Aliases &
Descriptions
for GOLGA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| golgin A51 2 | | rfg51 | | RFG52 3 5 | | Golgin subfamily A member 52 | | ret-II1 2 | | golgi integral membrane protein 52 | | golgin-841 2 | | RETII3 | | golgi autoantigen, golgin subfamily a, 51 2 | | Protein Ret-II3 | | GOLIM51 2 | | Golgin-843 | | Cell proliferation-inducing gene 31 protein2 3 | | PTC55 | | RET-fused gene 5 protein2 3 | | |
Export aliases for GOLGA5 gene to outside databasesPrevious GC identifers: GC14P090767 GC14P087077 GC14P091250 GC14P092330 GC14P093260 |
Summaries
for GOLGA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GOLGA5:
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway,consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubulesare thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodesone of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein thathas been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the retproto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5.(provided by RefSeq)
UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6Function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved inintra-Golgi retrograde transport
Gene Wiki entry for GOLGA5 |
Genomic Views
for GOLGA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GOLGA5 gene promoter:
RFX1 GATA-1 STAT5A MIF-1 FOXO3b FOXO3a STAT1beta STAT1alpha STAT1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for GOLGA5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GOLGA5  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14qGOLGA5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P073443: view genomic region
(about GC identifiers)
Start:
|
73,443,661 bp from pter |
End:
|
73,489,349 bp from pter |
Size:
|
45,689 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr14+ 93,260,650-93,306,304 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for GOLGA5 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6 (See
protein sequence)Recommended Name: Golgin subfamily A member 5 Size: 731 amino acids; 83024 Da
Subunit: Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1.Interacts with isoform CASP of CUX1
Subcellular location: Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Found throughout the Golgi,both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network
Sequence caution: Sequence=CAA33787.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originatingfrom chromosomes 14 and 10;
Secondary accessions: O95287 Q03962 Q2TS49 Q9UQQ7Alternative splicing: 2 isoforms: Q8TBA6-1 Q8TBA6-2 Explore the universe of human proteins at neXtProt for GOLGA5: NX_Q8TBA6
Post-translational modifications:
Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005104.2
ENSEMBL proteins: ENSP00000163416 ENSP00000401543 ENSP00000348252
Human Recombinant Proteins
5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10): About this table
GOLGA5 for ontologies About GeneDecksing
Antibodies for GOLGA5:
Assays for GOLGA5: |
Protein
Domains/
Families
for GOLGA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GOLGA5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TBA6ProtoNet protein and cluster: Q8TBA6 |
Gene Function
for GOLGA5 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6Function: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved inintra-Golgi retrograde transport
Genatlas biochemistry entry for GOLGA5:Golgi autoantigen,golgin-84,subfamily A,member 5,ubiquitously expressed,abundantly in testis,forming the RET-IIoncogene when fused by its coiled coil domain to the RET tyrosine kinase domain5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
GOLGA5 for ontologies About GeneDecksing
|
Pathways & Interactions
for GOLGA5 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for GOLGA5
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GOLGA5
1 Interacting protein for GOLGA5 (ENSP000001634163) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
GOLGA5 for ontologies About GeneDecksing
|
Drugs & Compounds
for GOLGA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
GOLGA5 for compounds About GeneDecksing
 Browse Tocris compounds for GOLGA5
1  Novoseek chemical compound relationship for GOLGA5 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
15.7 |
1 |
9915833 (1) |
About this table
|
Transcripts
for GOLGA5 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
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|
REFSEQ mRNAs for GOLGA5 gene: NM_005113.2 Additional cDNA sequence: AF085199.1 AJ132949.1 AK293077.1 AK303789.1 AY644768.1 BC010134.2 BC023021.1 BX248744.1 CR608254.1 12 DOTS entries: DT.418802 DT.120754669 DT.100026359 DT.101981921 DT.100798232 DT.100688610 DT.100798234 DT.100805827 DT.100798233 DT.100800338 DT.40122962 DT.80102031 24/212 AceView cDNA sequences (see all 212): AI346630 BM718473 AA127732 AA235507 BU163136 AA699342 BM458123 CR608254 BI793315 AA292442 AV651967 BQ014692 BX248744 AA292491 AA403145 AA706464 AV650230 BQ218736 AA464057 AV681596 CA389169 CD513087 AA402735 BG938455
