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GABPB1 Gene

protein-coding GIFtS: 49

GC15M027400

GA binding protein transcription factor, beta subunit 1
(Previous names: GA binding protein transcription factor, beta subunit 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GABPB2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
GA binding protein transcription factor, beta subunit 1¹ ²		GABPB-1² ³
GABPB¹ ² ³ ⁵		GABP subunit beta-2² ³
E4TF1B² ³ ⁵		NRF2B1² ⁵
E4TF1-47¹ ²		BABPB2² ⁵
Transcription factor E4TF1-47² ³		GA binding protein transcription factor, beta subunit 2¹
Nuclear respiratory factor 2² ³		NRF2B2²
Transcription factor E4TF1-53² ³		E4TF1²
GABPB2² ³		GA-binding protein subunit beta-1²
GABP subunit beta-1² ³		E4TF1-53²
GABPB-2² ³

External Ids:	HGNC: 4074¹	Entrez Gene: 2553²	Ensembl: ENSG00000104064⁷	UniProtKB: Q06547³

Export aliases for GABPB1 gene to outside databases

Previous GC identifers: GC15M046126 GC15M043615 GC15M048358 GC15M050569

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABPB1:

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex

with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in

activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a

similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding

distinct isoforms have been identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547

Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the

expression of the Adenovirus E4 gene

Gene Wiki entry for GABPB1 (GABPB2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for GABPB1
Other transcription factors

Search SABiosciences Chromatin IP Primers for GABPB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GABPB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.2

GABPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABPB1 gene location

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M027400: view genomic region (about GC identifiers)

Start:	27,400,324 bp from pter
End:	27,478,454 bp from pter
Size:	78,131 bases
Orientation:	minus strand

1 alternative location:

Chr15- 50,569,389-50,647,605

RefSeq DNA sequence:

NC_000015.9 NT_010194.17

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547 (See protein sequence)

Recommended Name: GA-binding protein subunit beta-1

Size: 395 amino acids; 42483 Da

Subunit: Heterotetramer of two alpha and two beta subunits. Interacts with HCFC1, causing repression of transcriptional

activity

Subcellular location: Nucleus

Secondary accessions: A8IE52 Q06545 Q12940 Q12941 Q12942 Q8IYD0

Alternative splicing: 4 isoforms: Q06547-1 Q06547-2 Q06547-3 Q06547-4

Explore the universe of human proteins at neXtProt for GABPB1: NX_Q06547

REFSEQ proteins (5 alternative transcripts):

NP_002032.2 NP_005245.2 NP_057738.1 NP_057739.1 NP_852092.1

ENSEMBL proteins:

ENSP00000220429 ENSP00000370259 ENSP00000351923 ENSP00000395771 ENSP00000379728

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): GABPB1
	GenScript Custom Purified and Recombinant Proteins Services for GABPB1
	Novus Biologicals Proteins for GABPB1
	Novus Biologicals Lysates for GABPB1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9857059
GO:0005739	mitochondrion	--	--

About this table

GABPB1 for ontologies About GeneDecksing

Antibodies for GABPB1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GABPB1
	Browse R&D Systems for Antibodies
	OriGene Antibodies: GABPB1
	GenScript Custom Superior Antibodies Services for GABPB1
	Novus Biologicals Antibodies for GABPB1
	Epitomics antibodies for GABPB1

Assays for GABPB1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GABPB1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GABPB1 for domains About GeneDecksing

2 InterPro domains/families:

IPR002110 Ankyrin_rpt

IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q06547

ProtoNet protein and cluster: Q06547

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547

Similarity: Contains 5 ANK repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547

Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the

expression of the Adenovirus E4 gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GABPB1 Sigma-Aldrich shRNA for GABPB1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): GABPB1 OriGene shRNA RFP (see all 5): GABPB1 OriGene basic RS shRNA (see all 5): GABPB1 OriGene siRNA (see all 5): GABPB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GABPB1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GABPB1
		Search SABiosciences for Assays for microRNAs that regulate GABPB1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): GABPB1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): GABPB1 OriGene untagged cDNA clones in CMV expression vector (see all 7): GABPB1 OriGene 3'-UTR clone (see all 5): GABPB1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GABPB1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GABPB1

