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GINS4 Gene

protein-coding GIFtS: 47

GC08P039914

GINS complex subunit 4 (Sld5 homolog)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
GINS complex subunit 4 (Sld5 homolog)¹ ²
SLD5¹ ² ³ ⁵
MGC14799¹ ²
DNA replication complex GINS protein SLD5²
SLD5 homolog²
GINS complex subunit 4³

External Ids:	HGNC: 28226¹	Entrez Gene: 84296²	Ensembl: ENSG00000147536⁷	UniProtKB: Q9BRT9³

Export aliases for GINS4 gene to outside databases

Previous GC identifers: GC08P041506 GC08P041388

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GINS4:

The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and

Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in

yeast and Xenopus egg extracts (Ueno et al., 2005 (PubMed 16287864)). See GINS1 for additional information about the

GINS complex.(supplied by OMIM)

UniProtKB/Swiss-Prot: SLD5_HUMAN, Q9BRT9

Function: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA

replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to

single-stranded DNA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GINS4 gene promoter:
         c-Myb   STAT5B   RORalpha1   RP58   HNF-1A   Nkx6-1   STAT5A   Egr-3   c-Myc   Max1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for GINS4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GINS4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.21 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.21

GINS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GINS4 gene location

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P039914: view genomic region (about GC identifiers)

Start:	39,914,514 bp from pter
End:	39,930,224 bp from pter
Size:	15,711 bases
Orientation:	plus strand

1 alternative location:

Chr8+ 41,386,725-41,402,565

RefSeq DNA sequence:

NC_000008.10 NT_167187.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SLD5_HUMAN, Q9BRT9 (See protein sequence)

Recommended Name: DNA replication complex GINS protein SLD5

Size: 223 amino acids; 26047 Da

Subunit: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable

subcomplex with GINS1. GINS complex interacts with DNA primase in vitro

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)

Mass spectrometry: Mass=98373; Mass_error=13; Method=Electrospray; Range=1-223; Note=This is the measured mass for the

GINS complex; Source=PubMed:17557111;

PDB structures from and Proteopedia :

2E9X (3D)

2EHO (3D)

2Q9Q (3D)

Secondary accessions: B2R8H5 Q8N648

Alternative splicing: 2 isoforms: Q9BRT9-1 Q9BRT9-2

Explore the universe of human proteins at neXtProt for GINS4: NX_Q9BRT9

REFSEQ proteins: NP_115712.1

ENSEMBL proteins:

ENSP00000428901 ENSP00000429581 ENSP00000429894 ENSP00000403443 ENSP00000276533 ENSP00000428754

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	OriGene Purified Protein: GINS4 OriGene Protein Over-expression Lysate: GINS4
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	Novus Biologicals Lysate for GINS4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--

About this table

GINS4 for ontologies About GeneDecksing

Antibodies for GINS4:

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	Browse antibodies at Epitomics

Assays for GINS4:

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	Browse ELISAs at Sigma-Aldrich
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GINS4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GINS4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GINS4 for domains About GeneDecksing

2 InterPro domains/families:

IPR008591 GINS_Sld5

IPR021151 GINS_complex

Graphical View of Domain Structure for InterPro Entry Q9BRT9

ProtoNet protein and cluster: Q9BRT9

UniProtKB/Swiss-Prot: SLD5_HUMAN, Q9BRT9

Similarity: Belongs to the GINS4/SLD5 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SLD5_HUMAN, Q9BRT9

Function: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA

replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to

single-stranded DNA

Induction: Significantly up-regulated in agressive melanomas

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GINS4 Sigma-Aldrich shRNA for GINS4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GINS4 OriGene shRNA RFP (see all 2): GINS4 OriGene basic RS shRNA (see all 2): GINS4 OriGene siRNA (see all 2): GINS4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GINS4

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GINS4
		Search SABiosciences for Assays for microRNAs that regulate GINS4

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GINS4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GINS4 OriGene untagged cDNA clones in CMV expression vector (see all 2): GINS4 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GINS4
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GINS4

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

GINS4 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for GINS4

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GINS4

5/11 Interacting proteins for GINS4 (ENSP00000276533³ Q9BRT9²) via UniProtKB, MINT, and/or STRING (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GINS2	Q9Y248²	STRING: ENSP00000253462 MINT-67068
GINS1	ENSP00000262460³	STRING: ENSP00000262460
CDC45	ENSP00000263201³	STRING: ENSP00000263201
MCM5	ENSP00000216122³	STRING: ENSP00000216122
MCM8	ENSP00000368164³	STRING: ENSP00000368164

About this table

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006260	DNA replication	IEA	--
GO:0006271	DNA strand elongation involved in DNA replication	TAS	--

