Aliases &
Descriptions
for GNAO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| guanine nucleotide binding protein (G protein), alpha activating activitypolypeptide O1 2 | | G-ALPHA-o1 2 | | guanine nucleotide binding protein, alpha activating polypeptide O2 | | DKFZp686O09622 | | guanine nucleotide-binding protein G(o) subunit alpha2 | | GNAO2 |
Export aliases for GNAO1 gene to outside databasesPrevious GC identifers: GC16P046608 GC16P056277 GC16P055961 GC16P056001 GC16P056000 GC16P054783 |
Summaries
for GNAO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in varioustransmembrane signaling systems. The G(o) protein function is not clear
 summary
for GNAO1: Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind
directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in
cAMP levels respectively.
Gene Wiki entry for GNAO1 |
Genomic Views
for GNAO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GNAO1 gene promoter:
GCNF-1 GCNF-2 FOXJ2 (long isoform) RREB-1 FOXO1a AP-2gamma AP-2alphaA E4BP4 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for GNAO1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GNAO1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13GNAO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P042096: view genomic region
(about GC identifiers)
Start:
|
42,096,140 bp from pter |
End:
|
42,261,995 bp from pter |
Size:
|
165,856 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr16+ 56,225,302-56,391,354 |
RefSeq DNA sequence:- NC_000016.9 NT_010498.15
|
Proteins
for GNAO1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471 (See
protein sequence)Recommended Name: Guanine nucleotide-binding protein G(o) subunit alpha Size: 354 amino acids; 40051 Da
Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotidebinding site
Secondary accessions: P29777 Q8TD72 Q9UMV4Alternative splicing: 2 isoforms: P09471-1 P09471-2, P29777-1 Explore the universe of human proteins at neXtProt for GNAO1: NX_P09471
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_066268.1 NP_620073.2
ENSEMBL proteins: ENSP00000262493 ENSP00000262494
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
GNAO1 for ontologies About GeneDecksing
Antibodies for GNAO1:
Assays for GNAO1: |
Protein
Domains/
Families
for GNAO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GNAO1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P09471ProtoNet protein and cluster: P09471 2 Blocks protein families: IPB001019 Alpha G-protein (transducin) signature IPB001408 G-protein alpha subunit group I signature
UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily |
Gene Function
for GNAO1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GNAO_HUMAN, P09471Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in varioustransmembrane signaling systems. The G(o) protein function is not clear
Genatlas biochemistry entry for GNAO1:guanine nucleotide binding protein (G protein),alpha activating,polypeptide O5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8): About this table
GNAO1 for ontologies About GeneDecksing
Animal Models: 11 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Gnao1):
GNAO1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GNAO1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GNAO1 for pathways About GeneDecksing
5/25  Millipore Pathways for GNAO1 (see all 25)
5/20  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GNAO1 (see all 20)
4  Kegg Pathways (Kegg details for GNAO1):
SABiosciences Pathway-Focused PCR Arrays including GNAO1: PAHS-057A PAHS-404A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GNAO1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNAO1
5/104 Interacting proteins for GNAO1 (ENSP000002624933 P094712) via UniProtKB, MINT, and/or STRING (see all 104)About this table
5/18 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 18): About this table
GNAO1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GNAO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for GNAO1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Mastoparan X | G protein activator peptide | [72093-22-2] | | NF 023 | Selective, competitive P2X antagonist | [104869-31-0] | | Mastoparan | Activates Gi and Go | [72093-21-1] | | Pertussis Toxin | Catalyzes ADP-ribosylation of Gi, Go and Gt | [70323-44-3] |
About this table
|
Transcripts
for GNAO1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GNAO1 gene (2 alternative transcripts): NM_020988.2 NM_138736.2 Additional cDNA sequence: AF493894.1 AF493895.1 AK056008.1 AK295680.1 AL512686.1 BC012202.1 BC030027.2 BX647214.1 CR936770.1 Y18213.1 15 DOTS entries: DT.216381 DT.102831207 DT.422663 DT.75159089 DT.70104759 DT.101974960 DT.95141709 DT.91806146 DT.100815630 DT.120682481 DT.75150315 DT.86840748 DT.95141707 DT.120682463 DT.97841585 24/167 AceView cDNA sequences (see all 167): BF946900 BP360315 BQ963023 W96534 BP360345 AF493895 BQ185884 BI601581 AL512686 AA917031 AW298733 BE382670 BQ890623 BE673944 AI675696 AL134364 BQ069504 AF493894 BQ272003 BI669552 AL565628 BX118409 BQ184195 BQ184493
 highest scoring ESTs for GNAO1:AI806372 AA130853 AA447093 AI138327 AI186254 AI348443 AI498791 AI675696 AI702996 AI870007 Unigene Cluster for GNAO1: Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Hs.644524 [show with all ESTs]Unigene Representative Sequence: NM_138736
