Aliases &
Descriptions
for GNB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| guanine nucleotide binding protein (G protein), beta polypeptide 11 2 | | Transducin beta chain 12 3 | | guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 12 | | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-12 | | G protein, beta-1 subunit2 | | beta subunit, signal-transducing proteins GS/GI2 |
Export aliases for GNB1 gene to outside databasesPrevious GC identifers: GC01M001274 GC01M001521 GC01M001585 GC01M001665 GC01M001748 |
Summaries
for GNB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GNB1:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effectorproteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of relatedgenes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as ofcertain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. (provided byRefSeq)
UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement ofGDP by GTP, and for G protein-effector interaction
 summary
for GNB1: Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.
Gene Wiki entry for GNB1 |
Genomic Views
for GNB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GNB1 gene promoter:
NF-kappaB1 NF-kappaB c-Fos c-Jun AP-1 Sp1 Chx10 p300 TFIID TBP
Other transcription factors
Search SABiosciences Chromatin IP Primers for GNB1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GNB1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33GNB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M000993: view genomic region
(about GC identifiers)
Start:
|
993,374 bp from pter |
End:
|
1,099,450 bp from pter |
Size:
|
106,077 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr1- 1,716,725-1,822,495 |
RefSeq DNA sequence:- NC_000001.10 NT_004350.19
|
Proteins
for GNB1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873 (See
protein sequence)Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Size: 340 amino acids; 37377 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2
PDB structure from  and Proteopedia  :2QNS (3D)
3KJ5 (3D)
Secondary accessions: B1AJZ7 P04697 P04901Explore the universe of human proteins at neXtProt for GNB1: NX_P62873
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002065.1
ENSEMBL proteins: ENSP00000399741 ENSP00000392765 ENSP00000367869 ENSP00000416870 ENSP00000388808 ENSP00000416651 ENSP00000367872
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
GNB1 for ontologies About GeneDecksing
Antibodies for GNB1:
Assays for GNB1: |
Protein
Domains/
Families
for GNB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GNB1 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry P62873ProtoNet protein and cluster: P62873 UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873Similarity: Belongs to the WD repeat G protein beta familySimilarity: Contains 7 WD repeats |
Gene Function
for GNB1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GBB1_HUMAN, P62873Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement ofGDP by GTP, and for G protein-effector interaction
Genatlas biochemistry entry for GNB1:guanine nucleotide binding protein (G protein),beta,polypeptide 15 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
GNB1 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gnb1):
GNB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GNB1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GNB1 for pathways About GeneDecksing
5/31  Millipore Pathways for GNB1 (see all 31)
5/29  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GNB1 (see all 29)
3  Kegg Pathways (Kegg details for GNB1):
SABiosciences Pathway-Focused PCR Array including GNB1: PAHS-057A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GNB1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GNB1
5/331 Interacting proteins for GNB1 (ENSP000003678723 P628732) via UniProtKB, MINT, and/or STRING (see all 331)About this table
5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006112 | energy reserve metabolic process |
TAS | -- | | GO:0007165 | signal transduction |
TAS | 7649993 | | GO:0007200 | activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger |
IEA | -- | | GO:0007204 | elevation of cytosolic calcium ion concentration |
IEA | -- | | GO:0007213 | muscarinic acetylcholine receptor signaling pathway |
TAS | 8717044 |
About this table
GNB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GNB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for GNB1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Gallein | Inhibitor of betagamma signaling | [2103-64-2] |
About this table
|
Transcripts
for GNB1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GNB1 gene: NM_002074.2 Additional cDNA sequence: AF070597.1 AF070603.1 AF501882.1 AK096614.1 AK122949.1 AK312614.1 BC004186.2 BC005888.2 BC008991.1 BC114618.1 BT007305.1 CR456784.1 CR591784.1 CR592893.1 CR595196.1 CR606385.1 CR619305.1 CR623427.1 M36430.1 24/52 DOTS entries (see all 52): DT.454208 DT.100888224 DT.100039426 DT.92016370 DT.92411260 DT.100888249 DT.121355192 DT.121355194 DT.100888223 DT.121355210 DT.40275341 DT.120545 DT.436291 DT.75121609 DT.95169880 DT.100888219 DT.97765262 DT.121355278 DT.91831230 DT.95169843 DT.95169863 DT.100039424 DT.100888214 DT.100888221 24/1164 AceView cDNA sequences (see all 1164): BE259807 BM668653 BM669608 BM763354 AI536851 AI198247 AA937146 BG419079 AA928650 CA390282 CA848920 BQ027213 BF726932 CA844362 BM770499 AA937799 BM796265 CR595196 AI758676 AW498745 CA446314 BM918099 BG250536 CA314476
