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GCN1L1 Gene

protein-coding   GIFtS: 58

GC12M117574
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
(Previous names: GCN1 (general control of amino-acid synthesis 1, yeast)-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)1 2     PRIC2952
KIAA02191 2 3     GCN1 (general control of amino-acid synthesis, yeast, homolog)-like2
GCN11 2     hsGCN12
GCN1 (general control of amino-acid synthesis 1, yeast)-like 11 2     translational activator GCN12
GCN1L1 2     peroxisome proliferator activated receptor interacting complex protein2
GCN1-like protein 12 3     HsGCN13

External Ids:    HGNC: 41991   Entrez Gene: 109852   Ensembl: ENSG000000891547   UniProtKB: Q926163   

Export aliases for GCN1L1 gene to outside databases

Previous GC identifers: GC12M119438 GC12M120091 GC12M120347 GC12M118976 GC12M119027 GC12M120565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
Function: Acts as a translation activator that mediates translational control and perform an EF3-related function on
the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity (By similarity)

Gene Wiki entry for GCN1L1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GCN1L1 gene promoter:
         AP-1   c-Jun   c-Fos   STAT5A   SRF   GCNF-1   GCNF-2   HOXA9B   Meis-1   NRSF form 2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GCN1L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GCN1L1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.2

GCN1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCN1L1 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M117574:  view genomic region     (about GC identifiers)

Start:
117,574,069 bp from pter
End:
117,641,060 bp from pter
Size:
66,992 bases
Orientation:
minus strand

1 alternative location:
Chr12- 120,565,016-120,632,513     
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616 (See protein sequence)
Recommended Name: Translational activator GCN1  
Size: 2671 amino acids; 292758 Da
Subunit: Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4) (By similarity)
Sequence caution: Sequence=AAC51648.1; Type=Frameshift; Positions=2657; Sequence=AAC83183.1; Type=Erroneous gene model
prediction; Sequence=BAA13209.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8KAY1 O95001 O95651 Q6P2S3 Q86X65 Q8N5I5 Q8WU80 Q99736 Q9UE60

Explore the universe of human proteins at neXtProt for GCN1L1: NX_Q92616 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006827.1  

    ENSEMBL proteins: 
    ENSP00000300648 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for GCN1L1 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm NAS9234705
    GO:0005840 ribosome NAS9234705
    About this table

    GCN1L1 for ontologies           About GeneDecksing



    Antibodies for GCN1L1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GCN1L1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for GCN1L1 
    Novus Biologicals Antibodies for GCN1L1
    Browse antibodies at Epitomics

    Assays for GCN1L1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GCN1L1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GCN1L1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GCN1L1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011989 ARM-like
     IPR022716 DUF3554
     IPR000225 Armadillo
     IPR021133 HEAT_type_2
     IPR000357 HEAT

    Graphical View of Domain Structure for InterPro Entry Q92616

    ProtoNet protein and cluster: Q92616

    2 Blocks protein families:
    IPB000225 Armadillo repeat
    IPB000847 Bacterial regulatory protein LysR


    UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
    Similarity: Belongs to the GCN1 family
    Similarity: Contains 24 HEAT repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
    Function: Acts as a translation activator that mediates translational control and perform an EF3-related function on
    the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for GCN1L1
    Sigma-Aldrich shRNA for GCN1L1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GCN1L1
    OriGene shRNA RFP (see all 2): GCN1L1
    OriGene basic RS shRNA (see all 2): GCN1L1
    OriGene siRNA (see all 2): GCN1L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GCN1L1 
    miRNA:Sigma-Aldrich microRNA Mimics for GCN1L1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GCN1L1 
    1 SABiosciences Assays for microRNA that regulate GCN1L1:
    hsa-miR-570

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GCN1L1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GCN1L1
    OriGene untagged cDNA clones in CMV expression vector: GCN1L1
    OriGene 3'-UTR clone: GCN1L1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: GCN1L1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GCN1L1 