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GNAO1 (see all 9)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
|---|
|
| SP1: | | | | | - | | - | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | - | | | | |
| SP2: | | | | | - | | - | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for GNAO1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262493(uc002eit.3 uc002eiu.3) ENST00000262494
|
Expression
for GNAO1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GNAO1 expression in normal and diseased human tissues
1 / 2 / 3 15 probe-sets matching GNAO1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 34138_at2, 3
|
U95-A |
2 |
1.00 |
0.97 |
0.14 |
0.54 |
M60165 |
0.20 |
1.00 |
0.72 |
1 |
| 34698_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
0.94 |
0.81 |
M60165 |
0.20 |
1.00 |
0.72 |
1 |
| 91782_f_at2, 3
|
U95-D |
1 |
0.80 |
1.00 |
0.85 |
0.95 |
AI188097 |
0.60 |
1.00 |
0.82 |
1 |
| 90648_at2, 3
|
U95-E |
1 |
0.75 |
1.00 |
0.95 |
1.78 |
AI806372 |
1.00 |
1.00 |
1.00 |
1 |
| 91785_r_at2, 3
|
U95-D |
1 |
0.62 |
1.00 |
0.44 |
1.35 |
AI188097 |
0.60 |
1.00 |
0.82 |
1 |
| 69489_at2, 3
|
U95-E |
1 |
0.62 |
1.00 |
0.45 |
0.83 |
AI652415 |
0.40 |
1.00 |
0.76 |
1 |
| 236_at2, 3
|
U95-A |
1 |
0.38 |
1.00 |
0.91 |
0.88 |
M60165 |
0.20 |
1.00 |
0.72 |
1 |
| 204763_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_020988 |
0.60 |
1.00 |
0.82 |
1 |
| 204762_s_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
BE670563 |
0.80 |
1.00 |
0.91 |
1 |
| 215912_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AA758795 |
0.60 |
1.00 |
0.82 |
1 |
| 231951_at2, 3
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
AL512686 |
0.40 |
1.00 |
0.76 |
1 |
| 204763_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 204762_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215912_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 231951_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GNAO1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACCAATCCTA
SOURCE GeneReport for Unigene cluster: Hs.644524
Expression variation in blood from EXPOLDB for GNAO1 SABiosciences Expression via Pathway-Focused PCR Arrays including GNAO1: PAHS-057A PAHS-404A
|
Orthologs
for GNAO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GNAO1 gene from 5/12 species (see all 12)
About this table Species with no ortholog for GNAO1
ENSEMBL Gene Tree for GNAO1 (if available) |
Paralogs
for GNAO1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GNAO1 gene
- GNAQ2 GNA112 GNA142 GNA152
GNAO1 for paralogs About GeneDecksing
|
Genomic Variants
for GNAO1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 16 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GNAO1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for GNAO1
3 CNVs: 77349 49723 4957 | | QIAGEN SeqTarget long-range PCR primers for resequencing GNAO1 |
|
Disorders & Mutations
for GNAO1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GNAO1 for disorders About GeneDecksing
OMIM: 139311
Human Genome Epidemiology (HuGE) Navigator: GNAO1 (2 documents)
Export disorders and mutations for GNAO1 gene to outside databases
|
Medical News
for GNAO1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GNAO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/70 PubMed articles for GNAO1 gene, integrated from 7 sources (see all 70):
(articles sorted by number of sources associating them with GNAO1)- Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels. (PubMed id 11395521)1, 3 Kinoshita M....Kaneko S. (2001)
- Identification and expression of GO1 and 2 alpha-subunit transcripts in human myometrium in relation to pregnancy. (PubMed id 10330115)1, 2 Duc-Goiran P....Ferre F. (1999)
- Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16. (PubMed id 1899283)1, 3 Murtagh J.J....Vaughan M. (1991)
- Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. (PubMed id 1901650)1, 2 Tsukamoto T.... Kaziro Y. (1991)
- Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. (PubMed id 3124840)1, 2 Lavu S....Kung H.-F. (1988)
- CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-reg ulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-c ycle progression. (PubMed id 20097574)1 Kim J....Ko J. (2010)
- Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1 RuaA+o G....Wu A.H. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness. (PubMed id 19666700)1 Beqollari D....Kammermeier P.J. (2009)
- RGS11 interacts preferentially with R7BP over Galpha( oa)--characterization of Gbeta5-free RGS11. (PubMed id 19497306)1 Saleem Y. and Kim K.S. (2009)
|
External Searches for GNAO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GNAO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GNAO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNAO1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GNAO1 gene:
Search GeneIP for patents involving GNAO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GNAO1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |
| | | |
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| | |
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 | Antibodies & Assays for GNAO1 (Gnao) |
| | | | Tocris compounds for GNAO1 |
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