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GAGE2D Gene

protein-coding   GIFtS: 29

GC0XP049209
G antigen 2D
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
G antigen 2D1 2 3     Cancer/testis antigen 4.83
GAGE81 2     CT4.83
OTTHUMP000000703102     GAGE-83
MGC263952     

External Ids:    HGNC: 319591   Entrez Gene: 7294082   Ensembl: ENSG000002402577   UniProtKB: Q9UEU53   

Export aliases for GAGE2D gene to outside databases

Previous GC identifers: GC0XU900855 GC0XP049096 GC0XP049098 GC0XP049099 GC0XP049191 GC0XP049206


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GAGE2D
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GAGE2D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

GAGE2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAGE2D gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049209:  view genomic region     (about GC identifiers)

Start:
49,188,104 bp from pter
End:
49,214,420 bp from pter
Size:
26,317 bases
Orientation:
plus strand

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GAGE8_HUMAN, Q9UEU5 (See protein sequence)
Recommended Name: G antigen 8  
Size: 116 amino acids; 12764 Da
Secondary accessions: A6NG46 A6NNR8 B7ZL76 Q4V325

Explore the universe of human proteins at neXtProt for GAGE2D: NX_Q9UEU5 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001091877.1  

    ENSEMBL proteins: 
    ENSP00000365346 ENSP00000386110 


    Human Recombinant Proteins 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GAGE2D for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008625 GAGE

    Graphical View of Domain Structure for InterPro Entry Q9UEU5

    ProtoNet protein and cluster: Q9UEU5

    1 Blocks protein family: IPB008625 GAGE

    UniProtKB/Swiss-Prot: GAGE8_HUMAN, Q9UEU5
    Similarity: Belongs to the GAGE family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    Sigma-Aldrich siRNA for GAGE2D
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    OriGene siRNA: GAGE2D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GAGE2D 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GAGE2D 
    Search SABiosciences for Assays for microRNAs that regulate GAGE2D

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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    OriGene GFP tagged cDNA clones in CMV expression vector: GAGE2D
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    Cell
    Lines:
      
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    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding ----
    About this table

    GAGE2D for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for GAGE2D 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE2D

    1 Interacting protein for GAGE2D (Q9UEU51, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GMCL1LQ8NEA91, 2EBI-751641,EBI-745707 MINT-68200
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968 cellular defense response ----
    About this table

    GAGE2D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAGE2D


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for GAGE2D
    Sigma-Aldrich shRNA for GAGE2D
    OriGene 29mer shRNA kits in GFP-retroviral vector: GAGE2D
    OriGene shRNA RFP: GAGE2D
    OriGene basic RS shRNA: GAGE2D
    OriGene siRNA: GAGE2D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GAGE2D 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GAGE2D 
    Search SABiosciences for Assays for microRNAs that regulate GAGE2D
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GAGE2D
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GAGE2D
    OriGene untagged cDNA clones in CMV expression vector: GAGE2D
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GAGE2D 
    Primers: OriGene genome-wide validated SYBR primer pairs: GAGE2D
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for GAGE2D

    REFSEQ mRNAs for GAGE2D gene: 

    NM_001098407.1  



    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376176(uc011mni.1) ENST00000404720(uc010njc.2 uc004dnt.3 uc004dnu.3 uc004dnv.3)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GAGE2D expression in normal and diseased human tissues

    1 Data from GNF BioGPS
        About these images

    GAGE2D gene expression
    GAGE2D gene electronic northern expression
    GAGE2D gene sage expression
    About these images

    CGAP SAGE TAG: --

    UniProtKB/Swiss-Prot: GAGE8_HUMAN, Q9UEU5
    Tissue specificity: Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of
    various histological origins

    Primers: OriGene genome-wide validated SYBR primer pairs: GAGE2D
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for GAGE2D
        SABiosciences Custom PCR Arrays for GAGE2D 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    ENSEMBL Gene Tree for GAGE2D (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for GAGE2D gene
    GAGE2E1 2  GAGE2C1 2  GAGE2B1 2  GAGE131 2  GAGE2A1 2  GAGE12I1 2  GAGE12G1 2  GAGE12F1 2  
    GAGE11 2  GAGE12J1 2  GAGE12D1 2  GAGE12C1 2  GAGE12E1 2  GAGE12H1 2  XAGE32  GAGE102  
    XAGE52  XAGE2B2  PAGE12  XAGE22  

    GAGE2D for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for GAGE2D
         5 CNVs: 33164 96665 83510 73974 31551
    Search QIAGEN SeqTarget long-range PCR primers for resequencing for GAGE2D 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GAGE2D for disorders           About GeneDecksing

    OMIM: 300735


    Export disorders and mutations for GAGE2D gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    5 PubMed articles for GAGE2D gene integrated from 7 sources:
    (articles sorted by number of sources associating them with GAGE2D)
    1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1 Gjerstorff M.F. and Ditzel H.J. (2008)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)2 De Backer O.... van der Bruggen P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729408 HGNC: 31959 Ensembl:ENSG00000240257 euGenes: HUgn729408 ECgene: GAGE2D
    H-InvDB: GAGE2D

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for GAGE2D gene:
    Search GeneIP for patents involving GAGE2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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