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GAPDHS Gene

protein-coding   GIFtS: 56

GC19P032529
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAPDS)
Products    

Aliases &
Descriptions
for GAPDHS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic1 2     GAPDS2 3
GAPD21 2 3 5     glyceraldehyde-3-phosphate dehydrogenase, testis-specific2
GAPDH-21 2 3     HSD-352
Spermatogenic glyceraldehyde-3-phosphate dehydrogenase2 3     EC 1.2.1.123
Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 22 3     GAPDH23

External Ids:    HGNC: 248641   Entrez Gene: 263302   Ensembl: ENSG000001056797   UniProtKB: O145563   

Export aliases for GAPDHS gene to outside databases

Previous GC identifers: GC19P040717 GC19P036024


Summaries
for GAPDHS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GAPDHS:
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an
important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in
a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde
3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in
regulating the switch between different energy-producing pathways, and it is required for sperm motility and male
fertility. (provided by RefSeq)

UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
Function: May play an important role in regulating the switch between different pathways for energy production during
spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)

Gene Wiki entry for GAPDHS

Genomic Views
for GAPDHS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAPDHS gene promoter:
         c-Myb   ZID   Pax-6   AREB6   Hlf   CUTL1   POU2F1   GATA-1   LUN-1   C/EBPalpha   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GAPDHS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GAPDHS 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

GAPDHS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAPDHS gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P032529:  view genomic region     (about GC identifiers)

Start:
 32,529,762 bp from pter
End:
 32,541,666 bp from pter
Size:
 11,905 bases
Orientation:
 plus strand

1 alternative location:
Chr19+ 36,024,314-36,036,221     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

Proteins
for GAPDHS gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556 (See protein sequence)
Recommended Name: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific  
Size: 408 amino acids; 44501 Da
Subunit: Homotetramer (By similarity). Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2
stimulation
Subcellular location: Cytoplasm (By similarity)
PDB structures from and Proteopedia :
3H9E (3D)    
Secondary accessions: B2RC82 O60823 Q6JTT9 Q9HCU6

Explore the universe of human proteins at neXtProt for GAPDHS: NX_O14556 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_055179.1  

    ENSEMBL proteins: 
    ENSP00000222286 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: GAPDHS
    OriGene Protein Over-expression Lysate: GAPDHS
    GenScript Custom Purified and Recombinant Proteins Services for GAPDHS 
    Novus Biologicals Protein for GAPDHS
    Novus Biologicals Lysates for GAPDHS
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol TAS--
    GO:0009434 microtubule-based flagellum IEA--
    GO:0019861 flagellum ----
    About this table

    GAPDHS for ontologies           About GeneDecksing



    Antibodies for GAPDHS: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GAPDHS
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for GAPDHS 
    Novus Biologicals Antibodies for GAPDHS
    Browse antibodies at Epitomics

    Assays for GAPDHS: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GAPDHS 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GAPDHS 

    Protein Domains/
    Families
    for GAPDHS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GAPDHS for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR020831 GlycerAld/Erythrose_P_DH
     IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
     IPR006424 Glyceraldehyde-3-P_DH_1
     IPR020830 GlycerAld_3-P_DH_AS
     IPR020829 GlycerAld_3-P_DH_cat

    Graphical View of Domain Structure for InterPro Entry O14556

    ProtoNet protein and cluster: O14556

    1 Blocks protein family: IPB000173 Glyceraldehyde 3-phosphate dehydrogenase

    UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
    Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family


    Gene Function
    for GAPDHS gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
    Function: May play an important role in regulating the switch between different pathways for energy production during
    spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)
    Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
    Enzyme Number (IUBMB): EC 1.2.1.12 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GAPDHS
    Sigma-Aldrich shRNA for GAPDHS
    OriGene 29mer shRNA kits in GFP-retroviral vector: GAPDHS
    OriGene shRNA RFP: GAPDHS
    OriGene basic RS shRNA: GAPDHS
    OriGene siRNA: GAPDHS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GAPDHS 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GAPDHS 
    Search SABiosciences for Assays for microRNAs that regulate GAPDHS

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GAPDHS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GAPDHS
    OriGene untagged cDNA clones in CMV expression vector: GAPDHS
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GAPDHS 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for GAPDHS 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity TAS10714828
    GO:0005515 protein binding IPI16820410
    GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity ----
    GO:0016491 oxidoreductase activity IEA--
    GO:0051287 NAD or NADH binding IEA--
    About this table

    GAPDHS for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Gapdhs):

    reproductive system

    GAPDHS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GAPDHS gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    GAPDHS for pathways           About GeneDecksing

    1 Millipore Pathway for GAPDHS
        Glycolysis and gluconeogenesis (short map)

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  GAPDHS
        Glycolysis/Gluconeogenesis

