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GLB1L3 Gene

protein-coding   GIFtS: 40

GC11P130101
galactosidase, beta 1-like 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
galactosidase, beta 1-like 31 2
FLJ902311 2
OTTHUMP000002057652
beta-galactosidase-1-like protein 32
galactosidase, beta 1 like 32
EC 3.2.1.-3

External Ids:    HGNC: 251471   Entrez Gene: 1129372   Ensembl: ENSG000001661057   UniProtKB: Q8NCI63   

Export aliases for GLB1L3 gene to outside databases

Previous GC identifers: GC11P133652 GC11P134145


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GLB1L3
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GLB1L3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q25   HGNC cytogenetic band: 11q25

GLB1L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GLB1L3 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P130101:  view genomic region     (about GC identifiers)

Start:
130,101,037 bp from pter
End:
130,144,384 bp from pter
Size:
43,348 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 134,145,464-134,189,458     
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GLBL3_HUMAN, Q8NCI6 (See protein sequence)
Recommended Name: Beta-galactosidase-1-like protein 3  
Size: 653 amino acids; 74823 Da
Secondary accessions: A6NEM0 A6NN15 Q6P3S3 Q96FF8
Alternative splicing: 3 isoforms:  Q8NCI6-1   Q8NCI6-2   Q8NCI6-4   

Explore the universe of human proteins at neXtProt for GLB1L3: NX_Q8NCI6 

REFSEQ proteins: NP_001073876.2  

ENSEMBL proteins: 
ENSP00000386533 ENSP00000374537 ENSP00000397929 ENSP00000396615 ENSP00000299136 ENSP00000388859 


Human Recombinant Proteins 
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Novus Biologicals Lysate for GLB1L3
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Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0009341 beta-galactosidase complex ----
About this table

GLB1L3 for ontologies           About GeneDecksing



Antibodies for GLB1L3: 
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Browse antibodies at Epitomics

Assays for GLB1L3: 
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OriGene Custom Immunoassay Development 
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for GLB1L3 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GLB1L3 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR017853 Glyco_hydro_catalytic_core
 IPR008979 Galactose-bd-like
 IPR013781 Glyco_hydro_sg_catalytic
 IPR001944 Glycoside_Hdrlase_35

Graphical View of Domain Structure for InterPro Entry Q8NCI6

ProtoNet protein and cluster: Q8NCI6

UniProtKB/Swiss-Prot: GLBL3_HUMAN, Q8NCI6
Similarity: Belongs to the glycosyl hydrolase 35 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GLB1L3
Sigma-Aldrich shRNA for GLB1L3
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GLB1L3
OriGene shRNA RFP (see all 2): GLB1L3
OriGene basic RS shRNA (see all 2): GLB1L3
OriGene siRNA (see all 2): GLB1L3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GLB1L3 
miRNA:Sigma-Aldrich microRNA Mimics for GLB1L3
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GLB1L3 
2 SABiosciences Assays for microRNAs that regulate GLB1L3:
hsa-miR-23b hsa-miR-23a

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: GLB1L3
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GLB1L3
OriGene untagged cDNA clones in CMV expression vector: GLB1L3
OriGene 3'-UTR clone: GLB1L3 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for GLB1L3 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for GLB1L3 

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA--
GO:0004565 beta-galactosidase activity ----
GO:0043169 cation binding IEA--
About this table

GLB1L3 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


GLB1L3 for pathways           About GeneDecksing

5/6 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GLB1L3 (see all 6)
    Glycosaminoglycan Degradation
Galactose Metabolism
Glycerolipid Metabolism
Sphingolipid Metabolism
Glycosphingolipid Biosynthesis - Ganglioseries

    SABiosciences Custom Pathway-Focused PCR Arrays for GLB1L3 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GLB1L3
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GLB1L3

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005975 carbohydrate metabolic process IEA--
About this table

GLB1L3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GLB1L3


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GLB1L3
Sigma-Aldrich shRNA for GLB1L3
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GLB1L3
OriGene shRNA RFP (see all 2): GLB1L3
OriGene basic RS shRNA (see all 2): GLB1L3
OriGene siRNA (see all 2): GLB1L3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GLB1L3 
miRNA: Sigma-Aldrich microRNA Mimics for GLB1L3
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GLB1L3 
2 SABiosciences Assays for microRNAs that regulate GLB1L3:
hsa-miR-23b hsa-miR-23a
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: GLB1L3
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GLB1L3
OriGene untagged cDNA clones in CMV expression vector: GLB1L3
OriGene 3'-UTR Clone: GLB1L3 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for GLB1L3 
Primers: OriGene genome-wide validated SYBR primer pairs: GLB1L3
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for GLB1L3: PPH20740A

REFSEQ mRNAs for GLB1L3 gene: 

NM_001080407.2  

Additional cDNA sequence: 

AK074712.1 BC011001.2 BC131702.1 

7 DOTS entries:

DT.101954563  DT.92053841  DT.100660936  DT.101981068  DT.95089170  DT.100727544  DT.40129379 

24/145 AceView cDNA sequences (see all 145):

