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GNB1 Gene

protein-coding   GIFtS: 64

GC01M000993
guanine nucleotide binding protein (G protein), beta polypeptide 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
guanine nucleotide binding protein (G protein), beta polypeptide 11 2
Transducin beta chain 12 3
guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 12
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-12
G protein, beta-1 subunit2
beta subunit, signal-transducing proteins GS/GI2

External Ids:    HGNC: 43961   Entrez Gene: 27822   Ensembl: ENSG000000783697   UniProtKB: P628733   

Export aliases for GNB1 gene to outside databases

Previous GC identifers: GC01M001274 GC01M001521 GC01M001585 GC01M001665 GC01M001748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GNB1:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector
proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related
genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of
certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. (provided by
RefSeq)

UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
GDP by GTP, and for G protein-effector interaction

summary for GNB1:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GNB1 gene promoter:
         NF-kappaB1   NF-kappaB   c-Fos   c-Jun   AP-1   Sp1   Chx10   p300   TFIID   TBP   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GNB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GNB1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

GNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GNB1 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M000993:  view genomic region     (about GC identifiers)

Start:
993,374 bp from pter
End:
1,099,450 bp from pter
Size:
106,077 bases
Orientation:
minus strand

1 alternative location:
Chr1- 1,716,725-1,822,495     
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873 (See protein sequence)
Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1  
Size: 340 amino acids; 37377 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2
PDB structure from and Proteopedia :
2QNS (3D)    3KJ5 (3D)    
Secondary accessions: B1AJZ7 P04697 P04901

Explore the universe of human proteins at neXtProt for GNB1: NX_P62873 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002065.1  

    ENSEMBL proteins: 
    ENSP00000399741 ENSP00000392765 ENSP00000367869 ENSP00000416870 ENSP00000388808 ENSP00000416651 
    ENSP00000367872 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GNB1
    GenScript Custom Purified and Recombinant Proteins Services for GNB1 
    Novus Biologicals Protein for GNB1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750 photoreceptor outer segment IEA--
    GO:0005834 heterotrimeric G-protein complex IDA1543505
    GO:0005886 plasma membrane TAS--
    About this table

    GNB1 for ontologies           About GeneDecksing



    Antibodies for GNB1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GNB1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for GNB1 
    Novus Biologicals Antibodies for GNB1
    Epitomics antibodies for GNB1

    Assays for GNB1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GNB1 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GNB1 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR016346 Guanine_nucleotide-bd_bsu
     IPR011046 WD40_repeat-like_dom
     IPR019781 WD40_repeat_sg

    Graphical View of Domain Structure for InterPro Entry P62873

    ProtoNet protein and cluster: P62873

    UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
    Similarity: Belongs to the WD repeat G protein beta family
    Similarity: Contains 7 WD repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873
    Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various
    transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of
    GDP by GTP, and for G protein-effector interaction

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for GNB1
    Sigma-Aldrich shRNA for GNB1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GNB1
    OriGene shRNA RFP (see all 2): GNB1
    OriGene basic RS shRNA (see all 2): GNB1
    OriGene siRNA: GNB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GNB1 
    miRNA:Sigma-Aldrich microRNA Mimics for GNB1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GNB1 
    1 SABiosciences Assays for microRNA that regulate GNB1:
    hsa-miR-101

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GNB1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GNB1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GNB1
    OriGene 3'-UTR clone: GNB1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: GNB1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GNB1 

    Genatlas biochemistry entry for GNB1:
    guanine nucleotide binding protein (G protein),beta,polypeptide 1

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664 G-protein-coupled receptor binding IEA--
    GO:0003924 GTPase activity IDA1543505
    GO:0004871 signal transducer activity IEA--
    GO:0005515 protein binding IEA--
    GO:0031702 type 1 angiotensin receptor binding IEA--
    About this table

    GNB1 for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gnb1):

    behavior/neurologicalcellularembryogenesislethality-prenatal/perinatalnervous system
    respiratory system

    GNB1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    GNB1 for pathways           About GeneDecksing

    5/31 Millipore Pathways for GNB1 (see all 31)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling

    5/29 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GNB1 (see all 29)
        Protein Kinase A Signaling
    CCR3 Signaling in Eosinophils
    Antiproliferative Role of Somatostatin Receptor 2
    Breast Cancer Regulation by Stathmin1
    Ephrin Receptor Signaling

    3 Kegg Pathways  (Kegg details for GNB1):
        hsa04062 Chemokine signaling pathway
    hsa04742 Taste transduction
    hsa04744 Phototransduction

        SABiosciences Pathway-Focused PCR Array including GNB1: PAHS-057A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GNB1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNB1