    Genatlas biochemistry entry for GCN1L1:
    translational regulator of the activator GCN4,potentially functioning on elongating ribosomes in activation of EIF2
    alpha kinase GCN2,yeast GCN1 general control of amino-acid synthesis,homolog-like 1

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding ----
    GO:0005515 protein binding IPI17353931
    GO:0008135 translation factor activity, nucleic acid binding NAS9234705
    About this table

    GCN1L1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for GCN1L1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GCN1L1

    5/869 Interacting proteins for GCN1L1 (Q926161, 2) via UniProtKB, MINT, and/or STRING (see all 869)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW01EBI-356221,EBI-1055224
    C20orf24Q9BUV81EBI-356221,EBI-1050079
    CASP4P496621EBI-356221,EBI-1057327
    MAGED1Q9Y5V31EBI-356221,EBI-716006
    MAST2Q6P0Q81EBI-356221,EBI-493777
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417 regulation of translation IEA--
    About this table

    GCN1L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GCN1L1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for GCN1L1
    Sigma-Aldrich shRNA for GCN1L1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GCN1L1
    OriGene shRNA RFP (see all 2): GCN1L1
    OriGene basic RS shRNA (see all 2): GCN1L1
    OriGene siRNA (see all 2): GCN1L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GCN1L1 
    miRNA: Sigma-Aldrich microRNA Mimics for GCN1L1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GCN1L1 
    1 SABiosciences Assays for microRNA that regulate GCN1L1:
    hsa-miR-570
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GCN1L1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GCN1L1
    OriGene untagged cDNA clones in CMV expression vector: GCN1L1
    OriGene 3'-UTR Clone: GCN1L1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: GCN1L1 
    Primers: OriGene genome-wide validated SYBR primer pairs: GCN1L1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GCN1L1: PPH16401A

    REFSEQ mRNAs for GCN1L1 gene: 

    NM_006836.1  

    Additional cDNA sequence: 

    AK297271.1 BC021129.1 BC032335.1 BC040172.1 BC046177.1 BC064346.1 BC113083.1 BC113084.1 
    BC153881.1 CR607697.1 D86973.2 U77700.1 U88836.1 U88837.1 

    24 DOTS entries:

    DT.95338247  DT.101969584  DT.40115774  DT.121112656  DT.92442294  DT.121113274  DT.102826929  DT.95343278 
    DT.121112917  DT.40223302  DT.75131390  DT.92044142  DT.95326127  DT.97798165  DT.100030746  DT.100650231 
    DT.100825974  DT.121113344  DT.75172344  DT.95075247  DT.99965505  DT.121112667  DT.65286828  DT.75150986 

    10 AceView cDNA sequences:

    CR607697 BC040172 D86973 BC046177 BC064346 BC021129 BC032335 U88837 
    U88836 U77700 

    highest scoring ESTs for GCN1L1:

    D86973 AI458099 AW196958 BF058449 BF356779 BF820350 BF893021 BG978274 BI028001 BI038647 

    Unigene Cluster for GCN1L1:

    GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
    Hs.298716  [show with all ESTs]
    Unigene Representative Sequence: NM_006836


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GCN1L1 (see all 8)

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^
    SP1:                                                                                      -                                         -                 -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^
    SP1:                          -                                                                                         -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57
    SP1:        -                             -                                                               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      

    About this scheme

    ECgene alternative splicing isoforms for GCN1L1
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000300648(uc001txo.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GCN1L1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching GCN1L1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36603_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D86973 0.80 0.80 0.80 1
    216232_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI697055 0.20 1.00 0.72 1
    212139_at2, 3 U133-A 1 1.00 1.00 -- -- D86973 0.80 0.80 0.80 1
    216232_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212139_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    GCN1L1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GCN1L1 gene expression
    GCN1L1 gene electronic northern expression
    GCN1L1 gene sage expression
    About these images

