Aliases &
Descriptions
for GH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| growth hormone 11 2 3 | | Pituitary growth hormone2 3 | | GH1 2 3 | | IGHD1B2 5 | | GH-N1 2 3 | | somatotropin2 | | GHN1 2 5 | | Growth hormone3 | | hGH-N1 2 | | |
Export aliases for GH1 gene to outside databasesPrevious GC identifers: GC17U990034 GC17M064420 GC17M062292 GC17M062424 GC17M062467 GC17M059348 GC17M061994 |
Summaries
for GH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GH1:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an importantrole in growth control. The gene, along with four other related genes, is located at the growth hormone locus onchromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought tohave evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity.Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversityand potential for specialization. This particular family member is expressed in the pituitary but not in placentaltissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene leadto growth hormone deficiency and short stature. (provided by RefSeq)
UniProtKB/Swiss-Prot: SOMA_HUMAN, P01241Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate theliver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. Italso stimulates amino acid uptake and protein synthesis in muscle and other tissues
Gene Wiki entry for GH1 (Growth hormone 1) |
Genomic Views
for GH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GH1 gene promoter:
STAT5B SREBP-1b SREBP-1c SREBP-1a NF-kappaB1 STAT5A RP58 FOXF2 POU3F2 (N-Oct-5b) POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GH1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q22-q24GH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M057362: view genomic region
(about GC identifiers)
Start:
|
57,362,255 bp from pter |
End:
|
57,363,890 bp from pter |
Size:
|
1,636 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 61,994,561-61,996,350 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for GH1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SOMA_HUMAN, P01241 (See
protein sequence)Recommended Name: Somatotropin precursor Size: 217 amino acids; 24847 Da
Subunit: Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymericand heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex
Subcellular location: Secreted
Miscellaneous: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translationalmodifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, andpotentially proteolytic processing
PDB structures from  and Proteopedia  :1A22 (3D)
1AXI (3D)
1BP3 (3D)
1HGU (3D)
1HUW (3D)
1HWG (3D)
1HWH (3D)
1KF9 (3D)
3HHR (3D)
Secondary accessions: Q14405 Q16631 Q5EB53 Q9HBZ1 Q9UMJ7 Q9UNL5Alternative splicing: 4 isoforms: P01241-1 P01241-2 P01241-3 P01241-4 (Additional isoforms seem to exist)Explore the universe of human proteins at neXtProt for GH1: NX_P01241
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (5 alternative transcripts):
NP_000506.2 NP_072053.1 NP_072054.1 NP_072055.1 NP_072056.1
ENSEMBL proteins: ENSP00000386136 ENSP00000407853 ENSP00000339278 ENSP00000343791 ENSP00000408486 ENSP00000312673 ENSP00000402287 ENSP00000415587 ENSP00000414142
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
GH1 for ontologies About GeneDecksing
Antibodies for GH1:
Assays for GH1: |
Protein
Domains/
Families
for GH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GH1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01241ProtoNet protein and cluster: P01241 1 Blocks protein family: IPB001400 Somatotropin hormone
UniProtKB/Swiss-Prot: SOMA_HUMAN, P01241Similarity: Belongs to the somatotropin/prolactin family |
Gene Function
for GH1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SOMA_HUMAN, P01241Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate theliver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. Italso stimulates amino acid uptake and protein synthesis in muscle and other tissues
Genatlas biochemistry entry for GH1:growth hormone 1 (N),anabolic and lipolytic,released from the anterior pituitary in a pulsatile and circadianmanner,expressed in lymphocytes5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
GH1 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gh):
GH1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GH1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GH1 for pathways About GeneDecksing
2  Millipore Pathways for GH1
5  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GH1
3  Kegg Pathways (Kegg details for GH1):  | hsa04060 Cytokine-cytokine receptor interaction | | hsa04080 Neuroactive ligand-receptor interaction | | hsa04630 Jak-STAT signaling pathway |
SABiosciences Pathway-Focused PCR Array including GH1: PAHS-017A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GH1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GH1
5/23 Interacting proteins for GH1 (ENSP000003126733 P012411) via UniProtKB, MINT, and/or STRING (see all 23)About this table
5/14 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 14): About this table
