Aliases &
Descriptions
for GNG10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| guanine nucleotide binding protein (G protein), gamma 101 2 | | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-102 | | guanine nucleotide binding protein 102 | | GNGT103 |
Export aliases for GNG10 gene to outside databasesPrevious GC identifers: GC09P105192 GC09P106125 GC09P107851 GC09P109773 GC09P111473 GC09P113435 GC09P113437 GC09P113439 GC09P113441 GC09P113443 GC09P113463 GC09P114423 |
Summaries
for GNG10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement ofGDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3
 summary
for GNG10: Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. There are several types of Galpha proteins; in addition, some
Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and
Gbetagamma coupled to M1 receptors can activate KIR channels.
|
Genomic Views
for GNG10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GNG10 gene promoter:
MRF-2 POU2F1 AhR LUN-1 Oct-B1 oct-B2 oct-B3 POU2F2 POU2F2 (Oct-2.1) POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for GNG10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GNG10  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q31.3GNG10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P084022: view genomic region
(about GC identifiers)
Start:
|
84,022,381 bp from pter |
End:
|
84,031,039 bp from pter |
Size:
|
8,659 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr9+ 114,423,615-114,432,504 |
RefSeq DNA sequence:- NC_000009.11 NT_008470.19
|
Proteins
for GNG10 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151 (See
protein sequence)Recommended Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 precursor Size: 68 amino acids; 7205 Da
Subunit: G proteins are composed of 3 units, alpha, beta and gamma
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q3B7K2 Q4VC27Explore the universe of human proteins at neXtProt for GNG10: NX_P50151
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001017998.1 NP_001185593.1
ENSEMBL proteins: ENSP00000384131 ENSP00000363411
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005834 | heterotrimeric G-protein complex |
IEA | -- | | GO:0005886 | plasma membrane |
TAS | -- |
About this table
GNG10 for ontologies About GeneDecksing
Antibodies for GNG10:
Assays for GNG10: |
Protein
Domains/
Families
for GNG10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GNG10 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P50151ProtoNet protein and cluster: P50151 1 Blocks protein family: IPB001770 Gamma G-protein (transducin) signature
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Similarity: Belongs to the G protein gamma family |
Gene Function
for GNG10 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement ofGDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
GNG10 for ontologies About GeneDecksing
|
Pathways & Interactions
for GNG10 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GNG10 for pathways About GeneDecksing
5/31  Millipore Pathways for GNG10 (see all 31)
5/26  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GNG10 (see all 26)
1  Kegg Pathway (Kegg details for GNG10):
SABiosciences Pathway-Focused PCR Array including GNG10: PAHS-057A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GNG10
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GNG10
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
GNG10 for ontologies About GeneDecksing
|
Drugs & Compounds
for GNG10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
GNG10 for compounds About GeneDecksing
Compounds for GNG10 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Gallein | Inhibitor of betagamma signaling | [2103-64-2] |
About this table
2 PharmGKB drug compound relationships for GNG10 geneAbout this table
|
Transcripts
for GNG10 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GNG10 gene (2 alternative transcripts): NM_001017998.3 NM_001198664.1 Additional cDNA sequence: AF493877.1 CR591877.1 CR600176.1 16 DOTS entries: DT.447210 DT.102825661 DT.100801491 DT.97859257 DT.100782535 DT.100804852 DT.102843169 DT.121161912 DT.100037643 DT.100801483 DT.121161927 DT.95324778 DT.97766995 DT.99940566 DT.91875463 DT.92444000 24/443 AceView cDNA sequences (see all 443): AA609936 AI246376 CR619882 BU789338 AF493877 AI017495 AV682714 AA282816 BQ435308 AW583628 AA285035 CR617193 CB163650 AA857327 AW628387 AI628655 AI942224 CR608208 AA643882 AW629006 AI133376 AI370774 BG171646 BU070845
 highest scoring ESTs for GNG10:U31383 AA028974 AA031966 AA131926 AA248353 AA285035 AA373814 AA460286 AA461574 AA503275 Unigene Clusters for GNG10: Guanine nucleotide binding protein (G protein), gamma 10 Hs.534196 [show with all ESTs], Hs.656890 [show with all ESTs]Unigene Representative Sequences: AF447177, BQ067907
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402373 ENST00000374293(uc011lws.1 uc004bfp.2)
|
Expression
for GNG10 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GNG10 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching GNG10 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37735_at2, 3
|
U95-A |
2 |
1.00 |
0.84 |
1.00 |
1.00 |
U31383 |
1.00 |
0.80 |
0.91 |
1 |
| 201921_at2, 3
|
U133-A |
2 |
1.00 |
0.91 |
-- |
-- |
NM_004125 |
0.60 |
1.00 |
0.82 |
1 |
| 201921_at2
|
U133Plus2 |
2 |
1.00 |
0.91 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GNG10 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAAATATTAC
SOURCE GeneReport for Unigene clusters: Hs.534196 Hs.656890
Expression variation in blood from EXPOLDB for GNG10 UniProtKB/Swiss-Prot: GBG10_HUMAN, P50151Tissue specificity: Abundantly and ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including GNG10: PAHS-057A
|
Orthologs
for GNG10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GNG10 gene from 5/8 species (see all 8)
About this table Species with no ortholog for GNG10
ENSEMBL Gene Tree for GNG10 (if available) |
Paralogs
for GNG10 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GNG10 gene
- GNG82 GNG22 GNG72 GNG52 GNG5P22 LOC1002890602 GNG32 GNG42
- GNG122
GNG10 for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for GNG10 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing GNG10 |
|
Disorders & Mutations
for GNG10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GNG10 for disorders About GeneDecksing
OMIM: 604389
1 PharmGKB disease relationship for GNG10 geneAbout this table
Export disorders and mutations for GNG10 gene to outside databases
|
Medical News
for GNG10 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GNG10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
7 PubMed articles for GNG10 gene integrated from 7 sources:
(articles sorted by number of sources associating them with GNG10)- Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. (PubMed id 7665596)1, 2, 3 Ray K.... Robishaw J.D. (1995)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. (PubMed id 12704389)5 Cheok M.H....Evans W.E. (2003)
- Glucagon and regulation of glucose metabolism. (PubMed id 12626323)1 Jiang G. and Zhang B.B. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GNG10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GNG10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GNG10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GNG10 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GNG10 gene:
Search GeneIP for patents involving GNG10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GNG10 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Tocris compounds for GNG10 |
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