    5/331 Interacting proteins for GNB1 (ENSP000003678723 P628732) via UniProtKB, MINT, and/or STRING (see all 331)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI2P048992STRING: ENSP00000312999 MINT-7135221
    NCF2P198782MINT-7135210 MINT-7135236
    MAP3K3Q997592MINT-48439
    RIPK3Q9Y5722MINT-49116
    OR10G4ENSP000003250763STRING: ENSP00000364161 STRING: ENSP00000325076
    About this table

    5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112 energy reserve metabolic process TAS--
    GO:0007165 signal transduction TAS7649993
    GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger IEA--
    GO:0007204 elevation of cytosolic calcium ion concentration IEA--
    GO:0007213 muscarinic acetylcholine receptor signaling pathway TAS8717044
    About this table

    GNB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GNB1 available from Tocris Bioscience
    CompoundAction CAS number
    GalleinInhibitor of betagamma signaling[2103-64-2]
    About this table




    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for GNB1
    Sigma-Aldrich shRNA for GNB1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GNB1
    OriGene shRNA RFP (see all 2): GNB1
    OriGene basic RS shRNA (see all 2): GNB1
    OriGene siRNA: GNB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GNB1 
    miRNA: Sigma-Aldrich microRNA Mimics for GNB1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GNB1 
    1 SABiosciences Assays for microRNA that regulate GNB1:
    hsa-miR-101
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GNB1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GNB1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GNB1
    OriGene 3'-UTR Clone: GNB1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: GNB1 
    Primers: OriGene genome-wide validated SYBR primer pairs: GNB1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GNB1: PPH02802A

    REFSEQ mRNAs for GNB1 gene: 

    NM_002074.2  

    Additional cDNA sequence: 

    AF070597.1 AF070603.1 AF501882.1 AK096614.1 AK122949.1 AK312614.1 BC004186.2 BC005888.2 
    BC008991.1 BC114618.1 BT007305.1 CR456784.1 CR591784.1 CR592893.1 CR595196.1 CR606385.1 
    CR619305.1 CR623427.1 M36430.1 

    24/52 DOTS entries (see all 52):

    DT.454208  DT.100888224  DT.100039426  DT.92016370  DT.92411260  DT.100888249  DT.121355192  DT.121355194 
    DT.100888223  DT.121355210  DT.40275341  DT.120545  DT.436291  DT.75121609  DT.95169880  DT.100888219 
    DT.97765262  DT.121355278  DT.91831230  DT.95169843  DT.95169863  DT.100039424  DT.100888214  DT.100888221 

    24/1164 AceView cDNA sequences (see all 1164):

    BE259807 BM668653 BM669608 BM763354 AI536851 AI198247 AA937146 BG419079 
    AA928650 CA390282 CA848920 BQ027213 BF726932 CA844362 BM770499 AA937799 
    BM796265 CR595196 AI758676 AW498745 CA446314 BM918099 BG250536 CA314476 

    highest scoring ESTs for GNB1:

    AK122949 AL045024 AL535393 AL559125 AL559927 AW239530 AW411381 BC004186 BC008991 BE019158 

    Unigene Cluster for GNB1:

    Guanine nucleotide binding protein (G protein), beta polypeptide 1
    Hs.430425  [show with all ESTs]
    Unigene Representative Sequence: NM_002074


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GNB1 (see all 7)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:              -     -                 -                                                                                                         
    SP2:                                                                                -     -                             -           -               
    SP3:                                                                                -     -                             -                           
    SP4:                                                                                                                    -           -               
    SP5:                                                                                                                                                

    About this scheme

    ECgene alternative splicing isoforms for GNB1
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439272 ENST00000434686 ENST00000471354 ENST00000378606 ENST00000472614
    ENST00000455156 ENST00000424622 ENST00000437146 ENST00000378609(uc001aif.2 uc009vky.2)
    ENST00000461893

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GNB1 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching GNB1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33341_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X04526 0.40 1.00 0.76 1
    200745_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF070603 0.60 1.00 0.82 1
    200746_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002074 0.60 1.00 0.82 1
    200744_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI741124 0.60 1.00 0.82 1
    200745_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    200746_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    200744_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    GNB1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GNB1 gene expression
    GNB1 gene electronic northern expression
    GNB1 gene sage expression
    About these images

