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GART Gene

protein-coding   GIFtS: 59

GC21M020354
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PRGS, PGFT)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section

Aliases & Descriptions
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide
synthetase, phosphoribosylaminoimidazole synthetase1 2
     AIRS2
PRGS2 3 5     GARTF2
PGFT2 3 5     trifunctional purine biosynthetic protein adenosine-32
OTTHUMP000000683332     MGC477642
GARS2     OTTHUMP000001979102
PAIS2     phosphoribosylglycinamide formyltransferase, EC 2.1.2.29

External Ids:    HGNC: 41631   Entrez Gene: 26182   Ensembl: ENSG000001591317   UniProtKB: P221023   

Export aliases for GART gene to outside databases

Previous GC identifers: GC21M031453 GC21M031536 GC21M033796 GC21M033798 GC21M034870


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GART:
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo
purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two
transcript variants encoding different isoforms. (provided by RefSeq)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GART gene promoter:
         SRY   Meis-1   HOXA9B   CUTL1   STAT5A   FOXO3b   FOXO3a   MIF-1   STAT6   STAT3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GART

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GART 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.1|21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11
Nature(405: 311-319) cytogenetic band:   21q22.11
GART Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GART gene location
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M020354:   GeneLoc Nature:405,311-319
Start:
20,354,547 bp from pter       20,452,917 bp from centromere
End:
20,393,666 bp from pter 20,491,053 bp from centromere
Size:
39,120 bases 38,137 bases
Orientation:
minus strand minus strand

2 alternative locations:
Chr21-,PATCHES 34,881,017-34,888,544      Chr21- 34,870,940-34,915,797     
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  

Whole chromosome sequencing:
cDNA sequence: X54199
genomic clones: pS590 pT604


(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102 (See protein sequence)
Recommended Name: Trifunctional purine biosynthetic protein adenosine-3  
Size: 1010 amino acids; 107767 Da
PDB structures from and Proteopedia :
1MEJ (3D)    1MEN (3D)    1MEO (3D)    1NJS (3D)    1RBM (3D)    1RBQ (3D)    1RBY (3D)    1RBZ (3D)    
1RC0 (3D)    1RC1 (3D)    1ZLX (3D)    1ZLY (3D)    2QK4 (3D)    2V9Y (3D)    
Secondary accessions: A8K945 A8KA32 O14659 Q52M77
Alternative splicing: 2 isoforms:  P22102-1   P22102-2   

Explore the universe of human proteins at neXtProt for GART: NX_P22102 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_000810.1  NP_001129477.1  NP_001129478.1  NP_780294.1  


    ENSEMBL proteins: 
    ENSP00000407783 ENSP00000371253 ENSP00000413803 ENSP00000354388 ENSP00000390003 ENSP00000420041 
    ENSP00000371236 ENSP00000416085 ENSP00000398631 ENSP00000413040 ENSP00000409771 ENSP00000371261 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for GART 
    Novus Biologicals Protein for GART
    Novus Biologicals Lysates for GART
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol TAS--
    About this table

    GART for ontologies           About GeneDecksing



    Antibodies for GART: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GART
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for GART 
    Novus Biologicals Antibodies for GART
    Browse antibodies at Epitomics

    Assays for GART: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GART 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GART 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GART for domains           About GeneDecksing

    5/18 InterPro domains/families (see all 18):
     IPR020560 PRibGlycinamide_synth_C-dom
     IPR020561 PRibGlycinamid_synth_ATP-grasp
     IPR016185 PreATP-grasp-like
     IPR020562 PRibGlycinamide_synth_N-dom
     IPR011761 ATP-grasp

    Graphical View of Domain Structure for InterPro Entry P22102

    ProtoNet protein and cluster: P22102

    3 Blocks protein families:
    IPB000115 Phosphoribosylglycinamide synthetase
    IPB000728 AIR synthase related protein
    IPB010918 AIR synthase related protein


    UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102
    Similarity: In the N-terminal section; belongs to the GARS family
    Similarity: In the central section; belongs to the AIR synthase family
    Similarity: In the C-terminal section; belongs to the GART family
    Similarity: Contains 1 ATP-grasp domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102
    Catalytic activity: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
    Catalytic activity: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate +
    5-amino-1-(5-phospho-D-ribosyl)imidazole
    Catalytic activity: 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate +
    N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GART
    Sigma-Aldrich shRNA for GART
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): GART
    OriGene shRNA RFP (see all 4): GART
    OriGene basic RS shRNA (see all 4): GART
    OriGene siRNA (see all 4): GART
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GART 
    miRNA:Sigma-Aldrich microRNA Mimics for GART
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GART 
    Search SABiosciences for Assays for microRNAs that regulate GART