GH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
GH1 for compounds About GeneDecksing
 Compounds for GH1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| GRF (ovine) | Stimulates growth hormone release | -- |
About this table
UniProtKB/Swiss-Prot: SOMA_HUMAN, P01241Pharmaceutical: Available under the names Nutropin or Protropin (Genentech), Norditropin (Novo Nordisk), Genotropin(Pharmacia Upjohn), Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormonedeficiency and for Turner's syndrome
10/132  Novoseek chemical compound relationships for GH1 gene (see all 132)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| octreotide |
87.8 |
459 |
1424206 (9), 15935982 (8), 12608933 (6), 16003295 (6) (see all 99) |
| lanreotide |
87 |
93 |
10090136 (5), 10468985 (4), 10822218 (4), 8027218 (4) (see all 34) |
| pegvisomant |
84.1 |
49 |
16046586 (4), 11443205 (4), 18498055 (3), 11932303 (2) (see all 23) |
| acth |
81 |
352 |
9876339 (7), 15163333 (7), 16832586 (5), 12379758 (4) (see all 99) |
| hexarelin |
78.9 |
156 |
9067986 (12), 8977750 (8), 9231048 (7), 9186817 (7) (see all 28) |
| ghrp |
77 |
146 |
9053785 (12), 8496311 (11), 8175966 (9), 11322505 (7) (see all 17) |
| pyridostigmine |
70.2 |
154 |
1902484 (8), 2220258 (6), 2225476 (5), 1358762 (5) (see all 32) |
| glucose |
69.5 |
643 |
15070919 (9), 7962288 (8), 12773135 (7), 15080775 (5) (see all 99) |
| bromocriptine |
68.9 |
94 |
1574954 (4), 9509075 (4), 1674920 (4), 1395069 (4) (see all 37) |
| cabergoline |
67.4 |
31 |
17530416 (4), 15638294 (3), 9024247 (2), 19439914 (2) (see all 16) |
About this table
|
Transcripts
for GH1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GH1 gene (5 alternative transcripts): NM_000515.3 NM_022559.2 NM_022560.2 NM_022561.2 NM_022562.2 Additional cDNA sequence: AF110644.1 AF185611.1 AY613431.1 AY613432.1 BC062475.1 BC075012.2 BC075013.2 BC090045.1 V00519.1 24/64 DOTS entries (see all 64): DT.91840785 DT.91964566 DT.95122564 DT.95278599 DT.91985433 DT.95273898 DT.91861058 DT.92057802 DT.97868481 DT.92012584 DT.92405319 DT.92054920 DT.100715588 DT.91899146 DT.100715496 DT.91728134 DT.100853872 DT.95191024 DT.120952114 DT.95214250 DT.95336076 DT.100729857 DT.91971970 DT.95231299 24/442 AceView cDNA sequences (see all 442): CR607493 CR618132 CR597599 CR607891 CR597749 CR622588 CR595921 CR599531 CR619097 CR620140 CR590740 CR624109 CR609696 CR596447 NM_022557 CR605118 CR613416 CR608232 CR590632 CR592104 NM_022642 CR604889 CR598457 CR598505
 highest scoring ESTs for GH1:AV746364 AV747827 AV748085 AV748778 AV749774 AV750176 BF996851 BG003300 BG003326 BI050252 Unigene Cluster for GH1: Growth hormone 1 Hs.655229 [show with all ESTs]Unigene Representative Sequence: CD516340
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GH1 (see all 6)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for GH1
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000408987 ENST00000441409(uc002jdl.2 uc002jdn.2) ENST00000342364
ENST00000351388 ENST00000458650 ENST00000323322 ENST00000427586 ENST00000417929(uc002jdm.2)
ENST00000452158(uc002jdi.2 uc002jdj.2 uc002jdk.2)
|
Expression
for GH1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GH1 expression in normal and diseased human tissues
1 / 2 / 3 13 probe-sets matching GH1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1332_f_at2, 3
|
U95-A |
4 |
0.75 |
0.85 |
1.00 |
1.00 |
V00520 |
0.20 |
1.00 |
0.72 |
1 |
| 211151_x_at2, 3
|
U133-A |
5 |
1.00 |
0.72 |
-- |
-- |
AF185611 |
0.40 |
0.67 |
0.55 |
1 |
| 206885_x_at2, 3
|
U133-A |
5 |
0.91 |
0.84 |
-- |
-- |
NM_022559 |
0.40 |
0.67 |
0.55 |
1 |
| 205840_x_at2, 3
|
U133-A |
5 |
0.91 |
0.80 |
-- |
-- |
NM_000515 |
0.40 |
0.67 |
0.55 |
1 |
| 206886_x_at2, 3
|
U133-A |
5 |
0.82 |
0.77 |
-- |
-- |
NM_022560 |
0.40 |
0.67 |
0.55 |
1 |
| 208068_x_at2, 3
|
U133-A |
5 |
0.82 |
0.69 |
-- |
-- |
NM_022562 |
0.40 |
0.67 |
0.55 |
1 |
| 208069_x_at2, 3
|
U133-A |
5 |
0.82 |
0.63 |
-- |
-- |
NM_022561 |
0.40 |
0.67 |
0.55 |
1 |
| 211151_x_at2
|
U133Plus2 |
5 |
1.00 |
0.72 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206885_x_at2
|
U133Plus2 |
5 |
0.91 |
0.84 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 205840_x_at2
|
U133Plus2 |
5 |
0.91 |
0.80 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206886_x_at2
|
U133Plus2 |
5 |
0.82 |
0.77 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208068_x_at2
|
U133Plus2 |
5 |
0.82 |
0.69 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208069_x_at2
|
U133Plus2 |
5 |
0.82 |
0.63 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GH1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.655229
SABiosciences Expression via Pathway-Focused PCR Array including GH1: PAHS-017A
|
Orthologs
for GH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GH1 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
mouse
(Mus musculus) |
Gh5 |
11 (68.89 cM) |
growth hormone |
-- |
X02891 |
About this table Species with no ortholog for GH1
ENSEMBL Gene Tree for GH1 (if available) |
Paralogs
for GH1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GH1 gene