Genatlas biochemistry entry for GABPB1:

GA binding protein,beta subunit 1,component of the nuclear respiratory factor 1,interacting with GABPA to form a high

affinity DNA-binding complex recognizing an important site for herpes simplex virus type I activation,putatively

involved in the activation of nuclear genes specifying mitochondrial function

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8441384
GO:0005515	protein binding	IPI	10675337
GO:0010843	promoter binding	IDA	9857059
GO:0016563	transcription activator activity	IDA	9857059
GO:0046982	protein heterodimerization activity	IDA	9857059

About this table

GABPB1 for ontologies About GeneDecksing

Animal Models: 5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gabpb1):

behavior/neurological

immune system

lethality-prenatal/perinatal

muscle

nervous system

GABPB1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

GABPB1 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for GABPB1

Agrin Interactions at Neuromuscular Junction

SABiosciences Custom Pathway-Focused PCR Arrays for GABPB1

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GABPB1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GABPB1

5 Interacting proteins for GABPB1 (Q06547^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HCFC1	P51610¹	EBI-618165,EBI-396176
MAGEB18	Q96M61¹	EBI-618165,EBI-741835
BAI2	O60241²	MINT-75010
CIC	Q96RK0²	MINT-2859081
--	Q8CGM1²	MINT-75011 MINT-75009 MINT-75008

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	8441384
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	IDA	9857059
GO:0045449	regulation of transcription	IEA	--

About this table

GABPB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GABPB1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GABPB1 Sigma-Aldrich shRNA for GABPB1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): GABPB1 OriGene shRNA RFP (see all 5): GABPB1 OriGene basic RS shRNA (see all 5): GABPB1 OriGene siRNA (see all 5): GABPB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GABPB1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GABPB1
		Search SABiosciences for Assays for microRNAs that regulate GABPB1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): GABPB1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): GABPB1 OriGene untagged cDNA clones in CMV expression vector (see all 7): GABPB1 OriGene 3'-UTR Clone (see all 5): GABPB1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GABPB1

Primers:		OriGene genome-wide validated SYBR primer pairs: GABPB1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for GABPB1

REFSEQ mRNAs for GABPB1 gene (5 alternative transcripts):

NM_002041.4 NM_005254.5 NM_016654.4 NM_016655.4 NM_181427.3

Additional cDNA sequence:

AK301350.1 AK303901.1 BC016910.1 BC036080.1 BC050702.1 BT006652.1 CR591958.1 D13316.1

D13317.1 EU159454.1 U13045.1 U13046.1 U13047.1 U13048.1

13 DOTS entries:

DT.97823854 DT.100688291 DT.100796128 DT.95271555 DT.100796127 DT.453073 DT.121078254 DT.121078274

DT.121078225 DT.121078268 DT.121078283 DT.446655 DT.121078313

24/196 AceView cDNA sequences (see all 196):

AA665626 BQ186620 AI804122 W38337 BC009935 AW003076 BU631828 AI803474

AI475518 AI468623 U13047 BQ430343 AI636537 NM_181427 BQ050762 AA764814

BC036080 AA913022 BQ421507 BC016910 BM684569 CA416618 AA136871 AI468559

Unigene Cluster for GABPB1:

GA binding protein transcription factor, beta subunit 1

Hs.654350 [show with all ESTs]

Unigene Representative Sequence: NM_005254

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GABPB1 (see all 7)

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10
SP1:							-												-								-		-
SP2:							-																				-		-
SP3:							-												-
SP4:							-
SP5:																			-

About this scheme

ECgene alternative splicing isoforms for GABPB1
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000220429 ENST00000380877(uc001zya.2 uc001zyb.2 uc010ufg.1)

ENST00000359031(uc001zyc.2 uc001zyf.2) ENST00000429662(uc001zyd.2 uc001zye.2)

ENST00000396464

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GABPB1 expression in normal and diseased human tissues