BG386617 BQ899101 AI805064 AI379142 BU173188 AI262635 AA035048 BE382579 
BC008326 AI436113 BU168671 BQ678746 BF589594 T07976 BM721777 BM450486 
BQ677578 AI553835 AA306370 BC040641 BQ678539 BQ068659 NM_138342 BP377297 

highest scoring ESTs for GLB1L3:

BC040605 NM_138416 NM_173581 AK074712 AK124514 BC011001 BC063875 BE798113 AI557246 AW291395 

Unigene Cluster for GLB1L3:

Galactosidase, beta 1-like 3
Hs.721382  [show with all ESTs]
Unigene Representative Sequence: NM_001080407


GeneLoc Exon Structure

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000410100(uc009zdf.2 uc001qho.3) ENST00000389887(uc010scs.1 uc010sct.1)
ENST00000486034(uc010scu.1) ENST00000498012 ENST00000455971 ENST00000467068
ENST00000431683 ENST00000299136 ENST00000425777

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GLB1L3 expression in normal and diseased human tissues

1  / 2

2 probe-sets matching GLB1L3 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1569886_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
1562888_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
GLB1L3 gene expression
GLB1L3 gene electronic northern expression
GLB1L3 gene sage expression
About these images

CGAP SAGE TAG: TGCTGAGTGG

SOURCE GeneReport for Unigene cluster: Hs.721382
Primers: OriGene genome-wide validated SYBR primer pairs: GLB1L3
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for GLB1L3: PPH20740A
    SABiosciences Custom PCR Arrays for GLB1L3 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GLB1L3 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
GLB1L31   -- galactosidase, beta 1-like 3 74.56(n)
66.96(a)
489267  XM_546385.2  XP_546385.2 
cow
(Bos taurus)
GLB1L31   -- galactosidase, beta 1-like 3 73.28(n)
68.1(a)
522360  XM_600640.3  XP_600640.3 
rat
(Rattus norvegicus)
Glb1l31   -- galactosidase, beta 1-like 3 73.52(n)
67.62(a)
500961  NM_001024358.1  NP_001019529.1 
mouse
(Mus musculus)
Glb1l31 , 5 9 (11.67 cM)5
galactosidase, beta 1 like 31, 5 73.76(n)1
68.14(a)1
708931  XM_983469.11  XP_988563.11 
 AK0148525  BB2819185  (see all 9)
About this table        Species with no ortholog for GLB1L3

ENSEMBL Gene Tree for GLB1L3 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for GLB1L3 gene
GLB1L2  GLB1L22  GLB12  

GLB1L3 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/441 NCBI SNPs in GLB1L3 are shown (see all 441)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs4722871,2
C,134151975(-) TGTAGG/CGGCCT 2 /P /R mis1 ref1 ese39Minor allele frequency- C:0.05NA WA 78
rs4737981,2
C,F,134164552(+) cagccC/Ttgggc 1 -- int16Minor allele frequency- T:0.12NA EA 168
rs4778321,2
C,134158681(-) AAACAA/GGCATA 1 -- int15Minor allele frequency- G:0.00NS EA NA 492
rs4812521,2
C,F,A,134188542(-) AACACA/GAATCC 2 F syn1 ref1 ese320Minor allele frequency- G:0.43NS EA NA WA 1372
rs4832441,2
C,H,134164712(+) ctcagT/Cgcttc 1 -- int18Minor allele frequency- C:0.44NA WA 134
rs4857521,2
C,F,A,134159213(-) ctcccC/Tctcag 1 -- int1 trp37Minor allele frequency- T:0.27NA EA WA 218
rs4863601,2
C,F,H,134185247(-) TGAGAG/TCCCTA 1 -- int113Minor allele frequency- T:0.21NS EA NA WA 614
rs4891311,2
C,H,134178959(-) CCAGTA/GAAATG 1 -- int18Minor allele frequency- G:0.13NA EA WA 176
rs4923831,2
C,F,134153518(+) GGACCG/AGGGGT 1 -- int14Minor allele frequency- A:0.20NA 78
rs4934981,2
--134179384(+) cccaaA/Gaacgt 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for GLB1L3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for GLB1L3
     15/17 CNVs (see all 17): 53709 75855 86096 86097 75854 48743 75856 101382 75853 86098 4764 86095 29921 48744 5280

QIAGEN SeqTarget long-range PCR primers for resequencing GLB1L3 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GLB1L3 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: GLB1L3 (1 document)

Export disorders and mutations for GLB1L3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

5 PubMed articles for GLB1L3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with GLB1L3)
  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 112937 HGNC: 25147 AceView: LOC89944 Ensembl:ENSG00000166105 euGenes: HUgn112937
ECgene: GLB1L3 H-InvDB: GLB1L3

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for GLB1L3 gene:
Search GeneIP for patents involving GLB1L3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 SeqTarget long-range PCR primers for resequencing GLB1L3
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
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