- GH22 CSH22 CSH12 CSHL12
GH1 for paralogs About GeneDecksing
|
Genomic Variants
for GH1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GH1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GH1
1 CNV: 67243 | | QIAGEN SeqTarget long-range PCR primers for resequencing GH1 |
|
Disorders & Mutations
for GH1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GH1 for disorders About GeneDecksing
OMIM: 139250 disorders: 262400 612781 173100 262650 UniProtKB/Swiss-Prot: SOMA_HUMAN, P01241
Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known aspituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patientshave an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known asdwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients havelow but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenousGH Defects in GH1 are the cause of Kowarski syndrome [MIM:262650]; also known as pituitary dwarfism VI Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is anautosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have apositive response and immunologic tolerance to growth hormone therapy
10/96 Novoseek disease relationships for GH1 gene (see all 96)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| acromegaly |
96 |
528 |
10427158 (5), 16625850 (5), 10197081 (5), 11701684 (4) (see all 99) |
| ighd ii |
89 |
47 |
12720086 (3), 17073157 (3), 17726075 (3), 20351314 (2) (see all 17) |
| pituitary adenoma |
88.6 |
120 |
2004472 (4), 1910948 (3), 1424206 (3), 8386895 (2) (see all 79) |
| growth hormone deficiency |
85.3 |
54 |
12435888 (3), 17073157 (3), 17308409 (2), 19770650 (2) (see all 41) |
| short stature |
84.1 |
189 |
2203797 (6), 7565946 (4), 12580940 (3), 11502828 (3) (see all 99) |
| pituitary tumors |
81.7 |
56 |
15765032 (2), 17594522 (2), 17975024 (2), 1646455 (1) (see all 47) |
| laron syndrome |
81.2 |
41 |
8726240 (2), 8977385 (2), 18462969 (2), 8808010 (1) (see all 25) |
| tsh deficiency |
80.9 |
22 |
7852536 (2), 9626142 (1), 9699131 (1), 15472232 (1) (see all 20) |
| panhypopituitarism |
80.4 |
18 |
10698595 (2), 11549674 (1), 12904605 (1), 16968807 (1) (see all 16) |
| hypopituitarism |
79.7 |
36 |
11701703 (2), 9652904 (2), 19549748 (2), 11527085 (1) (see all 27) |
About this table
Genatlas disease: GH1 dwarfism (GH-N deficiency,isolated),autosomal recessive and rare dominant forms
Human Gene Mutation Database (HGMD): GH1
Genetic Association Database (GAD): GH1
Human Genome Epidemiology (HuGE) Navigator: GH1 (34 documents)
Tumor Gene Database (TGDB): GH1
Export disorders and mutations for GH1 gene to outside databases
|
Medical News
for GH1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/2350 PubMed articles for GH1 gene, integrated from 7 sources (see all 2350):
(articles sorted by number of sources associating them with GH1)- Autosomal dominant GH deficiency due to an Arg183His GH-1 gene mutation: clinical and molecular evidence of impaired regulated GH secretion. (PubMed id 11502836)1, 2, 7 Deladoey J.... Mullis P.E. (2001)
- Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4, 7 Canzian F....Kaaks R. (2005)
- Polymorphism in the growth hormone gene, weight in infancy, and adult bone mass. (PubMed id 15472182)1, 4, 7 Dennison E.M....Cooper C. (2004)
- A novel dysfunctional growth hormone variant (Ile179Met) exhibits a decreased ability to activate the extracellular signal-regulated kinase pathway. (PubMed id 15001589)1, 2, 7 Lewis M.D.... Cooper D.N. (2004)
- Biologically inactive growth hormone caused by an amino acid substitution. (PubMed id 9276733)1, 2, 7 Takahashi Y.... Chihara K. (1997)
- A new mutation causing inherited growth hormone deficiency: a compound heterozygote of a 6.7 kb deletion and a two base deletion in the third exon of the GH-1 gene. (PubMed id 8364549)1, 2, 7 Igarashi Y....Koga J. (1993)
- Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (2006)
- Association between fetal growth restriction and polymorphisms at sites -1 and +3 of pituitary growth hormone: a case-control study. (PubMed id 15691369)1, 4 Adkins R.M....Boyd T.K. (2005)
- Pituitary growth hormone and growth hormone-releasing hormone receptor genes and associations with mammographic measures and serum growth hormone. (PubMed id 16284391)1, 4 Mulhall C....Boyd N.F. (2005)
- Association of polymorphisms and haplotypes in the human growth hormone 1 (GH1) gene with breast cancer. (PubMed id 16322331)1, 4 Wagner K....Forsti A. (2005)
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External Searches for GH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing GH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing GH1 gene
(According to HUGE)
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Specialized Databases showing GH1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for GH1 gene:
Search GeneIP for patents involving GH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GH1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
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