    CGAP SAGE TAG: CTGTAGAAAT

    SOURCE GeneReport for Unigene cluster: Hs.430425

    Expression variation in blood from EXPOLDB for GNB1

    Primers: OriGene genome-wide validated SYBR primer pairs: GNB1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GNB1: PPH02802A
        SABiosciences Expression via Pathway-Focused PCR Array including GNB1: PAHS-057A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GNB1 gene from 5/17 species (see all 17)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GNB11   -- guanine nucleotide binding protein (G protein), beta more 91.67(n)
    100(a)
    403912  NM_001003236.1  NP_001003236.1 
    chimpanzee
    (Pan troglodytes)
    GNB11   -- guanine nucleotide binding protein (G protein), beta more 94.46(n)
    93.75(a)
    469458  XM_524842.2  XP_524842.2 
    cow
    (Bos taurus)
    GNB11   -- guanine nucleotide binding protein (G protein), beta more 90.88(n)
    100(a)
    281201  NM_175777.3  NP_786971.2 
    rat
    (Rattus norvegicus)
    Gnb11   -- guanine nucleotide binding protein (G protein), beta more 90.1(n)
    98.82(a)
    24400  NM_030987.1  NP_112249.1 
    mouse
    (Mus musculus)
    Gnb11 , 5 4 (86.17 cM)5
    guanine nucleotide binding protein (G protein), beta more1, 5 90.2(n)1
    100(a)1
    146881  NM_008142.31  NP_032168.11 
     AA4092235  AB0428455  (see all 54)
    About this table        Species with no ortholog for GNB1

    ENSEMBL Gene Tree for GNB1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for GNB1 gene
    GNB22  GNB32  WDR472  GNB52  GNB42  

    GNB1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/910 NCBI SNPs in GNB1 are shown (see all 910)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9152921,2
    C,F,A,H,1792157(-) tctttT/Gttttt 1 -- int1 trp34Minor allele frequency- G:0.47NA EA 164
    rs10556381,2
    --1803779(-) TGCAGT/CGGGAA 1 -- int11Minor allele frequency- C:0.00MN 184
    rs10623631,2
    --1717618(-) TGTTTC/TCAAGA 1 -- ut31 ese30--------
    rs11243371,2
    H1789761(+) ACTGTC/GTTCTA 1 -- int14Minor allele frequency- G:0.38MN NS EA 458
    rs11243381,2
    H1789764(+) GTCTTC/GTAAAA 1 -- int15Minor allele frequency- G:0.00MN NS EA 602
    rs11339681,2
    --1803618(-) TACTTA/GAAGGA 1 -- int11Minor allele frequency- G:0.00MN 184
    rs11339691,2
    --1803592(-) attgtA/Ggcata 1 -- int10--------
    rs11948801,2
    --1798175(+) gatcaC/Tgaggt 1 -- int10--------
    rs12056181,2
    --1730573(+) ccaggA/Ctggtc 1 -- int10--------
    rs12123541,2
    --1798199(+) ccatcC/Ttggct 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for GNB1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for GNB1
         4 CNVs: 0002 97251 84002 3276
         2 Indels: 33196 74287

    QIAGEN SeqTarget long-range PCR primers for resequencing GNB1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GNB1 for disorders           About GeneDecksing

    OMIM: 139380

    1 Novoseek disease relationship for GNB1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 58.3 1 17167406 (1)
    About this table

    Genetic Association Database (GAD): GNB1
    Human Genome Epidemiology (HuGE) Navigator: GNB1 (3 documents)

    Export disorders and mutations for GNB1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/83 PubMed articles for GNB1 gene, integrated from 7 sources (see all 83):
    (articles sorted by number of sources associating them with GNB1)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. (PubMed id 14512443)1, 2 Niu J.... Voyno-Yasenetskaya T. (2003)
    3. Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (PubMed id 3095147)1, 2 Codina J.... Birnbaumer L. (1986)
    4. Association of the Asn306Ser variant of the SP4 trans cription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PubMed id 17356515)1, 7 Gao Y.Q....Farber D.B. (2007)
    5. A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa. (PubMed id 17167406)1, 7 Mylvaganam G.H....Dryja T.P. (2006)
    6. Differential regulation of phospholipase C-beta2 acti vity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2. (PubMed id 20007712)1 Gutman O....Henis Y.I. (2010)
    7. G protein betagamma subunits regulate cell adhesion t hrough Rap1a and its effector Radil. (PubMed id 20048162)1 Ahmed S.M....Angers S. (2010)
    8. Sex-specific proteome differences in the anterior cin gulate cortex of schizophrenia. (PubMed id 20381070)1 Martins-de-Souza D....Turck C.W. (2010)
    9. beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. (PubMed id 18729826)1 Yang M....Ye R.D. (2009)
    10. The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. (PubMed id 19917775)1 Knezevic N....Mehta D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2782 HGNC: 4396 AceView: GNB1 Ensembl:ENSG00000078369 euGenes: HUgn2782
    ECgene: GNB1 Kegg: 2782 H-InvDB: GNB1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for GNB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for GNB1 gene:
    Search GeneIP for patents involving GNB1

    GeneCards and IP:
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