 highest scoring ESTs for GOLGA5:AI628115 AA007590 AA055091 AA121507 AA127732 AA235507 AA292491 AA385269 AA401081 AA405148 Unigene Cluster for GOLGA5: Golgin A5 Hs.104320 [show with all ESTs]Unigene Representative Sequence: NM_005113
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000163416(uc001yaz.1) ENST00000439315 ENST00000355976(uc001yba.1)
|
Expression
for GOLGA5 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GOLGA5 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching GOLGA5 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 50346_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AI628115 |
1.00 |
1.00 |
1.00 |
1 |
| 218241_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_005113 |
0.60 |
1.00 |
0.82 |
1 |
| 218241_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GOLGA5 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTACAGGCTT
SOURCE GeneReport for Unigene cluster: Hs.104320
UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6Tissue specificity: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected atmuch lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa
SABiosciences Custom PCR Arrays for GOLGA5
|
Orthologs
for GOLGA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GOLGA5 gene from 5/13 species (see all 13)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
GOLGA51 |
-- |
golgi autoantigen, golgin subfamily a, 5 |
89.27(n)
90.96(a) |
480233 XM_537356.2 XP_537356.2 |
chimpanzee
(Pan troglodytes) |
GOLGA51 |
-- |
golgi autoantigen, golgin subfamily a, 5 |
99.32(n)
99.32(a) |
453119 XM_001148857.1 XP_001148857.1 |
cow
(Bos taurus) |
GOLGA51 |
-- |
golgi autoantigen, golgin subfamily a, 5 |
89.06(n)
89.33(a) |
510412 XM_587552.3 XP_587552.2 |
rat
(Rattus norvegicus) |
Golga51 |
-- |
golgi autoantigen, golgin subfamily a, 5 |
83.93(n)
84.75(a) |
299258 NM_001033065.1 NP_001028237.1 |
mouse
(Mus musculus) |
Golga51 , 5 |
12 (51.51 cM)5
|
golgi autoantigen, golgin subfamily a, 51, 5 |
83.36(n)1
84.32(a)1 |
272771 NM_013747.21 NP_038775.11
AA4149335 AB0167845 (see all 14) |
About this table Species with no ortholog for GOLGA5
ENSEMBL Gene Tree for GOLGA5 (if available) |
Paralogs
for GOLGA5 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for GOLGA5 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 14 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GOLGA5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GOLGA5
1 Indel: 58697 | | QIAGEN SeqTarget long-range PCR primers for resequencing GOLGA5 |
|
Disorders & Mutations
for GOLGA5 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GOLGA5 for disorders About GeneDecksing
OMIM: 606918 disorders: 188550 UniProtKB/Swiss-Prot: GOGA5_HUMAN, Q8TBA6
Defects in GOLGA5 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of thethyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillarycarcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections offibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberrationinvolving GOLGA5 is found in thyroid papillary carcinomas. Translocation t(10;14)(q11;q32) with RET. The translocationgenerates the RET/GOLGA5 (PTC5) oncogene which was found in 2 cases of PACT in children exposed to radioactive falloutafter Chernobyl
1 Novoseek disease relationship for GOLGA5 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
9443391 (1) |
About this table
Human Gene Mutation Database (HGMD): GOLGA5
Export disorders and mutations for GOLGA5 gene to outside databases
|
Medical News
for GOLGA5 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GOLGA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for GOLGA5 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with GOLGA5)- Detection of a novel type of Ret rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved Ret-fused gene RFG5. (PubMed id 9443391)1, 2, 3, 7 Klugbauer S.... Rabes H.M. (1998)
- Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing. (PubMed id 2734021)1, 2, 3 Ishizaka Y.... Nahao M. (1989)
- Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. (PubMed id 9915833)1, 2, 7 Bascom R.A.... Nussbaum R.L. (1999)
- The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. (PubMed id 12538640)1, 2, 7 Diao A.... Lowe M. (2003)
- Golgin tethers define subpopulations of COPI vesicles. (PubMed id 15718469)1, 2, 7 Malsam J.... Warren G. (2005)
- The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PubMed id 15004235)1, 3, 7 Oka T....Krieger M. (2004)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for GOLGA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GOLGA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GOLGA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GOLGA5 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GOLGA5 gene:
Search GeneIP for patents involving GOLGA5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GOLGA5 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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