Aliases &
Descriptions
for GAGE4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| G antigen 41 2 | | CT4.41 2 3 | | Cancer/testis antigen 4.42 3 | | GAGE-42 3 | | cancer/testis antigen family 4, member 42 |
Export aliases for GAGE4 gene to outside databasesPrevious GC identifers: GC0XU990067 GC0XP047420 GC0XP048024 GC0XP048252 GC0XP049028 GC0XP049103 GC0XP049056 GC0XP049069 GC0XP049088 GC0XP049213 |
Summaries
for GAGE4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GAGE4:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except forthe testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions.The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologouscytolytic T lymphocytes. (provided by RefSeq)
|
Genomic Views
for GAGE4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GAGE4
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAGE4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.4-p11.2 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.4-p11.2GAGE4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP049357: view genomic region
(about GC identifiers)
Start:
|
49,354,099 bp from pter |
End:
|
49,373,139 bp from pter |
Size:
|
19,041 bases |
Orientation:
|
plus strand |
3 alternative locations:
| ChrX+ 49,315,892-49,342,360 | ChrX+ 49,296,824-49,332,811 | ChrX+ 49,178,558-49,223,943 | |
|
Proteins
for GAGE4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GAGE4_HUMAN, Q13068 (See
protein sequence)Recommended Name: G antigen 4 Size: 117 amino acids; 12885 Da
Secondary accessions: A8MU85 Q6NT33Explore the universe of human proteins at neXtProt for GAGE4: NX_Q13068
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001465.1
ENSEMBL proteins: ENSP00000347280 ENSP00000406557 ENSP00000371119 ENSP00000385596 ENSP00000371128
Human Recombinant Proteins
Antibodies for GAGE4:
Assays for GAGE4: |
Protein
Domains/
Families
for GAGE4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAGE4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q13068ProtoNet protein and cluster: Q13068 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGE4_HUMAN, Q13068Similarity: Belongs to the GAGE family |
Gene Function
for GAGE4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
|
Pathways & Interactions
for GAGE4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for GAGE4
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE4
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006968 | cellular defense response |
-- | -- |
About this table
GAGE4 for ontologies About GeneDecksing
|
Drugs & Compounds
for GAGE4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for GAGE4
|
Transcripts
for GAGE4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GAGE4 gene: NM_001474.1 24/29 AceView cDNA sequences (see all 29): BM832793 NM_001474 BC024914 U19145 U19143 BX283580 NM_001472 BC005363 AW016546 AF055473 AW510753 BC018052 NM_012196 CF780547 BC069309 BX108227 BM836228 AA447559 BG120838 BG208433 AW102587 BP431265 AA738037 BG206349
 highest scoring ESTs for GAGE4:CF780497 BC081536 EC473459
GeneLoc Exon Structure
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355154(uc011mnu.1) ENST00000451387 ENST00000381700 ENST00000403519
ENST00000381709(uc004doj.2 uc004dok.1 uc004dol.1)
|
Expression
for GAGE4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GAGE4 expression in normal and diseased human tissues
1 / 2 / 3 13 probe-sets matching GAGE4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 31960_f_at2, 3
|
U95-A |
23 |
1.00 |
0.09 |
0.66 |
0.89 |
U19143 |
0.40 |
0.03 |
0.28 |
3 |
| 33680_f_at2, 3
|
U95-A |
23 |
0.94 |
0.08 |
0.49 |
0.75 |
AF058988 |
0.60 |
0.06 |
0.43 |
2 |
| 33671_f_at2, 3
|
U95-A |
23 |
0.88 |
0.08 |
0.88 |
0.81 |
U19145 |
0.60 |
0.06 |
0.43 |
2 |
| 31498_f_at2, 3
|
U95-A |
23 |
0.88 |
0.08 |
0.82 |
1.25 |
U19147 |
0.60 |
0.06 |
0.43 |
3 |
| 31954_f_at2, 3
|
U95-A |
23 |
0.88 |
0.08 |
0.58 |
0.44 |
AA447559 |
0.60 |
0.06 |
0.43 |
2 |
| 37065_f_at2, 3
|
U95-A |
23 |
0.88 |
0.08 |
0.63 |
1.19 |
U19146 |
0.60 |
0.06 |
0.43 |
2 |
| 31953_f_at2, 3
|
U95-A |
23 |
0.50 |
0.11 |
0.36 |
0.65 |
U19144 |
0.20 |
0.05 |
0.15 |
4 |
| 207739_s_at2
|
U133-A |
23 |
1.00 |
0.11 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208235_x_at2
|
U133-A |
20 |
0.73 |
0.08 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206640_x_at2
|
U133-A |
20 |
0.73 |
0.08 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 207739_s_at2
|
U133Plus2 |
23 |
1.00 |
0.11 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208235_x_at2
|
U133Plus2 |
20 |
0.73 |
0.08 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206640_x_at2
|
U133Plus2 |
20 |
0.73 |
0.08 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GAGE4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: GAGE4_HUMAN, Q13068Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis
SABiosciences Custom PCR Arrays for GAGE4
|
Orthologs
for GAGE4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for GAGE4 (if available) |
Paralogs
for GAGE4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GAGE4 gene
- XAGE32 GAGE2D2 GAGE12H2 GAGE102 GAGE12I2 XAGE52 XAGE2B2 GAGE12C2
- GAGE12E2 GAGE2E2 GAGE2C2 GAGE12D2 GAGE12F2 PAGE12 GAGE132 XAGE22
- GAGE12G2 GAGE2B2 GAGE2A2 GAGE12J2
GAGE4 for paralogs About GeneDecksing
|
Genomic Variants
for GAGE4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GAGE4
5 CNVs: 33164 96665 83510 73974 31551 |
Disorders & Mutations
for GAGE4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GAGE4 for disorders About GeneDecksing
OMIM: 300597
Export disorders and mutations for GAGE4 gene to outside databases
|
Medical News
for GAGE4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GAGE4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
7 PubMed articles for GAGE4 gene integrated from 7 sources:
(articles sorted by number of sources associating them with GAGE4)- A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PubMed id 7544395)1, 2, 3 van den Eynde B....Boon T. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1 Gjerstorff M.F. and Ditzel H.J. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)1 De Backer O.... van der Bruggen P. (1999)
- Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1 Chen M.E.... Sikes R.A. (1998)
|
External Searches for GAGE4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GAGE4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GAGE4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAGE4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GAGE4 gene:
Search GeneIP for patents involving GAGE4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GAGE4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for GAGE4 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for GAGE4 |
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