 highest scoring ESTs for GNB1:AK122949 AL045024 AL535393 AL559125 AL559927 AW239530 AW411381 BC004186 BC008991 BE019158 Unigene Cluster for GNB1: Guanine nucleotide binding protein (G protein), beta polypeptide 1 Hs.430425 [show with all ESTs]Unigene Representative Sequence: NM_002074
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GNB1 (see all 7)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for GNB1
10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000439272 ENST00000434686 ENST00000471354 ENST00000378606 ENST00000472614
ENST00000455156 ENST00000424622 ENST00000437146 ENST00000378609(uc001aif.2 uc009vky.2)
ENST00000461893
|
Expression
for GNB1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GNB1 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching GNB1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33341_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
X04526 |
0.40 |
1.00 |
0.76 |
1 |
| 200745_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF070603 |
0.60 |
1.00 |
0.82 |
1 |
| 200746_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_002074 |
0.60 |
1.00 |
0.82 |
1 |
| 200744_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AI741124 |
0.60 |
1.00 |
0.82 |
1 |
| 200745_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 200746_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 200744_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GNB1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGTAGAAAT
SOURCE GeneReport for Unigene cluster: Hs.430425
Expression variation in blood from EXPOLDB for GNB1 SABiosciences Expression via Pathway-Focused PCR Array including GNB1: PAHS-057A
|
Orthologs
for GNB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GNB1 gene from 5/17 species (see all 17)
About this table Species with no ortholog for GNB1
ENSEMBL Gene Tree for GNB1 (if available) |
Paralogs
for GNB1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GNB1 gene
- GNB22 GNB32 WDR472 GNB52 GNB42
GNB1 for paralogs About GeneDecksing
|
Genomic Variants
for GNB1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GNB1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for GNB1
4 CNVs: 0002 97251 84002 3276
2 Indels: 33196 74287 | | QIAGEN SeqTarget long-range PCR primers for resequencing GNB1 |
|
Disorders & Mutations
for GNB1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GNB1 for disorders About GeneDecksing
OMIM: 139380
1  Novoseek disease relationship for GNB1 gene
About this table
Genetic Association Database (GAD): GNB1
Human Genome Epidemiology (HuGE) Navigator: GNB1 (3 documents)
Export disorders and mutations for GNB1 gene to outside databases
|
Medical News
for GNB1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GNB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/83 PubMed articles for GNB1 gene, integrated from 7 sources (see all 83):
(articles sorted by number of sources associating them with GNB1)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. (PubMed id 14512443)1, 2 Niu J.... Voyno-Yasenetskaya T. (2003)
- Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (PubMed id 3095147)1, 2 Codina J.... Birnbaumer L. (1986)
- Association of the Asn306Ser variant of the SP4 trans cription factor and an intronic variant in the beta-subunit of transducin with digenic disease. (PubMed id 17356515)1, 7 Gao Y.Q....Farber D.B. (2007)
- A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa. (PubMed id 17167406)1, 7 Mylvaganam G.H....Dryja T.P. (2006)
- Differential regulation of phospholipase C-beta2 acti vity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2. (PubMed id 20007712)1 Gutman O....Henis Y.I. (2010)
- G protein betagamma subunits regulate cell adhesion t hrough Rap1a and its effector Radil. (PubMed id 20048162)1 Ahmed S.M....Angers S. (2010)
- Sex-specific proteome differences in the anterior cin gulate cortex of schizophrenia. (PubMed id 20381070)1 Martins-de-Souza D....Turck C.W. (2010)
- beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. (PubMed id 18729826)1 Yang M....Ye R.D. (2009)
- The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. (PubMed id 19917775)1 Knezevic N....Mehta D. (2009)
|
External Searches for GNB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GNB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GNB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNB1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GNB1 gene:
Search GeneIP for patents involving GNB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GNB1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Tocris compounds for GNB1 |
| |  |  |  |  | | | | |
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