    2 Kegg Pathways  (Kegg details for GAPDHS):
        hsa00010 Glycolysis / Gluconeogenesis
    hsa01100 Metabolic pathways

    UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
    Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5

        SABiosciences Custom Pathway-Focused PCR Arrays for GAPDHS 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GAPDHS
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAPDHS

    5/27 Interacting proteins for GAPDHS (ENSP000002222863 O145561) via UniProtKB, MINT, and/or STRING (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTHL1P785491EBI-1057431,EBI-1049350
    ACYP2ENSP000003064483STRING: ENSP00000306448
    ALDOAENSP000003369273STRING: ENSP00000336927
    ALDOBENSP000003639883STRING: ENSP00000363988
    ALDOCENSP000002262533STRING: ENSP00000226253
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975 carbohydrate metabolic process TAS--
    GO:0006006 glucose metabolic process TAS--
    GO:0006094 gluconeogenesis TAS--
    GO:0006096 glycolysis TAS--
    GO:0007286 spermatid development IEA--
    About this table

    GAPDHS for ontologies           About GeneDecksing



    Drugs & Compounds
    for GAPDHS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    GAPDHS for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAPDHS
    1 Novoseek chemical compound relationship for GAPDHS gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 78.5 6 7736666 (2), 17680766 (1), 16700075 (1), 10714828 (1) (see all 5)
    About this table



    Transcripts
    for GAPDHS gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GAPDHS
    Sigma-Aldrich shRNA for GAPDHS
    OriGene 29mer shRNA kits in GFP-retroviral vector: GAPDHS
    OriGene shRNA RFP: GAPDHS
    OriGene basic RS shRNA: GAPDHS
    OriGene siRNA: GAPDHS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GAPDHS 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GAPDHS 
    Search SABiosciences for Assays for microRNAs that regulate GAPDHS
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GAPDHS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GAPDHS
    OriGene untagged cDNA clones in CMV expression vector: GAPDHS
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GAPDHS 
    Primers: OriGene genome-wide validated SYBR primer pairs: GAPDHS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GAPDHS: PPH14985A

    REFSEQ mRNAs for GAPDHS gene: 

    NM_014364.4  

    Additional cDNA sequence: 

    AJ005371.1 AK225727.1 AK314980.1 AY306129.1 BC036373.2 

    3 DOTS entries:

    DT.432666  DT.75133827  DT.121504578 

    24/48 AceView cDNA sequences (see all 48):

    AJ005371 BX280438 BI520497 BG769351 BI826019 BM564052 R88358 BI520542 
    BU726467 BI520157 BM563402 BP371243 BF689842 BM554283 BG720276 BG761940 
    BM908146 BG765069 BP369787 BP370184 NM_014364 BU185616 BP369039 BI830649 

    highest scoring ESTs for GAPDHS:

    AJ005371 AY306129 BC036373 BF690226 BF980153 BI520802 BM563402 BU185616 BU726467 AI986320 

    Unigene Cluster for GAPDHS:

    Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
    Hs.248017  [show with all ESTs]
    Unigene Representative Sequence: NM_014364


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GAPDHS

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                               
    SP2:                                                                              
    SP3:              -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for GAPDHS
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000222286(uc002oaf.1)

    Expression
    for GAPDHS gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GAPDHS expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching GAPDHS gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34542_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 AJ005371 1.00 1.00 1.00 1
    207116_s_at2, 3 U133-A 1 0.64 1.00 -- -- NM_014364 0.60 1.00 0.82 1
    207116_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    GAPDHS for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GAPDHS gene expression
    GAPDHS gene electronic northern expression
    GAPDHS gene sage expression
    About these images

    CGAP SAGE TAG: GTGAAATAAA

    SOURCE GeneReport for Unigene cluster: Hs.248017

    Expression variation in blood from EXPOLDB for GAPDHS

    UniProtKB/Swiss-Prot: G3PT_HUMAN, O14556
    Tissue specificity: Testis specific

    Primers: OriGene genome-wide validated SYBR primer pairs: GAPDHS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GAPDHS: PPH14985A
        SABiosciences Custom PCR Arrays for GAPDHS 