About this table

GINS4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GINS4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GINS4 Sigma-Aldrich shRNA for GINS4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GINS4 OriGene shRNA RFP (see all 2): GINS4 OriGene basic RS shRNA (see all 2): GINS4 OriGene siRNA (see all 2): GINS4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GINS4

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GINS4
		Search SABiosciences for Assays for microRNAs that regulate GINS4

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GINS4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GINS4 OriGene untagged cDNA clones in CMV expression vector (see all 2): GINS4 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GINS4

Primers:		OriGene genome-wide validated SYBR primer pairs: GINS4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GINS4: PPH17087A

REFSEQ mRNAs for GINS4 gene:

NM_032336.2

Additional cDNA sequence:

AK095334.1 AK299207.1 AK313373.1 BC005995.1 CR614079.1

5 DOTS entries:

DT.209398 DT.40130185 DT.120632092 DT.100777124 DT.75166538

24/72 AceView cDNA sequences (see all 72):

AI122644 BX281988 CB108685 BE466748 AI206910 BE142513 BC027454 BX362611

BE671848 AW296892 CR614079 AA310026 CA416527 AA531549 AA232133 N39391

CA489427 AW962153 BQ933807 BF516364 BF932889 BX097150 AW002923 BQ772681

highest scoring ESTs for GINS4:

BG539217 BM553604 CA416527 CA489427 CF140376 AI656986 AA176910 BU955742 CN413400 AA730889

Unigene Cluster for GINS4:

GINS complex subunit 4 (Sld5 homolog)

Hs.656996 [show with all ESTs]

Unigene Representative Sequence: NM_032336

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GINS4

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b
SP1:
SP2:					-
SP3:

About this scheme

ECgene alternative splicing isoforms for GINS4
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000520631 ENST00000522642 ENST00000523277 ENST00000520710 ENST00000520354

ENST00000428802 ENST00000520736 ENST00000518430 ENST00000276533(uc003xnx.2 uc003xny.2)

ENST00000518671

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GINS4 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching GINS4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
87976_at²^{, 3}	U95-E	1	0.50	1.00	1.00	1.00	AI656986	0.80	0.80	0.80	1
211767_at²^{, 3}	U133-A	1	0.46	1.00	--	--	BC005995	0.60	0.75	0.68	1
235029_at²^{, 3}	U133-B	1	0.27	1.00	--	--	H52284	0.40	0.67	0.55	1
211767_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--
235029_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--
1554356_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

GINS4 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GINS4 gene electronic northern expression

About these images

CGAP SAGE TAG: TCCAACTGCA

SOURCE GeneReport for Unigene cluster: Hs.656996

Primers:		OriGene genome-wide validated SYBR primer pairs: GINS4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GINS4: PPH17087A

SABiosciences Custom PCR Arrays for GINS4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GINS4 gene from 5/15 species (see all 15)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GINS4¹	--	GINS complex subunit 4 (Sld5 homolog)	86.55(n) 88.79(a)	482843 XM_539958.2 XP_539958.2
chimpanzee (Pan troglodytes)	GINS4¹	--	GINS complex subunit 4 (Sld5 homolog)	99.55(n) 99.55(a)	736437 XM_001138293.1 XP_001138293.1
cow (Bos taurus)	GINS4¹	--	GINS complex subunit 4 (Sld5 homolog)	84.45(n) 84.75(a)	616799 XM_868912.2 XP_874005.2
rat (Rattus norvegicus)	Gins4¹	--	GINS complex subunit 4 (Sld5 homolog)	86.7(n) 88.79(a)	290842 NM_001030027.1 NP_001025198.1
mouse (Mus musculus)	Gins4^{1 , 5}	8 (11.42 cM)⁵	GINS complex subunit 4 (Sld5 homolog)^{1, 5}	87.14(n)¹ 87.89(a)¹	109145¹ NM_024240.4¹ NP_077202.1¹ AI845486⁵ AK016667⁵ (see all 15)

