse
(Mus musculus)
Fzd71 , 5 1 (30.08 cM)5
frizzled homolog 7 (Drosophila)1, 5 90.09(n)1
96.68(a)1
143691  NM_008057.21  NP_032083.21 
 AK0102395  AW1246505  (see all 10)
chicken
(Gallus gallus)
FZD71   -- frizzled homolog 7 (Drosophila) 84.59(n)
90.29(a)
374060  NM_204221.1  NP_989552.1 
About this table        Species with no ortholog for FZD7

ENSEMBL Gene Tree for FZD7 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for FZD7 gene
FZD32  FZD102  FZD12  FZD82  FZD52  FZD92  FZD22  FZD42  
FZD62  

FZD7 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/44 NCBI SNPs in FZD7 are shown (see all 44)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs167331,2
F202902881(-) TCGATTTTAAC/-
        
TTTAA
1 -- ut314Minor allele frequency- -:0.28EU NA EA 342
rs18018591,2
--202902962(+) ATCTTC/TTGTGC 1 -- ut310--------
rs22805091,2
C,F,202897368(+) ACCCCC/TGCAGG 1 -- ng5118Minor allele frequency- T:0.21EA NS MN NA 3534
rs46732221,2
C,F,202901910(+) AAGAAG/ATGATG 1 -- ut3117Minor allele frequency- A:0.17MN NS EA NA WA 1450
rs67079381,2
C,F,202897636(+) CACACG/CGGGCC 1 -- ng5110Minor allele frequency- C:0.06MN NS EA WA 878
rs115464131,2
--202900214(+) GGCGCC/TTCAGC 2 L F mis1 ref1 ese30--------
rs129945681,2
C,F,202897576(+) AAATGG/CTTGCT 1 -- ng5129Minor allele frequency- C:0.19NA NS EA MN WA 1950
rs130003171,2
C,202898137(+) GTCCTC/TGCTCC 1 -- ng517Minor allele frequency- T:0.28NA WA 132
rs130204971,2
C,F,202897519(+) TAGCCT/AGGTTT 1 -- ng5113Minor allele frequency- A:0.19NS EA NA WA 564
rs130342061,2
C,F,202901235(+) AAGTTC/TTTTGC 1 -- ut31 ese318Minor allele frequency- T:0.22NS EA NA MN WA 1841
About this table

HapMap Linkage Disequilibrium images for FZD7 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FZD7
     1 CNV: 68222

QIAGEN SeqTarget long-range PCR primers for resequencing FZD7 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FZD7 for disorders           About GeneDecksing

OMIM: 603410

2 Novoseek disease relationships for FZD7 gene

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma 46 1 15870913 (1)
gastric cancer 43.4 6 11408930 (4), 15870913 (1)
About this table

Human Genome Epidemiology (HuGE) Navigator: FZD7 (8 documents)
Tumor Gene Database (TGDB): FZD7

Export disorders and mutations for FZD7 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/37 PubMed articles for FZD7 gene, integrated from 7 sources (see all 37):
(articles sorted by number of sources associating them with FZD7)
  1. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2, 3, 7 Tanaka S.... Sugimachi K. (1998)
  2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 7 Sagara N.... Katoh M. (1998)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Down-regulation of frizzled-7 expression decreases su rvival, invasion and metastatic capabilities of colon cancer cells. (PubMed id 19773752)1, 7 Ueno K....Hinoda Y. (2009)
  5. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. (PubMed id 18313787)1, 7 Kim M....Wands J.R. (2008)
  6. Frizzled-7 as a potential therapeutic target in colorectal cancer. (PubMed id 18592008)1, 7 Ueno K....Hinoda Y. (2008)
  7. Variable FZD7 expression in colorectal cancers indica tes regulation by the tumour microenvironment. (PubMed id 19655379)1 Vincan E....Spaderna S. (2010)
  8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
  9. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
  10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8324 HGNC: 4045 AceView: FZD7 Ensembl:ENSG00000155760 euGenes: HUgn8324
ECgene: FZD7 Kegg: 8324 H-InvDB: FZD7

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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ATLAS Chromosomes in Cancer entry for FZD7 Genetics and Cytogenetics in Oncology and Haematology

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Patent Information for FZD7 gene:
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