    CGAP SAGE TAG: GCTAGGTCTG

    SOURCE GeneReport for Unigene cluster: Hs.298716

    Expression variation in blood from EXPOLDB for GCN1L1

    UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
    Tissue specificity: Ubiquitously expressed

    Primers: OriGene genome-wide validated SYBR primer pairs: GCN1L1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GCN1L1: PPH16401A
        SABiosciences Custom PCR Arrays for GCN1L1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GCN1L1 gene from 5/20 species (see all 20)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GCN1L11   -- GCN1 general control of amino-acid synthesis 1-like more 90.96(n)
    96.82(a)
    477505  XM_534701.2  XP_534701.2 
    chimpanzee
    (Pan troglodytes)
    GCN1L11   -- GCN1 general control of amino-acid synthesis 1-like more 99.53(n)
    99.7(a)
    742053  XM_001159608.1  XP_001159608.1 
    cow
    (Bos taurus)
    GCN1L11   -- GCN1 general control of amino-acid synthesis 1-like more 90.57(n)
    96.14(a)
    536143  XM_616264.3  XP_616264.3 
    rat
    (Rattus norvegicus)
    Gcn1l11   -- GCN1 general control of amino-acid synthesis 1-like more 87.76(n)
    94.27(a)
    690632  XM_001072108.1  XP_001072108.1 
    mouse
    (Mus musculus)
    Gcn1l11 , 5 5 (56.10 cM)5
    GCN1 general control of amino-acid synthesis 1-like more1, 5 87.42(n)1
    94.01(a)1
    2316591  NM_172719.21  NP_766307.21 
     AA5621395  AB0932175  (see all 29)
    About this table        Species with no ortholog for GCN1L1

    ENSEMBL Gene Tree for GCN1L1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/552 NCBI SNPs in GCN1L1 are shown (see all 552)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs24221,2
    C,F,O,A,H,120565188(-) TCTGAT/CCCCTG 1 -- ut31 ese316Minor allele frequency- C:0.48MN EA NS NA WA 2092
    rs10052601,2
    C,H,120567952(+) AAAATG/ACACCC 1 -- int110Minor allele frequency- A:0.00NS EA NA WA 434
    rs10495161,2
    H120599784(-) TCACTG/TCCTCC 2 A S ref1 mis1 ese35Minor allele frequency- T:0.00MN NS EA 586
    rs11665471,2
    --120610325(+) tttttA/Cttttt 1 -- int1 trp30--------
    rs11792531,2
    --120590501(+) atataC/Tataca 1 -- int10--------
    rs11792601,2
    --120619380(+) gctcaC/Tgcctg 1 -- int10--------
    rs11792611,2
    --120619441(+) agttcA/Gagacc 1 -- int10--------
    rs11792621,2
    --120619503(+) cgggcA/Gtggtg 1 -- int10--------
    rs11792631,2
    --120619650(+) aaaaaA/Taaaaa 1 -- int1 trp30--------
    rs11828531,2
    --120619386(+) gcctgC/Taatcc 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for GCN1L1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GCN1L1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing GCN1L1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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    GCN1L1 for disorders           About GeneDecksing

    OMIM: 605614


    Export disorders and mutations for GCN1L1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/18 PubMed articles for GCN1L1 gene, integrated from 7 sources (see all 18):
    (articles sorted by number of sources associating them with GCN1L1)
    1. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. (PubMed id 9234705)1, 2, 3, 7 Marton M.J....Hinnebusch A.G. (1997)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    6. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    7. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10985 HGNC: 4199 AceView: GCN1L1 Ensembl:ENSG00000089154 euGenes: HUgn10985
    ECgene: GCN1L1 H-InvDB: GCN1L1

    (According to HUGE)
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    HUGE: KIAA0219

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for GCN1L1 gene:
    Search GeneIP for patents involving GCN1L1

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