    Orthologs
    for GAPDHS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for GAPDHS gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 GAPDHS1   -- glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 84.49(n)
    86.07(a)    		 476483  XM_533693.2  XP_533693.2 
    chimpanzee
    (Pan troglodytes)    		 GAPDHS1   -- glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 99.18(n)
    98.77(a)    		 455951  XM_512590.2  XP_512590.2 
    cow
    (Bos taurus)    		 GAPDHS1   -- glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 85.57(n)
    86.84(a)    		 532231  NM_001040552.1  NP_001035642.1 
    rat
    (Rattus norvegicus)    		 Gapdhs1   -- glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 79.49(n)
    83.33(a)    		 66020  NM_023964.1  NP_076454.1 
    mouse
    (Mus musculus)    		 Gapdhs1 , 5 7 (19.23 cM)5
    		 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic1, 5 79.41(n)1
    82.6(a)1    		 144471  NM_008085.11  NP_032111.11 
     AK1318055  BC1529185  (see all 6)
    About this table        Species with no ortholog for GAPDHS

    ENSEMBL Gene Tree for GAPDHS (if available)

    Paralogs
    for GAPDHS gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for GAPDHS gene
    GAPDH2  

    GAPDHS for paralogs           About GeneDecksing


    Pseudogenes
    3 related pseudogenes



    Genomic Variants
    for GAPDHS gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/119 NCBI SNPs in GAPDHS are shown (see all 119)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs22399421,2
    		C,F,36030448(+) ACACAT/CACACA 1 -- int114Minor allele frequency- C:0.27EA NS WA NA 2480
    rs22399431,2
    		C,36030507(+) CTGTCC/TGGGCC 1 -- int16Minor allele frequency- T:0.38EA NA 1650
    rs22399441,2
    		C,H,36032301(+) gctgcG/Agtgag 1 -- int14Minor allele frequency- A:0.17NA 12
    rs22399451,2
    		C,F,36033460(+) TTCGTC/TATGGG 2 V ref1 syn1 ese324Minor allele frequency- T:0.30EA NA NS 3388
    rs22855141,2
    		C,F,H36029291(+) TCATTG/AACCCG 2 /N /D mis1 ref1 ese34Minor allele frequency- A:0.00NS EA 404
    rs22936811,2
    		C,36033825(+) TGTCCG/ATGCAC 1 -- int14Minor allele frequency- A:0.02EA NA 1552
    rs28719921,2
    		C,F36025785(-) TCAAAG/TGCACC 1 -- int14Minor allele frequency- T:0.01NS EA 420
    rs32168921,2
    		C36025095(+) CGCGC-/GCACACA 1 -- int11Minor allele frequency- GC:0.00NA 2
    rs44429311,2
    		--36033439(+) CCCTCA/GCCGGA 2 S ref1 syn1 ese30--------
    rs48061711,2
    		C,F,A,36022641(+) TATAAC/TGTGAA 1 -- ng51 tfbs312Minor allele frequency- N:0.00EA NA NS 798
    About this table

    HapMap Linkage Disequilibrium images for GAPDHS (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GAPDHS: --

    QIAGEN SeqTarget long-range PCR primers for resequencing GAPDHS 

    Disorders & Mutations
    for GAPDHS gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GAPDHS for disorders           About GeneDecksing

    OMIM: 609169

    Human Genome Epidemiology (HuGE) Navigator: GAPDHS (4 documents)

    Export disorders and mutations for GAPDHS gene to outside databases

    Medical News
    for GAPDHS gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for GAPDHS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/32 PubMed articles for GAPDHS gene, integrated from 7 sources (see all 32):
    (articles sorted by number of sources associating them with GAPDHS)
    1. Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells. (PubMed id 10714828)1, 2, 3, 7 Welch J.E.... Eddy E.M. (2000)
    2. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis. (PubMed id 16700075)1, 7 Welch J.E....O'Brien D.A. (2006)
    6. Investigation of glyceraldehyde-3-phosphate dehydrogenase from human sperms. (PubMed id 18298375)1, 7 Shchutskaya Y.Y....Schmalhausen E.V. (2008)
    7. Association of CR1, CLU and PICALM with Alzheimer's d isease in a cohort of clinically characterized and neuropathologically verified individuals. (PubMed id 20534741)1 Corneveaux J.J....Huentelman M.J. (2010)
    8. Exploration of 16 candidate genes identifies the asso ciation of IDE with Alzheimer's disease in Han Chinese. (PubMed id 20880607)1 Wang F....Jia J. (2010 Sep 27)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    10. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. (PubMed id 17192785)1 Bertram L....Tanzi R.E. (2007)

    External Searches for GAPDHS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing GAPDHS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26330 HGNC: 24864 AceView: GAPDS Ensembl:ENSG00000105679 euGenes: HUgn26330
    ECgene: GAPDHS Kegg: 26330 H-InvDB: GAPDHS

    Other Databases showing GAPDHS gene

    (According to HUGE)
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    Specialized Databases showing GAPDHS gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for GAPDHS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    		Patent Information for GAPDHS gene:
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    Products
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     ELISAs and CLIAs for GAPDHS
           

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