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): GART
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): GART
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GART
    OriGene 3'-UTR clone (see all 4): GART 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GART 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GART 

    Genatlas biochemistry entry for GART:
    glycineamide formyltransferase,catalyzing the third step of the de novo purine biosynthesis,leading to
    formylglycinamide ribonucleotide (FGAR)

    5/12 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003824 catalytic activity ----
    GO:0004637 phosphoribosylamine-glycine ligase activity TAS--
    GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity TAS--
    GO:0004644 phosphoribosylglycinamide formyltransferase activity TAS--
    About this table

    GART for ontologies           About GeneDecksing

    Animal Models: 1 MGI phenotypic allele for Gart (no phenotypes)


    GART for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    GART for pathways           About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GART
        Purine Metabolism
    One Carbon Pool by Folate

    3 Kegg Pathways  (Kegg details for GART):
        hsa00230 Purine metabolism
    hsa00670 One carbon pool by folate
    hsa01100 Metabolic pathways

    UniProtKB/Swiss-Prot: PUR2_HUMAN, P22102
    Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from
    N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2
    Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from
    5-phospho-alpha-D-ribose 1-diphosphate: step 2/2
    Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
    from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1

        SABiosciences Custom Pathway-Focused PCR Arrays for GART 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GART
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GART

    5/18 Interacting proteins for GART (P221021, 2 ENSP000003712363) via UniProtKB, MINT, and/or STRING (see all 18)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6P623301EBI-356297,EBI-638181
    IKBKGQ9Y6K92MINT-48228
    ALDH1L1ENSP000002734503STRING: ENSP00000273450
    ATICENSP000002369593STRING: ENSP00000236959
    FTCDENSP000003527073STRING: ENSP00000352707
    About this table

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006144 purine base metabolic process TAS--
    GO:0006164 purine nucleotide biosynthetic process IEA--
    GO:0006189 'de novo' IMP biosynthetic process IEA--
    GO:0009058 biosynthetic process IEA--
    GO:0009113 purine base biosynthetic process IEA--
    About this table

    GART for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    GART for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GART
    10/17 Novoseek chemical compound relationships for GART gene (see all 17)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycinamide ribonucleotide 97.9 58 11604543 (4), 15777723 (2), 7532005 (2), 2289000 (1) (see all 26)
    aminoimidazole ribonucleotide 88.8 10 17982461 (1), 9328467 (1), 9473452 (1), 8299947 (1)
    lometrexol 88.5 1 12234990 (1)
    phosphoribosylamine 88.2 4 7532005 (2), 8238909 (1)
    1843u89 86.2 2 12494465 (1)
    10-formyltetrahydrofolate 82.4 6 8806778 (2), 19007868 (1), 1848231 (1)
    purine 77.5 26 1887337 (2), 12234990 (1), 12501179 (1), 15777723 (1) (see all 12)
    aminopterin 76.1 2 12494465 (1)
    tomudex 73.6 2 12494465 (1)
    aicar 70.9 4 12501179 (1), 10888335 (1), 13129585 (1), 13129586 (1)
    About this table

    1 PharmGKB drug compound relationship for GART gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    methotrexatePD  15630450
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GART
    Sigma-Aldrich shRNA for GART
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): GART
    OriGene shRNA RFP (see all 4): GART
    OriGene basic RS shRNA (see all 4): GART
    OriGene siRNA (see all 4): GART
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GART 
    miRNA: Sigma-Aldrich microRNA Mimics for GART
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GART 
    Search SABiosciences for Assays for microRNAs that regulate GART
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): GART
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): GART
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GART
    OriGene 3'-UTR Clone (see all 4): GART 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GART 
    Primers: OriGene genome-wide validated SYBR primer pairs: GART
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GART: PPH10238A

    REFSEQ mRNAs for GART gene (4 alternative transcripts): 

    NM_000819.4  NM_001136005.1  NM_001136006.1  NM_175085.2  

    Additional cDNA sequence: 