About this table Species with no ortholog for GINS4

ENSEMBL Gene Tree for GINS4 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs933832^1,2	C,F,	41390754(-)	`TTACAG/TAAAGT`	1	--	int¹		7		NA EA WA	218
rs1559739^1,2	C,F,	41386411(-)	`CAGGCT/CGCTGC`	1	--	ng5¹		6		MN NA EA	350
rs2081499^1,2	C,F,A,	41390215(-)	`caacaC/Agcctg`	1	--	int¹		6		NA WA	12
rs3055452^1,2	--	41402616(-)	`AGCAA-/AACACTC`	1	--	ng3¹		0	--	--	--	--
rs3739369^1,2	C,F,A,H,	41402775(-)	`GATGAC/TGGATG`	1	--	ng3¹		11		EA NS NA WA	2128
rs3739370^1,2	C,F,A,	41402742(-)	`CATAGC/GGGCCT`	1	--	ng3¹		14		EA NA WA	1932
rs3808636^1,2	C,	41386465(+)	`CCGCCG/TCTCCC`	1	--	ng5¹		0	--	--	--	--
rs3808637^1,2	C,	41386531(+)	`CCGCAG/CAGCGG`	1	--	ng5¹		1		NA	2
rs3808638^1,2	C,F,	41386620(+)	`AGGCCG/TCCGCG`	1	--	ng5¹		4		NA WA	126
rs3808639^1,2	C,F,	41386674(+)	`CCCCGC/TTCTTC`	1	--	ng5¹ trp³		4		NA EA WA	212

About this table

HapMap Linkage Disequilibrium images for GINS4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GINS4: --

QIAGEN SeqTarget long-range PCR primers for resequencing GINS4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GINS4 for disorders About GeneDecksing

OMIM: 610611

Export disorders and mutations for GINS4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10 PubMed articles for GINS4 gene integrated from 7 sources:
(articles sorted by number of sources associating them with GINS4)

Structure of the human GINS complex and its assembly and functional interface in replication initiation. (PubMed id 17417653)^{1, 2} Kamada K.... Hanaoka F. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. (PubMed id 17611626)² Ryu B.... Alani R.M. (2007)
Crystal structure of the GINS complex and functional insights into its role in DNA replication. (PubMed id 17652513)² Chang Y.P.... Chen X.S. (2007)
The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. (PubMed id 17170760)² De Falco M....Pisani F.M. (2007)
Crystal structure of the human GINS complex. (PubMed id 17545466)² Choi J.M.... Cho Y. (2007)
Molecular architecture of the human GINS complex. (PubMed id 17557111)² Boskovic J.... Montoya G. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84296	HGNC: 28226	AceView: SLD5	Ensembl:ENSG00000147536	euGenes: HUgn84296
ECgene: GINS4	H-InvDB: GINS4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for GINS4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for GINS4 gene:
Search GeneIP for patents involving GINS4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GINS4		Antibodies for GINS4
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	Lentivirus-delivered shRNAs for GINS4		Browse microRNA Mimics at Sigma-Aldrich
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
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	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GINS4
	SeqTarget long-range PCR primers for resequencing GINS4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GINS4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GINS4

	GenScript Custom Purified and Recombinant Proteins Services for GINS4		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GINS4
	GenScript Custom Assay Services for GINS4		GenScript Custom Superior Antibodies Services for GINS4
	GenScript Custom overexpressing Cell Line Services for GINS4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GINS4 promoter
	Search Chromatin IP Primers for GINS4
	RT² qPCR Primer Assay for GINS4
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	SABiosciences Custom PCR Arrays for GINS4

Search Tocris compounds for GINS4

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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ELISAs and CLIAs for GINS4

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

GINS4 gene at Home site.

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GINS4 Gene

protein-coding GIFtS: 47

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Export list of displayed genes

GINS4 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor GINS4 gene

Summariesfor GINS4 gene

Genomic Viewsfor GINS4 gene

Proteinsfor GINS4 gene

Protein Domains/Familiesfor GINS4 gene

Gene Functionfor GINS4 gene

Pathways & Interactionsfor GINS4 gene

Drugs & Compoundsfor GINS4 gene

Transcriptsfor GINS4 gene

Expression for GINS4 gene

Orthologsfor GINS4 gene

Paralogsfor GINS4 gene

Genomic Variantsfor GINS4 gene

Disorders & Mutationsfor GINS4 gene

Medical Newsfor GINS4 gene

Publicationsfor GINS4 gene

External Searches for GINS4 gene

Genome Databases showing GINS4 gene

Other Databases showing GINS4 gene

Specialized Databases showing GINS4 gene

Intellectual Propertyfor GINS4 gene

Productsfor GINS4 gene

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Aliases &
Descriptions
for GINS4 gene

Summaries
for GINS4 gene

Genomic Views
for GINS4 gene

Proteins
for GINS4 gene

Protein Domains/
Families
for GINS4 gene

Gene Function
for GINS4 gene

Pathways & Interactions
for GINS4 gene

Drugs & Compounds
for GINS4 gene

Transcripts
for GINS4 gene

Expression
for GINS4 gene

Orthologs
for GINS4 gene

Paralogs
for GINS4 gene

Genomic Variants
for GINS4 gene

Disorders & Mutations
for GINS4 gene

Medical News
for GINS4 gene

Publications
for GINS4 gene

Intellectual Property
for GINS4 gene

Products
for GINS4 gene