¹ / ²

7 probe-sets matching GABPB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35943_s_at²	U95-A	1	1.00	1.00	0.04	0.45	--	--	--	--	--
37275_at²	U95-A	1	0.75	1.00	-0.16	0.39	--	--	--	--	--
35942_at²	U95-A	2	0.50	0.73	1.00	1.00	--	--	--	--	--
206173_x_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204618_s_at²	U133-A	1	0.82	1.00	--	--	--	--	--	--	--
206173_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204618_s_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

About this table

GABPB1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GABPB1 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.654350

Primers:		OriGene genome-wide validated SYBR primer pairs: GABPB1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for GABPB1

SABiosciences Custom PCR Arrays for GABPB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GABPB1 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GABPB1¹	--	GA binding protein transcription factor, beta subunit more	94.95(n) 100(a)	608465 XM_857380.1 XP_862473.1
chimpanzee (Pan troglodytes)	GABPB1¹	--	GA binding protein transcription factor, beta subunit more	99.83(n) 100(a)	453426 XM_001168421.1 XP_001168421.1
cow (Bos taurus)	GABPB1¹	--	GA binding protein transcription factor, beta subunit more	95.3(n) 100(a)	520313 NM_001075804.1 NP_001069272.1
rat (Rattus norvegicus)	Gabpb1l¹	--	GA binding protein transcription factor, beta subunit more	90.77(n) 98.59(a)	364738 XM_344606.3 XP_344607.2
mouse (Mus musculus)	Gabpb1^{1 , 5}	2 (61.76 cM)⁵	GA repeat binding protein, beta 1^{1, 5}	91.62(n)¹ 98.17(a)¹	14391¹ NM_207669.1¹ NP_997552.1¹ AK052828⁵ AK075646⁵ (see all 27)

About this table Species with no ortholog for GABPB1

ENSEMBL Gene Tree for GABPB1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GABPB1 gene

ANKRD39² GABPB2²

GABPB1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1645^1,2	C,F,O,A,H,	50641824(+)	`GATATG/ATTTCT`	4	--	int¹		26	NS EA WA NA CA CSAM MN	1996
rs8552^1,2		50646783(+)	`CACTGC/TCAACC`	4	--	int¹		1	MN	184
rs12470^1,2	--	50570061(-)	`GTTCTC/AGGAAG`	2	--	ut3¹ ese³		1	MN	184
rs12923^1,2	C,F,O,	50570036(-)	`ATAACT/CTGAAT`	2	--	ut3¹		25	MN NS EA NA WA	3148
rs504781^1,2	C,F,A,H,	50648339(+)	`AACTTA/C/TTAGCA`	4	--	ng5¹		9	NS NA WA	420
rs526045^1,2	C,F,O,H,	50645530(+)	`TAACAG/TCTTGA`	4	--	int¹		26	EA NA NS WA	1582
rs526952^1,2	C,F,A,H,	50645617(+)	`GTACAG/ATGGAG`	4	--	int¹		15	NS EA NA WA	1062
rs535648^1,2	C,F,A,	50649361(+)	`agtctC/Ttgttt`	4	--	ng5¹		16	NS EA NA WA	1024
rs717025^1,2	C,F,O,	50642739(-)	`TGGATA/GAAGAG`	4	--	int¹		17	NA EA NS WA	794
rs953159^1,2	C,F,A,	50648711(-)	`GGGGGC/AAACGA`	4	--	ng5¹		7	EA NA NS WA	474

About this table

HapMap Linkage Disequilibrium images for GABPB1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GABPB1
1 CNV: 58726
1 Indel: 45346

QIAGEN SeqTarget long-range PCR primers for resequencing GABPB1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GABPB1 for disorders About GeneDecksing

OMIM: 600610

Human Genome Epidemiology (HuGE) Navigator: GABPB1 (3 documents)

Export disorders and mutations for GABPB1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/52 PubMed articles for GABPB1 gene, integrated from 7 sources (see all 52):
(articles sorted by number of sources associating them with GABPB1)

Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. (PubMed id 7799916)^{1, 2, 7} Gugneja S.... Scarpulla R.C. (1995)
The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. (PubMed id 10675337)^{1, 2} Vogel J.L. and Kristie T.M. (2000)
Nuclear respiratory factors 1 and 2 utilize similar glutamine- containing clusters of hydrophobic residues to activate transcription. (PubMed id 8816484)^{1, 2} Gugneja S.... Scarpulla R.C. (1996)
Molecular and genetic characterization of GABP beta. (PubMed id 7958862)^{1, 3} de la Brousse F.C....McKnight S.L. (1994)
Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. (PubMed id 8383622)^{1, 2} Virbasius J.V.... Scarpulla R.C. (1993)
cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. (PubMed id 8441384)^{1, 2} Watanabe H.... Handa H. (1993)
Interaction between SNPs in the NRF2 gene and elite e ndurance performance. (PubMed id 20028934)^{1, 7} Eynon N....Meckel Y. (2010)
An empirical framework for binary interactome mapping . (PubMed id 19060904)¹ Venkatesan K....Vidal M. (2009)
PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression. (PubMed id 18343819)¹ Vercauteren K....Scarpulla R.C. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2553	HGNC: 4074	AceView: GABPB2	Ensembl:ENSG00000104064	euGenes: HUgn2553
ECgene: GABPB1	H-InvDB: GABPB1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for GABPB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for GABPB1 gene:
Search GeneIP for patents involving GABPB1

GeneCards and IP:
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Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Predesigned and custom siRNAs for GABPB1		Antibodies for GABPB1
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	Antibodies		Cell Culture Products
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GABPB1
	SeqTarget long-range PCR primers for resequencing GABPB1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GABPB1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GABPB1

	GenScript Custom Purified and Recombinant Proteins Services for GABPB1		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GABPB1
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	GenScript Custom overexpressing Cell Line Services for GABPB1		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Antibodies for GABPB1

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GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

GABPB1 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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GABPB1 Gene

protein-coding GIFtS: 49

Aliases &
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GABPB1 (Gene Symbol)
GA binding protein transcription factor, beta subunit 1
GABPB
E4TF1B
E4TF1-47
Transcription factor E4TF1-47
Nuclear respiratory factor 2
Transcription factor E4TF1-53
GABPB2
GABP subunit beta-1
GABPB-2
GABPB-1
GABP subunit beta-2
NRF2B1
BABPB2
GA binding protein transcription factor, beta subunit 2
NRF2B2
E4TF1
GA-binding protein subunit beta-1
E4TF1-53

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Export list of displayed genes

GABPB1 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor GABPB1 gene

Summariesfor GABPB1 gene

Genomic Viewsfor GABPB1 gene

Proteinsfor GABPB1 gene

Protein Domains/Familiesfor GABPB1 gene

Gene Functionfor GABPB1 gene

Pathways & Interactionsfor GABPB1 gene

Drugs & Compoundsfor GABPB1 gene

Transcriptsfor GABPB1 gene

Expression for GABPB1 gene

Orthologsfor GABPB1 gene

Paralogsfor GABPB1 gene

Genomic Variantsfor GABPB1 gene

Disorders & Mutationsfor GABPB1 gene

Medical Newsfor GABPB1 gene

Publicationsfor GABPB1 gene

External Searches for GABPB1 gene

Genome Databases showing GABPB1 gene

Other Databases showing GABPB1 gene

Specialized Databases showing GABPB1 gene

Intellectual Propertyfor GABPB1 gene

Productsfor GABPB1 gene

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Aliases &
Descriptions
for GABPB1 gene

Summaries
for GABPB1 gene

Genomic Views
for GABPB1 gene

Proteins
for GABPB1 gene

Protein Domains/
Families
for GABPB1 gene

Gene Function
for GABPB1 gene

Pathways & Interactions
for GABPB1 gene

Drugs & Compounds
for GABPB1 gene

Transcripts
for GABPB1 gene

Expression
for GABPB1 gene

Orthologs
for GABPB1 gene

Paralogs
for GABPB1 gene

Genomic Variants
for GABPB1 gene

Disorders & Mutations
for GABPB1 gene

Medical News
for GABPB1 gene

Publications
for GABPB1 gene

Intellectual Property
for GABPB1 gene

Products
for GABPB1 gene