    AB208785.1 AF008655.1 AK292560.1 AK292897.1 AK295980.1 BC038958.1 BC068438.1 BC093641.1 
    BC101565.1 BC107712.1 BX648124.1 CR593828.1 CR622715.1 D32051.1 M32082.1 X54199.1 

    24/26 DOTS entries (see all 26):

    DT.100036758  DT.121141404  DT.100819299  DT.456326  DT.121141007  DT.121141360  DT.75102580  DT.99940405 
    DT.121141111  DT.92446508  DT.427150  DT.91915247  DT.121141457  DT.92049909  DT.121141349  DT.92446506 
    DT.75116473  DT.121141517  DT.100819302  DT.92012505  DT.95184922  DT.121141430  DT.75100764  DT.95204743 

    24/426 AceView cDNA sequences (see all 426):

    BQ440805 AA714722 BI333329 BQ711422 AI261568 AA401379 BE301651 BQ051498 
    BU169489 AI824313 CD513460 BQ691119 AA946891 BM821416 BM973301 BU188141 
    CR593828 AW251087 AI984390 BE889817 BI092026 BU154331 BQ477393 AU103716 

    highest scoring ESTs for GART:

    X54199 AA545781 AL549507 AL552575 AL706291 AL710817 AU098888 AU127555 AU132979 BC038958 

    Unigene Cluster for GART:

    Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
    Hs.473648  [show with all ESTs]
    Unigene Representative Sequence: BC068438


    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for GART (see all 18)

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^
    SP1:                                            -     -     -                                                                             -     -           -   
    SP2:                                      -     -     -                                                                                   -     -           -   
    SP3:                                                                                                                                      -     -           -   
    SP4:                                                                                                                                      -     -           -   
    SP5:                                                                                                                                      -     -           -   

    ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28
    SP1:  -                                   -                                               -                                       
    SP2:  -                                   -                                               -                                       
    SP3:  -                                   -                                               -                                       
    SP4:  -                                                                                                                           
    SP5:                                                                                                                              

    About this scheme

    ECgene alternative splicing isoforms for GART
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000441403 ENST00000488791 ENST00000476524 ENST00000466882 ENST00000460305
    ENST00000487155 ENST00000482663 ENST00000381831 ENST00000438059 ENST00000497313
    ENST00000361093(uc002ysa.2) ENST00000424203(uc002yrz.2 uc010gmd.2 uc002yry.2)
    ENST00000492008 ENST00000381815(uc002yrx.2) ENST00000414353 ENST00000426819
    ENST00000430874 ENST00000366093

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GART expression in normal and diseased human tissues

    1  / 2  / 3

    13 probe-sets matching GART gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38384_at2, 3 U95-A 1 1.00 1.00 0.67 0.96 X54199 1.00 1.00 1.00 1
    50801_at2 U95-B 1 0.38 1.00 0.33 0.96 -- -- -- -- --
    87571_at*2, 3 U95-E 1 -- -- 0.15 1.11 AI961651 0.20 1.00 0.72 1
    212379_at2, 3 U133-A 1 1.00 1.00 -- -- BE966876 0.60 1.00 0.82 1
    217445_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF008655 0.40 1.00 0.76 1
    212378_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000819 0.60 1.00 0.82 1
    230097_at2, 3 U133-B 1 0.36 1.00 -- -- AI207338 0.40 1.00 0.76 1
    210005_at2, 3 U133-A 1 0.27 1.00 -- -- D32051 0.80 1.00 0.91 1
    212379_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    217445_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212378_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    230097_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    210005_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    GART for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GART gene expression
    GART gene electronic northern expression
    GART gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.473648

    Expression variation in blood from EXPOLDB for GART

    Primers: OriGene genome-wide validated SYBR primer pairs: GART
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GART: PPH10238A
        SABiosciences Custom PCR Arrays for GART 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GART gene from 5/22 species (see all 22)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    GART1   -- phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide more 99.5(n)
    99.31(a)
    458518  XM_514869.2  XP_514869.2 
    cow
    (Bos taurus)
    GART1   -- phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide more 88.02(n)
    88.42(a)
    281183  NM_001040473.2  NP_001035563.1 
    rat
    (Rattus norvegicus)
    Gart1   -- phosphoribosylglycinamide formyltransferase 83.89(n)
    86.53(a)
    288259  XM_573258.2  XP_573258.1 
    mouse
    (Mus musculus)
    Gart1 , 5 16 (53.18 cM)5
    phosphoribosylglycinamide formyltransferase1, 5 83.2(n)1
    85.94(a)1
    144501  NM_010256.21  NP_034386.21 
     AK1463555  AK1464785  (see all 53)
    chicken
    (Gallus gallus)
    GART1   -- phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide more 73.4(n)
    75.1(a)
    395315  NM_001001469.1  NP_001001469.1 
    About this table        Species with no ortholog for GART

    ENSEMBL Gene Tree for GART (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/299 NCBI SNPs in GART are shown (see all 299)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 21 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs87881,2
    C,F,H,34897113(-) AAGACA/G/TTCGGC 12 I V F mis1 ref126MN NS EA NA WA 2042
    rs89711,2
    C,F,34883618(-) GAGGGA/GTATCC 6 D G ref1 mis122Minor allele frequency- G:0.15MN EA NA NS 3256
    rs10231471,2
    C34888171(+) CTTTTG/AACCTA 3 -- int16Minor allele frequency- A:0.00NA NS EA 584
    rs10233531,2
    C34889118(+) ATAAAG/TACAGA 3 -- int10--------
    rs10510531,2
    F,H34896424(-) TTTTAT/ACACTG 4 -- int1 ut31 ese35Minor allele frequency- A:0.01MN NS EA 604
    rs18043851,2
    C,F,34896962(+) TATCAC/GTCCCA 4 -- int1 ut3114Minor allele frequency- G:0.16NA MN EA WA 900
    rs18043871,2
    C34911561(-) GGAAAC/TTTGCA 8 L F ref1 mis14Minor allele frequency- T:0.00NS EA 418
    rs20070411,2
    C,34894195(+) CAGGAC/TGCAGA 3 -- int15Minor allele frequency- T:0.10NA WA 10
    rs20070531,2
    C,F,O,A,H,34894315(+) CATGAT/CAGATG 3 -- int112Minor allele frequency- C:0.12NA NS EA WA 649
    rs20275921,2
    C,F,A,H,34902527(+) TGTGCA/CGAAAT 4 -- int19Minor allele frequency- C:0.27NS EA NA WA 426
    About this table

    HapMap Linkage Disequilibrium images for GART (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GART: --

    QIAGEN SeqTarget long-range PCR primers for resequencing GART 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GART for disorders           About GeneDecksing

    OMIM: 138440

    6 Novoseek disease relationships for GART gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 35.7 2 9328467 (1), 19007868 (1)
    amyotrophic lateral sclerosis 21.3 1 8358240 (1)
    leukemia 3.56 2 2040032 (1)
    tumors 0 4 12234990 (2), 7506026 (1)
    carcinoma 0 3 14517211 (2), 12234990 (1)
    cancer 0 1 17198385 (1)
    About this table

    1 PharmGKB disease relationship for GART gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1PD  15630450
    About this table

    Human Genome Epidemiology (HuGE) Navigator: GART (6 documents)

    Export disorders and mutations for GART gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/76 PubMed articles for GART gene, integrated from 7 sources (see all 76):
    (articles sorted by number of sources associating them with GART)
    1. Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations. (PubMed id 2183217)1, 2, 7 Schild D.... Barr P.J. (1990)
    2. Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes. (PubMed id 2050105)1, 3, 7 Gnirke A....Olson M.V. (1991)
    3. Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene. (PubMed id 9224613)1, 2, 7 Kan J.L.C. and Moran R.G. (1997)
    4. De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. (PubMed id 2147474)1, 2, 7 Aimi J.... Dixon J.E. (1990)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. (PubMed id 16026156)1, 2 Dahms T.E.... Smith J.L. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10- dideazaacyclic-5,6,7,8-tetrahydrofolic acid. (PubMed id 12755606)1, 2 Zhang Y.... Wilson I.A. (2003)
    9. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. (PubMed id 12450384)1, 2 Zhang Y....Wilson I.A. (2002)
    10. Mouse cDNAs encoding a trifunctional protein of de novo purine synthesis and a related single-domain glycinamide ribonucleotide synthetase. (PubMed id 8299947)1, 7 Kan J.L....Moran R.G. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2618 HGNC: 4163 AceView: GART Ensembl:ENSG00000159131 euGenes: HUgn2618
    ECgene: GART Kegg: 2618 H-InvDB: GART

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for GART gene:
    Search GeneIP for patents involving GART

    GeneCards and IP:
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     ELISAs and CLIAs for GART
           

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